Frontiers in Molecular Biosciences | Molecular Diagnostics and Therapeutics

Original Research

Published on 04 Jul 2025

Exploring potential therapeutic targets for colorectal tumors based on whole genome sequencing of colorectal tumors and paracancerous tissues

in Molecular Diagnostics and Therapeutics

Yufan Sheng
Sen Niu
Da Li
Chunyuan Meng
Tong Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1605117

478 views

Original Research

Accepted on 03 Jul 2025

ER stress-driven unfolded protein response fuels aging-related tumor aggressiveness in gliomas

in Molecular Diagnostics and Therapeutics

Shao Xiaodong
Shaolei Guo
Jia Yang
Junjie Dai
Cao Kaihua
Xia Cai
Tianshi Song
Shun Yao
Umar Raza
Kun Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1640038

104 views

Original Research

Published on 03 Jul 2025

A nomogram model based on tumor necrosis factor-like ligand 1A(TL1A) and death receptor-3(DR3) promoter methylation for predicting 90-day prognosis in patients with HBV-associated acute-on-chronic liver failure

in Molecular Diagnostics and Therapeutics

Xue-Fei Wei
Feng Zhang
Han-Xu Zhu
Zhe-Zhe Tian
Miao-Miao Xu
Yu-Chen Fan
Kai Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1614311

269 views

Original Research

Accepted on 02 Jul 2025

Maternal plasma microRNA profiles in twin-twin transfusion syndrome and normal monochorionic twin pregnancies

in Molecular Diagnostics and Therapeutics

Steven Papastefan
Morgan M Langereis
Catherine Redden
Daniel R Liesman
Cassandra Huerta
Lucas E Turner
Hee Kap Kang
Bethany T Stetson
Katherine C. Ott
William S Marriott

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1597215

Original Research

Published on 01 Jul 2025

Clinicopathologic and proteomic characteristics of low-grade undifferentiated spindle cell sarcoma

in Molecular Diagnostics and Therapeutics

Yani Wei
Hongjun Li
Shujin He
Min Li
Yongyu Chen
Huijuan Shi
Anjia Han

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1591644

329 views

Review

Accepted on 30 Jun 2025

Structure, function, and pathology of PHF23

in Molecular Diagnostics and Therapeutics

Linlin Liu
Yu Liu
Rui Liu
Gangming Wu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1625962

Original Research

Accepted on 30 Jun 2025

Targeting USP42 induces DNA damage and inhibits cell growth in prostate cancer

in Molecular Diagnostics and Therapeutics

Yinghao Zhou
Chenchen Chen
Yibo Meng
Jianchao Ge
Shengkui Meng
Xillong Wang
Yaozong Xu
Guowei Shi
Wandong Yu
Xuetao Hu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1646331

140 views

Original Research

Published on 30 Jun 2025

Patient-derived gastric cancer organoids model heterogeneity and stroma-mediated chemoresistance in poorly cohesive carcinoma

in Molecular Diagnostics and Therapeutics

Yi Yin
Shuhong Zeng
Hui Zhang
Shuangshuang Wang
Fei Ke
Qiang Rui
Jinyong Zhou
Yuwen Zhuang
Weixing Shen
Jun Qian

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1631168

620 views

Mini Review

Published on 30 Jun 2025

Estrogen, menopause, and Alzheimer’s disease: understanding the link to cognitive decline in women

in Molecular Diagnostics and Therapeutics

Nicholas Mervosh
Gayatri Devi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1634302

1,378 views

Review

Published on 30 Jun 2025

Emerging biomarkers in amyotrophic lateral sclerosis: from pathogenesis to clinical applications

in Molecular Diagnostics and Therapeutics

Farah Anjum
Maha Bakhuraysah
Abdulaziz Alsharif
Taj Mohammad
Anas Shamsi
Md. Imtaiyaz Hassan

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1608853

579 views

Original Research

Accepted on 27 Jun 2025

Expression and clinical significance of S100A8/9 in adults with secondary phagocytic lymphohistiocytosis

in Molecular Diagnostics and Therapeutics

Ziwei Fang
Xin Gao
Limin Duan
Jujuan Wang
Tian Tian
Ji Xu
Yongqian Shu
Guangli Yin
Hongxia Qiu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1607352

Original Research

Accepted on 27 Jun 2025

Prognostic value of positive lymph node ratio, tumor deposit, and perineural invasion in advanced colorectal signet-ring cell carcinoma

in Molecular Diagnostics and Therapeutics

Liang Chu
Han Wang
LING TAO
Shuhan Feng
Yucheng Ding
Yan Zhang
Ying Pan
Cenzhu Wang
Xiaohong Wang
Lei Liu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1617787

139 views

Original Research

Published on 27 Jun 2025

Recognition of pivotal immune genes NR1H4 and IL4R as diagnostic biomarkers in distinguishing ovarian clear cell cancer from high-grade serous cancer

in Molecular Diagnostics and Therapeutics

Yumin Ke
Meili Liang
Zhimei Zhou
Yajing Xie
Li Huang
Liying Sheng
Yueli Wang
Xinyan Zhou
Zhuna Wu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1600808

320 views

Original Research

Accepted on 26 Jun 2025

An Automatic Laryngoscopic Image Segmentation System Based on SAM Prompt Engineering: From Glottis Annotation to Vocal Fold Segmentation

in Molecular Diagnostics and Therapeutics

Yucong Zhang
Yuchen Song
Juan Liu
Ming Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1616271

Original Research

Accepted on 26 Jun 2025

Identification and validation of integrated stress response related genes as biomarkers for age-related macular degeneration

in Molecular Diagnostics and Therapeutics

Jingyi Niu
Ling Jin
Yijun Hu
Yiting Wang
Xiaoning Hao
Wenwen Geng
Ruirui Ma

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1583237

115 views

Original Research

Published on 26 Jun 2025

Identification of diagnostic hub genes related to energy metabolism in idiopathic pulmonary fibrosis

in Molecular Diagnostics and Therapeutics

S. Zhao
B. C. Sun
N. Liu
R. Huo
L. S. Liu
J. P. Wang
C. Y. Fang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1596364

603 views