REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Virus and Host
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1641405
The Diagnostic Potential of Extracellular Vesicles in Virus-Related Diseases
Provisionally accepted
Qing Gao
Yuqing Zhan
Huayuan Xiang
Z Jianhao
Dongyu Sun
Chenxuan Bao
Gao Qianqian
Zhang Mengyu
Jianjun Wang
Lingxiang Mao*- Department of Laboratory Medicine, Affiliated Kunshan Hospital of Jiangsu University, Suzhou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Extracellular vesicles (EVs), a heterogeneous population of lipid bilayer-enclosed membranous particles, are widely involved in cell-cell communication and pathophysiological regulation. Recent advances reveal their dual functionality in viral pathogenesis: while facilitating viral dissemination through transport of pathogenic components, they simultaneously orchestrate host antiviral defense mechanisms. The unique molecular cargo loading capacity and high stability of EVs in body fluids make them ideal biomarkers for early infection diagnosis, treatment monitoring, and prognostic evaluation of virus-related disease. Compared to traditional viral detection methods, EV-based liquid biopsy techniques exhibit distinct advantages, including non-invasiveness and enhanced sensitivity thresholds. This review systematically examines the diagnostic potential of EV biomarkers in viral infections, offering novel perspectives for developing precision diagnostics and therapeutic interventions.
Keywords: Extracellular vesicles1, virus2, diagnosis3, Biomarker4, virus-related diseases5
Received: 05 Jun 2025; Accepted: 02 Jul 2025.
Copyright: © 2025 Gao, Zhan, Xiang, Jianhao, Sun, Bao, Qianqian, Mengyu, Wang and Mao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lingxiang Mao, Department of Laboratory Medicine, Affiliated Kunshan Hospital of Jiangsu University, Suzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.