Frontiers in Immunology | Molecular Innate Immunity

Original Research

Published on 18 Sep 2025

Immunopathology in PMM2-CDG: Defective glycosylation impact in the TNFα -TNFR1 signalling pathway

in Molecular Innate Immunity

Carlota Pascoal
Pedro Granjo
Rebeka Kodríková
Marta Falcão
Ana C. Santos
Inês Teodoro
Zuzana Pakanová
Marek Nemčovič
Jan Mucha
Margarida Castro-Caldas

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655354

510 views

Original Research

Published on 18 Sep 2025

PRMT6 inhibitors promote fracture healing by modulating osteoclast glucose metabolism

in Molecular Innate Immunity

Nan Wu
Renkai Wang
Shensheng Nian
Hao Zhang
Panyu Zhou
Hao Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1637232

199 views

Original Research

Accepted on 17 Sep 2025

Increased Levels of Ficolin-1 and of C3dg are independently associated with high Risk of Infection in Patients with Chronic Kidney Disease: A Prospective Cohort Study

in Molecular Innate Immunity

Solbjørg Sagedal
Markus Hovd
Anders Åsberg
Tom E. Mollnes
Olav Klingenberg
Torbjørn Fossum Heldal
Bartlomiej Witczak
Trine Korsgaard Hejlesen
Anne Troldborg
Steffen Thiel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1645347

Original Research

Accepted on 17 Sep 2025

Multi-Omics Analysis Reveals Neutrophil Heterogeneity and Key Molecular Drivers in Sepsis-Associated Acute Kidney Injury

in Molecular Innate Immunity

Tianle Cheng
Yong Xu
Ziwei Liu
Yanchen Wang
Ze Zhang
Wenlin Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1637692

Original Research

Published on 17 Sep 2025

HERV-K10 as a mediator of immune modulation in hepatitis infections

in Molecular Innate Immunity

Salih Özer
Romano Strobelt
Anna D. Kosinska
Goar Frishman
Jochen M. Wettengel
Lisa Pleninger
Nina Körber
Wen Liang
Edanur Ates Öz
Marisol Zuniga

Frontiers in Immunology

doi 10.3389/fimmu.2025.1624774

262 views

Review

Published on 17 Sep 2025

Immunotherapy strategies targeting tumor-associated macrophages and their mechanisms of action in tumor progression

in Molecular Innate Immunity

Haixia Zhu
Jingjing Shao
Lili Shao
Liuhuan Cai
Chunyan Gu
Qin Ge
Jibin Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680455

258 views

Review

Published on 17 Sep 2025

The role of cGAS-STING signaling in the liver and gastrointestinal system: from signaling networks to target intervention

in Molecular Innate Immunity

Zhengli Tan
Jiayue Shi
Shiyi Zhang
Yanyao Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682992

339 views

Original Research

Published on 17 Sep 2025

Clinical laboratory analytes and platelet-associated parameters as surrogate markers of subclinical inflammation in latent tuberculosis infection

in Molecular Innate Immunity

Sivaprakasam T. Selvavinayagam
Adukkadukkam Anusree
Yean K. Yong
Sathish Sankar
Asha Frederick
Manivannan Rajeshkumar
Masilamani S. Kumar
Palani Sampath
Ganga Sankar
Chitrali L. Roy

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662454

737 views

Review

Accepted on 16 Sep 2025

Synthesis, Function and Therapeutic potential of Glycosphingolipids

in Molecular Innate Immunity

Liang Dong
Zhi Cao
Weidong Han
Zhiqiang Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1673713

Original Research

Accepted on 16 Sep 2025

Identification of novel amino acid variants in the Han Chinese population that impair Toll-like Receptor 4 signaling and confer hyporesponsiveness to lipopolysaccharide

in Molecular Innate Immunity

Bin Zhou
Zhaoying Lv
Ruijuan Zu
Jianbo Liu
Yuting Yang
Zong-Guang Zhou
Yuan Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1556600

Mini Review

Published on 16 Sep 2025

The innate immune axis drives aortic dissection pathogenesis through inflammation and presents novel therapeutic targets

in Molecular Innate Immunity

Can Xu
Wenping Chen
Xinyu Nie
Rui Xu
Xingyue Feng
Zhifen Chen
Dongjin Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1654622

271 views

Original Research

Accepted on 15 Sep 2025

Dual roles of in situ generated HSP70 in antigen delivery and immunoregulation

in Molecular Innate Immunity

Xinliang Kang
Zhuofan Li
Jayachandra Reddy Nakkala
Yibo Li
Labone Akter
Yiwen Zhao
Xinyuan Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638948

221 views

Review

Accepted on 11 Sep 2025

From Stress Signals to Fertility Challenges: The Role of Damage-Associated Molecular Patterns in Male Reproduction

in Molecular Innate Immunity

Heran Cao
Shujuan Liu
Shichao Cui
Hua Nie
Xiaohua Liu
Weibing Qin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1598451

954 views

Original Research

Published on 11 Sep 2025

SIFD-associated TRNT1 deficiency unveils importance of TSPO during macrophage antibacterial and antiviral responses

in Molecular Innate Immunity

Duale Ahmed
Angelo Slade
Thet Fatica
Stephen Baird
Krishna Bhattarai
Thérèse Atallah
Edana Cassol
Martin Holcik

Frontiers in Immunology

doi 10.3389/fimmu.2025.1497766

1,115 views

Mini Review

Published on 11 Sep 2025

Advance in therapies targeting tumor-associated macrophages in ovarian cancer

in Molecular Innate Immunity

Man Li
Yue Ma
Tinggeng Dai
Yongxin Wang
Ying Yue

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677839

910 views

Review

Accepted on 10 Sep 2025

Exploring the Pathogenesis of MAFLD from an Immunological Perspective: From the perspective of the cGAS/STING/NF-κB signaling pathway

in Molecular Innate Immunity

Ruiyuan Tian
Yong Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1674018