Innovations in targeting intestinal immunity for chronic inflammatory disorders

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ORIGINAL RESEARCH

Published on 05 Sep 2025

Simultaneous profiling of the blood and gut T and B cell repertoires in Crohn’s disease and symptomatic controls illustrates tissue-specific alterations in the immune repertoire of individuals with Crohn’s disease

Aya K. H. Mahdy
Valentina Schöpfel
Gert Huppertz-Hauss
Gøri Perminow
Florian Tran
Corinna Bang
Johannes R. Hov
May-Bente Bengtson
Petr Ricanek
7 more
Hesham ElAbd

doi 10.3389/fimmu.2025.1638522

192 views

ORIGINAL RESEARCH

Accepted on 04 Sep 2025

Peripheral Monocytes from Crohn's Disease Patients Retain Functional Responsiveness to GM-CSF during Active Disease

Paul Peter Winkel
Wendy Bergmann-Ewert
Johannes Reiner
Astrid Huth
Dana Kleimeier
Rosaely Casalegno Garduño
Ida Maria Wrobel
Grazyna Domanska
Jan Däbritz
Elisa Wirthgen

doi 10.3389/fimmu.2025.1663713

REVIEW

Accepted on 29 Aug 2025

The AhR/IL-22 Axis in Chronic Gut Inflammation: Unraveling Mechanisms and Therapeutic Prospects

Huimin Kang
Zheng Chen
Baodong Wang
Zheng Chen

doi 10.3389/fimmu.2025.1668173

334 views

REVIEW

Accepted on 25 Aug 2025

TNFSF14 (LIGHT) in Intestinal Inflammation: Balancing Immune Activation and Resolution in IBD

Rabia S. Mousa
Pietro Invernizzi
Joanne Louise Jones
Hani S. Mousa

doi 10.3389/fimmu.2025.1657071

710 views

ORIGINAL RESEARCH

Published on 11 Aug 2025

Zuoqing granules attenuate ulcerative colitis via macrophage polarization modulation: involvement of the PPAR-γ/NF-κB/STAT1 signaling axis

Heng Deng
Ming Li
Xiaoli Fang
Kun Tang
Shuqing Xu
Rui Ding
Zilong Li

doi 10.3389/fphar.2025.1646545

884 views

SYSTEMATIC REVIEW

Published on 30 Jul 2025

Preclinical evidence for luteolin in ulcerative colitis: a meta-analysis and systematic review

Yiyi Feng
Xingyao Lu
Enjia Guo
Jianling Mo
Yichuan Xv

doi 10.3389/fphar.2025.1639644

741 views

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Frontiers in Immunology

Mucosal Immunity

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Articles

Simultaneous profiling of the blood and gut T and B cell repertoires in Crohn’s disease and symptomatic controls illustrates tissue-specific alterations in the immune repertoire of individuals with Crohn’s disease

Peripheral Monocytes from Crohn's Disease Patients Retain Functional Responsiveness to GM-CSF during Active Disease

The AhR/IL-22 Axis in Chronic Gut Inflammation: Unraveling Mechanisms and Therapeutic Prospects

TNFSF14 (LIGHT) in Intestinal Inflammation: Balancing Immune Activation and Resolution in IBD

Zuoqing granules attenuate ulcerative colitis via macrophage polarization modulation: involvement of the PPAR-γ/NF-κB/STAT1 signaling axis

Preclinical evidence for luteolin in ulcerative colitis: a meta-analysis and systematic review

Frontiers in Immunology

Mucosal Immunity