Frontiers in Molecular Neuroscience

Mini Review

Published on 24 Oct 2025

Proteostasis disruption and lipid dyshomeostasis in neurodegeneration: exploring common druggable targets across sporadic and monogenic disorders

in Brain Disease Mechanisms

Priscila Pereira Sena
Lea Friedrich
Alcibiades Villarreal
Florian Fath
Liubovi Sopco
Mar Hernández-Guillamon
Maria Luiza Saraiva-Pereira
Gabrielle Britton
Jonasz Jeremiasz Weber
Thorsten Schmidt

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1681079

2,479 views

Review

Published on 23 Oct 2025

Ferroptosis as a potential therapeutic target for post-traumatic stress disorder

in Brain Disease Mechanisms

Qian Zhang
Jin-Dong Mao
Hui Chen
Min Wang
Yu-Mei Wu
Chuan Wang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1648047

3,139 views

Review

Published on 22 Oct 2025

Bridging prion biology and Alzheimer’s disease: from pathogenic seeds to precision therapeutics

in Brain Disease Mechanisms

Wenjin Wang
Zhanhui Feng
Lingfeng Shu
Yongmei Hu
Yuting Chen
Baihui Zhang
Hua Huang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1660151

2,911 views

Review

Published on 22 Oct 2025

Beyond cell-cell contact: therapeutic potential of Eph signaling in central nervous system tumors

in Brain Disease Mechanisms

Fernanda Cristina Poscai Ribeiro
Moisés Willian Aparecido Gonçalves
Aleff Mascarenhas Silva
Tayná Figueiredo Maciel
Reydson Alcides de Lima-Souza
João Figueira Scarini
Gary Chris Fillmore
Erika Said Abu Egal

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1658651

2,393 views

Review

Published on 21 Oct 2025

Targeting ER stress in skeletal muscle through physical activity: a strategy for combating neurodegeneration-associated muscle decline

in Brain Disease Mechanisms

Zhanguo Su
Lijuan Xiang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1639114

2,055 views

Mini Review

Published on 21 Oct 2025

Lysine α-ketoglutarate reductase as a therapeutic target for saccharopine pathway related diseases

in Brain Disease Mechanisms

Gabriel Vieira Valderrama
Gabriela Alves Moreira
Paulo Arruda

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1695490

1,855 views
1 citation

Original Research

Published on 14 Oct 2025

PGC-1α promotes the survival of newborn neurons within AD hippocampus through activation of the FNDC5/BDNF/TrkB signaling pathway

in Neuroplasticity and Development

Yi-Jie Wang
Yu-Xin Wang
Cheng-Zhi Zou
Wei-Jun Zhang
Wen Pan
Jia-Qing Wang
Hua Wang
Xin Qian
Guo-Jia-Hao Han
Feng-Guo Liu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1688694

1,960 views

Original Research

Published on 14 Oct 2025

Schizophrenia risk gene ZNF536 modulates retinoic acid response and neuronal gene networks in SH-SY5Y cells

in Methods and Model Organisms

Artemiy O. Kurishev
Dmitrii A. Abashkin
Dmitry S. Karpov
Ekaterina V. Marilovtseva
Yulia A. Chaika
Ekaterina V. Semina
Vera E. Golimbet

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1671354

3,061 views

Mini Review

Published on 09 Oct 2025

Food for thought: probiotic modulation of microglial activity in Parkinson's disease

in Brain Disease Mechanisms

Isabella Kroker Kimber
Marie-Ève Tremblay

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1690507

3,119 views
1 citation

Original Research

Published on 09 Oct 2025

Neuronal activity-dependent gene expression is stimulus-specific and changes with neuronal maturation

in Molecular Signalling and Pathways

Jeronimo Lukin
Maximiliano S. Beckel
Olivia Pedroncini
Sebastian A. Giusti
Giuliana C. Di Mauro
Ivana Marcela Linenberg
Ines Lucia Patop
Ariel Chernomoretz
Antonia Marin-Burgin
Sebastian Kadener

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1609772

3,609 views

Review

Published on 08 Oct 2025

Peripheral–central immune interactions in Parkinson’s disease: insights into innate and adaptive immunity

in Brain Disease Mechanisms

Jarika Jahan Tumpa
Qurat Ul Ain Hayder
Nowshin Sharmily Maisa
Md. Nazmul Islam

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1682006

3,015 views

Original Research

Published on 03 Oct 2025

SIRT3 inhibits autophagy-dependent ferroptosis of HUVECs in the progression of pregnancy-induced hypertension by activating the PI3K/Akt/mTOR axis

in Molecular Signalling and Pathways

Yanchuan Li
Yanfeng Liu
Ziyun Shi
Meiqing He

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1620184

2,461 views
1 citation

Mini Review

Published on 03 Oct 2025

Neurochemical crossroads: exploring the neurotransmitter network in chronic pain and depression comorbidity

in Pain Mechanisms and Modulators

Min Ma
Yue Zhang
Kunming Tao
Zhijie Lu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1675814

4,545 views
3 citations

Correction

Published on 29 Sep 2025

Correction: Endoglin alleviates neuropathic pain by protecting the blood–spinal cord barrier through the TGF-β/Smad2 signaling pathway

in Pain Mechanisms and Modulators

SiJing Liao
Fei-Ran Zhou
Qun Li
Tao Jin
Gui-Fang Xiang
Xin Wang
Yan Liu
Hq Zhu
Qing Liu
Yuexin Liu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1707410

1,671 views

Correction

Published on 26 Sep 2025

Correction: Neuroprotective effects of the pannexin-1 channel inhibitor: probenecid on spinal cord injury in rats

in Neuroplasticity and Development

Qi Qi
Xiao-Xuan Wang
Jing-Lu Li
Yu-Qing Chen
Jian-Rong Chang
Jin Xi
He-Zuo Lü
Yu-Xin Zhang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1698001

1,851 views

Review

Published on 25 Sep 2025

TRP channels in epileptogenesis: calcium dysregulation mechanisms and pharmacological targeting strategies

in Brain Disease Mechanisms

Guolong Deng
Dayuan Liu
Yunxiang Zhong
Muyao Wang
Baoshou Su
Hongli Jiang
Yihao Zhai
Hao Peng
Caicai Zhang
Jigao Feng

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1687359

2,874 views
1 citation

Original Research

Published on 22 Sep 2025

Cross-disease biomarker identification reveals shared diagnostic biomarkers for IVDD and NAFLD via bulk and single-cell RNA sequencing

in Molecular Signalling and Pathways

Jiasen Wei
Chenglong Ji
Lina Liu
Chen Yan
Linhui Han
Wenbo Lin
Ximing Xu
Kaiqiang Sun

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1639705

3,388 views

Review

Published on 22 Sep 2025

Advances in research on propofol-induced postoperative cognitive dysfunction via Piezo channels

in Molecular Signalling and Pathways

Han Xue
Xiaoyu Zhang
Chenxu Chou
Yulong Jia
Chunguang Hao
Xiaguang Duan

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1668523

3,786 views
1 citation

Editorial

Published on 22 Sep 2025

Editorial: Innovative approaches in glioma therapy: exploring new therapeutic frontiers

in Brain Disease Mechanisms

Pilar Marcos
Arturo Mangas
Rafael Coveñas

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1697606

2,284 views

Original Research

Published on 15 Sep 2025

Tamoxifen attenuates manganese-induced dysregulation of neuronal REST via the genomic ER-α mechanism

in Molecular Signalling and Pathways

Alexis Digman
Edward Pajarillo
Sanghoon Kim
Itunu Ajayi
Deok-Soo Son
Michael Aschner
Eunsook Lee

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1648904

2,430 views

Original Research

Published on 15 Sep 2025

Endoglin alleviates neuropathic pain by protecting the blood–spinal cord barrier through the TGF-β/Smad2 signaling pathway

in Pain Mechanisms and Modulators

SiJing Liao
Fei-Ran Zhou
Qun Li
Tao Jin
Gui-Fang Xiang
Xin Wang
Yan Liu
Hq Zhu
Qing Liu
Yuexin Liu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1603619

3,066 views

Original Research

Published on 12 Sep 2025

Neuroprotection against beta-amyloid toxicity by the novel estrogen receptor modulator STX requires convergent signaling pathways

in Brain Disease Mechanisms

Hun-Joo Lee
Zoe Bostick
John Doherty
Tracy L. Swanson
Martin J. Kelly
Joseph F. Quinn
Nora E. Gray
Philip F. Copenhaver

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1670646

3,210 views
1 citation

Original Research

Published on 12 Sep 2025

Divergent and subnucleus-specific gene expression responses to chronic stress hormone exposure in the amygdala

in Brain Disease Mechanisms

Shuhei Ueda
Manami Kakita
Masahito Hosokawa
Koji Arikawa
Kiyofumi Takahashi
Ryusuke Shiota
Masaki Kakeyama
Hiroko Matsunaga
Haruko Takeyama
Sayaka Takemoto-Kimura

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1659846

3,352 views

Correction

Published on 09 Sep 2025

Correction: S-9-PAHSA ameliorates cognitive decline in a type 2 diabetes mouse model by inhibiting oxidative stress and apoptosis via CAIII modulation

in Molecular Signalling and Pathways

Xin-Ru Wang
Shan-Shan Huang
Meng Wang
Jin-Hong Lin
Jian-Tao Wang
Jiao-Qi Ren
Cheng-Feng He
Wen-Jiao Xue
Yin Wang
Xue-Chun Wang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1688881

1,981 views

4,350 articles

articles

Proteostasis disruption and lipid dyshomeostasis in neurodegeneration: exploring common druggable targets across sporadic and monogenic disorders

Ferroptosis as a potential therapeutic target for post-traumatic stress disorder

Bridging prion biology and Alzheimer’s disease: from pathogenic seeds to precision therapeutics

Beyond cell-cell contact: therapeutic potential of Eph signaling in central nervous system tumors

Targeting ER stress in skeletal muscle through physical activity: a strategy for combating neurodegeneration-associated muscle decline

Lysine α-ketoglutarate reductase as a therapeutic target for saccharopine pathway related diseases

PGC-1α promotes the survival of newborn neurons within AD hippocampus through activation of the FNDC5/BDNF/TrkB signaling pathway

Schizophrenia risk gene ZNF536 modulates retinoic acid response and neuronal gene networks in SH-SY5Y cells

Food for thought: probiotic modulation of microglial activity in Parkinson's disease

Neuronal activity-dependent gene expression is stimulus-specific and changes with neuronal maturation

Peripheral–central immune interactions in Parkinson’s disease: insights into innate and adaptive immunity

SIRT3 inhibits autophagy-dependent ferroptosis of HUVECs in the progression of pregnancy-induced hypertension by activating the PI3K/Akt/mTOR axis

Neurochemical crossroads: exploring the neurotransmitter network in chronic pain and depression comorbidity

Correction: Endoglin alleviates neuropathic pain by protecting the blood–spinal cord barrier through the TGF-β/Smad2 signaling pathway

Correction: Neuroprotective effects of the pannexin-1 channel inhibitor: probenecid on spinal cord injury in rats

TRP channels in epileptogenesis: calcium dysregulation mechanisms and pharmacological targeting strategies

Cross-disease biomarker identification reveals shared diagnostic biomarkers for IVDD and NAFLD via bulk and single-cell RNA sequencing

Advances in research on propofol-induced postoperative cognitive dysfunction via Piezo channels

Editorial: Innovative approaches in glioma therapy: exploring new therapeutic frontiers

Tamoxifen attenuates manganese-induced dysregulation of neuronal REST via the genomic ER-α mechanism

Endoglin alleviates neuropathic pain by protecting the blood–spinal cord barrier through the TGF-β/Smad2 signaling pathway

Neuroprotection against beta-amyloid toxicity by the novel estrogen receptor modulator STX requires convergent signaling pathways

Divergent and subnucleus-specific gene expression responses to chronic stress hormone exposure in the amygdala

Correction: S-9-PAHSA ameliorates cognitive decline in a type 2 diabetes mouse model by inhibiting oxidative stress and apoptosis via CAIII modulation