Frontiers in Immunology

Clinical Trial

Accepted on 21 Apr 2025

A Phase 2a Double-Blind, Placebo-Controlled, Randomized Clinical Trial Evaluating the Efficacy and Safety of NuGel, a Novel Topical GPCR19-Mediated Inflammasome Inhibitor, in Patients with Mild to Moderate Atopic Dermatitis: A Proof-of-Concept Study with Post-Hoc Biomarker Analysis

in Inflammation

Gyeong Ho Baek
Bo Ri Kim
Jung-Won Shin
Chang Hun Huh
Jungjoong Hwang
Sungmin Ko
Siwon Kim
Pil-Su Ho
Kyu-Han Kim
Chun Wook Park

Frontiers in Immunology

doi 10.3389/fimmu.2025.1560447

156 views

Original Research

Accepted on 21 Apr 2025

Distinct proteomic signatures in Ethiopians predict acute and longterm sequelae of COVID-19

in Inflammation

Dawit Wolday
Abrha Gebrehiwot
An Nguyen Le Minh
Muhammed Ahmed Rameto
Saro Abdella
Atsbeha Gebreegziabxier Weldemariam
Wondwossen Amogne Degu
Tobias F. Rinke de Wit
Mesay Hailu Dangisso
Getachew Tollera

Frontiers in Immunology

doi 10.3389/fimmu.2025.1575135

Original Research

Accepted on 21 Apr 2025

Single-Cell RNA-Seq uncovers lineage-specific regulatory alterations of fibroblasts and endothelial cells in ligamentum flavum hypertrophy

in Inflammation

Yong Xin Chen
Jue Zhang
Cheng Xin Feng
Hong Qing Ma
Chao Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1569296

Case Report

Accepted on 21 Apr 2025

IgG4-RD-related ophthalmopathy combined with monoclonal gammopathy of undetermined significance

in Inflammation

Shanshan Liang
Wei Xu
Peiying Zhong
Chuanmin Tao
Li Zhang
Chengyao Jia

Frontiers in Immunology

doi 10.3389/fimmu.2025.1565388

Review

Accepted on 21 Apr 2025

Lactate and lactylation in liver diseases: energy metabolism, inflammatory immunity and tumour microenvironment

in Inflammation

Shiyi Cheng
Xiaoyu Xiao
Dingye Wang
Xiyuan Wang
Minlan Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1581582

Original Research

Accepted on 18 Apr 2025

Functional Immune Profiling of Hyper-and Hypo-inflammatory Subphenotypes of Critical Illness: A Secondary Analysis

in Inflammation

E. Scott Halstead
Daniel James McKeone
Abigail Samuelsen
Shouhao Zhou
Anthony Bonavia

Frontiers in Immunology

doi 10.3389/fimmu.2025.1520848

102 views

Original Research

Published on 17 Apr 2025

Defining a non-eosinophilic inflammatory subtype in COPD: the role of CXCL9 and type 1 immune responses

in Inflammation

Yin Chengsheng
Song Jiacui
Takehiro Hasegawa
Ling Yao
Takami Kondo
Li Huiping

Frontiers in Immunology

doi 10.3389/fimmu.2025.1576849

424 views

Brief Research Report

Published on 17 Apr 2025

Perivascular RELMα-positive synovial macrophages recruit monocytes at the onset of inflammatory arthritis

in Inflammation

Barbora Schonfeldova
Marah Chibwana
Rebecca Gentek
Kristina Zec
Irina A. Udalova

Frontiers in Immunology

doi 10.3389/fimmu.2025.1567661

406 views

Original Research

Published on 17 Apr 2025

Recombinant chymase inhibits fibrinolysis induced by endogenous plasmin in clotted human blood

in Inflammation

Laurence Vincent
Catherine Lapointe
Patrick P. McDonald
Christos Rammos
Tienush Rassaf
Maria Köllnberger
Hanna Tinel
Stefan Heitmeier
Pedro D’Orléans-Juste

Frontiers in Immunology

doi 10.3389/fimmu.2025.1511990

326 views

Original Research

Accepted on 16 Apr 2025

Identification of a Multiple DAMP Scavenger Mimicking TLR4's DAMP-Binding Site to Ameliorate Lethal Sepsis

in Inflammation

Takuya Murao
Gaifeng Ma
Atsushi Murao
Alok Jha
Jingsong Li
Yongchan Lee
Mian Zhou
Ping Wang
Monowar Aziz

Frontiers in Immunology

doi 10.3389/fimmu.2025.1540908

113 views

Original Research

Accepted on 16 Apr 2025

Gene Expression Profiling in Pure Neural Leprosy: insights into Pathogenesis and Diagnostic Biomarkers

in Inflammation

Mariana Martins De Athaide
Thyago Leal-Calvo
Tatiana Pereira Da Silva
Thabatta Leal Silveira Andrezo Rosa
Helen Ferreira
Bernardo Pascarelli
Ana Caroline Siquara de Sousa
Marcia Rodrigues Jardim
Roberta Olmo Pinheiro

Frontiers in Immunology

doi 10.3389/fimmu.2025.1550687

120 views

Original Research

Accepted on 16 Apr 2025

Differential activation of monocytes and PMNs in Orofacial Granulomatosis patients induced by bacterial and non-bacterial stimuli Short title: Innate Immune Cells in Orofacial Granulomatosis

in Inflammation

Francesco Palestra
Luca Modestino
Annagioia Ventrici
Arianna Monteforte
Gina Memoli
Anne Lise Ferrara
Leonardo Cristinziano
Remo Poto
Francesca Wanda Rossi
Gilda Varricchi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1522495

105 views

Original Research

Accepted on 16 Apr 2025

Hazards of Lunar Surface Exploration: Determining the Immunogenicity/Allergenicity of Lunar dust

in Inflammation

Audrie Ann Colorado
Cody L Gutierrez
Mayra Nelman-Gonzalez
Gailen D Marshall
J Torin Mccoy
Brian Crucian

Frontiers in Immunology

doi 10.3389/fimmu.2025.1539163

Original Research

Published on 16 Apr 2025

SARS-CoV-2 post-acute sequelae linked to inflammation via extracellular vesicles

in Inflammation

Sara Bachiller
Joana Vitallé
Lluís Camprubí-Ferrer
Manuel García
Isabel Gallego
Marina López-García
María Isabel Galvá
Julio Cañizares
Inmaculada Rivas-Jeremías
María Díaz-Mateos

Frontiers in Immunology

doi 10.3389/fimmu.2025.1501666

909 views

Mini Review

Published on 16 Apr 2025

Chromatin-associated cullin-RING E3 ubiquitin ligases: keeping transcriptionally active NF-κB in check

in Inflammation

Mengyao Gong
Junqi Luo
Qiankun Liang
Yi Liu
Yuejuan Zheng
Xiao-Dong Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1584999

212 views

Review

Published on 16 Apr 2025

Supersulfide donors and their therapeutic targets in inflammatory diseases

in Inflammation

Tianli Zhang
Yuexuan Pan
Tomohiro Sawa
Takaaki Akaike
Tetsuro Matsunaga

Frontiers in Immunology

doi 10.3389/fimmu.2025.1581385

315 views