REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Clinical Microbiology
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1608195
This article is part of the Research TopicAdvances in Vaginal Microbiome and Metabolite Research: Genetics, Evolution, and Clinical PerspectivesView all 7 articles
Advances in the interrelated nature of vaginal microecology, HPV infection, and cervical lesions
Provisionally accepted
- Department of Obstetrics and gynecology, The Second Norman Bethune Hospital of Jilin University, Changchun, China
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Vaginal microecology serves as a crucial defense mechanism in women's reproductive health. It encompasses vaginal anatomy, microbial flora, endocrine regulation, and immune responses.Lactobacillus species dominate this ecosystem, maintaining a dynamic balance essential for vaginal health. Studies have highlighted a strong association between vaginal microecology, human papillomavirus (HPV) infection, and cervical lesions. A well-balanced vaginal microenvironment enhances mucosal barriers and immune function, aiding in HPV prevention and clearance.Conversely, disruptions in vaginal microecology compromise these defenses, increasing susceptibility to HPV infection. Persistent high-risk HPV (HR-HPV) infections are key contributors to cervical lesions and may further destabilize the vaginal microbiota(VMB). Additionally, cervical lesion progression is influenced by local immune responses, with HPV infection potentially accelerating disease development by suppressing cervical immunity. This review explores the intricate association between vaginal microecology, HPV infection, and cervical lesions, offering insights into early diagnosis, prevention, and treatment strategies.
Keywords: Vagina, Microecology, HPV, cervical lesions, Cytokines
Received: 08 Apr 2025; Accepted: 28 May 2025.
Copyright: © 2025 Cui, Wu, Liu, Liu and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Limei Fan, Department of Obstetrics and gynecology, The Second Norman Bethune Hospital of Jilin University, Changchun, China
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