Frontiers in Medicine | Gene and Cell Therapy

Original Research

Published on 02 Sep 2025

Malignant epithelia cells-derived spermine induces APOE+ macrophages to suppress tumor immunity in adenocarcinoma of the esophagogastric junction

in Gene and Cell Therapy

Yan Zhang
Zhaoyang Liu
Huihui Sun
Zhenxiang Wang
Ye Chen
Zhiqian Hu
Xinxing Li
Kai Xu
Ying Chen
Yanping Xu

Frontiers in Medicine

doi 10.3389/fmed.2025.1636699

456 views

Systematic Review

Accepted on 30 Aug 2025

Contextual Effects of Mesenchymal Stem Cell Injections for Knee Osteoarthritis: Systematic Review and Meta-analysis of Randomized Controlled Trials

in Gene and Cell Therapy

Yin Fengsheng
Yu Zhang
Houdong Wu
Dan Tong
Gan Luo
Zhen Deng
Qinyi Yan

Frontiers in Medicine

doi 10.3389/fmed.2025.1636181

436 views

Original Research

Accepted on 29 Aug 2025

Intrathecal injection of bone marrow concentrate in children with autism spectrum disorder: A retrospective chart analysis

in Gene and Cell Therapy

Georg S. Kobinia
Adam J. Bukaty
Elisabeth Holly
Gloria M. Kobinia
Philipp R. Heuberer
Brenda Laky

Frontiers in Medicine

doi 10.3389/fmed.2025.1666486

361 views

Mini Review

Accepted on 28 Aug 2025

The advantages of NK cell vaccines in solid carcinoma clinical trials:Conducted by various biology Strategy and Technology

in Gene and Cell Therapy

Yizhe Hu
Limei Leng
Bing Li
Qiang Qiao

Frontiers in Medicine

doi 10.3389/fmed.2025.1656570

412 views

Review

Accepted on 25 Aug 2025

The Xenopus Model as a Tool for Investigating Craniofacial Developmental Disorders

in Gene and Cell Therapy

Qianying Kong
Huifang Peng
Qian Zhao
Hongwei Jiang
Xuechen Zhu

Frontiers in Medicine

doi 10.3389/fmed.2025.1671687

391 views

Review

Accepted on 25 Aug 2025

Trends in Mesenchymal Stem Cell-derived Extracellular Vesicles Clinical Trials 2014-2024: Is efficacy optimal in a narrow dose range?

in Gene and Cell Therapy

Yusong Wang
Junchi Zhu
Ma Qimin
Wei Zhou
Linshan Yang
Shuyue Sheng
Feng Zhu
Zhaofan Xia

Frontiers in Medicine

doi 10.3389/fmed.2025.1625787

367 views

Review

Published on 21 Aug 2025

Nanotechnology and natural killer cell immunotherapy: synergistic approaches for precise immune system adjustment and targeted cancer treatment in gastrointestinal tumors

in Gene and Cell Therapy

Xiwen Kang
Danyang Li
Rui Sun

Frontiers in Medicine

doi 10.3389/fmed.2025.1647737

1,188 views

Original Research

Accepted on 20 Aug 2025

High rate of seroeligibility among MYBPC3-associated hypertrophic cardiomyopathy patients for TN-201, an adeno-associated virus serotype 9 MYBPC3 gene therapy

in Gene and Cell Therapy

Milind Desai
Daniele Massera
Heng Wang
Timothy C Wong
Omar Wever-Pinzon
Neal K Lakdawala
John Giudicessi
Theodore Abraham
Sherif Nagueh
Florian Rader

Frontiers in Medicine

doi 10.3389/fmed.2025.1635586

309 views

Review

Published on 20 Aug 2025

Categories, applications, and potential of stem cells in bone regeneration: an overview

in Gene and Cell Therapy

Mingyang Jiao
Ting Shuai
Zhongfang Zhao
Yuwei Wu
Linwei Yu
Jingwen Sun
Raffaele De Caro
Veronica Macchi
Andrea Porzionato
Elena Stocco

Frontiers in Medicine

doi 10.3389/fmed.2025.1606100

1,001 views

Mini Review

Published on 06 Aug 2025

Clinical trials of nanoparticle-enhanced CAR-T and NK cell therapies in oncology: overcoming translational and clinical challenges - a mini review

in Gene and Cell Therapy

Xiaoqian Zhao
Jian Xiong
Danyang Li
Ying Zhang

Frontiers in Medicine

doi 10.3389/fmed.2025.1655693

1,232 views

Mini Review

Published on 02 Jul 2025

Toxicities associated with lymphoma-targeting bispecific antibodies—a review

in Gene and Cell Therapy

Christopher Doig
Costas Kleanthes Yannakou

Frontiers in Medicine

doi 10.3389/fmed.2025.1582975

2,237 views

Mini Review

Published on 25 Jun 2025

Cell therapy in pediatric blood diseases

in Gene and Cell Therapy

Rubí Romo-Rodríguez
Rosana Pelayo
Dalia Ramírez-Ramírez

Frontiers in Medicine

doi 10.3389/fmed.2025.1591287

2,058 views

Original Research

Published on 25 Jun 2025

Trends and emerging frontiers of mesenchymal stem cells in intervertebral disc degeneration: a bibliometric analysis (2000–2024)

in Gene and Cell Therapy

Jian Zhao
Shuwen Li
Jie Cheng
Xiang Xu
Ming Bai
Yingnan Yu
Meixia Liu
Heping Yin
Yimin Wu

Frontiers in Medicine

doi 10.3389/fmed.2025.1601806

1,434 views

Case Report

Published on 24 Jun 2025

Real-world outcomes of spinal muscular atrophy treatment with onasemnogene abeparvovec in Croatia: a comprehensive case series and literature review

in Gene and Cell Therapy

Ivan Lehman
Matija Matošević
Lovro Lamot
Branka Bunoza

Frontiers in Medicine

doi 10.3389/fmed.2025.1609072

2,092 views

Review

Published on 17 Jun 2025

Precision scalpels for the epigenome: next-gen editing tools in targeted therapies

in Gene and Cell Therapy

Ruiming Zhang
Tianqi Yao
Meiyin Fan
Xiaoying Jiang
Keshan Wang
Min Cui
Kaijian Bing
Xiaotian Xia

Frontiers in Medicine

doi 10.3389/fmed.2025.1613722

3,738 views

Original Research

Published on 11 Jun 2025

Identifying key genes associated with recurrence in non-small cell lung cancer through TCGA and single-cell analysis

in Gene and Cell Therapy

Weiyuan Li
Duo Han
Chunxiao Cao
Yuning Xie
Jingxia Shen

Frontiers in Medicine

doi 10.3389/fmed.2025.1549969

1,785 views