Frontiers in Molecular Neuroscience

Opinion

Published on 03 Dec 2025

Reelin signaling as a translational rheostat: linking synaptic homeostasis to neurodevelopment and neurodegeneration

in Neuroplasticity and Development

Murat S. Durakoglugil

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1731914

1,380 views

Original Research

Published on 02 Dec 2025

Regulation of granin neuropeptide gene expression in human brain during development

in Molecular Signalling and Pathways

Laura L. Demsey
Sonia Podvin
Vivian Hook

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1666795

1,622 views

Review

Published on 02 Dec 2025

Dynamic glycosylation remodeling in neurological disorders

in Brain Disease Mechanisms

Dan Xing
Yingxun Gong
Weiyi Xia
Huifang Tu
Limei Yuan
Yiqing Yin
Kaiyuan Wang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1674665

1,708 views

Review

Published on 01 Dec 2025

Interplay between lipid droplets and alpha-synuclein: implication in Parkinson’s disease pathogenesis

in Molecular Signalling and Pathways

Walid Idi
Razan Sheta
Abid Oueslati

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1681039

2,876 views
1 citation

Original Research

Published on 26 Nov 2025

A novel target for analgesic substances: physiological role of Na,K-ATPase as the signal transducer

in Pain Mechanisms and Modulators

Valentina A. Penniyaynen
Dmitriy M. Samosvat
Vera B. Plakhova
Svetlana A. Podzorova
Anna V. Berintseva
Irina P. Butkevich
Viktor A. Mikhailenko
Georgy G. Zegrya
Ke Ma
Ilya V. Dukhovlinov

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1717676

1,053 views

Original Research

Published on 25 Nov 2025

Construction of a diagnostic prediction model for ischemic stroke using lactylation-related genes

in Brain Disease Mechanisms

Jierong Mo
Deyuan Ning
Shuyi Chen
Tianen Zhou
Peiyi Liu
Zhiquan Li
Wenmin Tang
Lianshan Guo
Zhiyong Lin
Ran Zhan

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1672374

2,033 views

Editorial

Published on 25 Nov 2025

Editorial: Nutrient signaling and neuroendocrine pathways in brain-organ communication

in Molecular Signalling and Pathways

Hiroyuki Aizawa
Hiroaki Masuzaki

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1711443

941 views

Review

Published on 21 Nov 2025

The cone visual cycle and its disorders: insights from zebrafish

in Methods and Model Organisms

Ioanna S. Koutroumpa
Stephan C. F. Neuhauss

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1730071

1,514 views

Original Research

Published on 19 Nov 2025

Predictive value of circulating SNHG1/miR-194-5p and carotid ultrasound for the onset of cerebral infarction in patients with transient cerebral ischemia

in Brain Disease Mechanisms

Wei Wang
Mingjia Lv
Xin Zhang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1689127

1,005 views

Original Research

Published on 19 Nov 2025

Hypoxic preconditioning increases mitochondrial respiration and H2O2 production

in Brain Disease Mechanisms

Lisa Bergmeister
Carolina Doerrier
Barbara Fogli
Tímea Komlódi
Amrei Fischer
Kerstin Springer
Christoph Schwarzer
Erich Gnaiger

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1628567

2,202 views

Systematic Review

Published on 18 Nov 2025

C9orf72-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review

in Brain Disease Mechanisms

Seham Almalki
Mohamed Salama
Matthew J. Taylor
Zubair Ahmed
Richard I. Tuxworth

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1671906

3,582 views
1 citation

Review

Published on 17 Nov 2025

Alpha-neurexins in health and disease

in Molecular Signalling and Pathways

Nicolas Chofflet
Manni Wang
Mathilde Chofflet
Hideto Takahashi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1716782

1,913 views

Mini Review

Published on 14 Nov 2025

Habituation learning: insights from zebrafish larvae

in Methods and Model Organisms

Laura Köcher
Dominik Straumann

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1697688

1,990 views

Opinion

Published on 12 Nov 2025

One RNA-binding protein, many decisions: integrating the transcript life cycle into neuronal regulation

in Brain Disease Mechanisms

Epaminondas Doxakis
Yuan Chao Xue
Anca F. Savulescu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1716825

1,948 views

Original Research

Published on 10 Nov 2025

MicroRNAs and rs1803274 SNP-based BuChe downregulation are associated with metabolic syndrome through ghrelin hydrolysis and expression quantitative trait loci regulation in PD patients

in Brain Disease Mechanisms

Guenson Chevalier
Lucas Udovin
Matilde Otero-Losada
Sofia Bordet
Santiago Perez-Lloret
Francisco Capani

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1635201

1,400 views

Review

Published on 10 Nov 2025

The transcriptional and cellular landscape of cognitive resilience to Alzheimer’s disease

in Neuroplasticity and Development

Nina Khera
Ravikiran M. Raju
Stuart A. Lipton

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1665802

2,141 views
1 citation

Original Research

Published on 05 Nov 2025

Pex1 loss-of-function in zebrafish is viable and recapitulates hallmarks of Zellweger spectrum disorders

in Molecular Signalling and Pathways

Ursula Heins-Marroquin
Zlatan Hodzic
Beatriz Soares Carneiro da Silva
Agnes Hendriks
Floriane Gavotto
Marc O. Warmoes
Lisa Schlicker
Samy Omri
Christian Jäger
Enrico Glaab

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1634536

2,037 views

Brief Research Report

Published on 05 Nov 2025

Phosphoprofile reorganization of the actin binding protein Drebrin during long term depression

in Molecular Signalling and Pathways

Rafaela Pedro Silva
Till G. A. Mack
Marieluise Kirchner
Philipp Mertins
Britta J. Eickholt
Patricia Kreis

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1697642

1,653 views
1 citation

Original Research

Published on 03 Nov 2025

Focal postnatal deletion of Tsc2 causes epilepsy

in Brain Disease Mechanisms

Carlie McCoy
Mary Dusing
Lilian G. Jerow
Grace C. Winstel
Felix Zhan
Jason L. Rogers
Madison Wesley
J. Brian Otten
Steve C. Danzer
Candi L. LaSarge

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1686023

2,357 views

Systematic Review

Published on 31 Oct 2025

FUS-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review

in Brain Disease Mechanisms

Seham Almalki
Mohamed Salama
Matthew J. Taylor
Zubair Ahmed
Richard I. Tuxworth

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1671910

3,428 views
1 citation

Review

Published on 30 Oct 2025

The role and mechanisms of matrix metalloproteinase-9 in peripheral neuropathic pain

in Pain Mechanisms and Modulators

Shuai Ying Jia
Xiao-Jun Tang
Yao Su
Yu-Ning Liu
Zhi Ming
Jing-Yan Lin

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1647316

1,689 views

Original Research

Published on 28 Oct 2025

Analyses of exon 4a structure reveal the properties of Big tau related to distribution, function and aggregation

in Molecular Signalling and Pathways

Itzhak Fischer
Peter W. Baas

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1707820

1,336 views
1 citation

Original Research

Published on 28 Oct 2025

Transcriptomic profiling of neural cultures from the KYOU iPSC line via alternative differentiation protocols

in Methods and Model Organisms

Adelya Galiakberova
Sergey Ivanov
Arkadiy Golov
Alexander Artyuhov
Alexey Zolkin
Nikolay Kondratyev
Alexey Lagunin
Vera Golimbet
Erdem Dashinimaev

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1661986

2,014 views

Mini Review

Published on 24 Oct 2025

Proteostasis disruption and lipid dyshomeostasis in neurodegeneration: exploring common druggable targets across sporadic and monogenic disorders

in Brain Disease Mechanisms

Priscila Pereira Sena
Lea Friedrich
Alcibiades Villarreal
Florian Fath
Liubovi Sopco
Mar Hernández-Guillamon
Maria Luiza Saraiva-Pereira
Gabrielle Britton
Jonasz Jeremiasz Weber
Thorsten Schmidt

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1681079

2,479 views

4,349 articles

articles

Reelin signaling as a translational rheostat: linking synaptic homeostasis to neurodevelopment and neurodegeneration

Regulation of granin neuropeptide gene expression in human brain during development

Dynamic glycosylation remodeling in neurological disorders

Interplay between lipid droplets and alpha-synuclein: implication in Parkinson’s disease pathogenesis

A novel target for analgesic substances: physiological role of Na,K-ATPase as the signal transducer

Construction of a diagnostic prediction model for ischemic stroke using lactylation-related genes

Editorial: Nutrient signaling and neuroendocrine pathways in brain-organ communication

The cone visual cycle and its disorders: insights from zebrafish

Predictive value of circulating SNHG1/miR-194-5p and carotid ultrasound for the onset of cerebral infarction in patients with transient cerebral ischemia

Hypoxic preconditioning increases mitochondrial respiration and H2O2 production

C9orf72-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review

Alpha-neurexins in health and disease

Habituation learning: insights from zebrafish larvae

One RNA-binding protein, many decisions: integrating the transcript life cycle into neuronal regulation

MicroRNAs and rs1803274 SNP-based BuChe downregulation are associated with metabolic syndrome through ghrelin hydrolysis and expression quantitative trait loci regulation in PD patients

The transcriptional and cellular landscape of cognitive resilience to Alzheimer’s disease

Pex1 loss-of-function in zebrafish is viable and recapitulates hallmarks of Zellweger spectrum disorders

Phosphoprofile reorganization of the actin binding protein Drebrin during long term depression

Focal postnatal deletion of Tsc2 causes epilepsy

FUS-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review

The role and mechanisms of matrix metalloproteinase-9 in peripheral neuropathic pain

Analyses of exon 4a structure reveal the properties of Big tau related to distribution, function and aggregation

Transcriptomic profiling of neural cultures from the KYOU iPSC line via alternative differentiation protocols

Proteostasis disruption and lipid dyshomeostasis in neurodegeneration: exploring common druggable targets across sporadic and monogenic disorders