Frontiers in Cellular Neuroscience

Original Research

Published on 02 Oct 2025

Microglia-containing neural organoids as brain microphysiological systems for long-term culture

in Non-Neuronal Cells

Alex Rittenhouse
Caroline Krall
Jesse Plotkin
Dowlette-Mary Alam El Din
Breanne Kincaid
Jason Laird
Lena Smirnova

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1616470

1,187 views

Brief Research Report

Published on 23 Sep 2025

Endothelin-1 triggers oxidative stress and cytokine release in human microglia cells through ETRB-dependent mechanisms

in Non-Neuronal Cells

Yaritza Inostroza-Nieves
Shakira Bou
José Alvarado
Diego Capo-Ruiz
Jessica Garcia
Jean P. Moliere
Claudia P. Arenas

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1677457

551 views

Original Research

Published on 15 Sep 2025

Distinct reduction in relative microglial glucose uptake compared to astrocytes and neurons upon isolation from the brain environment

in Non-Neuronal Cells

Sebastian T. Kunte
Johannes Gnörich
Philipp Beumers
Laura M. Bartos
Stephan Wagner
Karin Wind-Mark
Adrien Holzgreve
Dennis Pötter
Rudolf A. Werner
Sibylle Ziegler

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1572431

1,327 views

Original Research

Accepted on 05 Sep 2025

Rotenone accelerates endogenous α-synuclein spreading and enhances neurodegeneration in an intra-striatal α-synuclein preformed fibril (PFF) injected mouse model of Parkinson's Disease

in Non-Neuronal Cells

Engila Khan
Nada Radwan
Mustafa T Ardah
Tohru Kitada
M Emdadul Haque

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1624593

1,428 views

Review

Published on 02 Sep 2025

Vascular endothelial growth factor: a key factor in the onset and treatment of depression

in Non-Neuronal Cells

Jing Wang
Fanhao Meng
Long Wang
Zeguang Li

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1645437

1,813 views

Original Research

Published on 01 Sep 2025

APOE genotype-dependent differences in human astrocytic energy metabolism

in Non-Neuronal Cells

Vanessa Budny
Chantal Bodenmann
Kathrin J. Zürcher
Maik Krüger
Sherida M. de Leeuw
Rebecca Z. Weber
Ruslan Rust
Luca Ravotto
Iván Ruminot
L. Felipe Barros

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1603657

2,277 views

Perspective

Published on 13 Aug 2025

Underestimation of mitochondrial respiratory capacity in gray matter voxels of the human brain map due to limited OXPHOS and TCA cycle in astrocytes

in Non-Neuronal Cells

Christos Chinopoulos

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1661231

1,288 views

Review

Published on 06 Aug 2025

Astrocyte alterations in α-synucleinopathies

in Non-Neuronal Cells

Manuela Rodríguez-Castañeda
Ana Campos-Ríos
Jose Antonio Lamas
Ana Covelo

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1650326

1,190 views

Original Research

Published on 29 Jul 2025

Validation of Hv1 channel functions in BV2 microglial cells using small molecule modulators

in Non-Neuronal Cells

Ashutosh Sharma
Nandini B. Kale
Priyanka Yadav
Shivani Yadav
Madhavi Ranawat
Valmik S. Shinde
Aravind Singh Kshatri

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1624224

2,181 views

Review

Published on 22 Jul 2025

Walking on the tightrope: the shared roles of the bridging pericytes in the brain

in Non-Neuronal Cells

Audrey Chagnot
Axel Montagne

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1615579

1,997 views

Original Research

Published on 21 Jul 2025

Modulating the serine metabolism in human differentiated astrocytes: an integrated multi omics approach

in Non-Neuronal Cells

Farida Tripodi
Elisa Maffioli
Silvia Sacchi
Valentina Rabattoni
Zoraide Motta
Claudia Bearzi
Gabriella Tedeschi
Loredano Pollegioni
Paola Coccetti

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1616911

1,691 views

Original Research

Published on 08 Jul 2025

AhR regulation of amyloid beta-induced inflammation in astrocyte cells

in Non-Neuronal Cells

Emmanuel Ojo
Temitope Adu
Raheem F. H. AI Aameri
Shelley A. Tischkau

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1618209

1,701 views

Methods

Published on 19 Jun 2025

Establishment of an AI-supported scoring system for neuroglial cells

in Non-Neuronal Cells

Annika Bitsch
Manfred Henrich
Svenja Susanne Erika Körber
Kathrin Büttner
Christiane Herden

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1584422

1,012 views

Editorial

Published on 10 Jun 2025

Editorial: The legacy of Sherrington and Adrian Nobel Prize: non-neuronal cells in information processing

in Non-Neuronal Cells

Wuhyun Koh
Zhuofan Lei

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1634743

1,247 views

Editorial

Published on 09 Jun 2025

Editorial: Non-neuronal cells in neurodegenerative diseases and psychiatric disorders

in Non-Neuronal Cells

Enrique Estudillo
Gilberto Pérez-Sánchez
Lenin Pavón
Adriana Jiménez

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1623523

1,729 views

Original Research

Published on 22 May 2025

Investigating the use of cuprizone and lysolecithin to model demyelination ex vivo in sagittal rat brain organotypic slice cultures

in Non-Neuronal Cells

Brooke Hawker
Bronwen Connor
Amy McCaughey-Chapman

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1609806

2,092 views