Frontiers in Medicine | Gene and Cell Therapy

Systematic Review

Published on 17 Sep 2025

Contextual effects of mesenchymal stem cell injections for knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials

in Gene and Cell Therapy

Fengsheng Yin
Houdong Wu
Dan Tong
Gan Luo
Zhen Deng
Qinyi Yan
Yu Zhang

Frontiers in Medicine

doi 10.3389/fmed.2025.1636181

4,978 views
1 citation

Original Research

Published on 12 Sep 2025

High rate of seroeligibility among MYBPC3-associated hypertrophic cardiomyopathy patients for TN-201, an adeno-associated virus serotype 9 MYBPC3 gene therapy

in Gene and Cell Therapy

Milind Y. Desai
Daniele Massera
Heng Wang
Timothy C. Wong
Omar Wever-Pinzon
Neal K. Lakdawala
John R. Giudicessi
Theodore Abraham
Sherif Nagueh
Florian Rader

Frontiers in Medicine

doi 10.3389/fmed.2025.1635586

2,400 views

Review

Published on 08 Sep 2025

The Xenopus model as a tool for investigating craniofacial developmental disorders

in Gene and Cell Therapy

Qianying Kong
Huifang Peng
Qian Zhao
Hongwei Jiang
Xuechen Zhu

Frontiers in Medicine

doi 10.3389/fmed.2025.1671687

2,532 views
1 citation

Original Research

Published on 02 Sep 2025

Malignant epithelia cells-derived spermine induces APOE+ macrophages to suppress tumor immunity in adenocarcinoma of the esophagogastric junction

in Gene and Cell Therapy

Yan Zhang
Zhaoyang Liu
Huihui Sun
Zhenxiang Wang
Ye Chen
Zhiqian Hu
Xinxing Li
Kai Xu
Ying Chen
Yanping Xu

Frontiers in Medicine

doi 10.3389/fmed.2025.1636699

2,749 views

Review

Published on 21 Aug 2025

Nanotechnology and natural killer cell immunotherapy: synergistic approaches for precise immune system adjustment and targeted cancer treatment in gastrointestinal tumors

in Gene and Cell Therapy

Xiwen Kang
Danyang Li
Rui Sun

Frontiers in Medicine

doi 10.3389/fmed.2025.1647737

3,398 views
5 citations

Review

Published on 20 Aug 2025

Categories, applications, and potential of stem cells in bone regeneration: an overview

in Gene and Cell Therapy

Mingyang Jiao
Ting Shuai
Zhongfang Zhao
Yuwei Wu
Linwei Yu
Jingwen Sun
Raffaele De Caro
Veronica Macchi
Andrea Porzionato
Elena Stocco

Frontiers in Medicine

doi 10.3389/fmed.2025.1606100

3,141 views
2 citations

Mini Review

Published on 06 Aug 2025

Clinical trials of nanoparticle-enhanced CAR-T and NK cell therapies in oncology: overcoming translational and clinical challenges - a mini review

in Gene and Cell Therapy

Xiaoqian Zhao
Jian Xiong
Danyang Li
Ying Zhang

Frontiers in Medicine

doi 10.3389/fmed.2025.1655693

5,410 views
8 citations

Mini Review

Published on 02 Jul 2025

Toxicities associated with lymphoma-targeting bispecific antibodies—a review

in Gene and Cell Therapy

Christopher Doig
Costas Kleanthes Yannakou

Frontiers in Medicine

doi 10.3389/fmed.2025.1582975

4,421 views
2 citations

Mini Review

Published on 25 Jun 2025

Cell therapy in pediatric blood diseases

in Gene and Cell Therapy

Rubí Romo-Rodríguez
Rosana Pelayo
Dalia Ramírez-Ramírez

Frontiers in Medicine

doi 10.3389/fmed.2025.1591287

4,170 views

Original Research

Published on 25 Jun 2025

Trends and emerging frontiers of mesenchymal stem cells in intervertebral disc degeneration: a bibliometric analysis (2000–2024)

in Gene and Cell Therapy

Jian Zhao
Shuwen Li
Jie Cheng
Xiang Xu
Ming Bai
Yingnan Yu
Meixia Liu
Heping Yin
Yimin Wu

Frontiers in Medicine

doi 10.3389/fmed.2025.1601806

3,109 views
1 citation

Case Report

Published on 24 Jun 2025

Real-world outcomes of spinal muscular atrophy treatment with onasemnogene abeparvovec in Croatia: a comprehensive case series and literature review

in Gene and Cell Therapy

Ivan Lehman
Matija Matošević
Lovro Lamot
Branka Bunoza

Frontiers in Medicine

doi 10.3389/fmed.2025.1609072

4,273 views

Review

Published on 17 Jun 2025

Precision scalpels for the epigenome: next-gen editing tools in targeted therapies

in Gene and Cell Therapy

Ruiming Zhang
Tianqi Yao
Meiyin Fan
Xiaoying Jiang
Keshan Wang
Min Cui
Kaijian Bing
Xiaotian Xia

Frontiers in Medicine

doi 10.3389/fmed.2025.1613722

6,989 views
3 citations

Original Research

Published on 11 Jun 2025

Identifying key genes associated with recurrence in non-small cell lung cancer through TCGA and single-cell analysis

in Gene and Cell Therapy

Weiyuan Li
Duo Han
Chunxiao Cao
Yuning Xie
Jingxia Shen

Frontiers in Medicine

doi 10.3389/fmed.2025.1549969

3,798 views
1 citation

Review

Published on 14 May 2025

Drug-tolerant persister cells in acute myeloid leukemia: pressing challenge and promising new strategies for treatment

in Gene and Cell Therapy

Meng Li
Xiaoli Wang
Wenjuan He
Hao Zhou

Frontiers in Medicine

doi 10.3389/fmed.2025.1586552

3,864 views
1 citation

Original Research

Published on 09 May 2025

Therapeutic effect of hUC-MSCs from different transplantation routes on acute liver failure in rats

in Gene and Cell Therapy

Yonghong Wang
Bei Wu
Yachao Tao
Menglan Wang
Dongbo Wu
Enqiang Chen
Hong Tang

Frontiers in Medicine

doi 10.3389/fmed.2025.1525719

1,650 views
1 citation

Review

Published on 07 May 2025

The multifaceted functions of SPC25 in cancer: from molecular pathways to targeted therapy

in Gene and Cell Therapy

Yigang Jin
Minjie Chen
Fei Chen
Zhaofeng Gao
Xiaoping Li
Lingyu Hu
Dandan Cai
Siqi Zhao
Zhengwei Song

Frontiers in Medicine

doi 10.3389/fmed.2025.1550901

2,277 views
1 citation

Original Research

Published on 17 Apr 2025

Integrative genomic analysis and diagnostic modeling of osteoporosis: unraveling the interplay of autophagy, osteogenesis, adipogenesis, and immune infiltration

in Gene and Cell Therapy

Lin-Jing Han
Jian-Zong Zhu
Hong-Cai Liu
Xiao-Sheng Lin
Shu-Zhong Yang

Frontiers in Medicine

doi 10.3389/fmed.2025.1544390

3,596 views
1 citation

Original Research

Published on 09 Apr 2025

m6A-related genes of peripheral white blood cell in spinal cord injury as potential targets for prognosis and treatment

in Gene and Cell Therapy

Mingran Luo
Qian Wang
Jian Chen
Guoyong Yin

Frontiers in Medicine

doi 10.3389/fmed.2025.1544719

2,072 views

Original Research

Published on 04 Apr 2025

Distinct infectivity and neutralization antibody responses in the highly homologous AAV Go.1 and AAV5

in Gene and Cell Therapy

Mei Li
Haixiao Ma
Yang Wu
Yunling Gao
Jie Wang
Hanbing Wang

Frontiers in Medicine

doi 10.3389/fmed.2025.1554449

2,901 views
1 citation

Review

Published on 02 Apr 2025

Advances in stem cell therapy for erectile dysfunction: preclinical evidence and emerging therapeutic approaches

in Gene and Cell Therapy

Xiaoliang Fu
Azar Sheikholeslami
Ulanbek Zhanbyrbekuly
Faezeh Davoodi Asl
Nadiar M. Mussin
Hoda Fazaeli
Karim Daniyalov
Nader Tanideh
Mahdi Mahdipour
Madina A. Kurmanalina

Frontiers in Medicine

doi 10.3389/fmed.2025.1519095

16,063 views
5 citations

Review

Published on 26 Mar 2025

Cell therapies for immune-mediated disorders

in Gene and Cell Therapy

Natalia Wiewiórska-Krata
Bartosz Foroncewicz
Krzysztof Mucha
Radosław Zagożdżon

Frontiers in Medicine

doi 10.3389/fmed.2025.1550527

3,849 views
4 citations

Review

Published on 12 Feb 2025

AAV-based vectors for human diseases modeling in laboratory animals

in Gene and Cell Therapy

Timur I. Aliev
Dmitry V. Yudkin

Frontiers in Medicine

doi 10.3389/fmed.2024.1499605

3,284 views
1 citation

Original Research

Published on 12 Feb 2025

Intelligent diagnosis and prediction of pregnancy induced hypertension in obstetrics and gynecology teaching by integrating GA

in Gene and Cell Therapy

Xiaolan Li
Fen Kang
Xiaojing Li

Frontiers in Medicine

doi 10.3389/fmed.2024.1433479

2,368 views

Systematic Review

Published on 06 Feb 2025

Comparison of the risk of obesity in the FTO rs9939609 genotype in a multiethnic group in Asia systematic review and meta-analysis

in Gene and Cell Therapy

Donna Pratiwi
Miko Sidartha
Elvan Wiyarta
I Wayan Agustinus Harimawan
Ni Made Dwi Asti Lestari
Bonglee Kim
Nurpudji Astuti Taslim
Trina Ekawati Tallei
Fahrul Nurkolis
Rony Abdi Syahputra

Frontiers in Medicine

doi 10.3389/fmed.2025.1522318

3,853 views
4 citations

171 articles

articles

Contextual effects of mesenchymal stem cell injections for knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials

High rate of seroeligibility among MYBPC3-associated hypertrophic cardiomyopathy patients for TN-201, an adeno-associated virus serotype 9 MYBPC3 gene therapy

The Xenopus model as a tool for investigating craniofacial developmental disorders

Malignant epithelia cells-derived spermine induces APOE+ macrophages to suppress tumor immunity in adenocarcinoma of the esophagogastric junction

Nanotechnology and natural killer cell immunotherapy: synergistic approaches for precise immune system adjustment and targeted cancer treatment in gastrointestinal tumors

Categories, applications, and potential of stem cells in bone regeneration: an overview

Clinical trials of nanoparticle-enhanced CAR-T and NK cell therapies in oncology: overcoming translational and clinical challenges - a mini review

Toxicities associated with lymphoma-targeting bispecific antibodies—a review

Cell therapy in pediatric blood diseases

Trends and emerging frontiers of mesenchymal stem cells in intervertebral disc degeneration: a bibliometric analysis (2000–2024)

Real-world outcomes of spinal muscular atrophy treatment with onasemnogene abeparvovec in Croatia: a comprehensive case series and literature review

Precision scalpels for the epigenome: next-gen editing tools in targeted therapies

Identifying key genes associated with recurrence in non-small cell lung cancer through TCGA and single-cell analysis

Drug-tolerant persister cells in acute myeloid leukemia: pressing challenge and promising new strategies for treatment

Therapeutic effect of hUC-MSCs from different transplantation routes on acute liver failure in rats

The multifaceted functions of SPC25 in cancer: from molecular pathways to targeted therapy

Integrative genomic analysis and diagnostic modeling of osteoporosis: unraveling the interplay of autophagy, osteogenesis, adipogenesis, and immune infiltration

m6A-related genes of peripheral white blood cell in spinal cord injury as potential targets for prognosis and treatment

Distinct infectivity and neutralization antibody responses in the highly homologous AAV Go.1 and AAV5

Advances in stem cell therapy for erectile dysfunction: preclinical evidence and emerging therapeutic approaches

Cell therapies for immune-mediated disorders

AAV-based vectors for human diseases modeling in laboratory animals

Intelligent diagnosis and prediction of pregnancy induced hypertension in obstetrics and gynecology teaching by integrating GA

Comparison of the risk of obesity in the FTO rs9939609 genotype in a multiethnic group in Asia systematic review and meta-analysis