Frontiers in Immunology | Molecular Innate Immunity

Original Research

Accepted on 10 Oct 2025

Expression of NEAT1 induced by influenza virus infection is regulated by activated STAT3 and contributes to STAT3-mediated antiviral immunity

in Molecular Innate Immunity

Rongrong Gu
Erying Xu
Jingjie Hong
Liqing Fan
Shasha Liu
Ji-Long Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1693884

Original Research

Accepted on 10 Oct 2025

The Peptide Genomic Therapy Increases Antibacterial Immunity and Survival in Sepsis by Reprograming the Gene Orthologs of Human Immunodeficiencies in the Spleen and Lungs

in Molecular Innate Immunity

Jacek Hawiger
Huan Qiao
Jozef Zienkiewicz
Yan Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1635081

Mini Review

Published on 09 Oct 2025

Roles of tumor-associated macrophages in triple-negative breast cancer progression

in Molecular Innate Immunity

Tianhai Wu
Yuling Liao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677363

762 views

Review

Published on 09 Oct 2025

Unveiling CD177: a key player in tumors, autoimmune diseases, and inflammatory disorders

in Molecular Innate Immunity

Dongmei Yang
Xiaobin Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1653587

1,009 views

Original Research

Published on 08 Oct 2025

Integrating bioinformatics and machine learning analyses to identify immune-related secretory proteins and therapeutic small-molecule drugs in calcific aortic valve disease with type 2 diabetes

in Molecular Innate Immunity

Xiang Zhang
Jiahui Wang
Qian Hu
Bangyu Guo
Mengjie Hu
Xiaobo Yu
Shunbo Wei
Qiujie Luo
Yuqing Zhang
Shentao Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634655

261 views

Brief Research Report

Published on 08 Oct 2025

Optimizing monocyte-derived immune cell cultures: comparing xeno-free and xenogeneic conditions

in Molecular Innate Immunity

Nora Marek
Anette S. B. Wolff
Harsh N. Dongre
Salwa Suliman

Frontiers in Immunology

doi 10.3389/fimmu.2025.1589553

903 views

Original Research

Accepted on 07 Oct 2025

Phospholipase D1 is a critical mediator of neutrophil extracellular trap formation and venous thrombosis

in Molecular Innate Immunity

Ryosuke Aihara
Masatomo Takahashi
Kenji Morino
Keisuke Matsuara
Kazufumi Kunimura
Akihiko Nishikimi
Yoshihiro Izumi
Takeshi Bamba
Yoshinori Fukui
Takehito Uruno

Frontiers in Immunology

doi 10.3389/fimmu.2025.1666184

102 views

Original Research

Published on 07 Oct 2025

Deciphering macrophage differentiation and cell death dynamics in heart failure: a single-cell sequencing odyssey

in Molecular Innate Immunity

Jin Wei
Yao Sun
Bao-xi Qu
Xin-xin Duan
Li-hong Yan
Wei An
Kun-lun Yin
Shui-yun Wang
Yan-hai Meng
Lei Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1604226

1,653 views

Review

Accepted on 06 Oct 2025

Innate Immunity in Tumors: Roles and Therapeutic Targets

in Molecular Innate Immunity

Songze Leng
Yuyue Ren
Yaoyao Tian
Weiwei Zhao
Yue Mou
Xingyu Chen
Hong Zhou
Wei Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689714

Original Research

Published on 03 Oct 2025

The interplay between hormonal vitamin D and lipopolysaccharide signaling on human neutrophil transcriptional responses

in Molecular Innate Immunity

Aiten Ismailova
Reyhaneh Salehi-Tabar
Nailya Ismailova
Olivia Dumas
James Saliba
Volker Blank
John H. White

Frontiers in Immunology

doi 10.3389/fimmu.2025.1683913

1,017 views

Original Research

Accepted on 02 Oct 2025

TNF-α-mediated downregulation of CD36 and phagocytic impairment of alveolar macrophages via upregulation of ADAM17 in Asthma

in Molecular Innate Immunity

Xingyue Liu
Ya Li
Feifei Shang
Minzhu Niu
Jiaqi Yan
Minyu Xie
Xiangnan Tao
Han Huang
Wenwen Wu
Shu Dong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663513

312 views

Review

Accepted on 02 Oct 2025

From mechanisms to therapies: the multifaceted roles of guanylate-binding protein 2 in immunity, cancer, and beyond

in Molecular Innate Immunity

Wenqi Cui
Tianlu Wang
Juan Feng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708319

103 views

Original Research

Published on 02 Oct 2025

SPP1+macrophages promote fibroblast-to-myofibroblast transformation during hypoxia in deep fascia of acute compartment syndrome

in Molecular Innate Immunity

Liujie Zheng
Guoqiang Li
Jingcheng Cao
Zihang Zhao
Haofei Wang
Qi Dong
Zhiyong Hou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1588926

689 views

Review

Published on 02 Oct 2025

Innate immunity of bile and cholangiocytes in primary biliary cholangitis

in Molecular Innate Immunity

Ran Chen
Yan Sun
Ying Hu
Wenlin Tai

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655287

1,274 views

Original Research

Published on 02 Oct 2025

Dual roles of in situ generated HSP70 in antigen delivery and immunoregulation

in Molecular Innate Immunity

Xinliang Kang
Zhuofan Li
Jayachandra Reddy Nakkala
Yibo Li
Labone Akter
Yiwen Zhao
Xinyuan Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638948

922 views

Mini Review

Published on 02 Oct 2025

m6A RNA modification in tumor-associated macrophages: emerging roles in cancer immunity

in Molecular Innate Immunity

Xi Chen
Shanrui Pu
Kun Lian
Lihua Li
Xiulin Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1693336

1,261 views