Frontiers in Immunology | Molecular Innate Immunity

Original Research

Published on 28 Oct 2025

The peptide genomic therapy increases antibacterial immunity and survival in sepsis by reprograming the gene orthologs of human immunodeficiencies in the spleen and lungs

in Molecular Innate Immunity

Huan Qiao
Jozef Zienkiewicz
Yan Liu
Jacek Hawiger

Frontiers in Immunology

doi 10.3389/fimmu.2025.1635081

180 views

Review

Accepted on 27 Oct 2025

Circular RNAs and Their Emerging Roles in Muscular Immune-Related Diseases

in Molecular Innate Immunity

Felicita Urzi
Anja Srpčič
Katja Lakota

Frontiers in Immunology

Original Research

Accepted on 27 Oct 2025

Comprehensive analysis of metabolism-related genes in sepsis reveals metabolic– immune heterogeneity and highlights GYG1 as a potential therapeutic target

in Molecular Innate Immunity

Jie Zheng
Kangjie Qin
Xiaoqin Wang
Banghai Feng
Yuting Zhang
Yiyu Wang
Qin Han
Qiuyu Dai
Xinxin Liu
Kun Yu

Frontiers in Immunology

Original Research

Accepted on 24 Oct 2025

Plasma Lipidomic Signatures Reveal Age-Associated Patterns of Septic Shock Risk and Immune Dysregulation in Sepsis

in Molecular Innate Immunity

Yuhan Sun
Ke Lin
Ling Wang
Jingwen Ai
Jingjing Zhao
Ruiwen Sun
Xiaoyang Cheng
Yanmin Wan
Peng Cui
Sen Wang

Frontiers in Immunology

324 views

Mini Review

Published on 24 Oct 2025

Endoplasmic reticulum stress and unfolded protein response in immune cell function

in Molecular Innate Immunity

Goshi Matsushima
Yuhki Yanase
Tadashi Nakagawa
Mitsuhiro Goda
Koichiro Ozawa
Toru Hosoi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694102

299 views

Original Research

Accepted on 23 Oct 2025

Unraveling the Gut Microbiota–SCFAs–Cathepsin C Pathway in Preeclampsia: A Novel Therapeutic Target

in Molecular Innate Immunity

Fan Lu
Houkang Lei
Xiang Xiao
Luzhu Yu

Frontiers in Immunology

276 views

Original Research

Accepted on 23 Oct 2025

Extracellular microRNAs modulate human microglial function through TLR8

in Molecular Innate Immunity

Hannah Weidling
Edyta Motta
Leonard D Kuhrt
Christina Krüger
Caio Andreeta Figueiredo
Thomas Wallach
Silke Frahm
Sebastian Diecke
Susanne Wolf
Helmut Kettenmann

Frontiers in Immunology

339 views

Original Research

Published on 23 Oct 2025

Expression of NEAT1 induced by influenza virus infection is regulated by activated STAT3 and contributes to STAT3-mediated antiviral immunity

in Molecular Innate Immunity

Rongrong Gu
Erying Xu
Jingjie Hong
Liqing Fan
Shasha Liu
Ji-Long Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1693884

531 views

Brief Research Report

Published on 23 Oct 2025

Dual-functional cerium oxide nanoparticles with antioxidant and DNase I activities to prevent and degrade neutrophil extracellular traps

in Molecular Innate Immunity

Hachem Dich
Ramy Abou Rjeily
Gabriela Rath
Mathéo Berthet
Bénédicte Dayde-Cazals
Jean-François Berret
Eduardo Angles-Cano

Frontiers in Immunology

doi 10.3389/fimmu.2025.1693809

527 views

Review

Published on 22 Oct 2025

Innate immunity in tumors: roles and therapeutic targets

in Molecular Innate Immunity

Songze Leng
Yuyue Ren
Yaoyao Tian
Weiwei Zhao
Yue Mou
Xingyu Chen
Hong Zhou
Wei Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689714

595 views

Original Research

Accepted on 21 Oct 2025

Deficiency of HMGN2 enhances antibacterial activity of macrophages by promoting H3 histone modification-mediated CD14/iNOS expression

in Molecular Innate Immunity

Zhen Yang
Xiao Zhang
ChaoQun Liu
Ning Huang
Yan Teng
Junming Miao

Frontiers in Immunology

295 views

Original Research

Accepted on 21 Oct 2025

Multi-Omics Discovery of a Kbhb–SSBP1 Axis Linking Mitochondrial Homeostasis to Temozolomide Resistance in Glioblastoma

in Molecular Innate Immunity

Yongjie Chen
Yifei Xiao
Jiangbin Ren
Qiang Gu
Yuanqi Chu
Ende Li
Ruisheng Ge
Yuwen Song
Kan Wang
Qinla Li

Frontiers in Immunology

126 views

Original Research

Published on 21 Oct 2025

Phospholipase D1 is a critical mediator of neutrophil extracellular trap formation and venous thrombosis

in Molecular Innate Immunity

Ryosuke Aihara
Masatomo Takahashi
Kenji Morino
Keisuke Matsubara
Kazufumi Kunimura
Akihiko Nishikimi
Yoshihiro Izumi
Takeshi Bamba
Yoshinori Fukui
Takehito Uruno

Frontiers in Immunology

doi 10.3389/fimmu.2025.1666184

729 views

Original Research

Accepted on 20 Oct 2025

Lactylation-Related Gene AKR1A1 Contributes to Osteoporosis via Metabolic–Immune Regulation: Evidence from Multi-Omics Integration, Single-Cell Transcriptomics, and In Vitro Validation

in Molecular Innate Immunity

ZiChen Shao
Qinqin Deng
Ling Cheng
Jianfeng Wu
Weikang SUN
Huanan Li

Frontiers in Immunology

Mini Review

Accepted on 20 Oct 2025

The Complement Pathway and the Pathophysiology of Fibroproliferative Cutaneous Scarring

in Molecular Innate Immunity

Ilja L Kruglikov
Katarzyna Walendzik
Philipp E Scherer

Frontiers in Immunology

Mini Review

Accepted on 20 Oct 2025

Immune Snapshots Along the Inflammation-to-Cancer Road in Bladder Urothelium

in Molecular Innate Immunity

Lingxiang Lu
Fei Wang
Zhenfan Wang
Shuai Guo
Minjun Jiang
Ma Zheng

Frontiers in Immunology