Monoclonal antibodies (mAbs) are potent antiviral therapeutics that offer advantages, including post-exposure protection and protection for immunocompromised individuals. They can be modified to express antigen-specific paratopes in mono-specific, bi-specific, and multi-specific formats. Most available mAbs are approved as cancer and auto-immune medications. However, the utility of antiviral mAbs has been underscored by their successful deployment against many viruses, such as Ebola virus, human respiratory syncytial virus, human cytomegalovirus, influenza virus, and SARS-CoV-2 (). This Research Topic, “Antiviral Monoclonal Antibody Therapies,” highlights recent advances in mAb development and their utility against rapidly evolving viral pathogens.
Production cost is a major hurdle that needs to be overcome to enable the widespread use of antiviral mAb treatments in low-income communities and countries. Shanmugaraj et al. demonstrate that Nicotiana benthamiana is a powerful cost-effective platform for producing mAbs in a scalable and affordable manner. This work describes the first report of SARS-CoV-2-specific mAbs produced in a plant expression system and characterizes their ability to retain neutralization properties in vitro.
Another important factor to consider with antiviral mAb therapeutics, is the emergence of escape variants and their recalcitrance to vaccines and mAb treatments. Two studies in this Research Topic describe different approaches to solving this problem. One highlights the utility of bispecific mAbs, which can be engineered to increase the breadth of mAbs (Yu et al.). The second delineates a simple and traditional hybridoma approach to mAb development and describes the development of a broadly neutralizing mouse anti-SARS-CoV-2-Spike mAb that neutralizes different SARS-CoV-2 variants (Wen et al.). Broadly reactive mAbs that target conserved epitopes are attractive targets because they are less likely to result in escape mutations due to the lower fitness of generated mutants.
Finally, Kim et al. performed a retrospective multicenter study in South Korea to analyze the effectiveness of Regdanvimab, a SARS-CoV-2-specific mAb, in a hospitalized COVID-19 cohort. They found that compared to the group that received supportive care, patients that received Regdanvimab had reduced progression to severe disease. This was true for the overall study population but not for the patients infected with the SARS-CoV-2 delta variant. This work highlights the potential clinical benefits of antiviral mAb treatments, but also demonstrates that treatment regimens need to be optimized as new variants emerge.
With this Research Topic of research articles, we aim to highlight recent advances in the development and production of antiviral mAbs. As emerging and re-emerging viral pathogens continue to cause outbreaks in human populations, a need for effective, flexible, and affordable antiviral treatments is ever-present.
Statements
Author contributions
CF: Conceptualization, Writing – original draft, Writing – review & editing. RJ: Conceptualization, Writing – review & editing. DH: Writing – review & editing.
Funding
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was partly supported by grants (R21AI156482 and P20GM134974 to RJ) from the National Institutes of Health, USA.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Author disclaimer
Opinions, conclusions, interpretations, and recommendations are those of the authors and are not necessarily endorsed by the US Department of the Army, the US Department of Defense, or the US Department of Health and Human Services.
Reference
1
PantaleoG.CorreiaB.FenwickC.JooV. S.PerezL. (2022). Antibodies to combat viral infections: development strategies and progress. Nat. Rev. Drug Discovery21, 676–696. doi: 10.1038/s41573-022-00495-3
Summary
Keywords
monoclonal Abs, antiviral, SARS-CoV-2, COVID, bispecific Ab
Citation
Florez C, Haslwanter D and Jangra RK (2024) Editorial: Antiviral monoclonal antibody therapies. Front. Cell. Infect. Microbiol. 14:1484448. doi: 10.3389/fcimb.2024.1484448
Received
21 August 2024
Accepted
16 September 2024
Published
10 October 2024
Volume
14 - 2024
Edited and reviewed by
Sherry Dunbar, Luminex, United States
Updates
Copyright
© 2024 Florez, Haslwanter and Jangra.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Catalina Florez, catalina.florez.ctr@health.mil; Denise Haslwanter, denise.haslwanter@gmail.com; Rohit K. Jangra, rohit.jangra@lsuhs.edu
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.