ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Clinical Infectious Diseases
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1690269
This article is part of the Research TopicPerspectives in Clinical Infectious Diseases: 2024/2025View all 17 articles
Prevalence of on time administration of carbapenem and its impact on PK/PD target attainment in hospitalized patients: a multicenter retrospective study
Provisionally accepted
- 1Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, China
- 2Taizhou Hospital of Zhejiang Province, Linhai, China
- 3Dongyang People's Hospital, Dongyang, China
- 4Department of Pharmacy, Sir Run Run Shaw Hospital, Hangzhou, China
- 5The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
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Objective: On time administration of carbapenem is important, but there are few data concerning the prevalence of timeliness and its impact on pharmacokinetic/pharmacodynamic (PK/PD) target achievement in hospitalized patients. Methods: This was a multicenter retrospective study. Inpatients who received imipenem or meropenem for more than 3 consecutive days were included according to preset criteria. Patient information and dosing information were collected. The actual administration intervals were compared to the scheduled intervals, and those within a 1-hour error interval were defined as standard time window administration (STWA); otherwise, they were defined as noncompliant time window administration (NTWA). The 100% fT>MIC and 100% fT>4×MIC targets were applied for PK/PD target attainment analysis. A multivariable logistic regression model was used to identify independent risk factors associated with timely administration and the PK/PD target attainment rate. Results: A total of 474 patients and 1,372 actual administration intervals were included in this study. Among these patients, 82 had drug concentration data and were analyzed for PK/PD target attainment. A total of 427 dosing intervals (31.12%) complied with the standard time window and were STWA, whereas 945 (68.88%) were NTWA. Weekend, night shift, and scheduled dosing intervals were found to be independent influencing factors for STWA. STWA was an independent influencing factor for the 100% fT>MIC and 100% fT>4×MIC target attainment rates. Conclusion: Our results indicate a low rate of on time carbapenem administration. The on time carbapenem administration was a risk factor for PK/PD target attainment and should be well controlled in clinical practice.
Keywords: Meropenem, Imipenem, Administration time, Therapeutic drug monitoring, PK/PD
Received: 21 Aug 2025; Accepted: 26 Sep 2025.
Copyright: © 2025 Song, Pang, Chen, Zhang, Ying, Xu and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhenwei Yu, yzw_srrsh@zju.edu.cn
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