Frontiers in Immunology | Cancer Immunity and Immunotherapy

Original Research

Published on 23 Jun 2025

The safety and effectiveness of sintilimab versus camrelizumab, both plus targeted drugs, in advanced hepatocellular carcinoma

in Cancer Immunity and Immunotherapy

Chenglong Zhao
Qiongni Zhu
Xiaoyan Qian
Zhonghua Fu
Wei Zhang
Yaqin Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1585956

101 views

Original Research

Published on 23 Jun 2025

Systematic pan-cancer analysis identifies PKNOX1 as a potential prognostic and immunological biomarker and its functional validation

in Cancer Immunity and Immunotherapy

Kan Liu
Yongkang Xu
Ye Mao
Shumin Fu
Shenglan Huang
Jianbing Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1533690

158 views

Original Research

Published on 23 Jun 2025

Matching-adjusted indirect comparison of tislelizumab plus lenvatinib versus sintilimab plus bevacizumab biosimilar as first-line treatment for unresectable hepatocellular carcinoma

in Cancer Immunity and Immunotherapy

Kunyuan Wang
Chang Liu
Xiaoling Song
Na Zhao
Xin Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1594935

198 views

Review

Published on 23 Jun 2025

Non-coding RNAs as key regulators in hepatitis B virus-related hepatocellular carcinoma

in Cancer Immunity and Immunotherapy

Prasanna Srinivasan Ramalingam
Liming Zhang
Md Sadique Hussain
Gyas Khan
Wedad Mawkili
Ali Hanbashi
Gaurav Gupta
Purushothaman Balakrishnan
Sivakumar Arumugam

Frontiers in Immunology

doi 10.3389/fimmu.2025.1602252

110 views

Review

Published on 23 Jun 2025

The tumor microenvironment across four dimensions: assessing space and time in cancer biology

in Cancer Immunity and Immunotherapy

Christina R. Larson
Ayushi Mandloi
Satwik Acharyya
Julienne L. Carstens

Frontiers in Immunology

doi 10.3389/fimmu.2025.1554114

146 views

Review

Accepted on 20 Jun 2025

CAR-T Therapy-Based Innovations in the Enhancement of Contemporary Anti-tumor Therapies

in Cancer Immunity and Immunotherapy

Wanying Zhang
Langyu Yang
Xingxing Fan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1622433

158 views

Original Research

Accepted on 20 Jun 2025

Hydrogels in cancer treatment: mapping the future of precision drug delivery

in Cancer Immunity and Immunotherapy

Xiang Liu
Qiang Zhou
Yue Yang
Xin Wu
Jie Chen
Ruoqin Wang
Erhua Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1607240

135 views

Editorial

Accepted on 20 Jun 2025

Cell network in antitumor immunity of pediatric and adult solid tumors: Volume II

in Cancer Immunity and Immunotherapy

Ombretta Melaiu
Elin Bernson
Silvia Pesce

Frontiers in Immunology

doi 10.3389/fimmu.2025.1649643

Original Research

Accepted on 20 Jun 2025

Bimodal Onset and Pan-Cancer Uniformity of Immune-Mediated Liver Injury: A Retrospective Cohort Study

in Cancer Immunity and Immunotherapy

Jiaojiao Song
Biying Xu
Lan Yu
Haiwei Fu
Binliang Wang
Mo Zhou
Yumin Hu
Yang Xia

Frontiers in Immunology

doi 10.3389/fimmu.2025.1612287

Original Research

Published on 20 Jun 2025

Exercise-related immune gene signature for hepatocellular carcinoma: machine learning and multi-omics analysis

in Cancer Immunity and Immunotherapy

Cheng Pu
Lei Pu
Xiaoyan Zhang
Qian He
Jiacheng Zhou
Jianyue Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1606711

355 views

Original Research

Published on 20 Jun 2025

A retrospective efficacy and safety study of pembrolizumab/cetuximab neoadjuvant therapy in locally advanced hypopharyngeal cancer

in Cancer Immunity and Immunotherapy

Guangnan Yao
Xiaobo Wu
Hanqing Lin
Zhihong Chen
Chang Lin
Gongbiao Lin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1574988

198 views

Systematic Review

Published on 20 Jun 2025

Research progress on the role of dendritic cells in glioma during 1992-2024: a bibliometric analysis

in Cancer Immunity and Immunotherapy

Linglei Zhu
Linpeng Zhang
Shuqi Han
Xuan Zhou
Hai Pan
Fanghe Li
Kuo Gao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1510549

275 views

Review

Published on 20 Jun 2025

The role of notch signaling pathway and non-coding RNAs in cancer and inflammation: progress, therapeutic insights, and future directions

in Cancer Immunity and Immunotherapy

Rong-Zu Nie
Hang Wang
Shuang-Shuang Wang
Chen Chen
Huo-Min Luo
Hao-Kun Zhang
Zhao-Hui Jing
Pei-Feng Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1567040

307 views

Review

Published on 20 Jun 2025

Antibody treatment of hepatocellular carcinoma: a review of current and emerging approaches

in Cancer Immunity and Immunotherapy

Sherif A. El-Kafrawy
Mostafa S. Elkafrawy
Esam I. Azhar
Anwaar Saeed
Ashraf A. Tabll

Frontiers in Immunology

doi 10.3389/fimmu.2025.1533874

381 views

Original Research

Published on 20 Jun 2025

Overexpression of CTLA-4 and fibronectin, and lower expression of CD137 (4-1BB) is associated with brain metastasis of primary skin melanomas. An analysis of local immune response by digital spatial profiling

in Cancer Immunity and Immunotherapy

Shiva Najjary
Nur al Amery
Mengqi Huang
Disha Vadgama
Alexander C. J. van Akkooi
H. Jacobus Gilhuis
Zineb Belcaid
Dana Mustafa
Johan M. Kros

Frontiers in Immunology

doi 10.3389/fimmu.2025.1578986

273 views

Original Research

Published on 20 Jun 2025

Total neoadjuvant immunochemotherapy for proficient mismatch repair or microsatellite stable locally advanced rectal cancer

in Cancer Immunity and Immunotherapy

Xing Li
Ligong Tang
Fangyuan Cheng
Yongchao Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1611386

304 views