It has been kindly pointed out to us by Dr. Omer Dushek of Oxford University that the thermodynamic constraints (arising from the principle of detailed balance) impose the following condition on the parameters: which means that the parameter ν is fixed once γkin and δ have each been assigned a value. The objective of the paper was to exhibit the range of qualitative behaviors that is possible when pMHCI/CD8 kinetics interacts with TCR/pMHCI kinetics and to show how varying levels of the co-receptor at the T-cell surface may be able to modulate the functional sensitivity of the T-cell to various ligands in a differential fashion. These qualitative phenomena remain very much the same when we choose parameter values that respect the constraint ν = γkinδ, as shown in the corrected figures that follow below (Figures 2–4). It is these qualitative patterns that are currently guiding experimental research to elucidate CD8-mediated ligand focusing in the T-cell system. The main thrust of the paper is therefore unaltered.
Figure 2
Figure 3
Figure 4
Figure 5
The kinetic scheme (Figure 1) and the equations are all unaltered, except for a typographical error in the subscript of a quantity appearing in one of the equations. Specifically, equation (23) in the published text should read:
We apologize profusely for any inconvenience our oversight may have caused.
Statements
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Summary
Keywords
corrigendum, T cell, T cell receptor, T cell repertoire, T cell response
Citation
Szomolay B, Williams T, Wooldridge L and van den Berg HA (2014) Corrigendum: Co-Receptor CD8-Mediated Modulation of T-Cell Receptor Functional Sensitivity and Epitope Recognition Degeneracy. Front. Immunol. 5:443. doi: 10.3389/fimmu.2014.00443
Received
06 August 2014
Accepted
31 August 2014
Published
16 September 2014
Volume
5 - 2014
Edited by
Bruno Laugel, Cardiff University School of Medicine, UK
Reviewed by
Brian M. Baker, University of Notre Dame, USA; Yoram Louzoun, Bar-Ilan University, Israel
Copyright
© 2014 Szomolay, Williams, Wooldridge and van den Berg.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: hugo@maths.warwick.ac.uk
This article was submitted to T Cell Biology, a section of the journal Frontiers in Immunology.
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