Frontiers in Immunology

Original Research

Published on 14 Oct 2025

Hyaluronic acid synthase 2 dysfunction exacerbates elastase-induced neutrophilic airway inflammation and emphysema in mice

in Inflammation

Kengo Nishino
Takumi Kiwamoto
Masashi Matsuyama
Zhenting Wei
Sosuke Matsumura
Kenya Kuramoto
Yuki Yabuuchi
Kai Yazaki
Kazufumi Yoshida
Yosuke Matsuno

Frontiers in Immunology

doi 10.3389/fimmu.2025.1683385

988 views

Mini Review

Published on 14 Oct 2025

Functional heterogeneity of mast cells in cutaneous inflammation: implications for precision medicine

in Inflammation

Surui A
Dugarmaa Ulzii
Enkhtur Yadamsuren
Jihai Shi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680574

365 views

Brief Research Report

Published on 14 Oct 2025

Low-dose emapalumab treatment in refractory macrophage activation syndrome secondary to adult onset still’s disease/systemic lupus erythematosus: insights from nine cases

in Inflammation

Jie Chen
Liling Zhao
Yanwei Lin
Xinyue Lian
Haiting Wang
Liyang Gu
Ran Wang
Xiaodong Wang
Shuang Ye
Qiong Fu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1676749

205 views

Original Research

Accepted on 13 Oct 2025

Multi-omic analysis of PBMCs in sepsis reveals widespread cytotoxic dysfunction and an increased population of CD69 expressing naïve CD4+ T cells

in Inflammation

Joshua Flynn
Anne-Marie Baird
Eamon Breen
Michael Carty
Ciara S McNevin
Lisa Mcdermott
Elaine Kenny
John Davis Coakley
Thomas Ryan
Derek G Doherty

Frontiers in Immunology

doi 10.3389/fimmu.2025.1667186

Original Research

Accepted on 13 Oct 2025

Electrode Impedance Dynamics in Sequential Cochlear Implant Users: Insights into Cochlear Immunity

in Inflammation

Logan L Flom
Eva L Rasche
Jacob J Oleson
Rachel A Scheperle
Marlan R Hansen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1702549

Correction

Accepted on 13 Oct 2025

Correction: Identification and Analysis of Diverse Cell Death Patterns in Osteomyelitis via Microarray-Based Transcriptome Profiling and Clinical Data

in Inflammation

Tianxuan Feng
Peisheng Chen
Fengfei Lin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1721889

Original Research

Accepted on 13 Oct 2025

Decoding Immune-Metabolic Crosstalk in ARDS: A Transcriptomic Exploration of Biomarkers, Cellular Dynamics, and Therapeutic Pathways

in Inflammation

Ting Wu
Yuan Lu
Qin Wang
Wei Zhou
Ming Ding
Jing Huang
Jingyuan Xu
Shuzhen Wei
Min Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1615748

Original Research

Accepted on 13 Oct 2025

Acute exercise alters immune responses in older adults, with extracellular vesicle changes observed in a high-intensity intervention

in Inflammation

Alejandra P. Garza
Lorena Morton
Anna-Lena Motsch
Christian Puta
Marvin Stiebler
Yves Lading
Sabyasachi Chakrabarty
Stefanie Schreiber
Edit I. Buzas
Rüdiger Braun-Dullaeus

Frontiers in Immunology

doi 10.3389/fimmu.2025.1661161

Original Research

Accepted on 13 Oct 2025

A murine model of prurigo nodularis-like skin lesions induced by persistent scratching under type 2 inflammatory conditions

in Inflammation

Jiali Wu
Xiahong Li
Siqi Huang
Siyi Tang
Kaoyuan Zhang
Jiamin Yan
Xiaofan Chen
Xia Dou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648830

Original Research

Accepted on 13 Oct 2025

Circulating NETs Enable Early Identification of Thrombotic Risk in Sepsis at Emergency Care Onset

in Inflammation

Sofía Tejada
Antonio Clemente
Antonia Socias
Maria Aranda
Alberto Del Castillo
Joana Mena
Joana Mª Ribas
Luisa Martín
Karla Milagritos Llerena
María Magdalena Arellano

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664108

Original Research

Accepted on 13 Oct 2025

NF-κB/IL-6 Axis Drives Impaired Corneal Wound Healing in Aqueous-Deficient Dry Eye

in Inflammation

Cuipei Lin
Jiaxin Wu
Yuxin Jing
Jingbin Xie
Jiayan Xiang
Qiwei Fan
Jiangman Liu
Jingheng Du
Xiukui Tan
Zhudan Zhuang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1684290

109 views

Original Research

Accepted on 10 Oct 2025

Identification of CAF signature genes and construction of CAF-based risk signature in hepatocellular carcinoma by multi-omics analysis

in Inflammation

Wenchen Qian
Kezhi Wu
Bowen Ni
Haojie Zheng
Yawei Liu
Manlan Guo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1690174

398 views

Review

Accepted on 10 Oct 2025

Research Progress on Cellular Behavior of CaSR in Cardiovascular Diseases

in Inflammation

Xinyu Liu
Tao Xie
Javeria Qadir
Shuang Li
Tianshuang Xu
Yang Lu
Xiaotian Ge
Hui Yuan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1672536

Review

Accepted on 10 Oct 2025

The mechanotransduction-immune axis in organ fibrosis: dual regulatory mechanisms and translational therapeutic perspectives

in Inflammation

Chao Lei
Dongjie Wu
Houyan Zhang
Zhiya Yang
Bohao Huang
Jie Wang
Yanbo Li
Wenliang Lv

Frontiers in Immunology

doi 10.3389/fimmu.2025.1670213

129 views

Original Research

Published on 10 Oct 2025

Integrated bioinformatics and molecular docking analysis reveal potential hub genes and targeted therapeutics in sepsis-associated acute lung injury

in Inflammation

Qiongyan Chen
Yifeng Mao
Shangwen Cai
Xijiang Zhang
Chenghao Zeng
Qingqing Chen
Cheng Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1684774

541 views

Original Research

Published on 10 Oct 2025

Identification of sex- and inflammation-associated heterogeneity in the mouse omentum

in Inflammation

Yi Ding
Shu-Yu Xiao
Jun-Jie Wang
Zhi-Yi Ren
Xiao-Cao Miao
Xian-Ting Ding
Xin Xing
Dong-Xue Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1670112

361 views