REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Extra-intestinal Microbiome
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1559870
This article is part of the Research TopicNavigating the Microbial Landscape: Integrating Mass Spectrometry Imaging and Other Multimodal Imaging Approaches for Spatially Resolved Microbial StudiesView all articles
Microbiome in cancer metastasis: Biological insights and emerging spatial omics methods
Provisionally accepted
- 1Department of Life Sciences and Medicine, University of Luxembourg, Belvaux, Luxembourg, Luxembourg
- 2Luxembourg Institute of Science and Technology (LIST), Esch-sur-Alzette, Luxembourg
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The role of the microbiome in cancer metastasis has emerged as a critical area of research, with growing evidence suggesting that microbial composition and interactions within the tumour microenvironment may significantly influence metastatic progression. This review explores the role of the microbiome in cancer metastasis, as well as potential key bacteria and their mechanisms through which they could impact tumour dissemination, seeding and growth. Biological models used to study metastasis are discussed to provide context for the further investigation of these interactions. In order to answer unresolved questions regarding the microbiome's involvement in metastatic dissemination, recent advancements in spatial biology techniques are examined, including spatial genomics, transcriptomics, proteomics and metabolomics, which enable the spatial mapping of microbial interactions within the tumour microenvironment. Additionally, multimodal-omics imaging approaches are highlighted for their potential to integrate multiple molecular layers, offering comprehensive insights into the microbiome’s role in cancer metastasis. The review also addresses the challenges and limitations of these techniques, underscoring the complexity of studying microbiome-tumour interactions and offering directions for future research to better explore and target the microbiological landscape in metastatic cancer.
Keywords: cancer metastasis, microbiome, spatial omics, Host-Microbiome Interactions, tumour microenvironment
Received: 14 Jan 2025; Accepted: 05 May 2025.
Copyright: © 2025 Meyers, Stoffels, Frache, Letellier and Feucherolles. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Maureen Feucherolles, Luxembourg Institute of Science and Technology (LIST), Esch-sur-Alzette, Luxembourg
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