Frontiers in Immunology

Original Research

Accepted on 05 Jun 2026

Astrocyte-Derived HMGB1 Compromises the Integrity of the Blood-Brain Barrier through the CaM /CaMKII / AQP4 Pathway and the Protective Function of Trifluoperazine

in Inflammation

Song-Song Zou
Li- LI Chen
Min Cui

Frontiers in Immunology

373 views

Review

Accepted on 05 Jun 2026

Mitochondrial DNA Efflux Drives Systemic Inflammatory Network Rewiring in HFpEF

in Inflammation

Xingwei Zhao
Shengyu Huang
Qiulin Li
Chunxiang Zhang
YANG YU

Frontiers in Immunology

165 views

Original Research

Accepted on 05 Jun 2026

Integrative Genetic and Expression Profiling Prioritizes LIPA in Mononuclear Phagocytes as a Candidate Regulator of Carotid Plaque

in Inflammation

Zhuyuan Yu
Shuhua Mao
Ying Song
Xiangyuan Meng
Jianing Yu
Ziyu Zong
Tianlin Gao
Hao Chen

Frontiers in Immunology

141 views

Original Research

Accepted on 05 Jun 2026

Protective Effect and Mechanisms of Buyang Huanwu Decoction Against Hypobaric Hypoxia-Induced Brain Injury in Mice: Involvement of Inflammatory Responses and HIF-1/PI3K-Akt-Related Pathways

in Inflammation

Zhixing Wang
Bowei Li
Xin Shen
Baoying Shen
Chunqi Yang
Lijun Huang
Hong Cai
Chengcai Lai
Yue Gao

Frontiers in Immunology

147 views

Original Research

Accepted on 05 Jun 2026

Hyperglycemia and systemic inflammation differentially shape immune dysregulation, tissue destruction, and microbiota in experimental periodontitis and peri-implantitis in diabetic mice

in Inflammation

Takumi Memida
Jacques Christopher Jaar
Tsute Chen
Guoqin Cao
Nanako Kuriki
Elaheh Dalir Abdolahinia
Motoki Okamoto
Satoru Shindo
Shohei Yamashita
Xuesong He

Frontiers in Immunology

Review

Accepted on 05 Jun 2026

Necroptosis in Asthma: A Critical Driver of Immune Dysregulation and Airway

in Inflammation

Zebo Jiang
Feng-Xian Ni
Jie Hu
Pei-Sheng Chen
Huihui Chen
Dong-Hui Huang

Frontiers in Immunology

Original Research

Accepted on 05 Jun 2026

Blomia tropicalis allergens induce lung DNA methylation changes in neuroimmune genes in a mouse model of airway inflammation

in Inflammation

Kevin Llinás-Caballero
Nathalie Acevedo
Simon Kebede Merid
Karen Donado
Ernesto Mondol
Randy Reina
Ronald Regino
Ines Benedetti
Josefina Zakzuk
Leonardo Puerta

Frontiers in Immunology

Perspective

Accepted on 05 Jun 2026

The SGK1/ENaC axis in renal injury during salt-sensitive hypertension: from sodium sensing to inflammation

in Inflammation

Yan Wang
Meixiang Wu
Jinlan Ma
Ruixin Liu
Delong Duo

Frontiers in Immunology

Review

Accepted on 05 Jun 2026

Cross-talk among Novel Programmed Cell Death Pathways: A Decisive Network in Renal Ischemia-Reperfusion Injury

in Inflammation

Yalin Lou
Jueheng Wu
Shilei Cheng
Guanghan Wu
Liang Guo
Yang Fan
Jianbo Wu

Frontiers in Immunology

Original Research

Published on 05 Jun 2026

Identification and analysis of diagnostic senescence-related gene signatures for acute myocardial infarction based on multi-omics data and machine learning

in Inflammation

Hanmo Zhang
Hongyu Huang
Zhuo Jiang
Shuangqi Qian
Xiandu Jin
Zeyan Peng
Fan Huang
Peipei Li
Liping Wei
Zhi Qi

Frontiers in Immunology

doi 10.3389/fimmu.2026.1775092

554 views

Review

Published on 05 Jun 2026

Canonical and emerging regulatory mechanisms of tissue remodeling: shared principles across organs and therapeutic opportunities

in Inflammation

Meiyu Wu
Zichao Han
Wenhao Wei
Yewen Niu
Hao Wang
Fanchao Meng
Qingmei Wu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1842892

602 views

Review

Published on 05 Jun 2026

VSMCs and the immune microenvironment: a multidimensional regulatory network driving vascular injury and repair

in Inflammation

Yuxin Wei
Yuanpeng Liao
Cong Zhang
Jiawei Guo

Frontiers in Immunology

doi 10.3389/fimmu.2026.1844567

711 views

Review

Published on 05 Jun 2026

Immune cell senescence and chronic bone diseases: osteoimmune mechanisms and therapeutic perspectives

in Inflammation

Zhi Wen
Min Yu
Siren Li
Fan Zeng
Jing Li
Jiabin Li
Guiping Liang
Kang Wang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1855772

330 views

Review

Published on 05 Jun 2026

Neutrophil in sepsis: functional aberration and regulated cell death

in Inflammation

Li Liu
Yanli Yang
Haixia Yang
Meng Yang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1863084

482 views

Brief Research Report

Published on 05 Jun 2026

Reduced CARS2 expression elicits a low-grade pro-inflammatory signature in THP-1 macrophages

in Inflammation

Anh-Thu Dang
Paulina Lau
Sébastien Soubeyrand
Ruth McPherson

Frontiers in Immunology

doi 10.3389/fimmu.2026.1786365

319 views

Review

Published on 05 Jun 2026

NF-κB signaling in osteoarthritis: integrating mechanical stress, innate immunity, and cartilage degeneration

in Inflammation

Peng Wan
Yimin Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2026.1842443

843 views

Original Research

Published on 05 Jun 2026

Tocilizumab but not Siltuximab prevents systemic inflammation in a humanized mouse model

in Inflammation

Liang Zhang
Jacqueline Wax
Torsten Goldmann
Afsaneh Mehrpouyan
Antje Müller
Frank Petersen
Gabriela Riemekasten
Xinhua Yu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1813955

440 views

General Commentary

Published on 05 Jun 2026

Commentary: SEMA3B is associated with disease activity and infliximab response in IBD patients but does not contribute to the development of intestinal inflammation in vivo

in Inflammation

Yang Yu
Liang Zhan
Zhenzhen Tang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1836065

383 views

Brief Research Report

Published on 05 Jun 2026

Elevated serum levels of interleukin-11 and matrix metalloproteinase-9 in myalgic encephalomyelitis/chronic fatigue syndrome

in Inflammation

Baskaran Chinnappan
Duraisamy Kempuraj
Kristina K. Aenlle
Ashley Middleton
Katie S. Day
Sai Puneeth Kothuru
Rhitik Samir Joshi
Nancy G. Klimas
Theoharis C. Theoharides

Frontiers in Immunology

doi 10.3389/fimmu.2026.1827700

1,504 views

Review

Accepted on 04 Jun 2026

The Gut-Liver-Kidney-Brain Axis in Wilson Disease: Copper Speciation-Flux and Barrier-Mediated Organ Crosstalk

in Inflammation

Nannan Qian
Sihuan Zhu
Yuqi Song
Yulong Yang
HAN WANG
Hui Han
Guocun Xu
Wenjie Hao
Hailin Jiang
Yue Yang

Frontiers in Immunology

Original Research

Published on 04 Jun 2026

Staphylococcus aureus serine protease-like protein B elicits a type 1/type 2 immune response in atopic dermatitis patients

in Inflammation

Rebecca Pospich
Goran Abdurrahman
Tatjana Honstein
Maria Nordengrün
Stephan Traidl
Gabriele Begemann
Petra Kienlin
Thomas Werfel
Barbara M. Bröker
Lennart M. Roesner

Frontiers in Immunology

doi 10.3389/fimmu.2026.1798583

959 views

Review

Published on 04 Jun 2026

Endothelial ferroptosis in blood–brain barrier dysfunction and neuroinflammation: mechanisms and immune–vascular crosstalk

in Inflammation

Yue Liu
Lei Yin
Peng Zhang
Wangwen Li

Frontiers in Immunology

doi 10.3389/fimmu.2026.1825000

799 views

Original Research

Accepted on 03 Jun 2026

Integrated Multi-Omics Identifies CRP as a Prognostic Biomarker and Reveals Complement Consumption in HIV-Associated AECOPD

in Inflammation

Tao Qin
Wenlong Huang
Changwei Yang
Tianming Lu
Jun Wang
jie chen
Linli Chen
Tianyu Yan
Tingting Qian
Hao Yang

Frontiers in Immunology

113 views

Original Research

Accepted on 03 Jun 2026

IL-33 Induces Stronger Responses in Female Mast Cells and Neutrophils: A role for the JNK Pathway

in Inflammation

Sydney Ann Kee
Tania D. Maldonado
John M. Ching
Catherine Nelson
Zakaria Y Hussain
An Z. Yao
Aditya Kotha
Hadi Hamze
Jason Burchett
John Joseph Ryan

Frontiers in Immunology

129 views

6,251 articles

articles

Astrocyte-Derived HMGB1 Compromises the Integrity of the Blood-Brain Barrier through the CaM /CaMKII / AQP4 Pathway and the Protective Function of Trifluoperazine

Mitochondrial DNA Efflux Drives Systemic Inflammatory Network Rewiring in HFpEF

Integrative Genetic and Expression Profiling Prioritizes LIPA in Mononuclear Phagocytes as a Candidate Regulator of Carotid Plaque

Protective Effect and Mechanisms of Buyang Huanwu Decoction Against Hypobaric Hypoxia-Induced Brain Injury in Mice: Involvement of Inflammatory Responses and HIF-1/PI3K-Akt-Related Pathways

Hyperglycemia and systemic inflammation differentially shape immune dysregulation, tissue destruction, and microbiota in experimental periodontitis and peri-implantitis in diabetic mice

Necroptosis in Asthma: A Critical Driver of Immune Dysregulation and Airway

Blomia tropicalis allergens induce lung DNA methylation changes in neuroimmune genes in a mouse model of airway inflammation

The SGK1/ENaC axis in renal injury during salt-sensitive hypertension: from sodium sensing to inflammation

Cross-talk among Novel Programmed Cell Death Pathways: A Decisive Network in Renal Ischemia-Reperfusion Injury

Identification and analysis of diagnostic senescence-related gene signatures for acute myocardial infarction based on multi-omics data and machine learning

Canonical and emerging regulatory mechanisms of tissue remodeling: shared principles across organs and therapeutic opportunities

VSMCs and the immune microenvironment: a multidimensional regulatory network driving vascular injury and repair

Immune cell senescence and chronic bone diseases: osteoimmune mechanisms and therapeutic perspectives

Neutrophil in sepsis: functional aberration and regulated cell death

Reduced CARS2 expression elicits a low-grade pro-inflammatory signature in THP-1 macrophages

NF-κB signaling in osteoarthritis: integrating mechanical stress, innate immunity, and cartilage degeneration

Tocilizumab but not Siltuximab prevents systemic inflammation in a humanized mouse model

Commentary: SEMA3B is associated with disease activity and infliximab response in IBD patients but does not contribute to the development of intestinal inflammation in vivo

Elevated serum levels of interleukin-11 and matrix metalloproteinase-9 in myalgic encephalomyelitis/chronic fatigue syndrome

The Gut-Liver-Kidney-Brain Axis in Wilson Disease: Copper Speciation-Flux and Barrier-Mediated Organ Crosstalk

Staphylococcus aureus serine protease-like protein B elicits a type 1/type 2 immune response in atopic dermatitis patients

Endothelial ferroptosis in blood–brain barrier dysfunction and neuroinflammation: mechanisms and immune–vascular crosstalk

Integrated Multi-Omics Identifies CRP as a Prognostic Biomarker and Reveals Complement Consumption in HIV-Associated AECOPD

IL-33 Induces Stronger Responses in Female Mast Cells and Neutrophils: A role for the JNK Pathway