REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1563061
This article is part of the Research TopicUnderstanding the Role of Microbiome in Alteration of Cellular Metabolism and Cancer DevelopmentView all 9 articles
Microbiota and gastric cancer: From molecular mechanisms to therapeutic strategies
Provisionally accepted
- 1Gansu Provincial Hospital, Lanzhou, Gansu Province, China
- 2First Hospital of Lanzhou University, Lanzhou, Gansu Province, China
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Gastric cancer, a prevalent malignancy globally, is influenced by various factors. The imbalance in the gut microbiome and the existence of particular intratumoural microbiota could have a strong connection with the onset and progression of gastric cancer. High-throughput sequencing technology and bioinformatics analysis have revealed a close correlation between abnormal abundance of specific microbial communities and the risk of gastric cancer. These microbial communities contribute to gastric cancer progression through mechanisms including increasing cellular genomic damage, inhibiting DNA repair, activating abnormal signaling pathways, exacerbating tumor hypoxia, and shaping a tumor immune-suppressive microenvironment. This significantly impacts the efficacy of gastric cancer treatments, including chemotherapy and immunotherapy. Probiotic, prebiotic, antibiotic, carrier-based, dietary interventions, fecal microbiota transplantation, and traditional Chinese medicine show potential applications in gastric cancer treatment. However, the molecular mechanisms regarding dysbiosis of microbiota, including gut microbiota, and intra-tumoral microbiota during the progression of gastric cancer, as well as the therapeutic efficacy of microbiota-related applications, still require extensive exploration through experiments.
Keywords: gastric cancer, microbiota, Molecular mechanisms, Tumor Microenvironment, targeted therapy
Received: 19 Jan 2025; Accepted: 15 May 2025.
Copyright: © 2025 Chen, Jin, Hu, Guan, Bai and Gou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yunjiu Gou, Gansu Provincial Hospital, Lanzhou, 730000, Gansu Province, China
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