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CORRECTION article

Front. Cell. Infect. Microbiol.

Sec. Molecular Viral Pathogenesis

This article is part of the Research TopicPerspectives in Molecular Viral Pathogenesis: 2025View all 5 articles

Correction: "SARS-CoV-2 exploits steroidogenic machinery, triggers lipid metabolism for viral replication and induces immune response in Leydig cells of K18-hACE2 mice"

Provisionally accepted
Salmo Azambuja de OliveiraSalmo Azambuja de Oliveira1André Acácio Souza Da SilvaAndré Acácio Souza Da Silva1Barry T HintonBarry T Hinton2Giovanni Freitas GomesGiovanni Freitas Gomes3Thiago Mattar CunhaThiago Mattar Cunha3Paulo Sergio CerriPaulo Sergio Cerri4ESTELA SASSO CERRIESTELA SASSO CERRI4,5*
  • 1Universidade Federal de Sao Paulo, São Paulo, Brazil
  • 2University of Virginia, Charlottesville, United States
  • 3Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto, Ribeirao Preto, Brazil
  • 4Universidade Estadual Paulista Julio de Mesquita Filho, São Paulo, Brazil
  • 5Department of Anthropology, Politics and Philosophy, Faculty of Sciences and Letters, São Paulo State University, Araraquara, Brazil

This article is a correction to:

  1. SARS-CoV-2 exploits steroidogenic machinery, triggers lipid metabolism for viral replication and induces immune response in Leydig cells of K18-hACE2 mice

    1. Read original article

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Correction: "SARS-CoV-2 exploits steroidogenic machinery, triggers lipid metabolism for viral replication and induces immune response in Leydig cells of K18-hACE2 mice" Correction on: de Oliveira SA, da Silva AAS, Hinton BT, Gomes GF, Cunha TM, Cerri PS and Sasso-Cerri E (2025) SARS-CoV-2 exploits steroidogenic machinery, triggers lipid metabolism for viral replication and induces immune response in Leydig cells of K18-hACE2 mice. Front. Cell. Infect. Microbiol. 15:1538461. doi: 10.3389/fcimb.2025.1538461. Error in figure 4F In the published article, figure 4F was retouched to eliminate three artifacts from toluidine blue staining. These artifactual blue deposits were retouched for aesthetic purposes, and the retouching does not impact the interpretation of the data nor the conclusions of the study. The original figure is illustrated below. Error in table 1 In the published article, there were errors in Table 1. The antibody "Donkey anti IL-6 (M19) polyclonal antibody" is incorrect. The actual antibody used was "Goat anti-IL-6 (M19) polyclonal antibody". The "mouse anti-17beta-HSD7 antibody; 1:500 sc-393936; Santa Cruz Biotechnology, USA AB_2891064" is incorrect. The actual antibody used was the "Rabbit anti-17beta-HSD6; 2μg/ml; sc-101878; Santa Cruz Biotechnology, USA". Regarding Alexa Fluor® 488 anti-mouse antibody, the "catalog number (A11001), manufacturer (Molecular Probes by Life Technologies) and RRID" are incorrect. The correct is "catalog number ab150113; manufacturer (Abcam, Cambridge, UK) and RRID (AB_2576208)". The data regarding the "Alexa Fluor® 594 anti-rabbit antibody" are incorrect. The correct is "Alexa Fluor® 647 anti-rabbit antibody; dilution 1:1000, catalog number (ab150075); manufacturer (Abcam, Cambridge, UK); RRID (AB_2752244)". The "Alexa Fluor® 647 anti-donkey polyclonal antibody" is incorrect. The correct is "Alexa Fluor® 647 anti-goat antibody; dilution 1:1000; RRID (AB_2687955)". The "Alexa Fluor® 488 anti-rabbit antibody, Alexa Fluor® 594 anti-mouse antibody, and their respective dilution, catalog number, manufacturer and RRID" were missing and were added to Table 1. The corrected Table 1 is below. Table 1. Primary and secondary antibodies Antibody name Dilution Catalog number Manufacturer RRID Mouse anti-ACE2 monoclonal antibody 1:50 sc-73668 Santa Cruz Biotechnology, USA AB_2861379 Rabbit anti-SARS-CoV-2 Spike Protein S1 Recombinant monoclonal antibody 1:250 MA5-36247 Invitrogen by Thermo Fisher Scientific AB_2890589 Rabbit anti-SARS-CoV-2 nucleocapsid protein monoclonal antibody 1:3000 ab271180 Abcam, Cambridge, UK - Rabbit anti-IL-1β polyclonal antibody 1:400 ab9722 Abcam, Cambridge, UK AB_308765 Goat anti-IL-6 (M19) polyclonal antibody 1:400 sc-1265 Santa Cruz Biotechnology, USA AB_2127470 Mouse anti-TNF-α monoclonal [52B83] antibody 1:200 ab1793 Abcam, Cambridge, UK AB_302615 Rabbit anti-CD163 monoclonal antibody 1:100 ab182422 Abcam, Cambridge, UK AB_2753196 Rabbit anti-CD68 polyclonal antibody 1:100 ab125212 Abcam, Cambridge, UK AB_10975465 Rabbit anti-17β-HSD6 polyclonal antibody 1:500 sc-393936 Santa Cruz Biotechnology, USA AB_2891064 Rabbit anti-StAR polyclonal antibody 1:1000 PAS-95765 Invitrogen by Thermo Fisher Scientific - Mouse anti-testosterone polyclonal antibody 1:100 ab217912 Abcam, Cambridge, UK AB_308765 Rabbit anti-IL-10 polyclonal antibody 1:500 sc-8438 Santa Cruz Biotechnology, USA AB_627793 Rabbit anti-MIF polyclonal antibody 1:200 251415 ABBIOTEC, USA AB_10636927 Rabbit anti-β-tubulin monoclonal antibody 1:8000 ab108342 Abcam, Cambridge, UK AB_10866289 HRP-conjugated anti-rabbit secondary antibody 1:9000 A9169 Sigma-Aldrich, USA Alexa Fluor®488 anti-mouse antibody 1:1000 ab150113 Abcam, Cambridge, UK AB_2576208 Alexa Fluor®488 anti-rabbit antibody 1:1000 ab150077 Abcam, Cambridge, UK AB_2630356 Alexa Fluor®594 anti-mouse antibody 1:1000 ab150116 Abcam, Cambridge, UK AB_2650601 Alexa Fluor® 647 anti-rabbit antibody 1:1000 ab150075 Abcam, Cambridge, UK AB_2752244 Alexa Fluor®647 anti-goat antibody 1:1000 ab150135 Abcam, Cambridge, UK AB_2687955

Keywords: COVID-19, Cholesterol, Cytokines, Electron microscopy, Lipogenesis, Macrophages, Nucleocapsid, Testosterone

Received: 09 Sep 2025; Accepted: 28 Nov 2025.

Copyright: © 2025 de Oliveira, Souza Da Silva, Hinton, Gomes, Cunha, Cerri and CERRI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: ESTELA SASSO CERRI

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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