Frontiers in Immunology | Cancer Immunity and Immunotherapy

Original Research

Published on 12 Feb 2026

BDCA2 plays a central role in the binding, internalization and response of plasmacytoid dendritic cells to vidutolimod

in Cancer Immunity and Immunotherapy

Caitlin D. Lemke-Miltner
Sue E. Blackwell
Chaobo Yin
Travis D. Fischer
George J. Weiner

Frontiers in Immunology

doi 10.3389/fimmu.2026.1769287

109 views

Mini Review

Published on 12 Feb 2026

Clinically oriented immune heterogeneity in prostate cancer: emerging targets and strategies

in Cancer Immunity and Immunotherapy

MingWei Zhan
BinBin Zhao
Junjie Wu
Kai Li
Yibo Chen
Haote Chen
Lin Zhao
Jingyu Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1753718

146 views

Original Research

Published on 12 Feb 2026

NCF2 facilitates M2 macrophage polarization in glioblastoma through activation of the notch1–osteopontin axis

in Cancer Immunity and Immunotherapy

Yinsong Zhang
Na Li
Hongbo Cheng
Yi Xiang
Guozhu Sun

Frontiers in Immunology

doi 10.3389/fimmu.2026.1743950

270 views

Original Research

Published on 12 Feb 2026

Decoding the role of RPL38 in lung adenocarcinoma: a multi-omics approach

in Cancer Immunity and Immunotherapy

Lu Zhang
Fei Teng
Yuan Wang
Yang Chen
Qiuxia Liu
Fengsheng Dai
Liang Yu
Chenguo Yao
Zhiqiang Wang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1778481

126 views

Case Report

Published on 12 Feb 2026

Temporal association of diffuse large B-cell lymphoma with PD-1 inhibitor therapy in a patient with gastric adenocarcinoma: a case report

in Cancer Immunity and Immunotherapy

Yiqing Jiang
Kun Wu
Jia Hu
Mingxin Yu
Yuhang Xu
Zihan Xu
Rongxuan Cao
Yi Zhang
Yanfang Gao
Shuzhen Liu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1763711

292 views

Editorial

Published on 12 Feb 2026

Editorial: Mechanisms and therapeutic opportunities of T-cell impairment in cancer immunity and immunotherapy

in Cancer Immunity and Immunotherapy

Guillaume Beyrend-Frizon

Frontiers in Immunology

doi 10.3389/fimmu.2026.1795868

293 views

Mini Review

Published on 12 Feb 2026

Tumor immune-vascular crosstalk: synergy and translation of immune checkpoint inhibitors and anti-angiogenic agents in melanoma

in Cancer Immunity and Immunotherapy

Yijie Xie
I. Ho
Zhipeng Liu
Keyu Chen
Minjie Zhou
Guodong Ha
Lincheng Duan
Zhengyu Zhao
Dingjun Cai

Frontiers in Immunology

doi 10.3389/fimmu.2026.1760044

338 views

Correction

Published on 12 Feb 2026

Correction: Editorial: Unveiling the next generation of cancer immunity & immunotherapy

in Cancer Immunity and Immunotherapy

Mohanraj Sadasivam
Nethaji Muniraj
Chellappagounder Thangavel

Frontiers in Immunology

doi 10.3389/fimmu.2026.1784505

162 views

Review

Published on 12 Feb 2026

The emerging role of m6A methylation in prostate-related diseases: mechanisms and clinical implications

in Cancer Immunity and Immunotherapy

Qinghua Xie
Hongyan Zhao
Xuan Yang
Hongqi Zhang
Hong Liu
Jinghua Pan
Yan Li
Danping Fan
Xinrong Fan

Frontiers in Immunology

doi 10.3389/fimmu.2026.1685015

135 views

Original Research

Published on 12 Feb 2026

Identification and validation of prognostic genes related to glycolysis and M2 macrophage in hepatocellular carcinoma: an integrated analysis of bulk RNA sequencing and single-cell RNA sequencing

in Cancer Immunity and Immunotherapy

Anqi Wang
Lina You
Ming Zuo
Zhanao He
Hong Yang
Wukui Huang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1710411

276 views

Original Research

Published on 12 Feb 2026

Nocardia rubra cell wall skeleton-induced MARCO expression: implications for improved phagocytosis and cytokine secretion in tumor-associated macrophages

in Cancer Immunity and Immunotherapy

Guiyuan Zhou
Wei Chen
Xiaomin Dong
Qianyu Guo
Xue Bai
Yan Zheng
Lei Zhang
Suxia Shao

Frontiers in Immunology

doi 10.3389/fimmu.2026.1611476

187 views

Original Research

Published on 12 Feb 2026

Baseline glucose-to-lymphocyte ratio predicts nivolumab outcomes in advanced non-small cell lung cancer: a multicenter retrospective study

in Cancer Immunity and Immunotherapy

Mustafa Ersoy
Umut Kefeli
Devrim Cabuk
Ertugrul Bayram
Duygu Bayir
Oktay Bozkurt
Muslih Ürün
Ramazan Coşar
Teoman Sakalar
Emel Mutlu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1714533

197 views

Original Research

Published on 12 Feb 2026

A composite biomarker based on early dynamic changes in lactate dehydrogenase and PD-L1 expression enhances outcome prediction for immunochemotherapy in HER2-negative advanced gastric cancer

in Cancer Immunity and Immunotherapy

Yue Zhang
Yang Tian
Xiaoli Wei
Lu Bai
Meiqi Song
Yuanzhi Guo
Tianlai Liu
Xing Li
Weiqi Shan
Huaxing Wu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1659007

Original Research

Published on 12 Feb 2026

ALDH1L2 orchestrates redox–growth coupling in renal carcinoma: pan-cancer evidence and mechanistic validation of the ROS–Akt/mTOR/S6K axis

in Cancer Immunity and Immunotherapy

Chao Jiang
Songsong Liu
Liwen Zhang
Shiji Li
Jinyou Wang
Yi Wang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1768010

116 views

Systematic Review

Published on 12 Feb 2026

Correlation between PD-L1 expression and clinical pathology, immunobiological markers, and prognosis in gastroenteropancreatic neuroendocrine neoplasms: a systematic review and meta-analysis

in Cancer Immunity and Immunotherapy

Qiming Zheng
Shangbo Jin
Xinyue Xie
Qingjun Guo
Chiyi Chen
Wentao Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1772011

Original Research

Published on 12 Feb 2026

Construction of circadian clock signature for tumor microenvironment in predicting survival of esophageal squamous cell carcinoma

in Cancer Immunity and Immunotherapy

Yiping Xiang
Xuelian Cui
Zhe Cui

Frontiers in Immunology

doi 10.3389/fimmu.2026.1738892

463 views

Original Research

Published on 12 Feb 2026

Association between peripheral IFN-γ+ cytotoxic lymphocytes and response to PD-1/PD-L1-based therapy in hepatocellular carcinoma

in Cancer Immunity and Immunotherapy

Hui Lu
Huijuan Fang
Mengqi Ruan
Zhi Duang
Yan Wang
Wenwen Liu
Qin Wang
Qiang Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2026.1738116

Original Research

Published on 12 Feb 2026

Development and evaluation of an inhalable nanoemulsion system for enhancing NK cell function against osteosarcoma pulmonary metastases

in Cancer Immunity and Immunotherapy

Sookyung Hwang
Paul D. Bates
Vasiliki Valkanioti
Chih-Chun Chang
Sandro Mecozzi
Christian M. Capitini

Frontiers in Immunology

doi 10.3389/fimmu.2026.1772375

191 views

Original Research

Accepted on 11 Feb 2026

Single-Cell Profiling of PBMCs Reveals an Immune Signature of irAEs in Anti-PD-1-Treated Acral Melanoma Patients

in Cancer Immunity and Immunotherapy

Qi Bao
Jie Pan
Zhefang Wang

Frontiers in Immunology

Original Research

Accepted on 11 Feb 2026

MRPS28 serves as a biomarker of diagnostic, prognostic, and immune modulation in pan-cancer and promotes breast cancer malignant phenotypes

in Cancer Immunity and Immunotherapy

Xiangdong Guo
Shixing Wang
Yunlong Lu
Rensang Cai
Zhifei Luo
Jiaying Hu
Fenggui Xue
Haiyan Niu

Frontiers in Immunology

Systematic Review

Accepted on 11 Feb 2026

Comparison of drug regimens for recurrent or metastatic cervical cancer: a systematic review and network meta-analysis

in Cancer Immunity and Immunotherapy

Jin Zhou
Wentao Ye
Stéphanie Nirina Ranarisoa
Tian Lei

Frontiers in Immunology

Review

Accepted on 11 Feb 2026

Targeting MDSCs in Cancer: Emerging Immunotherapeutic and Metabolic Strategies

in Cancer Immunity and Immunotherapy

Shubhankar Dash
Patryk Firmanty
Monika Chomczyk
Vakul Mohanty
Wenxue Ma
Natalia Baran

Frontiers in Immunology

Original Research

Accepted on 11 Feb 2026

UNRAVELLING THE COMPLEXITY OF THE INTERACTIONS AMONG VACCIMEL, BCG AND BLOOD MONOCYTES

in Cancer Immunity and Immunotherapy

Erika Schwab
Brenda Carles
ALICIA INES BRAVO
María Victoria Echenique
Agustina De Franc
Mariano Guillermo Bonanno
María Marcela Barrio
José Mordoh

Frontiers in Immunology

Original Research

Accepted on 11 Feb 2026

A Combined Immune–Nutritional Score (GRIm–CONUT) as a Prognostic Indicator in Neoadjuvant-Treated Esophageal Squamous Cell Carcinoma

in Cancer Immunity and Immunotherapy

Qichang Xie
Junpeng Zhan
Xiaolin Ye
Cheng Huang
Chun Chen
Bin Zheng
Guobing Xu
Zhang Yang
Yong Zhu

Frontiers in Immunology

9,586 articles

articles

BDCA2 plays a central role in the binding, internalization and response of plasmacytoid dendritic cells to vidutolimod

Clinically oriented immune heterogeneity in prostate cancer: emerging targets and strategies

NCF2 facilitates M2 macrophage polarization in glioblastoma through activation of the notch1–osteopontin axis

Decoding the role of RPL38 in lung adenocarcinoma: a multi-omics approach

Temporal association of diffuse large B-cell lymphoma with PD-1 inhibitor therapy in a patient with gastric adenocarcinoma: a case report

Editorial: Mechanisms and therapeutic opportunities of T-cell impairment in cancer immunity and immunotherapy

Tumor immune-vascular crosstalk: synergy and translation of immune checkpoint inhibitors and anti-angiogenic agents in melanoma

Correction: Editorial: Unveiling the next generation of cancer immunity & immunotherapy

The emerging role of m6A methylation in prostate-related diseases: mechanisms and clinical implications

Identification and validation of prognostic genes related to glycolysis and M2 macrophage in hepatocellular carcinoma: an integrated analysis of bulk RNA sequencing and single-cell RNA sequencing

Nocardia rubra cell wall skeleton-induced MARCO expression: implications for improved phagocytosis and cytokine secretion in tumor-associated macrophages

Baseline glucose-to-lymphocyte ratio predicts nivolumab outcomes in advanced non-small cell lung cancer: a multicenter retrospective study

A composite biomarker based on early dynamic changes in lactate dehydrogenase and PD-L1 expression enhances outcome prediction for immunochemotherapy in HER2-negative advanced gastric cancer

ALDH1L2 orchestrates redox–growth coupling in renal carcinoma: pan-cancer evidence and mechanistic validation of the ROS–Akt/mTOR/S6K axis

Correlation between PD-L1 expression and clinical pathology, immunobiological markers, and prognosis in gastroenteropancreatic neuroendocrine neoplasms: a systematic review and meta-analysis

Construction of circadian clock signature for tumor microenvironment in predicting survival of esophageal squamous cell carcinoma

Association between peripheral IFN-γ+ cytotoxic lymphocytes and response to PD-1/PD-L1-based therapy in hepatocellular carcinoma

Development and evaluation of an inhalable nanoemulsion system for enhancing NK cell function against osteosarcoma pulmonary metastases

Single-Cell Profiling of PBMCs Reveals an Immune Signature of irAEs in Anti-PD-1-Treated Acral Melanoma Patients

MRPS28 serves as a biomarker of diagnostic, prognostic, and immune modulation in pan-cancer and promotes breast cancer malignant phenotypes

Comparison of drug regimens for recurrent or metastatic cervical cancer: a systematic review and network meta-analysis

Targeting MDSCs in Cancer: Emerging Immunotherapeutic and Metabolic Strategies

UNRAVELLING THE COMPLEXITY OF THE INTERACTIONS AMONG VACCIMEL, BCG AND BLOOD MONOCYTES

A Combined Immune–Nutritional Score (GRIm–CONUT) as a Prognostic Indicator in Neoadjuvant-Treated Esophageal Squamous Cell Carcinoma