Frontiers in Immunology | Cancer Immunity and Immunotherapy

Original Research

Published on 15 Jul 2025

Targeting the KLF5/PI3K/AKT axis as a therapeutic strategy to overcome neoadjuvant chemoresistance in colorectal cancer

in Cancer Immunity and Immunotherapy

Meiling Gao
Jiahao Qian
Ping Xia
Wancheng Liu
Yunjia Jiang
Yuchang Xia
Xin Yao
Qingqing Jiao
Minggang Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1593639

114 views

Original Research

Published on 15 Jul 2025

Lactylation prognostic signature identifies DHCR7 as a modulator of chemoresistance and immunotherapy efficacy in bladder cancer

in Cancer Immunity and Immunotherapy

Yuanqiao Zhao
Zhuo Xing
Yongqi Zhao
Haozhe Xu
Ruilin Liu
Tiejun Yang
Yinhuai Wang
Xuan Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1585727

188 views

Editorial

Published on 15 Jul 2025

Editorial: Single-cell sequencing of the immune microenvironment in cancer

in Cancer Immunity and Immunotherapy

David G. Coffey

Frontiers in Immunology

doi 10.3389/fimmu.2025.1660831

Review

Published on 15 Jul 2025

Clinical application prospects of traditional Chinese medicine as adjuvant therapy for metabolic reprogramming in colorectal cancer

in Cancer Immunity and Immunotherapy

Liu Zhexian
Guo Xingqi
Dong Xinxin
Xia Tong
Ma Siping
Li Yanxi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1630279

151 views

Original Research

Accepted on 14 Jul 2025

Predicting Recurrence and Recurrence-Free Survival in Initially Unresectable Hepatocellular Carcinoma: A Novel Nomogram for Patients Undergoing Conversion Hepatectomy with Lenvatinib, PD-1 Inhibitor, and Interventional Therapy

in Cancer Immunity and Immunotherapy

Cheng Xu
Zhihong Tang
Meng Wei
Danxi Liu
Qingqing Pang
Baishan Huang
Xinglin Mo
Feixiang Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1602327

Review

Accepted on 14 Jul 2025

Targeting myeloid cells to improve cancer immune therapy

in Cancer Immunity and Immunotherapy

Hui Chen
Zihan Xu
Judith Varner

Frontiers in Immunology

doi 10.3389/fimmu.2025.1623436

Editorial

Accepted on 14 Jul 2025

Editorial: Biomarkers in the era of cancer immunotherapy: zooming in from the periphery to the tumor microenvironment II

in Cancer Immunity and Immunotherapy

Jehad Charo
Cristina Maccalli

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662278

Original Research

Accepted on 14 Jul 2025

Serum profiling of the antibody response to HPV in women with or without abnormal cervical cytology undergoing cervical cancer screening

in Cancer Immunity and Immunotherapy

Radwa Ewaisha
Mack T Ruffin
Stacy Williams
Yunro Chung
Cecilia R Degraffinreid
Electra Diane Paskett
Paul Reiter
Ji Qiu
Dean E Brenner
Karen Anderson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1612761

Original Research

Accepted on 14 Jul 2025

Fc-optimized CD276 antibody enhances NK cell activation against non-small cell lung cancer

in Cancer Immunity and Immunotherapy

Sylwia A. Stefańczyk
Xenija Kaiser
Ilona Hagelstein
Samuel J Holzmayer
Latifa Zekri
Susanne Jung
Melanie Märklin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1624751

Mini Review

Accepted on 14 Jul 2025

HPV infection and the Immune Microenvironment in Cervical Cancer

in Cancer Immunity and Immunotherapy

Yibo Li
Jingui Deng
Yayong Liu
Shuangfeng Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1645019

Case Report

Accepted on 14 Jul 2025

When Dual Immune Checkpoint Blockade Strikes Back: Cadonilimab-Induced Hypersensitivity in Solid Tumors -A Case Series and Review

in Cancer Immunity and Immunotherapy

Ping Song
Yuqi Jin
Linglin Fu
Yinuo Tan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1643279

Original Research

Accepted on 14 Jul 2025

A Multi-Cohort Validated OXPHOS Signature Predicts Survival and Immune Profiles in Grade II/III Glioma Patients

in Cancer Immunity and Immunotherapy

Jun Mou
Min Zhang
Fumin Qin
Yajie Cui
Keyou Xu
Baoye Pang
Xinyue Li
Wanyi Tan
Aiqi Yang
Yaxin Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638824

Original Research

Accepted on 14 Jul 2025

Circulating memory B-cell receptor repertoire identifies novel candidate antibodies against metastatic melanoma in immunotherapy-responsive patients

in Cancer Immunity and Immunotherapy

Fabio Nicolini
Anna Gaimari
Lucia Mazzotti
Anna De Lucia
Miriana Ghirelli
Valentina Ancarani
Patricia Borges de Souza
Matteo Zurlo
Luca Gazzola
Chiara Magnoni

Frontiers in Immunology

doi 10.3389/fimmu.2025.1636722

Original Research

Accepted on 14 Jul 2025

Pathological Regression Patterns Following Neoadjuvant Chemo-immunotherapy in Head and Neck Squamous Cell Carcinoma: A Pilot Study

in Cancer Immunity and Immunotherapy

Dikan Wang
Fanning Zeng
Sien Zhang
Wan-Ming Hu
Yahui Wang
Daiqiao Ouyang
滨曾
Guozhong Zeng
Jingyuan Li
Guiqing Liao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1627442

Review

Accepted on 14 Jul 2025

PKM2-driven Metabolic Reprogramming in Digestive System Tumors: Mechanisms, Therapeutic Advances, and Clinical Challenges

in Cancer Immunity and Immunotherapy

Xinyao Huang
Jianjun He
Haonan Sun
Yi Wu
Renjun Gu
Ziyun Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634786

Brief Research Report

Accepted on 14 Jul 2025

Pretreatment immune-inflammatory prognostic score in predicting clinical outcomes in esophageal squamous cell carcinoma receiving neoadjuvant immunochemotherapy

in Cancer Immunity and Immunotherapy

Qiang Zhao
Liang Wang
Xun Yang
Ji-Feng Feng
Qi-Xun Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1617681