ORIGINAL RESEARCH article
Front. Clin. Diabetes Healthc.
Sec. Diabetes Cardiovascular Complications
This article is part of the Research TopicResidual Cardiovascular Risk in Diabetes: Current State and Future PerspectivesView all 5 articles
Association of Serum Levels of Soluble Triggering Receptor Expressed on Myeloid Cells-1 with Endothelial Dysfunction in Patients with Type 2 Diabetes
Provisionally accepted
- 1Shanghai Putuo Central School of Clinical Medicine, Anhui Medical University, Hefei, Anhui Province, China
- 2Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China, Shanghai, China
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Background The correlation between TREM-1 and vascular complications in patients with type 2 diabetes was a subject of debate. This study aimed to investigate the potential correlation between TREM-1 and flow-mediated dilatation (FMD) in patients with type 2 diabetes mellitus. Methods In this retrospective cohort research, 201 patients with type 2 patients diabetes were enrolled. The FMD Vascular Endothelial Cell Function Test Instrument was used to evaluate endothelial dysfunction. The serum levels of TREM-1 were measured using enzyme-linked immunosorbent assay. The Spearman correlation test was employed to determine the association between TREM-1 and FMD. Univariable logistic regression analysis was conducted to assess the relationship between TREM-1 and FMD. Additionally, receiver operating characteristic curve analysis was used to determine the TREM-1's predictive value. The statistical significance was evaluated using a two-tailed P-value >0.05. Results The study involved dichotomizing diabetic patients into low FMD (n = 138) and high FMD (n = 63) groups. The results showed that serum TREM-1 levels were significantly higher in the low FMD group than in the high FMD group (33.6 vs 58.0 pg/ml, P<0.001). A univariate logistic regression analysis revealed a statistically significant association between FMD and TREM-1 (P<0.05). The area under the curve for the receiver operating characteristic curve for model 1 (TREM-1) analysis was 0.66 (0.58-0.74) (P 0.001). Using the criteria of maximal Youden index, the threshold value for TREM-1 was found to be 38.16 ng/ml. This value showed a sensitivity of 75.4% and a specificity of 54% in predicting endothelial dysfunction in patients with type 2 diabetes mellitus. Conclusion Serum TREM-1 levels were associated with FMD, indicating that TREM-1 could be a valuable biomarker for assessing endothelial function in T2DM patients.
Keywords: Patients with type 2 diabetes mellitus, flow-mediated dilation, Endothelial Function, TREM-, Diabetic
Received: 05 Jan 2025; Accepted: 24 Nov 2025.
Copyright: © 2025 Kong, Lei, Sha and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tao Lei
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