Frontiers in Medicine | Gene and Cell Therapy

Original Research

Published on 29 Oct 2025

Preclinical biodistribution and toxicology assessment of an AAV5-based subretinal modifier gene therapy for retinitis pigmentosa

in Gene and Cell Therapy

Arun Upadhyay
Selina Drag
Pushpendra Singh
Kalpana Rajanala
Rasappa Arumugham

Frontiers in Medicine

doi 10.3389/fmed.2025.1679619

1,280 views

Correction

Published on 27 Oct 2025

Correction: Precision scalpels for the epigenome: next-gen editing tools in targeted therapies

in Gene and Cell Therapy

Ruiming Zhang
Tianqi Yao
Meiyin Fan
Xiaoying Jiang
Keshan Wang
Min Cui
Kaijian Bing
Xiaotian Xia

Frontiers in Medicine

doi 10.3389/fmed.2025.1722848

332 views

Systematic Review

Published on 24 Oct 2025

Ferroptosis research based on bibliometric and visual analysis: mechanism exploration and clinical application prospects in gastric cancer, prostate cancer, leukemia, and brain tumors

in Gene and Cell Therapy

Mingkun Yu
Wenze Cui
Yinghua Hu
Wenhuan Song
Zujun Wang
Wenyu Chen
Xiaolu Ji
Chen Tang
Jiantao Lv
Tao Hao

Frontiers in Medicine

doi 10.3389/fmed.2025.1640497

615 views

Original Research

Published on 22 Oct 2025

Developing and optimizing a biocompatible tauopathy model using extracellular vesicle-mediated gene delivery

in Gene and Cell Therapy

Samaneh Ghadami
Kristen Dellinger

Frontiers in Medicine

doi 10.3389/fmed.2025.1672046

1,075 views

Original Research

Published on 21 Oct 2025

Exploring the impact of SNPs rs2476601, rs2488457, and rs33996649 on PTPN22 expression, structure, and anti-CCP level in rheumatoid arthritis of the Indian population: a case-control and computational study

in Gene and Cell Therapy

S. Aswini
S. Asha Devi

Frontiers in Medicine

doi 10.3389/fmed.2025.1688505

617 views

Mini Review

Published on 17 Oct 2025

The advantages of NK cell vaccines in solid carcinoma clinical trials: conducted by various biology strategy and technology

in Gene and Cell Therapy

Yizhe Hu
Limei Leng
Bing Li
Qiang Qiao

Frontiers in Medicine

doi 10.3389/fmed.2025.1656570

1,541 views

Review

Published on 16 Oct 2025

AAV viral vectors as therapeutic interventions for inherited or non-inherited cardiac disorders: current aspects and future prospects

in Gene and Cell Therapy

Vivek Kumar
Kalimuthu Kalishwaralal
Charu Chauhan
Gurpal Singh
Ravi Pratap Barnwal
Sachin Sharma

Frontiers in Medicine

doi 10.3389/fmed.2025.1678325

1,797 views

Review

Published on 09 Oct 2025

Mechanical signal-chromatin interactions: molecular networks from nuclear membrane force transmission to epigenetic regulation

in Gene and Cell Therapy

Shili Yang
Huaiquan Liu
Bo Chen
Haiyang Kou
Lingyan Lai
Xinyan Zhang
Yunling Xu
Yu Sun

Frontiers in Medicine

doi 10.3389/fmed.2025.1631645

999 views

Review

Published on 08 Oct 2025

Novel applications of gene and cell therapies in the treatment of gynecological disorders

in Gene and Cell Therapy

Huiping He
Chufan Zhou
Jian Xiong
Jiaying Fan

Frontiers in Medicine

doi 10.3389/fmed.2025.1658357

8,866 views

Original Research

Published on 18 Sep 2025

Intrathecal injection of bone marrow concentrate in children with autism spectrum disorder: a retrospective chart analysis

in Gene and Cell Therapy

Georg S. Kobinia
Adam Bukaty
Elisabeth Holly
Gloria Kobinia
Philipp R. Heuberer
Brenda Laky

Frontiers in Medicine

doi 10.3389/fmed.2025.1666486

2,306 views

Review

Published on 18 Sep 2025

Trends in mesenchymal stem cell-derived extracellular vesicles clinical trials 2014–2024: is efficacy optimal in a narrow dose range?

in Gene and Cell Therapy

Yusong Wang
Junchi Zhu
Qimin Ma
Wei Zhou
Linshan Yang
Shuyue Sheng
Feng Zhu
Zhaofan Xia

Frontiers in Medicine

doi 10.3389/fmed.2025.1625787

2,232 views

Systematic Review

Published on 17 Sep 2025

Contextual effects of mesenchymal stem cell injections for knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials

in Gene and Cell Therapy

Fengsheng Yin
Houdong Wu
Dan Tong
Gan Luo
Zhen Deng
Qinyi Yan
Yu Zhang

Frontiers in Medicine

doi 10.3389/fmed.2025.1636181

2,327 views

Original Research

Published on 12 Sep 2025

High rate of seroeligibility among MYBPC3-associated hypertrophic cardiomyopathy patients for TN-201, an adeno-associated virus serotype 9 MYBPC3 gene therapy

in Gene and Cell Therapy

Milind Y. Desai
Daniele Massera
Heng Wang
Timothy C. Wong
Omar Wever-Pinzon
Neal K. Lakdawala
John R. Giudicessi
Theodore Abraham
Sherif Nagueh
Florian Rader

Frontiers in Medicine

doi 10.3389/fmed.2025.1635586

1,629 views

Review

Published on 08 Sep 2025

The Xenopus model as a tool for investigating craniofacial developmental disorders

in Gene and Cell Therapy

Qianying Kong
Huifang Peng
Qian Zhao
Hongwei Jiang
Xuechen Zhu

Frontiers in Medicine

doi 10.3389/fmed.2025.1671687

1,576 views

Original Research

Published on 02 Sep 2025

Malignant epithelia cells-derived spermine induces APOE+ macrophages to suppress tumor immunity in adenocarcinoma of the esophagogastric junction

in Gene and Cell Therapy

Yan Zhang
Zhaoyang Liu
Huihui Sun
Zhenxiang Wang
Ye Chen
Zhiqian Hu
Xinxing Li
Kai Xu
Ying Chen
Yanping Xu

Frontiers in Medicine

doi 10.3389/fmed.2025.1636699

1,701 views

Review

Published on 21 Aug 2025

Nanotechnology and natural killer cell immunotherapy: synergistic approaches for precise immune system adjustment and targeted cancer treatment in gastrointestinal tumors

in Gene and Cell Therapy

Xiwen Kang
Danyang Li
Rui Sun

Frontiers in Medicine

doi 10.3389/fmed.2025.1647737

2,190 views
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