Frontiers in Immunology | Cancer Immunity and Immunotherapy

Original Research

Published on 01 Sep 2025

Efficacy and safety of DEB-TACE combined with transarterial TQB2450 infusion and oral Anlotinib as first-line treatment in advanced hepatocellular carcinoma: a single-arm phase II study

in Cancer Immunity and Immunotherapy

Hang Yuan
Yan Li
Ke Zhao
Ya-Nan Zhao
Quan-Jun Yao
Xiang Geng
Li-Feng Wang
Ho-Young Song
Hong-Tao Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1667785

107 views

Original Research

Published on 01 Sep 2025

A multi-omic analysis reveals a predictive value of tertiary lymphoid structures in improving the prognosis of colorectal cancer patients with BRAF mutation

in Cancer Immunity and Immunotherapy

Chao Qin
Shumin Cheng
Jingyun Ma
Lujing Li
Yun Leng
Lei Zheng
Huiying Chen
Hui Mo
Shi Li
Yuhong Liang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662573

194 views

Brief Research Report

Published on 01 Sep 2025

Associations between chemoradiotherapy-based immune checkpoint blockade and posttreatment depression and anxiety in head and neck cancer patients: a cross-sectional study

in Cancer Immunity and Immunotherapy

Yang Zhang
Yunhao Chen
Xianxing Zhang
Yafang Hong
Zihan Zhou
Xingchen Ding

Frontiers in Immunology

doi 10.3389/fimmu.2025.1649486

219 views

Original Research

Published on 01 Sep 2025

Liquid-liquid phase separation in gastric cancer: identifying novel biomarkers and therapeutic targets through gene signature analysis

in Cancer Immunity and Immunotherapy

Xianhui Wen
Miaomiao Cui
Junhua Zhang
Hai Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1620390

218 views

Case Report

Published on 01 Sep 2025

Case Report: Durable complete response to antigen-specific cytotoxic T lymphocyte therapy in advanced EGFR-TKI resistant lung adenocarcinoma: a case of adoptive cellular immunotherapy overcoming acquired targeted resistance

in Cancer Immunity and Immunotherapy

Chenghao Fu
Chengyu Bian
Weiyou Zhu
Haonan Du
Linrui Han
Jian Zhu
Jun Wang
Lei Cao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1637165

349 views

Original Research

Published on 01 Sep 2025

Urokinase-type plasminogen activator deficiency enhances CD8+ T cell infiltration and anti-PD-1 therapy efficacy in prostate cancer

in Cancer Immunity and Immunotherapy

Xiaoyi Li
Xiao Zhang
Xing Fu
Hong Wu
Xinyu Ye
Xin Huang
Yuhao Cui
Chao-Nan Qian
Yi Lu
Jian Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1625226

175 views

Original Research

Published on 01 Sep 2025

Neutrophil elastase promotes low molecular weight cyclin E1 formation to accelerate osteosarcoma proliferation

in Cancer Immunity and Immunotherapy

Jiuhui Xu
Qianyu Shi
Fanwei Zeng
Tingting Ren
Ran Wei
Xiaodong Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1647913

160 views

Mini Review

Published on 01 Sep 2025

Cancer-associated fibroblasts in osteosarcoma: key players in immune escape and targeted therapy

in Cancer Immunity and Immunotherapy

Junjie Fan
Yujie Jin
Feng Lv
Weidong Wu
Li Sun
Churong Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1668535

247 views

Case Report

Published on 01 Sep 2025

Case Report: Split liver transplantation for graft liver failure due to antibody-mediated rejection after immune checkpoint inhibitor therapy

in Cancer Immunity and Immunotherapy

Hui Tang
Binsheng Fu
Qing Yang
Jia Yao
Kaining Zeng
Xiao Feng
Yang Yang
Shuhong Yi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1556851

430 views

Mini Review

Published on 01 Sep 2025

Personalised immunotherapy strategies informed by single cell profiling in thyroid cancer: a mini review

in Cancer Immunity and Immunotherapy

Ruyu Chen
Zhimin Wang
Xueying Chen
Yangling Huang
Fengnuan Zhang
Tianshu Gao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651088

181 views

Original Research

Published on 01 Sep 2025

Single-cell RNA sequencing and proteomics uncover SIRPα-CD47 immune checkpoint and glycolysis-driven immune evasion in cardiac myxoma

in Cancer Immunity and Immunotherapy

Xinyuan Zhu
Qingle Gao
Xintong Dai
Baofa Sun
Yanping Li
Hongyan Zhai
Changliang Shan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1652645

257 views

Original Research

Published on 01 Sep 2025

Evaluating the toxicity profile of combination immune checkpoint inhibitors: a disproportionality analysis of real-world adverse events from the FDA Adverse Event Reporting System for tremelimumab, durvalumab, ipilimumab, and nivolumab

in Cancer Immunity and Immunotherapy

Zhuoyang Li
Yuxuan Xie
Tianhong Wang
Yuwei Liu
Yining Tian
Yusi Hua

Frontiers in Immunology

doi 10.3389/fimmu.2025.1631273

299 views

Original Research

Published on 01 Sep 2025

Safety and clinical outcomes of orelabrutinib, lenalidomide plus sintilimab for relapsed/refractory diffuse large B-cell lymphoma

in Cancer Immunity and Immunotherapy

Lingling Wang
Yongfen Huang
Dan Xu
Xiaoyong Wang
Hailiang Chu
Chunling Wang
Hao Xu
Wei Sang
Yuexin Cheng
Yuqing Miao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629224

142 views

Original Research

Published on 01 Sep 2025

Role of necroptosis-related genes in immune activity and prognosis of colorectal cancer

in Cancer Immunity and Immunotherapy

Lulu Tan
Shuaifeng Wang
Weilong Chang
Xiaoying Zhang
Rui Deng
Huifang Yan
Weiwei Zhu
Huifen Wang
Yudie Cai
Zhibo Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1619749

148 views

Mini Review

Published on 01 Sep 2025

Sepsis-driven metabolic reprogramming shapes cancer immunotherapy efficacy, metastatic potential, and drug sensitivity

in Cancer Immunity and Immunotherapy

Leyi Wang
Changdong Wu
Ming Hou
Zhiwei Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1642477

135 views

Review

Accepted on 31 Aug 2025

Glutamine Metabolism and Ammonia Death: Targeted Modulation for Enhanced Cancer Immunotherapy

in Cancer Immunity and Immunotherapy

Fei Du
Linlin Xiao
Wang Guojun
Qian Dai
Junxin Li
Xin Zhao
Qimin Zhang
Lan Yang
Yujie Liu
Yidan Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1643017