Frontiers in Immunology | Molecular Innate Immunity

General Commentary

Published on 20 Nov 2025

Commentary: Complement genetic variants and FH desialylation in S. pneumoniae-haemolytic uraemic syndrome

in Molecular Innate Immunity

Laura M. Baas
Nicole C. A. J. van de Kar
Marloes A. H. M. Michels
Lambertus P. van den Heuvel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707529

165 views

Review

Accepted on 19 Nov 2025

Epigenetic modifications in Vascular inflammation

in Molecular Innate Immunity

Linyi Tang
Liyun Li
Yang Liu
Xin Zhang
Xinglin Wang
Ping Yang
Haoran Wu

Frontiers in Immunology

Original Research

Published on 19 Nov 2025

Plasma lipidomic signatures reveal age-associated patterns of septic shock risk and immune dysregulation in sepsis

in Molecular Innate Immunity

Yuhan Sun
Ke Lin
Ling Wang
Jingwen Ai
Jingjing Zhao
Ruiwen Sun
Xiaoyang Cheng
Yanmin Wan
Peng Cui
Sen Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1659425

492 views

Original Research

Published on 19 Nov 2025

Manganese mediates antiviral effects by driving an ATM -TBK1 phosphorylation signaling pathway

in Molecular Innate Immunity

Hongyan Sui
Rosana Wiscovitch-Russo
Silvia Cachaco
Jun Yang
Whitney Bruchey
Sylvain Laverdure
Qian Chen
Tomozumi Imamichi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708516

348 views

Original Research

Published on 19 Nov 2025

Significant alterations in peripheral lymphocyte subsets and immune-related protein profiles in patients with periprosthetic joint infection

in Molecular Innate Immunity

Zhuo Li
Fan Yang
Jun Fu
Zhi-Yuan Li
Li-Bo Hao
Lin Yuan
Ji-Ying Chen
Chi Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648150

216 views

Original Research

Published on 18 Nov 2025

RIG-I drives protective type I interferon production by glial cells in response to Neisseria meningitidis and Streptococcus pneumoniae challenge

in Molecular Innate Immunity

Krishna J. Majithia
M. Brittany Johnson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692421

571 views

Mini Review

Accepted on 17 Nov 2025

Tumor Associated Macrophages in Gastric Cancer Dual Roles in Immune Evasion and Clinical Implications for Targeted Therapy

in Molecular Innate Immunity

Chang Wang
Xu Fan
Xiaomeng Sun
Yi Xu
Yanna Sun
Jidong Liu

Frontiers in Immunology

112 views

Editorial

Accepted on 17 Nov 2025

Editorial: Role of Endogenous Regulators of Innate Immunity in Sepsis

in Molecular Innate Immunity

Haichao Wang
Xianzhong Meng
Daolin Tang
Yong Ming Yao

Frontiers in Immunology

Editorial

Accepted on 17 Nov 2025

Editorial: Unraveling circRNAs and miRNAs: Key Regulators in Immune-Related Diseases

in Molecular Innate Immunity

Mohamad S. Hakim
Aqsa Ikram
Mounir M. Salem Bekhit
Zulqarnain Baloch

Frontiers in Immunology

Original Research

Accepted on 17 Nov 2025

Accumulation of free nuclei denotes defective phagocytic capacity of macrophages and occurs after infection with Listeria monocytogenes and Lymphocytic Choriomeningitis Virus (LCMV)

in Molecular Innate Immunity

Theresa Charlotte Christ
Justa Friebus-Kardash
Michael Bergerhausen
Abdelrahman Elwy
Hossam Abdelrahman
Lisa Holnsteiner
Elisa Wiebeck
Ilka Geuer
Alexander Gerbaulet
Philipp A Lang

Frontiers in Immunology

Original Research

Published on 17 Nov 2025

Comprehensive analysis of metabolism-related genes in sepsis reveals metabolic–immune heterogeneity and highlights GYG1 as a potential therapeutic target

in Molecular Innate Immunity

Jie Zheng
Kangjie Qin
Xiaoqin Wang
Banghai Feng
Yuting Zhang
Yiyu Wang
Han Qin
Qiuyu Dai
Xinxin Liu
Kun Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682846

400 views

Original Research

Published on 17 Nov 2025

Unraveling the gut microbiota–SCFAs–cathepsin C pathway in preeclampsia: a novel therapeutic target

in Molecular Innate Immunity

Fan Lu
Houkang Lei
Xiang Xiao
Luzhu Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700781

658 views

Original Research

Accepted on 14 Nov 2025

Differential DNA methylation in infants with IgE- and non-IgE-mediated cow’s milk allergy and its association with acquired tolerance

in Molecular Innate Immunity

Rebeca López-Gómez
Marta Gil-Martínez
Ana Ladrón-Guevara
Jose Manuel Rodrigo-Muñoz
Clara Lorente-Sorolla
Daniel Rodríguez-González
Zahara García De Castro
Gema Guillén-Sánchez
Antonio Serrano
Raquel Mirasierra-Pérez

Frontiers in Immunology

Review

Accepted on 14 Nov 2025

Neutrophils as Key Drivers of Pulmonary Fibrosis: Unveiling Mechanisms and Therapeutic Implications

in Molecular Innate Immunity

Xiuping Liang
Li Yanhong
Ziyi Tang
Yubin Luo
Yi Liu

Frontiers in Immunology

Mini Review

Accepted on 14 Nov 2025

From Neuroinflammation to Gliomagenesis: Immune Drivers of Malignant Transformation in the CNS

in Molecular Innate Immunity

Yingshi Bao
Yutong Su
Zixuan Chen
Tingting Guo
Huaping Du
Xianjun Jia

Frontiers in Immunology

Original Research

Published on 14 Nov 2025

Extracellular microRNAs modulate human microglial function through TLR8

in Molecular Innate Immunity

Hannah Weidling
Edyta Motta
Leonard D. Kuhrt
Christina Krüger
Caio Andreeta Figueiredo
Thomas Wallach
Silke Frahm
Sebastian Diecke
Susanne A. Wolf
Helmut Kettenmann

Frontiers in Immunology

doi 10.3389/fimmu.2025.1645062

932 views