Frontiers in Immunology | Systems Immunology

Original Research

Accepted on 09 Jul 2025

Antimicrobial and Immunomodulatory Activity of Natural Bioactive Compounds -an in vitro Investigation with Potential Applications in Managing Hidradenitis Suppurativa

in Systems Immunology

Valentina Alexandra Bădăluță
Adrian Ionascu
Lia-Mara Ditu
Curutiu Carmen
Alina Maria Holban
Eliza Oprea
Yiannis Kourkoutas
Mara Madalina Mihai
Corina Ioana Cucu
Ariana Hudita

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608269

Review

Accepted on 08 Jul 2025

Considering Local Immunity for Innovative Immunomodulatory Approaches: Pulmonary Sepsis as a use case

in Systems Immunology

Emilie Vernay
Elisabeth Cerrato
François Santinon
Céline Monard
Pauline Perez
Florence Allantaz
Anne-Claire Lukaszewicz
Jean-François Llitjos

Frontiers in Immunology

doi 10.3389/fimmu.2025.1627313

174 views

Original Research

Accepted on 08 Jul 2025

A Comprehensive Bioinformatics Analysis of Pathways and Biomarkers Shared Between Type 2 Diabetes Mellitus and Chronic Obstructive Pulmonary Disease

in Systems Immunology

Tingting Hu
Xiaomei Duan
Jiale Gao
Zheng Li
Dan Xu
Jing Jing
Fengsen Li
Jianbing Ding
Li Ma
Min Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1536551

351 views

Correction

Published on 08 Jul 2025

Corrigendum: Mapping knowledge structure and research of the biologic treatment of asthma: a bibliometric study

in Systems Immunology

Jiamin Sun
Shiyao Bai
Jieyu Zhao
Danling Li
Xueqing Ma
Lin Ma
Xinming Su

Frontiers in Immunology

doi 10.3389/fimmu.2025.1630817

138 views

Original Research

Published on 08 Jul 2025

Complement and coagulation cascade cross-talk in endometriosis and the potential of Janus Kinase inhibitors—a network meta-analysis

in Systems Immunology

Monika Golinska
Aleksander Rycerz
Matylda Sobczak
Jedrzej Chrzanowski
Konrad Stawiski
Wojciech Fendler

Frontiers in Immunology

doi 10.3389/fimmu.2025.1619434

333 views

Original Research

Accepted on 07 Jul 2025

Decoupled Dynamics of Absolute and Relative Lymphocyte Counts and Age-Polarized CD4 + /CD8 + Ratio in Infants versus Older Adults

in Systems Immunology

Jianchun Yu
Ting Ge
Guixin He
Qian Cui
Shuangcui Wang
Zekun Wang
Yingying Xie
Yuanyuan Tian
Juyue Zhou
Wentao Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1599515

141 views

Review

Accepted on 07 Jul 2025

Emerging IO checkpoints in gastrointestinal oncology

in Systems Immunology

Alireza Tojjari
Anwaar Saeed
Ludimila Cavalcante

Frontiers in Immunology

doi 10.3389/fimmu.2025.1575713

120 views

Original Research

Accepted on 03 Jul 2025

Comprehensive characterization of multi-omics landscapes between gut microbial metabolites and the druggable genome in sepsis

in Systems Immunology

Jun Liu
Tong Li
Li Xing
Xingyu Li
Jianbo Zhang
Peng Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1597676

119 views

Original Research

Published on 03 Jul 2025

CD79A and GADD45A as novel immune-related biomarkers for respiratory syncytial virus severity in children: an integrated machine learning analysis and clinical validation

in Systems Immunology

Juan Juan Chen
Zhang Ze Lu
Yu Xin Jing
Xing Mei Nong
Yi Qin
Jin Yang Huang
Na Lin
Jie Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1609183

486 views

Original Research

Accepted on 02 Jul 2025

Role of hypoxia-related genes and immune infiltration in intervertebral disc degeneration: molecular mechanisms and diagnostic potential

in Systems Immunology

Kai Zhou
Jiaxiang Zhou
XianJin Luo
Yan Chen
Jian Ao
Wei Wu
Bo Yang
Zhongyuan He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1606905

Original Research

Published on 02 Jul 2025

Identification and validation of glycosylation-related gene signatures for prognostic stratification in sepsis

in Systems Immunology

Chunyang Li
Haiyan Xue
Lihe Chen
Fengxue Zhu
Jie Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608082

338 views

Original Research

Published on 02 Jul 2025

Prediction and immune landscape study of potentially key autophagy-related biomarkers in preeclampsia with gestational diabetes mellitus

in Systems Immunology

Qin Wang
Xiaoqi Li
Wen Ye
Lin Lin
Kejun Ye
Mengjia Peng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1571795

839 views

Original Research

Published on 02 Jul 2025

Multi-omics analysis reveals glutathione metabolism-related immune suppression and constructs a prognostic model in lung adenocarcinoma

in Systems Immunology

Yuxiang Chi
Guoyuan Ma
Qiang Liu
Yunzhi Xiang
Defeng Liu
Jiajun Du

Frontiers in Immunology

doi 10.3389/fimmu.2025.1608407

424 views

Review

Accepted on 01 Jul 2025

Exercise Workload: A Key Determinant of Immune Health -A Narrative Review

in Systems Immunology

XinXin Shi
LuNuo Hu
David Christopher Nieman
Fei Li
Peijie Chen
Hui Shi
Yue Shi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1617261

219 views

Original Research

Accepted on 27 Jun 2025

Immune Composition of the Mononuclear Cell Fraction of Human Umbilical Cord Blood

in Systems Immunology

Karen Kikuta
Esmond Lee
Talia Menezes
Hannah Fung
Alvaro Amorin
Aditi Agrawal
Theodore L Roth
Matthew Porteus

Frontiers in Immunology

doi 10.3389/fimmu.2025.1614230

125 views

Original Research

Accepted on 27 Jun 2025

Experimental Validation of Cuproptosis-Associated Molecular Signatures and Their Immunological Implications in Pulmonary Tuberculosis

in Systems Immunology

Xiaofang Liu
Qianqian Ma
Zhiming Li
Yong Xue
Jie Mi
Yuxi Li
Chunfeng Bai
Donglin Guo
Yinping Liu
Yan Liang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1570992