Frontiers in Immunology | Comparative Immunology

Original Research

Accepted on 19 Sep 2025

Anti-inflammatory Mechanism of Total Flavonoids from Polygala fallax Hemsl. Based on Network Pharmacology, Molecular Docking, and Experimental Validation

in Comparative Immunology

Chunhong Liao
Hua Su
Fengzhen Li
Chenglong Wang
Sufang Yang
Zujie Qin
Ning Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1690388

Original Research

Accepted on 19 Sep 2025

Mitochondrial dysfunction in PRRSV-2 infected macrophages

in Comparative Immunology

Thien-Phong Vu Manh
Alba Frias-De-Diego
Abigail Williams
John Byrne
Chaitawat Sirisereewan
Julie Hicks
Hsiao-Ching Liu
Elisa Crisci

Frontiers in Immunology

doi 10.3389/fimmu.2025.1670488

Original Research

Accepted on 18 Sep 2025

Carotenoid-based immune response in sea cucumbers relies on newly identified coelomocytes – the carotenocytes

in Comparative Immunology

Wambreuse Noé
Estelle Bossiroy
Frank David
Celine Vanwinge
Laurence Fievez
Fabrice Bureau
Sylvain GABRIELE
Tania Karasiewicz
Cyril Mascolo
Ruddy Wattiez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1668167

232 views

Original Research

Published on 18 Sep 2025

Anthropogenic noise exposure suppresses the immune response in Mytilus spp. following Vibrio splendidus challenge

in Comparative Immunology

Ambre F. Chapuis
Matthew A. Wale
Morgan Bailey
Hannah M. Farley
Tim P. Bean
Tim Regan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657667

1,346 views

Original Research

Accepted on 17 Sep 2025

High-Content Stimulated Raman Pathology Imaging and Transcriptomics Reveal Leukemia Subtype-Specific Lipid Metabolic Heterogeneity

in Comparative Immunology

Xuelian Cheng
Jing Liu
Ming Chen
Haoyu Wang
Shuxu Dong
Yuan Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662281

465 views

Original Research

Accepted on 15 Sep 2025

Bulk and single-cell transcriptome profiling revealed dynamic immune response of Granulomatous Amebic Encephalitis caused by Balamuthia mandrillaris, a cohort study

in Comparative Immunology

Jingjia Zhang
Xinmiao Jia
Bin Yang
Ying Ge
Wei Jiang
Yang Cong
Huanwen Wu
Liu Huifang
Jingjing Tian
Ying-Chun Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677014

866 views

Original Research

Published on 12 Sep 2025

Parenteral micronutrient supplementation enhances mammary immune function and colostrum–milk quality by modulating cytokine profiles and oxidative stress in transition crossbred cows

in Comparative Immunology

Yallappa M. Somagond
Pravasini Das
Ajay Kumar Dang
Dhawal K. Yadav
Priyanka M. Kittur
Bibhudatta S.K. Panda
Pooja Devi
Aarti Kamboj
Mohanned Naif Alhussien

Frontiers in Immunology

doi 10.3389/fimmu.2025.1669246

1,716 views

Review

Published on 11 Sep 2025

Local and systemic immunological response in feline chronic gingivostomatitis: a critical review

in Comparative Immunology

Rafael S. Lopes
Pedro P. Carvalho
Maria A. Pires
Paulo Rodrigues-Santos
Eduardo Costa
João F. Requicha

Frontiers in Immunology

doi 10.3389/fimmu.2025.1572631

1,298 views

Original Research

Accepted on 10 Sep 2025

Metformin-Associated Gut Microbiota Remodeling Correlates with Reinvigorated Splenic Immunity in Aged Mice: Microbiome-Immune Crosstalk via the Gut-Spleen Axis

in Comparative Immunology

Shu-Qin Ding
Xinyi Lyu
Shi-Yu Zhou
Yi-Wan Fang
Hao-Xin Ji
Jiang-Yan Li
He-Zuo Lü

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633486

1,255 views

Original Research

Accepted on 10 Sep 2025

Mass Cytometric Analysis of Circulating Immune Landscape in Primary Central Nervous System Lymphoma

in Comparative Immunology

Yuchen Wu
Liwei Lv
Jing Liu
Xuefei Sun
Chunji Gao
Shengjun Sun
Nan Ji
Wenjing Wang
Yuanbo Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658015

916 views

Original Research

Accepted on 09 Sep 2025

Resveratrol suppresses OSCC invasion and migration by regulating macrophage polarization via Syk signaling pathway

in Comparative Immunology

Weibo Li
Ying Qi
Yafei Li
Lu Liu
Xiaodan Dong
Bo Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1660851

268 views

Original Research

Accepted on 09 Sep 2025

Genomic Characterization of the T-Cell Receptor loci in Ambystoma mexicanum

in Comparative Immunology

Diana L. Pacheco-Olvera
Stephanie Saint Remy-Hernández
E. Ernestina Godoy-Lozano
Juan Téllez-Sosa
Humberto Valdovinos-Torres
Everardo Curiel Quesada
Constantino López-Macías
Jesus Martinez-Barnetche

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656386

181 views

Editorial

Published on 08 Sep 2025

Editorial: The roles of autophagy and cell death in the host immune response in aquatic animals

in Comparative Immunology

Quanyuan Wan
Junji Zhu
Zhendong Qin
Yongyao Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1688035

1,103 views

Original Research

Published on 08 Sep 2025

Polyfunctionality of CD4+ T lymphocytes in buffaloes and cattle: comparative antigen-specific cytokine responses in bovine tuberculosis infection

in Comparative Immunology

Susana Flores-Villalva
Giovanna De Matteis
Francesco Grandoni
Maria Carmela Scatà
Anna Donniacuo
Lorena Schiavo
Giulia Franzoni
Piera Mazzone
Mahmoud Elnaggar
Esterina De Carlo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608065

961 views

Original Research

Accepted on 05 Sep 2025

Deciphering the Regulatory Mechanisms of Honeysuckle (Lonicera japonica) on Lipopolysaccharide-Induced Inflammatory Responses in Loach (Misgurnus anguillicaudatus) through Small RNA Sequencing

in Comparative Immunology

Ruike Fan
Zihan Sun
Li-Shang Dai
Xiajuan Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1683771

756 views

Original Research

Published on 05 Sep 2025

Evolutionary analysis of CD300A and CD300C paired receptors in primates

in Comparative Immunology

Carolina Dias
Francesca Levi-Schaffer
Pedro José Esteves

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633323

944 views