ORIGINAL RESEARCH article
Front. Clin. Diabetes Healthc.
Sec. Diabetes Multiorgan Complications
Predictive Power of Glycemic and Inflammatory Profiles in Short-Term Recurrence of Type 2 Diabetes Mellitus with Condyloma Acuminatum
Provisionally accepted
- 1Bozhou Hospital Affiliated to Anhui Medical University,, Bozhou, China
- 2The People's Hospital of Bozhou, Bozhou, China
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Objective To evaluate the predictive value of post-treatment glycemic variability, interleukin-6 (IL-6), and serum tumor necrosis factor-α (TNF-α) for short-term recurrence in Type 2 diabetes mellitus with condyloma acuminatum (T2DM-CA) undergoing combined CO₂ laser and imiquimod therapy (CO₂-I). Methods This study enrolled 136 T2DM-CA patients treated with CO₂-I at Bozhou People's Hospital between August 2020 and December 2022. All participants underwent continuous 72-hour glucose monitoring post-treatment, with mean amplitude of glycemic excursions (MAGE) calculated. Patients were followed for 6 months post-discharge to track recurrence. Based on outcomes, they were stratified into recurrence (n=34) and non-recurrence (n=102) groups for comparative analysis. Results The recurrence rate was 25.00% (34/136). The recurrence group exhibited significantly higher MAGE (P<0.001), IL-6 (P<0.05), and TNF-α levels (P<0.05) compared to the non-recurrence group. Multivariate logistic regression identified elevated MAGE (≥3.9 mmol/L; OR=1.527, P<0.001), anogenital erosion (OR=2.786, P=0.016), high TNF-α (≥6.39 μg/L; OR=1.746, P=0.001), and low IL-6 (<5.26 pg/mL; OR=1.725, P=0.001) as independent risk factors for recurrence. Conclusion Post-CO₂-I therapy, T2DM-CA patients with greater glycemic variability, higher TNF-α, lower IL-6 levels, and anogenital erosions demonstrate increased short-term recurrence risk. These biomarkers serve as independent predictors and show clinical utility for prognostic evaluation.
Keywords: Condyloma acuminatum, Glycemic variability, HPV infection, Inflammatory markers, recurrence prediction, type 2 diabetes mellitus
Received: 15 Sep 2025; Accepted: 11 Dec 2025.
Copyright: © 2025 Wang, Wang and Tu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Sheng Tu
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