BRIEF RESEARCH REPORT article
Front. Cell. Infect. Microbiol.
Sec. Parasite and Host
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1592281
This article is part of the Research TopicHost Cell Entry by Malaria ParasitesView all articles
Majority of the erythrocyte binding proteins of Pvfam 'a' family of Plasmodium vivax interact with Basigin to assist parasite entry into host cell
Provisionally accepted
- All India Institute of Medical Sciences, New Delhi, India
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Molecular mechanisms of red cell invasion by the Plasmodium vivax parasite remain obscure since information on receptor-ligand interaction is scarce. Several proteins of P. vivax Pvfam 'a' family are known to bind with host erythrocytes. Some of them share their erythrocyte receptors with each other and vice versa, but the identification of these receptors is awaited with the exception of PvTRAg38. Here, we demonstrate by using solid phase binding assay, and Surface Plasmon Resonance that majority (seven out of ten) of these erythrocyte binding proteins (PvTRAg, PvTRAg33.5, PvTRAg35.2, PvTRAg34, PvTRAg36, PvTRAg38, and PvTRAg69.4) interact with erythrocyte receptor Basigin. These interactions seem to be important for parasite's survival since each of these proteins interfered with the parasite growth in a heterologous culture system. Furthermore, a higher parasite growth inhibition rate was observed with the combination of these proteins suggesting the significance of multiple parasite ligand's interaction with the same erythrocyte receptor during invasion process. These results will be helpful in understanding P. vivax biology and developing the therapeutics for vivax malaria.
Keywords: Vivax malaria, Erythrocyte receptor, Red cell invasion, protein-protein interactions, Parasite growth inhibition
Received: 12 Mar 2025; Accepted: 28 May 2025.
Copyright: © 2025 Tripathi, Santoshi, Sharma and Rathore. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Sumit Rathore, All India Institute of Medical Sciences, New Delhi, India
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