Frontiers in Immunology

Review

Published on 16 Dec 2025

Metabolic reprogramming as a therapeutic target for modulating the Th17/Treg balance in autoimmune diseases: a comprehensive review

in T Cell Biology

Yuehong Hu
Qihan Zhao
Haoran Dai
Yadi Wu
Xinyue Tang
Naiqian Zhang
Hanxue Jiang
Hongliang Rui
Baoli Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1687755

356 views

Review

Published on 16 Dec 2025

Pyroptosis-driven immune dysregulation in COPD: molecular mechanisms and therapeutic implications

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Feng-Xian Ni
Hui-Xian Wang
Jie Hu
Pei-Sheng Chen
Hua-Jing Huang
Hui-Hui Chen
Dong-Hui Huang
Ze-Bo Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686175

281 views

Case Report

Published on 16 Dec 2025

Adult-onset Still’s disease presenting with aseptic meningitis: a case report

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Xiao-Fen Li
Amy Ker
Hong-Li Liao
Yuan Liu
James Cheng-Chung Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1660434

235 views

Case Report

Published on 16 Dec 2025

Case Report: Abscopal effect of radiotherapy in a patient with metastatic duodenal adenocarcinoma and resistance to chemoimmunotherapy

in Cancer Immunity and Immunotherapy

Yongping Hao
Jin Wang
Yinling Wang
Zihui Wang
Guangwei Tian
Nan Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1643197

349 views

Original Research

Published on 16 Dec 2025

Immunogenicity of a CXCL8-based biopharmaceutical drug candidate in comparison to its wildtype form

in Immunological Tolerance and Regulation

Elisa Talker
Tanja Gerlza
Philippe Stas
Christina Trojacher
Tiziana Adage
Andreas J. Kungl

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679409

275 views

Original Research

Published on 16 Dec 2025

Next-generation cell lines for profiling different proteasome forms and their implications in cancer

in Cancer Immunity and Immunotherapy

Alexander Burov
Anastasia Yakovleva
Georgy Linovskiy
Andrei Fedotov
Vladimir Popenko
Olga Leonova
Aleksandr Lanin
Marina Drutskaya
Vadim Karpov
Alexey Morozov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1672000

423 views

Original Research

Accepted on 15 Dec 2025

Analysis of CDR3 Region Diversity with Different Lengths in Bovine Immunoglobulin Heavy Chain Genes

in Comparative Immunology

Haidong Zhao
Xiaoqin Tang
Yuelang Zhang
Mingli Wu

Frontiers in Immunology

201 views

Systematic Review

Accepted on 15 Dec 2025

Efficacy and Safety of Cadonilimab in the Treatment of Recurrent/Metastatic and Advanced Cervical Cancer: A Systematic Review and Meta-Analysis

in Cancer Immunity and Immunotherapy

Qiuqi Zhuang
Yan Liu

Frontiers in Immunology

196 views

Original Research

Accepted on 15 Dec 2025

Unveiling the hidden cardiovascular risk of sipuleucel-T: A pharmacovigilance analysis using the FDA Adverse Event Reporting System, 2010–2025

in Cancer Immunity and Immunotherapy

Wensheng Liu
Xue Song
Linlin Wang
Jiyong Liu
Qiong Du

Frontiers in Immunology

180 views

Editorial

Accepted on 15 Dec 2025

Editorial – Research Topic Systemic Vasculitis: Advances in Pathogenesis and Therapies Volume II

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Alexandre Wagner Silva De Souza
Joshua Daniel Ooi
Jun Deng
Stefania Croci
Poh-Yi Gan
Kelly L Brown

Frontiers in Immunology

202 views

Original Research

Accepted on 15 Dec 2025

TENS alleviates CP/CPPS-related inflammation and pain by modulating Kir2.1-dependent macrophage polarization

in Inflammation

Ting Hong
Xinyu Liu
Zepai Chi
Guoyuan Liu
Yuanfeng Zhang
Xuanhao Lin
Peixiu Yao
Qingyun Gong
Yonghai Zhang
Xuwei Hong

Frontiers in Immunology

103 views

Original Research

Accepted on 15 Dec 2025

A Lipid Nanoparticle Encapsulated CPA-CTD mRNA Vaccine Provides Protection Against Clostridium perfringens -Driven Diseases

in Comparative Immunology

Qi Jia
Haoyu Xiang
Ting Le
Jing Wang
Jitao Chang
Fang Wang
SUN CHAO
WANBO TAI
Zhigang Jiang
Xin Yin

Frontiers in Immunology

Original Research

Accepted on 15 Dec 2025

A Multi-Omics Analysis of Pancreatitis: Bridging Familial Genetics and Disease Progression

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Fu Li
Jin-xin Huang
Wen-jie Sun
Jingqing Zeng
Ke-xin Gan
Biao Gong
Jian-mei Ji
Jian Chen
Zhaohui Deng
Dongliang Xu

Frontiers in Immunology

126 views

Review

Accepted on 15 Dec 2025

Bromodomain and Extra-Terminal Proteins in Solid Tumors: Regulators of Immune Microenvironment and Emerging Therapeutic Targets

in Cancer Immunity and Immunotherapy

Deeksha Sharma
Grace Bushnell
Alexander Kalman
Chloe Hutchens
Monika Burness

Frontiers in Immunology

115 views

Original Research

Accepted on 15 Dec 2025

Comparative Risk of Systemic Autoimmune Diseases in Juvenile Idiopathic Arthritis Treated With TNF-α or IL-6 Inhibitors: A Real-World Cohort Study

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Jih-Jin Tsai
Li-Teh Liu
Ping-Chang Lin
Yu-Hsun Wang
Yung-Heng Lee
James Cheng-Chung Wei

Frontiers in Immunology

Mini Review

Accepted on 15 Dec 2025

The Gut Microbiota Influences Neurodegenerative Diseases Through the Gut-Brain Axis: Molecular Mechanisms and Effects on Immune Function

in Multiple Sclerosis and Neuroimmunology

Jia Heng Yang
Xiang zhun Song
Su Yan
Qian xun Li
Wen ying Yang

Frontiers in Immunology

107 views

Original Research

Accepted on 15 Dec 2025

Single-cell transcriptome-wide Mendelian randomization identifies mitochondrial targets in immune cells for Major Depressive Disorder

in Multiple Sclerosis and Neuroimmunology

Yangyi Zhang
Fei Zhang
Xingyi Shen
Maoyuan Ni
Jiayi Zhang
Shunling Zhang
Jingwen Lin
Zhaoyang Yang
Huangwei Lei

Frontiers in Immunology

Original Research

Accepted on 15 Dec 2025

Hemoglobin alpha regulates T-lymphocyte activation and mitochondrial function

in T Cell Biology

Emily Reed
Tatlock H. Lauten
Tamara Natour
Lauren Jane Pitts
Caroline N. Jojo
Brooke L. Griffin
Sreeram Pasupuleti
Adam J Case

Frontiers in Immunology

Brief Research Report

Accepted on 15 Dec 2025

B-cell–driven relapse and anti-CD20 rescue therapy after Alemtuzumab in RRMS: case report and literature review

in Multiple Sclerosis and Neuroimmunology

Pietro Antonio Bruno
Stefania Barone
Angelo Pascarella
Pier Luigi Lanza
Emanuele Tinelli
Antonio Gambardella
Paola Valentino

Frontiers in Immunology

184 views

Correction

Accepted on 15 Dec 2025

Corrigendum: Distinct Arnica montana L. extracts modulate human T cell activation in different ways via differential inhibition of NFκB and NFAT pathways

in T Cell Biology

Karina M Berschneider
Bernhard Wetterauer
Carsten Sticht
Christian Orlik
Beate Jahraus
Henning Kirchgeßner
Anastasiia Zuieva
Stefan Wölfl
Divya Lairikyengbam
Verena Beier

Frontiers in Immunology

130 views

Review

Accepted on 15 Dec 2025

Viral Glycoprotein-Mediated Entry and Antibody-Mediated Immunity in HIV-1 and SARS-CoV-2 Infection

in Viral Immunology

Michael W. Grunst
Wenwei Li
Walther Mothes

Frontiers in Immunology

148 views

Original Research

Accepted on 15 Dec 2025

Integrative analysis of bulk and single-cell transcriptomics identifies factors related to immunosuppressive microenvironment to predict unfavorable prognosis in inflammatory breast cancer

in Cancer Immunity and Immunotherapy

Kexuan Feng
Xiaoduo Li
Xiaoqian Li
Junjie Liu
Rui Zhang
Heyan Chen
Yunpeng Zhang
Jianjun He
Huimin Zhang

Frontiers in Immunology

Original Research

Accepted on 15 Dec 2025

Lung epithelial and alveolar macrophage-like cell interactions significantly modify innate responses to bacterial endotoxin with the involvement of direct cellular contacts, TNF-α, ICAM1 and MCP-1

in Inflammation

Connor Wood
Shagun Khera
Minjeong Woo
Vikram Sharma
Justyna Lopatecka
Frederic Coulon
Zaheer Ahmad Nasir
Vincent Delorme
Simon Jackson
Gyorgy Fejer

Frontiers in Immunology

Review

Accepted on 15 Dec 2025

Exploring Cell Death Mechanisms in Liver Transplantation: Implications for Graft Survival

in Inflammation

Hirofumi Hirao
Takeshi Watanabe
Yoichiro Uchida
Etsuro Hatano

Frontiers in Immunology

106 views

48,461 articles

articles

Metabolic reprogramming as a therapeutic target for modulating the Th17/Treg balance in autoimmune diseases: a comprehensive review

Pyroptosis-driven immune dysregulation in COPD: molecular mechanisms and therapeutic implications

Adult-onset Still’s disease presenting with aseptic meningitis: a case report

Case Report: Abscopal effect of radiotherapy in a patient with metastatic duodenal adenocarcinoma and resistance to chemoimmunotherapy

Immunogenicity of a CXCL8-based biopharmaceutical drug candidate in comparison to its wildtype form

Next-generation cell lines for profiling different proteasome forms and their implications in cancer

Analysis of CDR3 Region Diversity with Different Lengths in Bovine Immunoglobulin Heavy Chain Genes

Efficacy and Safety of Cadonilimab in the Treatment of Recurrent/Metastatic and Advanced Cervical Cancer: A Systematic Review and Meta-Analysis

Unveiling the hidden cardiovascular risk of sipuleucel-T: A pharmacovigilance analysis using the FDA Adverse Event Reporting System, 2010–2025

Editorial – Research Topic Systemic Vasculitis: Advances in Pathogenesis and Therapies Volume II

TENS alleviates CP/CPPS-related inflammation and pain by modulating Kir2.1-dependent macrophage polarization

A Lipid Nanoparticle Encapsulated CPA-CTD mRNA Vaccine Provides Protection Against Clostridium perfringens -Driven Diseases

A Multi-Omics Analysis of Pancreatitis: Bridging Familial Genetics and Disease Progression

Bromodomain and Extra-Terminal Proteins in Solid Tumors: Regulators of Immune Microenvironment and Emerging Therapeutic Targets

Comparative Risk of Systemic Autoimmune Diseases in Juvenile Idiopathic Arthritis Treated With TNF-α or IL-6 Inhibitors: A Real-World Cohort Study

The Gut Microbiota Influences Neurodegenerative Diseases Through the Gut-Brain Axis: Molecular Mechanisms and Effects on Immune Function

Single-cell transcriptome-wide Mendelian randomization identifies mitochondrial targets in immune cells for Major Depressive Disorder

Hemoglobin alpha regulates T-lymphocyte activation and mitochondrial function

B-cell–driven relapse and anti-CD20 rescue therapy after Alemtuzumab in RRMS: case report and literature review

Corrigendum: Distinct Arnica montana L. extracts modulate human T cell activation in different ways via differential inhibition of NFκB and NFAT pathways

Viral Glycoprotein-Mediated Entry and Antibody-Mediated Immunity in HIV-1 and SARS-CoV-2 Infection

Integrative analysis of bulk and single-cell transcriptomics identifies factors related to immunosuppressive microenvironment to predict unfavorable prognosis in inflammatory breast cancer

Lung epithelial and alveolar macrophage-like cell interactions significantly modify innate responses to bacterial endotoxin with the involvement of direct cellular contacts, TNF-α, ICAM1 and MCP-1

Exploring Cell Death Mechanisms in Liver Transplantation: Implications for Graft Survival