Frontiers in Cell and Developmental Biology

Original Research

Published on 04 Jun 2025

Platinum(IV) anticancer therapies and cathepsin B: innovative strategies for overcoming resistance in glioblastoma cells

in Cancer Cell Biology

Claudio Casali
Ludovica Gaiaschi
Enrico Pelloni
Federica Gola
Margherita Cavallo
Gloria Milanesi
Mauro Ravera
Marco Biggiogera
Fabrizio De Luca
Maria Grazia Bottone

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1506206

184 views

Original Research

Published on 04 Jun 2025

Identifying a prognostic signature for clear cell renal cell carcinoma: the convergence of single-cell and bulk sequencing with machine learning

in Cancer Cell Biology

Yude Hong
Xiao Hu
Libo Chen
Mingyong Li
Mingxiao Zhang
Weiming Deng

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1560095

242 views

Original Research

Published on 04 Jun 2025

Mechanistic insights curcumin’s anti-inflammatory in pancreatic cancer: experimental and computational evidence implicating IL1B interference via IL10RA upregulation and NLRP3/TLR3 downregulation

in Cancer Cell Biology

Jun-Feng Cao
Kuan Hang
Hao Zhang
Qingjie Xia
Xiao Zhang
Jie Men
Jin Tian
Zengliang Xia
Dunshui Liao
Kezhou Li

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1601908

291 views

Original Research

Published on 03 Jun 2025

Deep spatial sequencing revealing differential immune responses in human hepatocellular carcinoma

in Cancer Cell Biology

Yan-Ping Yu
Caroline Obert
Bao-Guo Ren
Marielle Krivit
Kyle Metcalfe
Jia-Jun Liu
Tuval Ben-Yehezkel
Silvia Liu
Jian-Hua Luo

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1600129

270 views

Original Research

Published on 03 Jun 2025

Intercellular communication between extracellular vesicles from conditioned macrophages and breast cancer cells drives endocrine therapy resistance

in Cancer Cell Biology

María C. Rodriguez-Baili
Miguel Palma-Cobo
César G. Prucca
María Yáñez-Mó
German A. Gil

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1548724

372 views

Review

Accepted on 02 Jun 2025

The role and therapeutic potential of glucose metabolism in multidrug resistance of cancer

in Cancer Cell Biology

Ping Lin
Qijing Wang
Kai Li
Liang Li
Qin Li
Yanyu Qi
Kai Liu
Hang Yuan

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1584630

Mini Review

Published on 02 Jun 2025

Microbiota dysbiosis impact on the metabolism of T3 and T4 hormones and its association with thyroid cancer

in Cancer Cell Biology

Santiago Cadena-Ullauri
Patricia Guevara-Ramírez
Elius Paz-Cruz
Viviana A. Ruiz-Pozo
Rafael Tamayo-Trujillo
Ana Karina Zambrano

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1589726

313 views

Review

Accepted on 30 May 2025

The Role of SIRT1 in The Development of Gastrointestinal Tumors

in Cancer Cell Biology

Yueming Zhang
Xiaokai Zhou
Jinghui Zhai
Jie Ma
Sixi Zhang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1606530

122 views

Review

Published on 30 May 2025

NK cell activity in the tumor microenvironment

in Cancer Cell Biology

A. V. Kuznetsova
X. A. Glukhova
I. P. Beletsky
A. A. Ivanov

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1609479

322 views

Original Research

Accepted on 23 May 2025

ELOVL2 Mediated Stabilization of AR Contributes to Enzalutamide Resistance in Prostate Cancer

in Cancer Cell Biology

Jinpeng Cen
Jiading Guo
Xianzi Zeng
Xianlu Song
Shengdong Ge
Mingkun Chen
Qianyi Li
Yuzhong Yu
Daojun Lv
Shanchao Zhao

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1598400

389 views

Original Research

Published on 23 May 2025

A dual inhibitor of TrxR1 and XIAP induces pyroptosis in melanoma

in Cancer Cell Biology

Yuan Wang
Xiangmei Li
Xinyue Dong
Haokun Yuan
Ruiqin Fang
Ran Zhang
Wei-jia Wang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1542356

365 views

Review

Published on 23 May 2025

Atypical Hippo signaling network: uncovering novel insights into head and neck cancer biology and advancements in precision intervention

in Cancer Cell Biology

Pengfei Yang
Shujuan Li

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1610471

377 views

Review

Published on 22 May 2025

Organoids technology in cancer research: from basic applications to advanced ex vivo models

in Cancer Cell Biology

Luca Varinelli
Oscar Illescas
Ewelina Julia Lorenc
Davide Battistessa
Marzia Di Bella
Susanna Zanutto
Manuela Gariboldi

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1569337

646 views

Review

Published on 15 May 2025

Hypoxia-driven angiogenesis and metabolic reprogramming in vascular tumors

in Cancer Cell Biology

Lu Liu
Jiayun Yu
Yang Liu
Liang Xie
Fan Hu
Hanmin Liu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1572909

652 views

Review

Published on 14 May 2025

Insights into the mechanisms of angiogenesis in hepatoblastoma

in Cancer Cell Biology

Meng Kong
Yunpeng Zhai
Hongzhen Liu
Shisong Zhang
Shuai Chen
Wenfei Li
Xiang Ma
Yi Ji

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1535339

939 views

Original Research

Published on 14 May 2025

FLAIR-based radiomics signature from brain-tumor interface for early prediction of response to EGFR-TKI therapy in NSCLC patients with brain metastasis

in Cancer Cell Biology

Chunna Yang
Yiyao Sun
Mingchen Jiang
Ying Fan
Yanjun Hu
Qianhui Zhang
Yan Zhang
Yan Wang
Xiran Jiang
Zekun Wang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1525989

834 views