Frontiers in Molecular Biosciences | Molecular Diagnostics and Therapeutics

Original Research

Published on 08 May 2026

Association and predictive value of systemic immune–inflammation index and body mass index in cervical ossification of the posterior longitudinal ligament

in Molecular Diagnostics and Therapeutics

Tingxiao Zhao
Shanggao Xie
Yanlei Li
Liangjian Xu
Kaifeng Ding
Yazeng Huang
Xijing He

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1823906

427 views

Original Research

Published on 08 May 2026

Diagnostic and short-term prognosis value of serum ox-LDL/LOX-1 and GDF-15 in elderly patients with acute coronary syndrome

in Molecular Diagnostics and Therapeutics

Jinlin Wang
Tong Guo
Fengzhen Liu
Xueliang Pei
Fengxia Guo
Hanxiao Li
Facai Cui

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1811738

360 views

Original Research

Published on 08 May 2026

Tumor-directed evolution of VSVΔ51M produces novel viruses with enhanced antitumor efficacy

in Molecular Diagnostics and Therapeutics

Omar A. Albaradie
Abdulaziz Molham Moglan
Yahya Marwan Samman
Fares Fayez Alsayegh
Hussam Mohsen Alharbi
Nada Almarghalani
Khulood Alotaibi
Mohammed M. Jalal
Malik A. Altayar
Nizar H. Saieedi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1656006

454 views

Original Research

Accepted on 07 May 2026

A Pan-Cancer Atlas of Metabolic Regulatory Circuitries Integrating Multi-Omic, Immune, and Clinical Dimensions

in Molecular Diagnostics and Therapeutics

Higor Almeida Cordeiro Nogueira
Emanuell Rodrigues De Souza
Victor dos Santos Lopes
Prof. Enrique Medina-Acosta, M.Sc., Ph.D.

Frontiers in Molecular Biosciences

131 views

Original Research

Accepted on 06 May 2026

Novel pathogenic variant in ARMC4 identified by Whole exome sequencing in a Turkish family with Primary Ciliary Dyskinesia

in Molecular Diagnostics and Therapeutics

Elif Arik Sever
Rim Hjeij
Pınar ATA
Ela Erdem Eralp
Emine Atağ
Heymut Omran
Bülent Taner Karadağ
Osman Ugur Sezerman

Frontiers in Molecular Biosciences

General Commentary

Accepted on 06 May 2026

Commentary: A comprehensive review of diagnostic approaches for hepatitis D

in Molecular Diagnostics and Therapeutics

Sally Ann Baylis
Gabriele Unger
Karin Metzner

Frontiers in Molecular Biosciences

Original Research

Accepted on 06 May 2026

Circulating MiRNAs in Pediatric Obesity: A Single-Centre Exploratory Study of Their Potential Association with Renal Functions

in Molecular Diagnostics and Therapeutics

Mariella Valenzise
Selene Francesca Anna Drago
Francesca Polito
Giuseppina Salzano
Irene Gasparo
Marieme Khouyyi
Laura Licitri
Anna Maria Mirabello
Silvia Romano
Valentina Mottola

Frontiers in Molecular Biosciences

Original Research

Accepted on 06 May 2026

Dual-Branch Heterogeneous Collaborative Network for Accurate Meniscus Diagnosis in MRI Imaging

in Molecular Diagnostics and Therapeutics

Xiaojuan Li
Rong Huang
Huan Wang
Hua Wang

Frontiers in Molecular Biosciences

Editorial

Accepted on 05 May 2026

The Role of Immunity and Inflammation in Aging and Aging-Related Diseases

in Molecular Diagnostics and Therapeutics

Luca Soraci
Liangliang Dai

Frontiers in Molecular Biosciences

117 views

Editorial

Accepted on 05 May 2026

Editorial: Drug Target Discovery and Molecular Tools for Parasites and Host-Pathogen Interactions

in Molecular Diagnostics and Therapeutics

Namrata Anand
Vikky Awasthi
Surendra Kumar Prajapati
Yash Gupta

Frontiers in Molecular Biosciences

138 views

Review

Accepted on 05 May 2026

Single-cell Transcriptomics of Granulocytes in Asthma and Atopic Diseases

in Molecular Diagnostics and Therapeutics

Nicholas Taylor Hogan
Alexis Garduno
Francisco Santos
Eugenia Winata
John-Wesley Pabalate
Praveen Akuthota
Gregory Seumois

Frontiers in Molecular Biosciences

174 views

Original Research

Accepted on 05 May 2026

Establishment of a rapid and highly sensitive Direct-RAA-RDB detection platform: application in non-deletion α-thalassemia

in Molecular Diagnostics and Therapeutics

Yan Wei
Yi Lian Zhao
Chao Ye
Xiaoxing Zhou
Xie Mengru
Jinghui Ma
Xinchu Liu
Qing Jilin
Zhizhong Chen

Frontiers in Molecular Biosciences

Original Research

Accepted on 04 May 2026

Vitamin D3 contribution to systemic and local control of Salmonella Typhimurium infection in an in vivo mouse model

in Molecular Diagnostics and Therapeutics

Michela Tarantino
Dorotea Ippolito
Giorgia Barbieri
Paola Petrucci
Alessia Tammaro
Roberta Tassinari
Francesca Maranghi
Emma Michetti
Serena Ammendola
Massimiliano Francia

Frontiers in Molecular Biosciences

165 views

Original Research

Accepted on 04 May 2026

Peripheral blood circMAN1A2 as a novel diagnostic biomarker for gout: integrated transcriptomic analysis and clinical validation

in Molecular Diagnostics and Therapeutics

Wenyan Guo
kaixi liu
jianhong sun
Zhang Qiaoxin
xiaoyang jiao
yanrong chen
peiting ru
Xinran Yang

Frontiers in Molecular Biosciences

105 views

Original Research

Published on 01 May 2026

Machine learning-based prediction of treatment outcomes and quantitative analysis of contributing factors in fertility induction therapy for adolescent male patients with congenital hypogonadotropic hypogonadism

in Molecular Diagnostics and Therapeutics

Xinyu Dou
Qin Zhang
Yi Wang
Zheng Yuan
Chunxiu Gong

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1828462

449 views

Original Research

Accepted on 30 Apr 2026

Metabolic Alterations and Potential Biomarkers in Unstable Angina Investigated by Lipidomic Analysis

in Molecular Diagnostics and Therapeutics

Nan Feng
Linhe Wang
Guoan Zhao
Yanlin Zhou

Frontiers in Molecular Biosciences

162 views

Original Research

Accepted on 30 Apr 2026

Multi-omics and machine learning-based exploration of key genes associated with abdominal aortic aneurysm

in Molecular Diagnostics and Therapeutics

Ming Xie
Yong Xue
YuFeng Zhang
Lei Zhang
Xiandeng Li
Guobao Chen
Jia Liu
Haibing Hua

Frontiers in Molecular Biosciences

200 views

Review

Published on 30 Apr 2026

Evolving computational paradigms for noncoding variant pathogenicity prediction

in Molecular Diagnostics and Therapeutics

Beibei Wang
Siyuan Song
Song Cheng
Yihang Lin
Liang Yu
Yan Li
Xiang Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1761673

622 views

Review

Published on 30 Apr 2026

Chemerin/ChemerinR1 axis and inflammation-related diseases

in Molecular Diagnostics and Therapeutics

Jun Li
Changhao Mao
Ke Li
Yan Huang
Yuhan Yang
Kunyi Li
Shuang Li
Lan Wen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1785693

421 views

Original Research

Published on 30 Apr 2026

HSF1 modulates lipid metabolism and ferroptosis in sarcopenia: a novel diagnostic biomarker and therapeutic target

in Molecular Diagnostics and Therapeutics

Dalu Cheng
Zhitao Shangguan
Xiaoqing Ye
Gang Chen
Qiong Lin
Jiandong Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1727633

673 views

Original Research

Published on 29 Apr 2026

Integrating multi-omics, machine learning, and molecular dynamics simulations to identify glutamate metabolism-related biomarkers and drug candidates in rheumatoid arthritis

in Molecular Diagnostics and Therapeutics

Bingrui Zhu
Baoliang Li
Shuxu Zhang
Wenzhuo Qi
Zhou Mu
Peng Kong
Yingguang Han
Zhigang Shi

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1834429

486 views

Original Research

Published on 29 Apr 2026

Integrated bioinformatics analysis and experimental validation of SRF as a potential senescence biomarker in MASLD

in Molecular Diagnostics and Therapeutics

Mengyue Li
Chang Gao
Yuhui Shi
Wenyu Peng
Yuan Yin
Bin Lu
Zhang Fu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1745039

458 views

Editorial

Published on 28 Apr 2026

Editorial: Transforming chronic disease treatment with AI and big data

in Molecular Diagnostics and Therapeutics

Xiaoyan Xing
Zhuolun Sun
Kuo Yang
Shizhang Wei

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1848975

532 views

Review

Published on 28 Apr 2026

Beyond mechanical revascularization: thrombo-inflammatory mechanisms and vascular bed–specific design of intracranial stents

in Molecular Diagnostics and Therapeutics

Yingjun Liu
Jinquan Li
Liuxun Hu
Junzhe Zhu
Qingzhu An
Guo Yu

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2026.1785666

435 views

2,207 articles

articles

Association and predictive value of systemic immune–inflammation index and body mass index in cervical ossification of the posterior longitudinal ligament

Diagnostic and short-term prognosis value of serum ox-LDL/LOX-1 and GDF-15 in elderly patients with acute coronary syndrome

Tumor-directed evolution of VSVΔ51M produces novel viruses with enhanced antitumor efficacy

A Pan-Cancer Atlas of Metabolic Regulatory Circuitries Integrating Multi-Omic, Immune, and Clinical Dimensions

Novel pathogenic variant in ARMC4 identified by Whole exome sequencing in a Turkish family with Primary Ciliary Dyskinesia

Commentary: A comprehensive review of diagnostic approaches for hepatitis D

Circulating MiRNAs in Pediatric Obesity: A Single-Centre Exploratory Study of Their Potential Association with Renal Functions

Dual-Branch Heterogeneous Collaborative Network for Accurate Meniscus Diagnosis in MRI Imaging

The Role of Immunity and Inflammation in Aging and Aging-Related Diseases

Editorial: Drug Target Discovery and Molecular Tools for Parasites and Host-Pathogen Interactions

Single-cell Transcriptomics of Granulocytes in Asthma and Atopic Diseases

Establishment of a rapid and highly sensitive Direct-RAA-RDB detection platform: application in non-deletion α-thalassemia

Vitamin D3 contribution to systemic and local control of Salmonella Typhimurium infection in an in vivo mouse model

Peripheral blood circMAN1A2 as a novel diagnostic biomarker for gout: integrated transcriptomic analysis and clinical validation

Machine learning-based prediction of treatment outcomes and quantitative analysis of contributing factors in fertility induction therapy for adolescent male patients with congenital hypogonadotropic hypogonadism

Metabolic Alterations and Potential Biomarkers in Unstable Angina Investigated by Lipidomic Analysis

Multi-omics and machine learning-based exploration of key genes associated with abdominal aortic aneurysm

Evolving computational paradigms for noncoding variant pathogenicity prediction

Chemerin/ChemerinR1 axis and inflammation-related diseases

HSF1 modulates lipid metabolism and ferroptosis in sarcopenia: a novel diagnostic biomarker and therapeutic target

Integrating multi-omics, machine learning, and molecular dynamics simulations to identify glutamate metabolism-related biomarkers and drug candidates in rheumatoid arthritis

Integrated bioinformatics analysis and experimental validation of SRF as a potential senescence biomarker in MASLD

Editorial: Transforming chronic disease treatment with AI and big data

Beyond mechanical revascularization: thrombo-inflammatory mechanisms and vascular bed–specific design of intracranial stents