Frontiers in Medicine | Gene and Cell Therapy

Mini Review

Published on 04 Feb 2026

Does tumor-infiltrating lymphocyte therapy improve survival outcomes in patients with advanced melanoma?

in Gene and Cell Therapy

Piper Ridley-Parish

Frontiers in Medicine

doi 10.3389/fmed.2026.1775031

781 views

Methods

Accepted on 02 Feb 2026

Enhancing the transduction efficiency of lentiviral vectors in CAR-T cell therapy through an optimization workflow

in Gene and Cell Therapy

Rita Ferreira
Jaciara Gama
Ana Godinho-Santos
João Gonçalves

Frontiers in Medicine

Opinion

Published on 20 Jan 2026

Whole tumor transcriptome: a possibility for diagnosis, prognosis, and therapy in precision oncology using computational analysis

in Gene and Cell Therapy

Ian Jhemes Oliveira Sousa
Kerolayne de Melo Nogueira
Ester Miranda Pereira

Frontiers in Medicine

doi 10.3389/fmed.2026.1759083

473 views

Review

Published on 15 Jan 2026

Current status and future prospects of nanocarrier-mediated miRNA delivery for osteoarthritis therapy

in Gene and Cell Therapy

Longyin Li
Zhengguang Xu
Feng Gao
Junjie Xu

Frontiers in Medicine

doi 10.3389/fmed.2025.1728944

746 views

Review

Accepted on 14 Jan 2026

Advances in Immunotherapy for Thyroid Malignancies: From Molecular Targets to Clinical Outcomes

in Gene and Cell Therapy

Shuo Lv
Jinbao Wang
Guhao Chen
Yongshun Wang
Naiqing Liu

Frontiers in Medicine

266 views

Original Research

Published on 13 Jan 2026

Identification of CD320, SLC44A1 and TNFRSF13B as potential novel therapeutic targets for CAR T-cell therapy in multiple myeloma

in Gene and Cell Therapy

Francesca Garofano
Anna Maria Corsale
Marta Biondo
Andrea Romano
Ingo Schmidt-Wolf
Anna Maria Gullà
Sergio Siragusa
Cirino Botta

Frontiers in Medicine

doi 10.3389/fmed.2025.1737919

954 views

Original Research

Published on 13 Jan 2026

CAR-T cell therapy in TP53-mutated CNS lymphoma: overcoming a high-risk genetic barrier

in Gene and Cell Therapy

Danyang Li
Rui Liu
Zhonghua Fu
Fan Yang
Lixia Ma
Miaomiao Cao
Yuelu Guo
Biping Deng
Alex H. Chang
Qinlong Zheng

Frontiers in Medicine

doi 10.3389/fmed.2025.1731589

742 views

Review

Published on 12 Jan 2026

Recent trends in gene-targeted therapies and their influence on surgical decision-making in rheumatoid arthritis affecting the hands, feet, and ankles

in Gene and Cell Therapy

Xiaolong Du
Xingxing Yu
Xuehai Ou
Deliang Cheng
Changming Zheng
Shaoyan Shi

Frontiers in Medicine

doi 10.3389/fmed.2025.1742313

503 views

Mini Review

Published on 09 Jan 2026

Viral and non-viral cellular therapies for neurodegeneration

in Gene and Cell Therapy

Jyotsna Srivastav
Sachin Sharma

Frontiers in Medicine

doi 10.3389/fmed.2025.1718669

1,784 views

Original Research

Published on 17 Dec 2025

A machine learning-based predictive model for stem cell therapy outcomes in plastic surgery

in Gene and Cell Therapy

Lingang Xu
Ying Lian
Zhen Song
Dongyi Zhang
Hongfeng Zhai

Frontiers in Medicine

doi 10.3389/fmed.2025.1683758

1,815 views

Original Research

Published on 26 Nov 2025

SPP1, LYZ, and MCM5: potential diagnostic biomarkers for rheumatoid arthritis and cervical cancer comorbidity

in Gene and Cell Therapy

Xiaoyang Liu
Wenhao Wang
Yuhui Zhao
Xueying Gu
Ruihe Wu
Kaili Qin
Xiaofeng Li
Chong Gao
Caihong Wang

Frontiers in Medicine

doi 10.3389/fmed.2025.1693787

1,513 views

Mini Review

Published on 19 Nov 2025

Innovative gene targeted treatments for osteosarcoma: a mini review of current clinical evidence and future prospects

in Gene and Cell Therapy

Dong Hu
Xingxing Yu
Junkui Xu
Bingbing Li
Xuehai Ou
Shaoyan Shi

Frontiers in Medicine

doi 10.3389/fmed.2025.1699287

2,044 views

Case Report

Published on 19 Nov 2025

Coexistence of ulcerative colitis and neurofibromatosis type 1: a case report and literature review

in Gene and Cell Therapy

Xiuqiang Huang
Shuhua Lyu
Jin Zhong
Yiming Li
Luyao Zhao
Manyi Sun

Frontiers in Medicine

doi 10.3389/fmed.2025.1723026

1,471 views

Original Research

Published on 29 Oct 2025

Preclinical biodistribution and toxicology assessment of an AAV5-based subretinal modifier gene therapy for retinitis pigmentosa

in Gene and Cell Therapy

Arun Upadhyay
Selina Drag
Pushpendra Singh
Kalpana Rajanala
Rasappa Arumugham

Frontiers in Medicine

doi 10.3389/fmed.2025.1679619

3,215 views

Correction

Published on 27 Oct 2025

Correction: Precision scalpels for the epigenome: next-gen editing tools in targeted therapies

in Gene and Cell Therapy

Ruiming Zhang
Tianqi Yao
Meiyin Fan
Xiaoying Jiang
Keshan Wang
Min Cui
Kaijian Bing
Xiaotian Xia

Frontiers in Medicine

doi 10.3389/fmed.2025.1722848

843 views

Systematic Review

Published on 24 Oct 2025

Ferroptosis research based on bibliometric and visual analysis: mechanism exploration and clinical application prospects in gastric cancer, prostate cancer, leukemia, and brain tumors

in Gene and Cell Therapy

Mingkun Yu
Wenze Cui
Yinghua Hu
Wenhuan Song
Zujun Wang
Wenyu Chen
Xiaolu Ji
Chen Tang
Jiantao Lv
Tao Hao

Frontiers in Medicine

doi 10.3389/fmed.2025.1640497

2,371 views
1 citation

Original Research

Published on 22 Oct 2025

Developing and optimizing a biocompatible tauopathy model using extracellular vesicle-mediated gene delivery

in Gene and Cell Therapy

Samaneh Ghadami
Kristen Dellinger

Frontiers in Medicine

doi 10.3389/fmed.2025.1672046

2,244 views

Original Research

Published on 21 Oct 2025

Exploring the impact of SNPs rs2476601, rs2488457, and rs33996649 on PTPN22 expression, structure, and anti-CCP level in rheumatoid arthritis of the Indian population: a case-control and computational study

in Gene and Cell Therapy

S. Aswini
S. Asha Devi

Frontiers in Medicine

doi 10.3389/fmed.2025.1688505

1,575 views

Mini Review

Published on 17 Oct 2025

The advantages of NK cell vaccines in solid carcinoma clinical trials: conducted by various biology strategy and technology

in Gene and Cell Therapy

Yizhe Hu
Limei Leng
Bing Li
Qiang Qiao

Frontiers in Medicine

doi 10.3389/fmed.2025.1656570

3,879 views

Review

Published on 16 Oct 2025

AAV viral vectors as therapeutic interventions for inherited or non-inherited cardiac disorders: current aspects and future prospects

in Gene and Cell Therapy

Vivek Kumar
Kalimuthu Kalishwaralal
Charu Chauhan
Gurpal Singh
Ravi Pratap Barnwal
Sachin Sharma

Frontiers in Medicine

doi 10.3389/fmed.2025.1678325

3,737 views
1 citation

Review

Published on 09 Oct 2025

Mechanical signal-chromatin interactions: molecular networks from nuclear membrane force transmission to epigenetic regulation

in Gene and Cell Therapy

Shili Yang
Huaiquan Liu
Bo Chen
Haiyang Kou
Lingyan Lai
Xinyan Zhang
Yunling Xu
Yu Sun

Frontiers in Medicine

doi 10.3389/fmed.2025.1631645

2,789 views
1 citation

Review

Published on 08 Oct 2025

Novel applications of gene and cell therapies in the treatment of gynecological disorders

in Gene and Cell Therapy

Huiping He
Chufan Zhou
Jian Xiong
Jiaying Fan

Frontiers in Medicine

doi 10.3389/fmed.2025.1658357

10,277 views

Original Research

Published on 18 Sep 2025

Intrathecal injection of bone marrow concentrate in children with autism spectrum disorder: a retrospective chart analysis

in Gene and Cell Therapy

Georg S. Kobinia
Adam Bukaty
Elisabeth Holly
Gloria Kobinia
Philipp R. Heuberer
Brenda Laky

Frontiers in Medicine

doi 10.3389/fmed.2025.1666486

3,353 views

Review

Published on 18 Sep 2025

Trends in mesenchymal stem cell-derived extracellular vesicles clinical trials 2014–2024: is efficacy optimal in a narrow dose range?

in Gene and Cell Therapy

Yusong Wang
Junchi Zhu
Qimin Ma
Wei Zhou
Linshan Yang
Shuyue Sheng
Feng Zhu
Zhaofan Xia

Frontiers in Medicine

doi 10.3389/fmed.2025.1625787

5,687 views
3 citations

171 articles

articles

Does tumor-infiltrating lymphocyte therapy improve survival outcomes in patients with advanced melanoma?

Enhancing the transduction efficiency of lentiviral vectors in CAR-T cell therapy through an optimization workflow

Whole tumor transcriptome: a possibility for diagnosis, prognosis, and therapy in precision oncology using computational analysis

Current status and future prospects of nanocarrier-mediated miRNA delivery for osteoarthritis therapy

Advances in Immunotherapy for Thyroid Malignancies: From Molecular Targets to Clinical Outcomes

Identification of CD320, SLC44A1 and TNFRSF13B as potential novel therapeutic targets for CAR T-cell therapy in multiple myeloma

CAR-T cell therapy in TP53-mutated CNS lymphoma: overcoming a high-risk genetic barrier

Recent trends in gene-targeted therapies and their influence on surgical decision-making in rheumatoid arthritis affecting the hands, feet, and ankles

Viral and non-viral cellular therapies for neurodegeneration

A machine learning-based predictive model for stem cell therapy outcomes in plastic surgery

SPP1, LYZ, and MCM5: potential diagnostic biomarkers for rheumatoid arthritis and cervical cancer comorbidity

Innovative gene targeted treatments for osteosarcoma: a mini review of current clinical evidence and future prospects

Coexistence of ulcerative colitis and neurofibromatosis type 1: a case report and literature review

Preclinical biodistribution and toxicology assessment of an AAV5-based subretinal modifier gene therapy for retinitis pigmentosa

Correction: Precision scalpels for the epigenome: next-gen editing tools in targeted therapies

Ferroptosis research based on bibliometric and visual analysis: mechanism exploration and clinical application prospects in gastric cancer, prostate cancer, leukemia, and brain tumors

Developing and optimizing a biocompatible tauopathy model using extracellular vesicle-mediated gene delivery

Exploring the impact of SNPs rs2476601, rs2488457, and rs33996649 on PTPN22 expression, structure, and anti-CCP level in rheumatoid arthritis of the Indian population: a case-control and computational study

The advantages of NK cell vaccines in solid carcinoma clinical trials: conducted by various biology strategy and technology

AAV viral vectors as therapeutic interventions for inherited or non-inherited cardiac disorders: current aspects and future prospects

Mechanical signal-chromatin interactions: molecular networks from nuclear membrane force transmission to epigenetic regulation

Novel applications of gene and cell therapies in the treatment of gynecological disorders

Intrathecal injection of bone marrow concentrate in children with autism spectrum disorder: a retrospective chart analysis

Trends in mesenchymal stem cell-derived extracellular vesicles clinical trials 2014–2024: is efficacy optimal in a narrow dose range?