REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Molecular Viral Pathogenesis
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1593445
This article is part of the Research TopicCytokine Signaling and Innate Host Defense in Modulation of Viral Infections and The Viral EvasionView all 4 articles
The emerging roles of ubiquitin-like modifications in regulating HIV replication and host defense
Provisionally accepted
- 1Institute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun, Jilin Province, China
- 2Department of Hepatobiliary and Pancreatic Surgery, First Hospital of Jilin University, Changchun, Jilin Province, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
As a post-translational modification (PTM) mechanism analogous to ubiquitination, ubiquitin-like (UBL) modification plays a crucial regulatory role in virus-host interactions. With the increasing discovery of UBL modification types, their roles in diverse biological process, including HIV infection, have gained growing attention. Rather than merely serving as anti-HIV defenses or being exploited by the virus, UBLs often exert dual roles by modulating both host restriction factors and viral proteins, thereby impacting key steps of HIV life cycle, immune evasion, and intracellular signaling. This article summarizes recent advances on the contribution of UBLs in regulating HIV replication and host defense, highlighting their indispensable roles in arms races between HIV and host, aiming to provide a theoretical framework for developing novel therapeutic strategies against HIV-1 targeting virus-host interactions.
Keywords: UBLs1, HIV-12, SUMOylation3, ISGylation4, NEDDylation5, ATG8ylation6, FAT10ylation7
Received: 14 Mar 2025; Accepted: 22 May 2025.
Copyright: © 2025 Huan, Sun, Yuan and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chen Huan, Institute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun, Jilin Province, China
Xiaodong Sun, Department of Hepatobiliary and Pancreatic Surgery, First Hospital of Jilin University, Changchun, Jilin Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.