REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders
This article is part of the Research TopicInnovations in targeting intestinal immunity for chronic inflammatory disordersView all 21 articles
Trichuris suis Ova in Inflammatory Bowel Disease
Provisionally accepted
- 1Department of Pharmacy, Sichuan GEM Flower Hospital, Cheng Du, China
- 2Chengdu Seventh People's Hospital, Chengdu, Sichuan Province, China
- 3Mianyang Central Hospital, Mianyang, China
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This article reviews the mechanisms and clinical trial findings of Trichuris suis ova (TSO) for inflammatory bowel disease (IBD).The results show TSO may exert potential effects on IBD via multiple pathways, yet no significant efficacy has been confirmed in clinical trials. Given its promising anti-inflammatory properties, further research is warranted. However, many knowledge gaps still exist in this field.Future trials should standardize study designs. Considering IBD complexity, priority should be given to precision medicine, with identifying TSO therapy's target populations as a core step. Additionally, enhanced safety monitoring is essential to fully assess short-and long-term risks of TSO treatment. Given the inherent uncertainties of live biotherapeutics, multi-omics and gene-editing tools should be adopted to clarify TSO's anti-inflammatory mechanisms and achieve its "artificial domestication", enabling stable therapeutic performance across diverse clinical settings. The breakthroughs will deepen insights into IBD pathogenesis and advance microbiome-based interventions from empirical practice to the precision medicine era.
Keywords: Challenges and prospects, inflammatory bowel disease, Potential mechanisms, precision medicine, Trichuris suis ova
Received: 14 Apr 2025; Accepted: 05 Feb 2026.
Copyright: © 2026 Zhou, Tang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yu Wang
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