Abstract
Background:
Both cancer and diabetes are complex chronic diseases that have high economic costs for society. The co-occurrence of these two diseases in people is already well known. The causal effects of diabetes on the development of several malignancies have been established, but the reverse causation of these two diseases (e.g., what type of cancer can cause T2D) has been less investigated.
Methods:
Multiple Mendelian randomization (MR) methods, such as the inverse-variance weighted (IVW) method, weighted median method, MR-Egger, and MR pleiotropy residual sum and outlier test, were performed to evaluate the causal association of overall and eight site-specific cancers with diabetes risk using genome-wide association study summary data from different consortia, such as Finngen and UK biobank.
Results:
A suggestive level of evidence was observed for the causal association between lymphoid leukaemia and diabetes by using the IVW method in MR analyses (P = 0.033), indicating that lymphoid leukaemia increased diabetes risk with an odds ratio of 1.008 (95% confidence interval, 1.001-1.014). Sensitivity analyses using MR-Egger and weighted median methods showed consistent direction of the association compared with the IVW method. Overall and seven other site-specific cancers under investigation (i.e., multiple myeloma, non-Hodgkin lymphoma, and cancer of bladder, brain, stomach, lung, and pancreas) were not causally associated with diabetes risk.
Conclusions:
The causal relationship between lymphoid leukaemia and diabetes risk points to the necessity of diabetes prevention amongst leukaemia survivors as a strategy for ameliorating the associated disease burden.
Introduction
One of the twenty-first century’s major threats to public health is the elevation of diabetes mellitus prevalence worldwide (1). An initial stage of insulin resistance and compensatory hyperinsulinemia which contribute to β-cell failure defines type 2 diabetes (T2D) (2). T2D is characterized by chronic hyperglycaemia, which damages end organs over time (2). The World Health Organization reports that out of six deaths, one is attributed to cancer, which makes cancer the second primary cause of mortality worldwide (3). Both cancer and diabetes are complex chronic diseases and have high economic costs for society. The co-occurrence of these two diseases in people has already been reported for more than 50 years (4). It is presumed that these two diseases may have similar developmental pathways, such as the malfunction of immunological regulation and cytokine activity (5). Common risk factors, such as obesity, genetic predisposition, and exposure to certain environmental factors, have been identified in the development of cancer and diabetes (5, 6). Given that abdominal adiposity has been found to promote a proinflammatory condition throughout the body, which increases the risk of cancer and diabetes, obesity has been proposed as one of the underlying reasons for these two diseases (6).
Epidemiological evidence has indicated that several malignancies are more likely to occur in people with T2D (7). For instance, diabetes significantly increases the relative risk of liver and pancreatic cancer (PC) (8, 9), but less evidence has been observed for other cancers. Because the development of some malignancies can precede and cause T2D, the potential reverse causation of these two diseases should also be considered. For instance, PC is likely to promote the development of T2D (10). According to a recent study from Korea, cancer can enhance the risk of developing diabetes among cancer survivors, independent of conventional diabetes risk factors (11). The diabetes risk was most significant in the first two years after cancer diagnosis, and elevated risk was continuously observed for as long as 10 years (11). Moreover, circulating cytokines aggravate hyperglycaemia in cancer patients by promoting insulin resistance and increasing hepatic gluconeogenesis (12). A standard tumour marker for PC is a higher level of CA19-9, and elevated serum CA19-9 levels have been related to the severity of inadequate glucose regulation (13, 14). It has been proposed that survivors of cancer treatment are at higher risk for endocrinopathies, such as diabetes and metabolic syndrome, for the rest of their lives (15). For example, recent work has revealed that diabetes is more likely to develop in people who survived childhood cancer (15). In addition, a long latency may exist between cancer treatment and the onset of different treatment-related conditions, emphasizing the necessity for lifelong awareness and monitoring (16).
Observational epidemiological research can be hampered by various potential biases caused by residual confounding (17). Moreover, the possible reverse causation of the exposure and outcome in these works makes it difficult to determine the direction of the correlations (17). The Mendelian randomization (MR) method, which uses genetic variants as instrumental variables, can infer the causal effects of exposure on outcomes. Because genetic variations are fixed at birth and normally cannot be modified by outcomes, MR analyses are less affected by reverse causality (18). Considering that the effects of cancer from different sites on diabetes risk may be different (19), the current study used the MR method to estimate the causal effects of overall and eight site-specific cancers on the risk of diabetes.
Methods
Study design
MR examines the causal relationship between exposures and diseases using genetic variants (e.g., single nucleotide polymorphisms [SNPs]) as instrumental variables (IVs). In our analyses, the summary statistics of IVs were taken from genome-wide association study (GWAS) datasets of overall and site-specific cancers. Three requirements should be met for the selection of IVs. First, IVs are not directly associated with outcomes, and they only influence outcomes through exposure. Second, strong correlations exist between IVs and exposure. Third, IVs are not associated with the confounders (no horizontal pleiotropy exists). An MR framework was employed using GWAS summary data from different consortia to evaluate the causal association between overall and eight site-specific cancers and diabetes risk.
Data sources
Summary-level genetic data for overall and site-specific cancers were gathered from Finngen (20), the international lung cancer consortium (ILCCO) (21), the UK biobank (UKB) (22) and the genetic epidemiology research on aging (GERA) (23). Supplementary Table 1 provides more information on the data sources. GWAS datasets were used to extract the IVs for overall and lung cancer, in which the SNPs reached a genome-wide significance level (P < 5 × 10–8). We lowered the P value threshold for including SNPs as IVs to P < 1 × 10-5 if fewer than five IVs were selected (Supplementary Table 1). This threshold-lowering method has been previously adopted in MR studies (24). SNPs within 10,000 kb of each other were then clumped, with a linkage disequilibrium threshold of R2 > 0.001. The F-statistics of the IVs, an indicator of the ability of the IVs to predict the exposures (25), were estimated, and all exposures had F-statistics higher than 10 (Supplementary Table 2). The GWAS datasets for T2D, as the outcome, were from the Diabetes Meta-analysis of Trans-ethnic Association Studies (DIAMANTE) consortium (26).
Statistical analysis
The major method used to ascertain the relationships between different types of cancer and diabetes risk was the inverse-variance weighted (IVW) MR method. For sensitivity analyses, the weighted median (WM) method, MR-Egger, and MR pleiotropy residual sum and outlier (MR-PRESSO) test were also conducted. The potential heterogeneity was estimated by Cochrane’s Q statistic, and the potential pleiotropy was assessed by the intercept of the MR-Egger test. Scatter plots were used to present the results of different MR methods. The estimate of the effect of SNPs after removing each SNP one by one was achieved by “leave-one-out” analysis. The causal effects of overall and site-specific cancer were represented using odds ratios (ORs) and 95% confidence intervals (CIs). The statistical significance of the MR analyses was adjusted using Bonferroni correction. The testing results that did not survive Bonferroni correction but had a P < 0.05 were defined as associations with suggestive level of evidence. R software was used for these analyses, in which the “TwoSampleMR” and “MR-PRESSO” R packages were employed.
Results
We first performed the MR analyses to examine the possible causal association of overall and eight site-specific cancers with diabetes using GWAS summary statistics from various consortia. Detailed information, as well as P threshold for IV selection for each GWAS summary dataset, is given in Supplementary Table 1. The results indicated that none of the tested associations survived Bonferroni correction with a P threshold of 0.05/9 = 0.006, but a suggestive level of evidence was observed for the causal association between lymphoid leukaemia and diabetes (IVW method, P = 0.033), indicating that lymphoid leukaemia increased diabetes risk, with an OR of 1.008 (95% CI, 1.001-1.014) (Figures 1, 2; Supplementary Figure 1, Supplementary Table 3). The F-statistic of the IVs used in these analyses ranged from 15.7 to 151.5, with a mean of 25.4, suggesting strong ability of the IVs to predict the exposures (Supplementary Table 2). For the observed causal association between lymphoid leukaemia and diabetes, sensitivity analyses using the MR-Egger and WM methods showed a consistent direction of the association compared with the IVW method. In addition, the leave-one-out sensitivity analysis revealed that the association of lymphoid leukaemia with diabetes became marginally significant after removing several SNPs, including rs147576549, rs17480734, rs59261129, rs61915331, and rs763477, with a P value ranging from 0.050 to 0.072 (Figure 3). Furthermore, no significant heterogeneity or horizontal pleiotropy was detected in the analysis of causality between lymphoid leukaemia and diabetes (Supplementary Tables 4, 5, respectively). MR-PRESSO consistently revealed no outlier IV in the analysis of lymphoid leukaemia, and the results were identical for the analyses of bladder cancer and PC after correcting for the identified outlier SNPs (Supplementary Table 6).
Figure 1
Figure 2
Figure 3
Discussion
Our study screened the possible causal association of a total of eight site-specific cancers with diabetes using MR methods based on GWAS summary datasets, and we found that lymphoid leukaemia was causally associated with diabetes risk. This observation is also reflected by the results of MR-Egger and WM MR analyses that showed a consistent direction of association. In addition, the MR-Egger intercept test and MR-PRESSO global test revealed that the causal association between lymphoid leukaemia and diabetes was not due to horizontal pleiotropy.
A class of deadly hematologic malignancies known as leukaemia is defined by malignant growth of white blood cells and their precursor cell (27). On the one hand, an increased leukaemia risk has been reported in patients with diabetes. For instance, a study in Sweden showed that patients with T2D had a noticeably higher incidence of leukaemia after hospitalization (28). Meta-analysis of 11 publications indicated that the OR of leukaemia for people with T2D was estimated to be 1.22 (29). On the other hand, leukaemia has been proposed as one of the childhood cancers that leads to higher risk of diabetes (30). Indeed, childhood cancer survivors were more likely to develop diabetes compared with their sibling controls according to one study from the childhood cancer survivor study (CCSS) group (31). Consistent results were observed in studies conducted in Scandinavia (32) and Canada (33).
Several mechanisms underlying the higher diabetes risk in patients with leukaemia have been proposed. Leukaemia cells can directly infiltrate the pancreas (34), and chemotherapeutic treatment using L-asparagine can also lead to β-cell malfunction, causing hyperglycaemia in acute lymphocytic leukaemia (34), one of the most prevalent cancers among children (35). For chronic lymphocytic leukaemia, one case report indicated that a patient developed diabetes after being treated with fludarabine and cyclophosphamide therapy, which could potentially disrupt the local immune-regulatory balance (36). Corticosteroids are normally used as an integral part of combination chemotherapy in leukaemia treatment (37). However, some complications might arise during the usage of corticosteroids, of which two of the most common are hyperglycaemia and chemotherapy-induced diabetes (CID) (38). The development of diabetes after abdominal radiation is often linked to damage to the pancreas tail induced by the radiation, which leads to pancreatic insufficiency (39). For hematopoietic cell transplantation patients suffering from high-risk hematologic cancers, the precondition is normally achieved by total body irradiation (TBI) (40). The entire body is exposed to radiation during TBI, which affects the hypothalamic-pituitary axis and increases the risk of endocrinopathies (e.g., growth hormone deficiency) in cancer survivors (41). The risks of developing diabetes have been documented amongst children survivors exposed to TBI treatment, with a 12.6-fold risk ratio compared with their sibling controls (31). The major pathophysiologic mechanisms that contribute to the post-TBI development of diabetes have been proposed to be insulin resistance and hyperinsulinemia, rather than pancreatic insufficiency (16). It is also not uncommon for survivors of TBI exposure to present abnormality processes, such as altered adipokines and occurrence of inflammation (42).
CID contributes to poor clinical outcomes in leukaemia patients (43), and the underlying reasons could be multifactorial. One explanation is the increased susceptibility to infections in patients with CID undergoing intensive chemotherapy (44). Hyperglycaemia and hyperinsulinemia can further stimulate the neoplastic process, leading to unfavourable clinical outcomes in patients with leukaemia and CID (45). In patients suffering from acute myeloid leukaemia, researchers also reported an alteration in the glucose metabolism signature, which contributes to undesirable clinical outcomes (46). Thus, early commencement of CID screenings and relevant strategies to reduce its negative impact is advised because cancer survivors have an elevated chance of developing premature cardiovascular morbidity (47). Further research is warranted to elucidate the complex metabolic abnormality in cancer survivors, which could guide preventive and therapeutic endeavours to improve the quality of life of cancer survivors.
The association between cancer and diabetes can be site specific. For example, the risks of developing diabetes have been reported to be comparatively higher for survivors of PC compared with other types of cancers (48). A significant portion of patients recently diagnosed with PC present hyperglycaemia or T2D (49). In addition, T2D is alleviated after tumour removal, which reinforces the idea that T2D is related to PC (50). The risk of diabetes is elevated by PC because it promotes the secretion of insulin that leads to insulin resistance (51). Furthermore, pancreatic tissue destruction with an accompanying β-cell loss can also occur in patients with PC, which contributes to the development of diabetes (52). However, the causal effects of PC on T2D subtypes may be different. One MR analysis suggested that PC is causally associated with newly onset T2D but not long-standing T2D (53). The GWAS summary dataset of T2D used in our MR analysis did not separate subtypes of T2D, and the results indicated no causal association between PC and T2D. Similar to PC, six other site-specific cancers under investigation, including multiple myeloma, non-Hodgkin lymphoma and cancers of the bladder, brain, stomach, and lung, were also not causally associated with diabetes.
There were several areas of strength in this study. First, we employed an MR design to reduce the biases that can be introduced by reverse causality and residual confounding in conventional observational studies, which may lead to false-positive results. Second, numerous SNPs were used as IVs for overall and site-specific cancers, which was essential in facilitating the analysis of horizontal pleiotropy. Third, for sensitivity analyses aimed at estimating pleiotropy, several MR methods, such as MR-PRESSO and MR-Egger, were utilized. Lastly, the participants within the initial GWAS were mainly of European descent, which helped to reduce the bias attributable to population stratification. Despite the strengths, there were also several shortcomings in the present study, a key of which was the inability to completely exclude the possible effect of pleiotropy. Additionally, the interpretation of the results was limited to a certain ethnicity because the GWAS summary datasets were of European origin.
Conclusion
This comprehensive MR analysis has established a causal relationship between lymphoid leukaemia and diabetes risk, which points to the necessity of diabetes prevention amongst leukaemia survivors as a strategy for ameliorating the associated disease burden.
Statements
Data availability statement
The original contributions presented in the study are included in the article/Supplementary Material. Further inquiries can be directed to the corresponding authors.
Ethics statement
The GWAS used in the current work were approved by their relevant review board, and informed consent were collected from all participants.
Author contributions
RX and CG concepted the study. RX, TZ, CO, and XD performed the statistical analyses, and drafted the manuscript. All authors contributed to the article and approved the submitted version.
Funding
This study is supported by Quanzhou Science and Technology Project (Grant No. 2018N111S and 2019N076S), Science Foundation of the Fujian Province (Grant No. 2020J011287), and Fujian Health Science and Technology Plan Project (Grant No. 2020QNA081).
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Supplementary material
The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fendo.2023.1110523/full#supplementary-material
Supplementary Figure 1Funnel plot of the MR analyses investigating the causal effects of site-specific cancer and diabetes. Abbreviations: MR: Mendelian randomization; SE: standard error; IVs: instrumental variables.
Supplementary Table 1Information of GWAS summary datasets used in MR analyses.
Supplementary Table 2The F-statistics of IVs.
Supplementary Table 3MR analysis results.
Supplementary Table 4Heterogeneity test results.
Supplementary Table 5MR-Egger pleiotropy test results.
Supplementary Table 6MR-PRESSO test results.
Abbreviations
SNP, single nucleotide polymorphism; GWAS, genome-wide association studies; MR, Mendelian Randomization; IVW, inverse-variance weighted; WM, weighted median; MR-PRESSO, Mendelian Randomization Pleiotropy RESidual Sum and Outlier; LD, linkage disequilibrium; ORs, odds ratios; CIs, confidence intervals; T2D, type 2 diabetes; PC, pancreatic cancer; UKB, UK Biobank; IVs, Instrumental variable; ILCCO, the international lung cancer consortium; GERA, the genetic epidemiology research on aging; DIAMANTE, the Diabetes Meta-analysis of Trans-ethnic Association Studies; TBI, total body irradiation; CID, chemotherapy-induced diabetes; CCSS, the childhood cancer survivor study.
References
1
ZimmetPAlbertiKGMaglianoDJBennettPH. Diabetes mellitus statistics on prevalence and mortality: Facts and fallacies. Nat Rev Endocrinol (2016) 12(10):616–22. doi: 10.1038/nrendo.2016.105
2
FonsecaVA. Defining and characterizing the progression of type 2 diabetes. Diabetes Care (2009) 32(Suppl 2):S151–6. doi: 10.2337/dc09-S301
3
López-GómezMMalmiercaEde GórgolasMCasadoE. Cancer in developing countries: the next most preventable pandemic. the global problem of cancer. Crit Rev Oncol Hematol (2013) 88(1):117–22. doi: 10.1016/j.critrevonc.2013.03.011
4
GiovannucciEHarlanDMArcherMCBergenstalRMGapsturSMHabelLAet al. Diabetes and cancer: A consensus report. Diabetes Care (2010) 33(7):1674–85. doi: 10.2337/dc10-0666
5
GaoRManTSLiangJHWangLZhuHYWuWet al. Diabetes mellitus is associated with inferior prognosis in patients with chronic lymphocytic leukemia: A propensity score-matched analysis. Cancer Res Treat (2020) 52(1):189–206. doi: 10.4143/crt.2019.122
6
García-JiménezCGutiérrez-SalmerónMChocarro-CalvoAGarcía-MartinezJMCastañoADe la ViejaAet al. From obesity to diabetes and cancer: epidemiological links and role of therapies. Br J Cancer (2016) 114(7):716–22. doi: 10.1038/bjc.2016.37
7
JohnsonJACarstensenBWitteDBowkerSLLipscombeLRenehanAG. Diabetes and cancer (1): Evaluating the temporal relationship between type 2 diabetes and cancer incidence. Diabetologia (2012) 55(6):1607–18. doi: 10.1007/s00125-012-2525-1
8
LiD. Diabetes and pancreatic cancer. Mol Carcinog (2012) 51(1):64–74. doi: 10.1002/mc.20771
9
LaiMSHsiehMSChiuYHChenTH. Type 2 diabetes and hepatocellular carcinoma: A cohort study in high prevalence area of hepatitis virus infection. Hepatology (2006) 43(6):1295–302. doi: 10.1002/hep.21208
10
LiYBianXWeiSHeMYangY. The relationship between pancreatic cancer and type 2 diabetes: cause and consequence. Cancer Manag Res (2019) 11:8257–68. doi: 10.2147/CMAR.S211972
11
HwangboYKangDKangMKimSLeeEKKimYAet al. Incidence of diabetes after cancer development: A Korean national cohort study. JAMA Oncol (2018) 4(8):1099–105. doi: 10.1001/jamaoncol.2018.1684
12
ErionDMShulmanGI. Diacylglycerol-mediated insulin resistance. Nat Med (2010) 16(4):400–2. doi: 10.1038/nm0410-400
13
ScaràSBottoniPScatenaR. CA 19-9: Biochemical and clinical aspects. Adv Exp Med Biol (2015) 867:247–60. doi: 10.1007/978-94-017-7215-0_15
14
EsteghamatiAHafezi-NejadNZandiehASheikhbahaeiSEmamzadeh-FardSNakhjavaniM. CA 19-9 is associated with poor glycemic control in diabetic patients: Role of insulin resistance. Clin Lab (2014) 60(3):441–7. doi: 10.7754/Clin.Lab.2013.121243
15
Casano-SanchoPIzurieta-PachecoAC. Endocrine late effects in childhood cancer survivors. Cancers (Basel) (2022) 14(11). doi: 10.3390/cancers14112630
16
FriedmanDNTonorezosESCohenP. Diabetes and metabolic syndrome in survivors of childhood cancer. Horm Res Paediatr (2019) 91(2):118–27. doi: 10.1159/000495698
17
LawlorDAHarbordRMSterneJATimpsonNDavey SmithG. Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology. Stat Med (2008) 27(8):1133–63. doi: 10.1002/sim.3034
18
RichardsonTGSandersonEElsworthBTillingKDavey SmithG. Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study. Bmj (2020) 369:m1203. doi: 10.1136/bmj.m1203
19
ShikataKNinomiyaTKiyoharaY. Diabetes mellitus and cancer risk: review of the epidemiological evidence. Cancer Sci (2013) 104(1):9–14. doi: 10.1111/cas.12043
20
KurkiMIKarjalainenJPaltaPSipiläTPKristianssonKDonnerKet al. FinnGen: Unique genetic insights from combining isolated population and national health register data. medRxiv (2022), 2022.03.03.22271360. doi: 10.1101/2022.03.03.22271360
21
McCormackVAHungRJBrennerDRBickeböllerHRosenbergerAMuscatJEet al. Aspirin and NSAID use and lung cancer risk: a pooled analysis in the international lung cancer consortium (ILCCO). Cancer Causes Control (2011) 22(12):1709–20. doi: 10.1007/s10552-011-9847-z
22
SudlowCGallacherJAllenNBeralVBurtonPDaneshJet al. UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PloS Med (2015) 12(3):e1001779. doi: 10.1371/journal.pmed.1001779
23
KvaleMNHesselsonSHoffmannTJCaoYChanDConnellSet al. Genotyping informatics and quality control for 100,000 subjects in the genetic epidemiology research on adult health and aging (GERA) cohort. Genetics (2015) 200(4):1051–60. doi: 10.1534/genetics.115.178905
24
WoottonREGreenstoneHSRAbdellaouiADenysDVerweijKJHMunafòMRet al. Bidirectional effects between loneliness, smoking and alcohol use: Evidence from a mendelian randomization study. Addiction (2021) 116(2):400–6. doi: 10.1111/add.15142
25
TeumerA. Common methods for performing mendelian randomization. Front Cardiovasc Med (2018) 5:51. doi: 10.3389/fcvm.2018.00051
26
MahajanASpracklenCNZhangWNgMCYPettyLEKitajimaHet al. Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. Nat Genet (2022) 54(5):560–72. doi: 10.1038/s41588-022-01058-3
27
LiYZhuRMiLCaoYYaoD. Segmentation of white blood cell from acute lymphoblastic leukemia images using dual-threshold method. Comput Math Methods Med 2016 (2016) p:9514707. doi: 10.1155/2016/9514707
28
HemminkiKLiXSundquistJSundquistK. Risk of cancer following hospitalization for type 2 diabetes. Oncologist (2010) 15(6):548–55. doi: 10.1634/theoncologist.2009-0300
29
CastilloJJMullNReaganJLNemrSMitriJ. Increased incidence of non-Hodgkin lymphoma, leukemia, and myeloma in patients with diabetes mellitus type 2: a meta-analysis of observational studies. Blood (2012) 119(21):4845–50. doi: 10.1182/blood-2011-06-362830
30
BanihashemAGhasemiAGhaemiNMoazzenNAmirabadiA. Prevalence of transient hyperglycemia and diabetes mellitus in pediatric patients with acute leukemia. Iran J Ped Hematol Oncol (2014) 4(1):5–10.
31
MeachamLRSklarCALiSLiuQGimpelNYasuiYet al. Diabetes mellitus in long-term survivors of childhood cancer. increased risk associated with radiation therapy: a report for the childhood cancer survivor study. Arch Intern Med (2009) 169(15):1381–8. doi: 10.1001/archinternmed.2009.209
32
HolmqvistASOlsenJHAndersenKKde Fine LichtSHjorthLGarwiczSet al. Adult life after childhood cancer in Scandinavia: diabetes mellitus following treatment for cancer in childhood. Eur J Cancer (2014) 50(6):1169–75. doi: 10.1016/j.ejca.2014.01.014
33
LegaICPoleJDAustinPCLauCNathanPCBaxterNNet al. Diabetes risk in childhood cancer survivors: A population-based study. Can J Diabetes (2018) 42(5):533–9. doi: 10.1016/j.jcjd.2018.01.004
34
SchwartzJBShamsuddinAM. The effects of leukemic infiltrates in various organs in chronic lymphocytic leukemia. Hum Pathol (1981) 12(5):432–40. doi: 10.1016/S0046-8177(81)80023-8
35
NessKKArmenianSHKadan-LottickNGurneyJG. Adverse effects of treatment in childhood acute lymphoblastic leukemia: General overview and implications for long-term cardiac health. Expert Rev Hematol (2011) 4(2):185–97. doi: 10.1586/ehm.11.8
36
AkabaKEnangOIgwiloHNEdakabasiA. Dilemma in diagnosis of diabetes in a patient with chronic lymphocytic leukemia treated with cyclophosphamide – a paradoxical effect of immunosuppressive agent: a case report. Egypt J Haematol (2020) 45:118. doi: 10.4103/ejh.ejh_64_19
37
KhwajaABjorkholmMGaleRELevineRLJordanCTEhningerGet al. Acute myeloid leukaemia. Nat Rev Dis Primers (2016) 2(1):16010. doi: 10.1038/nrdp.2016.10
38
EgbuonuFAntonioFAEdavalathM. Effect of inhaled corticosteroids on glycemic status. Open Respir Med J (2014) 8:101–5. doi: 10.2174/1874306401408010101
39
OeffingerKCSklarCA. Abdominal radiation and diabetes: one more piece in the puzzle. Lancet Oncol (2012) 13(10):961–2. doi: 10.1016/S1470-2045(12)70340-6
40
BernardFAuquierPHerrmannIContetAPoireeMDemeocqFet al. Health status of childhood leukemia survivors who received hematopoietic cell transplantation after BU or TBI: An LEA study. Bone Marrow Transplant (2014) 49(5):709–16. doi: 10.1038/bmt.2014.3
41
CrowneEGleesonHBenghiatHSangheraPToogoodA. Effect of cancer treatment on hypothalamic-pituitary function. Lancet Diabetes Endocrinol (2015) 3(7):568–76. doi: 10.1016/S2213-8587(15)00008-X
42
KetterlTGChowEJLeisenringWMGoodmanPKovesIHPetrykAet al. Adipokines, inflammation, and adiposity in hematopoietic cell transplantation survivors. Biol Blood Marrow Transplant (2018) 24(3):622–6. doi: 10.1016/j.bbmt.2017.11.024
43
JacobPChowdhuryTA. Management of diabetes in patients with cancer. QJM: Int J Med (2014) 108(6):443–8. doi: 10.1093/qjmed/hcu218
44
JungS-HJangH-CLeeS-SAhnJ-SYangD-HKimY-Ket al. The impact of hyperglycemia on risk of severe infections during early period of induction therapy in patients with newly diagnosed multiple myeloma. BioMed Res Int (2014) 2014:413149. doi: 10.1155/2014/413149
45
SuoSSLiCYZhangYWangJHLouYJYuWJet al. Characteristics of chemotherapy-induced diabetes mellitus in acute lymphoblastic leukemia patients. J Zhejiang Univ Sci B (2020) 21(9):740–4. doi: 10.1631/jzus.B1900719
46
SongKLiMXuXXuanLIHuangGLiuQet al. Resistance to chemotherapy is associated with altered glucose metabolism in acute myeloid leukemia. Oncol Lett (2016) 12(1):334–42. doi: 10.3892/ol.2016.4600
47
YusufSWCipollaCDurandJBLenihanDJ. Cancer and cardiovascular disease. Cardiol Res Pract (2011) 2011:943748. doi: 10.4061/2011/943748
48
FernandezCJGeorgeASSubrahmanyanNAPappachanJM. Epidemiological link between obesity, type 2 diabetes mellitus and cancer. World J Methodol (2021) 11(3):23–45. doi: 10.5662/wjm.v11.i3.23
49
SalvatoreTMarfellaRRizzoMRSassoFC. Pancreatic cancer and diabetes: A two-way relationship in the perspective of diabetologist. Int J Surg (2015) 21:S72–7. doi: 10.1016/j.ijsu.2015.06.063
50
BalzanoGDugnaniEPasqualeVCaprettiGRadaelliMGGaritoTet al. Clinical signature and pathogenetic factors of diabetes associated with pancreas disease (T3cDM): a prospective observational study in surgical patients. Acta Diabetol (2014) 51(5):801–11. doi: 10.1007/s00592-014-0614-y
51
LiuJKnezeticJAStrömmerLPermertJLarsson Jr AdrianTE. The intracellular mechanism of insulin resistance in pancreatic cancer patients*. J Clin Endocrinol Metab (2000) 85(3):1232–8. doi: 10.1210/jc.85.3.1232
52
JaveedNSagarGDuttaSKSmyrkTCLauJSBhattacharyaSet al. Pancreatic cancer-derived exosomes cause paraneoplastic β-cell dysfunction. Clin Cancer Res (2015) 21(7):1722–33. doi: 10.1158/1078-0432.CCR-14-2022
53
Molina-MontesECosciaCGómez-RubioPFernándezABoeninkRRavaMet al. Deciphering the complex interplay between pancreatic cancer, diabetes mellitus subtypes and obesity/BMI through causal inference and mediation analyses. Gut (2021) 70(2):319–29. doi: 10.1136/gutjnl-2019-319990
Summary
Keywords
site-specific cancer, diabetes, lymphoid leukaemia, Mendelian randomization, causality
Citation
Xu R, Zheng T, Ouyang C, Ding X and Ge C (2023) Causal associations between site-specific cancer and diabetes risk: A two-sample Mendelian randomization study. Front. Endocrinol. 14:1110523. doi: 10.3389/fendo.2023.1110523
Received
28 November 2022
Accepted
03 February 2023
Published
13 February 2023
Volume
14 - 2023
Edited by
Sen Li, Beijing University of Chinese Medicine, China
Reviewed by
Jing Shi, Beijing Hospital, Peking University, China; Jian You, Zhejiang University, China
Updates
Copyright
© 2023 Xu, Zheng, Ouyang, Ding and Ge.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Rong Xu, xurongabc0806@163.com; Chenjin Ge, gechenjin@yeah.net
†These authors have contributed equally to this work and share first authorship
This article was submitted to Clinical Diabetes, a section of the journal Frontiers in Endocrinology
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