CASE REPORT article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1561110
Vanishing Bile Duct Syndrome in Hodgkin's Lymphoma: A Case Highlighting Jaundice and Lymphadenopathy as Early Clues
Provisionally accepted
- 1Department of Hematology, The First Hospital of China Medical University, Shenyang, China
- 2The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
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Vanishing bile duct syndrome is a specific pathologic process characterized by ductopenia and intrahepatic cholestasis, which may be a unique paraneoplastic syndrome of Hodgkin's lymphoma with an unfavorable prognosis. We report a 34-year-old woman with acute jaundice and lymphadenopathy, which was subsequently confirmed to be Hodgkin's lymphoma with concurrent vanishing bile duct syndrome based on a liver biopsy. The patient agreed to combination chemotherapy with brentuximab vedotin and achieved a complete response. Liver function recovered within 4 months. This article reviews the literature and provides insight for addressing similar clinical challenges.
Keywords: Jaundice, Hodgkin's lymphoma, Vanishing bile duct syndrome, liver biopsy, Brentuximab Vedotin (BV)
Received: 15 Jan 2025; Accepted: 29 Apr 2025.
Copyright: © 2025 Ma, Cai, Miao, Deng, Yan and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaojing Yan, Department of Hematology, The First Hospital of China Medical University, Shenyang, China
Ran Gao, Department of Hematology, The First Hospital of China Medical University, Shenyang, China
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