Frontiers in Immunology

Original Research

Published on 13 May 2026

Prediction of clinical outcomes of advanced cutaneous squamous cell carcinoma to PD-1 inhibition directly from histopathology slides using inferred transcriptomics

in Cancer Immunity and Immunotherapy

Bohdana Chayen
Gal Dinstag
Omer Tirosh
Leon Gugel
Tuvik Beker
Tzivia Gottlieb
Anna Elia
Eli Pikarsky
Michal Lotem
Mordechai Avner

Frontiers in Immunology

doi 10.3389/fimmu.2026.1822422

244 views

Original Research

Published on 13 May 2026

Metabolic reprogramming of cholesterol biosynthesis drives macrophage-mediated immune suppression in HPV-negative cervical adenocarcinoma

in Cancer Immunity and Immunotherapy

Jianing Zhang
Wenjuan Wei
Yajun Zhang
Daqing Wang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1808107

262 views

Case Report

Published on 13 May 2026

Anti–interferon-γ autoantibody–associated adult-onset immunodeficiency with occult immunological abnormalities and sequential intracellular infections: a case report

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Xiran Zhou
Panjie Hu
Qingxia Fu
Huanchang Chen
Juan Pan
Endian Sun
Shiyi Shi
Jianzhong Ye
Deyi Zhao
Tieli Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2026.1840699

197 views

Original Research

Published on 13 May 2026

Data-driven computational modeling of CAR-T cell function

in Systems Immunology

Viren Shah
Justin A. Womack
Katie Palen
Bryon D. Johnson
Peiman Hematti
Tyce J. Kearl
Nirav N. Shah
Scott S. Terhune
Ranjan K. Dash

Frontiers in Immunology

doi 10.3389/fimmu.2026.1707783

248 views

Original Research

Published on 13 May 2026

Integrated single-cell and bulk transcriptomic analyses reveal a stem-like epithelial subpopulation in adenocarcinoma of the esophagogastric junction and identify VASN as a novel regulator of tumor stemness

in Cancer Immunity and Immunotherapy

Hang Zheng
Shuaibo Wang
Heshu Liu
Jing Wang
Bin Hu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1817030

277 views

Original Research

Published on 13 May 2026

Single-cell and spatial transcriptomic profiling reveals the expression characteristics of PTPRR in epithelial cells and its potential implications in pancreatic cancer metastasis

in Cancer Immunity and Immunotherapy

Runyang Li
Xuechun Xu
Wenqing Zhang
Yan-yan Zhan

Frontiers in Immunology

doi 10.3389/fimmu.2026.1843505

157 views

Original Research

Published on 13 May 2026

Dynamic changes in peripheral blood lymphocyte subsets predict the efficacy and prognosis of immune checkpoint inhibitors in metastatic osteosarcoma

in Cancer Immunity and Immunotherapy

Longqing Li
Jinlei Liu
Yuan Zhao
Songtao Pang
Bin Zhang
Jia Wen
Yongkui Liu
Yi Zhang
Yan Zhang
Jiazhen Li

Frontiers in Immunology

doi 10.3389/fimmu.2026.1766639

151 views

Original Research

Published on 13 May 2026

Sex-specific reporting patterns and onset timing of immune-related adverse events associated with nivolumab and pembrolizumab: a dual-database pharmacovigilance analysis

in Cancer Immunity and Immunotherapy

Yu Bai
Hong Liu
Hao Meng

Frontiers in Immunology

doi 10.3389/fimmu.2026.1837640

154 views

Perspective

Published on 13 May 2026

Divergent immune cascades activated by metabolic versus mechanical exercise intensity: revisiting cytokine heterogeneity in “moderate-intensity exercise”

in Cytokines and Soluble Mediators in Immunity

Jia-wen Wang
Jian-Jun Xun
Li-Na Jian

Frontiers in Immunology

doi 10.3389/fimmu.2026.1846052

159 views

Original Research

Published on 13 May 2026

Serum interleukin-6 as a neuroinflammatory biomarker across the spectrum of neurological disorders: a large-scale retrospective cohort study of 6,465 individuals

in Multiple Sclerosis and Neuroimmunology

Lingjun Zhao
Zhaoming Tang
Chengliang Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1825206

229 views

Original Research

Published on 13 May 2026

The significance of CEACAM60, a carcinoembryonic antigen (CEA) homolog, as a tumor antigen in the porcine cancer model

in Comparative Immunology

Jinsil Lee
Clara Cañas Crespo
Tim Hammacher
Andrei Lazar
Eva M Guenther
Marie Johne
Wiebke Weiß
Tung Huy Dau
Pavlo Maksimov
Krzysztof Flisikowski

Frontiers in Immunology

doi 10.3389/fimmu.2026.1813834

283 views

Review

Published on 13 May 2026

Convergent death programs in chronic obstructive pulmonary disease: how pyroptotic and ferroptotic crosstalk reshapes therapeutic paradigms

in Inflammation

Aisi Huang
Shiming Liu
Jiao Lan

Frontiers in Immunology

doi 10.3389/fimmu.2026.1827181

186 views

Original Research

Published on 13 May 2026

Refractory immune cytopenia successfully treated with mycophenolate mofetil in four adolescents with del22q11.2 syndrome

in Primary Immunodeficiencies

Cristina Cifaldi
Lucia Pacillo
Chiara Rossetti
Silvia Di Cesare
Michele La Manna
Veronica Santilli
Beatrice Rivalta
Elisabetta Lembo
Mattia Moratti
Lucia Colucci

Frontiers in Immunology

doi 10.3389/fimmu.2026.1819182

247 views

Original Research

Published on 13 May 2026

miRNA profiling shows shared signatures in pediatric asthma, obesity and their comorbidity

in Inflammation

Harshita Shailesh
Mohamed Nadhir Djekidel
Safa Noor
Lena Hayati
Stefan Worgall
Souhaila Al Khodor
Ibrahim Janahi

Frontiers in Immunology

doi 10.3389/fimmu.2026.1792996

169 views

Original Research

Published on 13 May 2026

Generation of functional canine TIL products for solid tumors

in Comparative Immunology

Kay M. Foos
Veethika Pandey
Michael W. Jennings
Daniel J. Powell
Nicola J. Mason

Frontiers in Immunology

doi 10.3389/fimmu.2026.1810955

176 views

Mini Review

Published on 13 May 2026

Wnt signaling as a regulator of memory T cells: implications for CAR-T cell therapy

in Cancer Immunity and Immunotherapy

Tatiana Fourfouris
Ki Jun Lee
Samantha Hurwitz
Asher Ahdoot
Alexander Lee
Maiah Zarrabi
Michael Kahn
Yong-Mi Kim

Frontiers in Immunology

doi 10.3389/fimmu.2026.1843548

189 views

Review

Published on 13 May 2026

Neutrophil extracellular traps in gout: from immune defense to pathological dynamic equilibrium

in Inflammation

Fangfang Wang
Ning Tie
Yong Jin
Hongbin Li

Frontiers in Immunology

doi 10.3389/fimmu.2026.1826191

205 views

Original Research

Published on 13 May 2026

Gallic acid exerts therapeutic effects on sciatica by reducing inflammatory responses through the regulation of NOX4-mediated oxidative stress

in Molecular Innate Immunity

Zenni Chen
Zifeng Zhuang
Shaozi Lin
Yuting Hao
Xiaokang Xie
Hongling Chen
Lan Lin
Yixuan Li
Lili Fan
Shiquan Chang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1748652

240 views

Brief Research Report

Published on 13 May 2026

Risk of intestinal involvement in mucocutaneous-onset Behçet’s disease: data from the AIDA network registry

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Antonio Vitale
Valeria Caggiano
Jessica Sbalchiero
Francesco Gavioli
Giuseppe Lopalco
Gaafar Ragab
Silvana Guerriero
Ibrahim Almaglouth
Abdurrahman Tufan
Roberto Giacomelli

Frontiers in Immunology

doi 10.3389/fimmu.2026.1778171

357 views

Review

Published on 13 May 2026

The role of the complement system in gastrointestinal-related diseases

in Mucosal Immunity

Bo Yong
Zixiang Luo
Bo Luo
Jinbo Liu
Zhangrui Zeng
Xiaoli Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2026.1801628

221 views

Original Research

Published on 13 May 2026

Prognostic significance of lymphocyte PD-1 expression in combination with clinical scoring systems in patients with liver cirrhosis complicated by sepsis

in T Cell Biology

Zhao Liu
Fengwei Shi
Nan Geng
Wen Pan
Bo Liu
Qinghua Meng

Frontiers in Immunology

doi 10.3389/fimmu.2026.1749708

163 views

Review

Published on 13 May 2026

Immunometabolic reprogramming in rheumatoid arthritis: the epitranscriptomic role of N6-methyladenosine in innate and adaptive immunity

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Jin Yang
Lei Wan
Hongbo Chen
Shu Li
Yuwei Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2026.1834919

115 views

Brief Research Report

Published on 13 May 2026

Complement activation in patients with post-acute sequelae after SARS-CoV-2 infection

in Viral Immunology

Madlene Holmqvist
Dick J. Sjöström
Katherine Carlson
Birgitta Gullstrand
Anders A. Bengtsson
Robin Kahn
Tom E. Mollnes
Per Åkesson
Per H. Nilsson
Fredrik Kahn

Frontiers in Immunology

doi 10.3389/fimmu.2026.1779393

333 views

Editorial

Published on 13 May 2026

Editorial: Understanding eQTLs and their Association with Spondyloarthropathies

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Matteo Vecellio

Frontiers in Immunology

doi 10.3389/fimmu.2026.1868391

224 views

52,166 articles

articles

Prediction of clinical outcomes of advanced cutaneous squamous cell carcinoma to PD-1 inhibition directly from histopathology slides using inferred transcriptomics

Metabolic reprogramming of cholesterol biosynthesis drives macrophage-mediated immune suppression in HPV-negative cervical adenocarcinoma

Anti–interferon-γ autoantibody–associated adult-onset immunodeficiency with occult immunological abnormalities and sequential intracellular infections: a case report

Data-driven computational modeling of CAR-T cell function

Integrated single-cell and bulk transcriptomic analyses reveal a stem-like epithelial subpopulation in adenocarcinoma of the esophagogastric junction and identify VASN as a novel regulator of tumor stemness

Single-cell and spatial transcriptomic profiling reveals the expression characteristics of PTPRR in epithelial cells and its potential implications in pancreatic cancer metastasis

Dynamic changes in peripheral blood lymphocyte subsets predict the efficacy and prognosis of immune checkpoint inhibitors in metastatic osteosarcoma

Sex-specific reporting patterns and onset timing of immune-related adverse events associated with nivolumab and pembrolizumab: a dual-database pharmacovigilance analysis

Divergent immune cascades activated by metabolic versus mechanical exercise intensity: revisiting cytokine heterogeneity in “moderate-intensity exercise”

Serum interleukin-6 as a neuroinflammatory biomarker across the spectrum of neurological disorders: a large-scale retrospective cohort study of 6,465 individuals

The significance of CEACAM60, a carcinoembryonic antigen (CEA) homolog, as a tumor antigen in the porcine cancer model

Convergent death programs in chronic obstructive pulmonary disease: how pyroptotic and ferroptotic crosstalk reshapes therapeutic paradigms

Refractory immune cytopenia successfully treated with mycophenolate mofetil in four adolescents with del22q11.2 syndrome

miRNA profiling shows shared signatures in pediatric asthma, obesity and their comorbidity

Generation of functional canine TIL products for solid tumors

Wnt signaling as a regulator of memory T cells: implications for CAR-T cell therapy

Neutrophil extracellular traps in gout: from immune defense to pathological dynamic equilibrium

Gallic acid exerts therapeutic effects on sciatica by reducing inflammatory responses through the regulation of NOX4-mediated oxidative stress

Risk of intestinal involvement in mucocutaneous-onset Behçet’s disease: data from the AIDA network registry

The role of the complement system in gastrointestinal-related diseases

Prognostic significance of lymphocyte PD-1 expression in combination with clinical scoring systems in patients with liver cirrhosis complicated by sepsis

Immunometabolic reprogramming in rheumatoid arthritis: the epitranscriptomic role of N6-methyladenosine in innate and adaptive immunity

Complement activation in patients with post-acute sequelae after SARS-CoV-2 infection

Editorial: Understanding eQTLs and their Association with Spondyloarthropathies