Frontiers in Immunology

Original Research

Published on 14 May 2026

MAPRE2 is associated with macrophage-enriched innate immune dysregulation and malignant phenotypes in hepatocellular carcinoma

in Molecular Innate Immunity

Xiuqin An
Yanfang Gao
Shangyumeng Zhao
Wei He
Xinda Yang
Yujie Wu
Jihao Li
Runxi Yi
Yue Han
Mingxuan Li

Frontiers in Immunology

doi 10.3389/fimmu.2026.1849407

196 views

Mini Review

Published on 14 May 2026

Tumor antigen-associated autoantibodies: generation mechanisms, roles in tumorigenesis and progression, and clinical application prospects

in Cancer Immunity and Immunotherapy

Wenqi Tai
Cuiling Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2026.1717454

160 views

Review

Published on 14 May 2026

T-cell exhaustion in tumor immunology: mechanisms, heterogeneity, and therapeutic strategies

in Cancer Immunity and Immunotherapy

Ruoxuan Wang
Yingjie Guo

Frontiers in Immunology

doi 10.3389/fimmu.2026.1841281

538 views

Original Research

Published on 14 May 2026

Characterization of the tumor microenvironment in locally advanced gastric cancer and identification of spatially predictive biomarkers associated with beneficial neoadjuvant immunochemotherapy

in Cancer Immunity and Immunotherapy

Xiaohong Xu
Jun Fan
Li Peng
Zhengkai Xiang
Danju Luo
Chenggong Ma
Bo Huang
Xiu Nie
Xiaochuan Dong

Frontiers in Immunology

doi 10.3389/fimmu.2026.1823308

140 views

Mini Review

Published on 14 May 2026

Antibody targeting of the TNF–TNFR2 axis to overcome tumor immune resistance

in Cancer Immunity and Immunotherapy

Xiaozhen Kang
Xiangmin Tong
Shibing Wang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1809305

251 views

Systematic Review

Published on 14 May 2026

First-line immunotherapy for advanced hepatocellular carcinoma: a network meta-analysis of randomized trials with overall and HBV/HCV-stratified efficacy and safety

in Cancer Immunity and Immunotherapy

Wei Chen
Boyan Chen
Chunbin Hu
Qiance Wei
Lili Zhang
Wenwen Fu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1693251

181 views

Review

Published on 14 May 2026

Adoptive cell therapies in solid tumors: current clinical landscape, challenges, and future directions

in Cancer Immunity and Immunotherapy

Joe Rizkallah
Bahaa El Deen Wehbeh
Waseem Wassouf
Elio Salameh
Adnan Joumaa
Francois Jose Haddad
Lama Hamade
Nicole Charbel
Ghada M. Bakri
Ali Awada

Frontiers in Immunology

doi 10.3389/fimmu.2026.1800292

341 views

Original Research

Published on 14 May 2026

Reference intervals for plasma IFN-α, TNF-α, IL-12p70, and IFN-γ by flow cytometry in healthy adults from eastern China: a single-center study

in Cytokines and Soluble Mediators in Immunity

Qian Liu
Linru Zhang
Xuanxuan Jiao
Yefu Sun
Fang Yang
Fumeng Yang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1806685

186 views

Original Research

Published on 14 May 2026

The effect of staphylococcal infection on cathelicidin and β-defensin mRNA levels in epithelial cells lining the mammary gland cistern

in Cytokines and Soluble Mediators in Immunity

Emilia Bagnicka
Adrianna Szprynca
Ewa Kościuczuk
Justyna Jarczak
Magdalena Rzewuska
Tomasz Sakowski
Magdalena Zalewska

Frontiers in Immunology

doi 10.3389/fimmu.2026.1804785

249 views

Review

Published on 14 May 2026

Redox-metabolic circuits as a central regulator of T cell-based immunotherapy

in Cancer Immunity and Immunotherapy

Sarah McPhedran
Tian Zhao
Julian J. Lum

Frontiers in Immunology

doi 10.3389/fimmu.2026.1807087

172 views

Original Research

Published on 14 May 2026

Sex-related peripheral immune profile in ulcerative colitis: links to fatigue

in Inflammation

Thyra Albrecht
Elisa Wider-Eberspächer
Alejandra P. Garza
Lorena Morton
Sabrina Sulzer
Verena Keitel-Anselmino
Rosa Rosania
Ildiko R. Dunay

Frontiers in Immunology

doi 10.3389/fimmu.2026.1824822

239 views

Original Research

Published on 14 May 2026

A scissor-guided single-cell framework defines a macrophage-derived risk score for prognostic and immunotherapy stratification in lung adenocarcinoma

in Cancer Immunity and Immunotherapy

Yueyue Shi
Linyue Hai
Guoqing Hou
Zhiqiang Wang
Lanju Wang
Zhenyu Lv
Xinjian Hao
Shiran Chen
Rong Xia
Junzheng Cao

Frontiers in Immunology

doi 10.3389/fimmu.2026.1827555

198 views

Mini Review

Published on 14 May 2026

Microfluidic chips for decoding cancer-immune crosstalk in immunotherapy

in Cancer Immunity and Immunotherapy

Xianlei Cai
Xia Xiao
Congcong Zhang
Weiming Yu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1825593

145 views

Original Research

Published on 14 May 2026

Comprehensive analysis of fatty acid desaturase 3 in clear cell renal cell carcinoma: insights into tumor progression, immune microenvironment, and clinical outcomes

in Cancer Immunity and Immunotherapy

Si-Tao Chen
Duan-Rui Zhou
Yun-Jun Ge
Lei Chang
Shu-Hui Guo
Guo-Sheng Wu
Ning-Han Feng

Frontiers in Immunology

doi 10.3389/fimmu.2026.1817492

195 views

Review

Published on 14 May 2026

Infection-driven proliferative phase impairment in chronic wounds: a mechanistic framework for precision regenerative therapy

in Microbial Immunology

Qingmei Yang
Chuyu Liu
Qi Wang
Jing An
Yulan Cai

Frontiers in Immunology

doi 10.3389/fimmu.2026.1803023

187 views

Brief Research Report

Published on 14 May 2026

Global landscape analysis of antibody-drug conjugate clinical trials for prostatic neoplasms: current status, opportunities and challenges

in Cancer Immunity and Immunotherapy

Shuyu Ren
Fangfang Pan
Jie Jin

Frontiers in Immunology

doi 10.3389/fimmu.2026.1774353

372 views

Original Research

Published on 14 May 2026

Diagnostic value of inflammatory biomarkers of IgA vasculitis based on Olink technology

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Jin-Yue Huang
Zi-Bo Zhang
Ning Wang
Hui Ma
Li Liu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1810681

129 views

Systematic Review

Published on 14 May 2026

Studies on allergic diseases and B cells in the past 20 years: a bibliometric analysis via CiteSpace and VOSviewer

in Molecular Innate Immunity

Weiyuan Mai
Xiaoqu Chen
Wanlin Ye
Guangshen Zhang
Wenyu Liang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1760388

106 views

Original Research

Published on 14 May 2026

HOPX is required for the generation of umbilical cord blood-derived memory-like NK cells induced by three cytokines

in Cancer Immunity and Immunotherapy

Zhiqing Liu
Yangyang Lei
Jiaxin Chen
Dan Mo
Xinyang Li
Xinrui Chen
Ruyu Liu
Dongmei Wang
Li Yan
Yan Ju

Frontiers in Immunology

doi 10.3389/fimmu.2026.1808687

216 views

Review

Published on 14 May 2026

From structural code to immunomodulation: the structure-activity relationship, molecular mechanisms, and translational medicine challenges of yam (Dioscorea opposita Thunb) polysaccharides

in Cytokines and Soluble Mediators in Immunity

Xiaoling Ding
Bo Wang
Xin Ma
Shan He
Noundara
Xuebing Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2026.1821913

467 views

Original Research

Published on 14 May 2026

Angioedema due to acquired C1 inhibitor deficiency: patient experience, conceptual disease model, and assessment of patient-reported outcome measures

in Molecular Innate Immunity

Mats de Lange
Danny M. Cohn
Delphine Gobert
Marc A. Riedl
Andrea Zanichelli
Kelsie Brewer
Sarah Clifford
Swaha Pattanaik
Beverly Romero
Maggie Chen

Frontiers in Immunology

doi 10.3389/fimmu.2026.1810851

344 views

Original Research

Published on 14 May 2026

Comprehensive exploration of the role of multimodal programmed cell death- associated lncRNAs in the prognosis and immunity of glioma

in Cancer Immunity and Immunotherapy

Shuaishuai Wu
Xiangji Meng
Yanran Hu
Qi Wang
Yanfen Yao
Haiyan Jia
Zhen Ma
Yang Liu
Zhongxu Sun
Yahu Bai

Frontiers in Immunology

doi 10.3389/fimmu.2026.1765882

177 views

Original Research

Accepted on 13 May 2026

A Multivariable Probability Score Integrating Routine Immunoassay Results for the Immunological Assessment of Antisynthetase Syndrome

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Juan Francisco Luchoro
Maria Torradeflot
Carmen Domènech
Lucía Marcelo-Torreras
Mario Framil
Raül Jordà-Sánchez
Andrea García-López
Sergio Prieto-González
Estíbaliz Ruiz-Ortiz

Frontiers in Immunology

Perspective

Accepted on 13 May 2026

CAR-T cell therapy for autoimmune diseases: current clinical trial landscape and the next wave of development

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Qingyu Chen
Yuxin Zhu
Qianqi Xu
Yemeng He
Yaoyi Wang
Ziyue Wang

Frontiers in Immunology

52,196 articles

articles

MAPRE2 is associated with macrophage-enriched innate immune dysregulation and malignant phenotypes in hepatocellular carcinoma

Tumor antigen-associated autoantibodies: generation mechanisms, roles in tumorigenesis and progression, and clinical application prospects

T-cell exhaustion in tumor immunology: mechanisms, heterogeneity, and therapeutic strategies

Characterization of the tumor microenvironment in locally advanced gastric cancer and identification of spatially predictive biomarkers associated with beneficial neoadjuvant immunochemotherapy

Antibody targeting of the TNF–TNFR2 axis to overcome tumor immune resistance

First-line immunotherapy for advanced hepatocellular carcinoma: a network meta-analysis of randomized trials with overall and HBV/HCV-stratified efficacy and safety

Adoptive cell therapies in solid tumors: current clinical landscape, challenges, and future directions

Reference intervals for plasma IFN-α, TNF-α, IL-12p70, and IFN-γ by flow cytometry in healthy adults from eastern China: a single-center study

The effect of staphylococcal infection on cathelicidin and β-defensin mRNA levels in epithelial cells lining the mammary gland cistern

Redox-metabolic circuits as a central regulator of T cell-based immunotherapy

Sex-related peripheral immune profile in ulcerative colitis: links to fatigue

A scissor-guided single-cell framework defines a macrophage-derived risk score for prognostic and immunotherapy stratification in lung adenocarcinoma

Microfluidic chips for decoding cancer-immune crosstalk in immunotherapy

Comprehensive analysis of fatty acid desaturase 3 in clear cell renal cell carcinoma: insights into tumor progression, immune microenvironment, and clinical outcomes

Infection-driven proliferative phase impairment in chronic wounds: a mechanistic framework for precision regenerative therapy

Global landscape analysis of antibody-drug conjugate clinical trials for prostatic neoplasms: current status, opportunities and challenges

Diagnostic value of inflammatory biomarkers of IgA vasculitis based on Olink technology

Studies on allergic diseases and B cells in the past 20 years: a bibliometric analysis via CiteSpace and VOSviewer

HOPX is required for the generation of umbilical cord blood-derived memory-like NK cells induced by three cytokines

From structural code to immunomodulation: the structure-activity relationship, molecular mechanisms, and translational medicine challenges of yam (Dioscorea opposita Thunb) polysaccharides

Angioedema due to acquired C1 inhibitor deficiency: patient experience, conceptual disease model, and assessment of patient-reported outcome measures

Comprehensive exploration of the role of multimodal programmed cell death- associated lncRNAs in the prognosis and immunity of glioma

A Multivariable Probability Score Integrating Routine Immunoassay Results for the Immunological Assessment of Antisynthetase Syndrome

CAR-T cell therapy for autoimmune diseases: current clinical trial landscape and the next wave of development