Frontiers in Molecular Neuroscience | Brain Disease Mechanisms

Original Research

Published on 22 Aug 2025

Organelle stresses and energetic metabolisms promote endothelial–to–mesenchymal transition and fibrosis via upregulating FOSB and MEOX1 in Alzheimer’s disease

in Brain Disease Mechanisms

Fatma Saaoud
Mohammed Ben Issa
Lu Liu
Keman Xu
Yifan Lu
Ying Shao
Baosheng Han
Xiaohua Jiang
Xiaolei Liu
Avrum Gillespie

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1605012

273 views

Original Research

Accepted on 20 Aug 2025

Neuroprotection Against Beta-Amyloid Toxicity By The Novel Estrogen Receptor Modulator STX Requires Convergent Signaling Pathways

in Brain Disease Mechanisms

Hun-Joo Lee
Zoe Bostick
John Doherty
Tracy L Swanson
Martin J Kelly
Joseph F Quinn
Nora E Gray
Philip F Copenhaver

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1670646

101 views

Review

Accepted on 15 Aug 2025

IDH Mutant High-Grade Gliomas

in Brain Disease Mechanisms

Santosh Valvi
Maryam Fouladi
Michael J Fisher
Nicholas G Gottardo

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1662414

132 views

Editorial

Published on 14 Aug 2025

Editorial: Imaging brain network and brain energy metabolism impairments in brain disorders

in Brain Disease Mechanisms

Yuhei Takado
Mor Mishkovsky
Tomokazu Tsurugizawa

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1676946

300 views

Original Research

Published on 13 Aug 2025

ACTN2, regulated by PRDM9, affects the growth and inflammation of vascular smooth muscle cells by interacting with PDLIM1 in intracranial aneurysms

in Brain Disease Mechanisms

Guangxu Zhang
Jinbing Zhao
Zhiqiang Yu
Hongyi Liu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1606973

334 views

Original Research

Published on 08 Aug 2025

Neuronal expression of S100B triggered by oligomeric Aβ peptide contributes to protection against cytoskeletal damage and synaptic loss

in Brain Disease Mechanisms

Joana Saavedra
Mariana Nascimento
António J. Figueira
Marina I. Oliveira da Silva
Tiago Gião
João Oliveira
Márcia A. Liz
Cláudio M. Gomes
Isabel Cardoso

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1636365

761 views

Review

Published on 06 Aug 2025

Is postoperative cognitive dysfunction a disease of microglial inflammatory memory? A state-transition model from metabolic stress to epigenetic lock-in

in Brain Disease Mechanisms

Xiangyu Wu
Tingye He
Fei He
Li Liu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1648161

583 views

Original Research

Accepted on 01 Aug 2025

Delayed structural maturation of inner hair cell ribbon synapses in a mouse model of fragile X syndrome

in Brain Disease Mechanisms

Magdalena Chojnacka
Anna Skupien-Jaroszek
Magdalena Dziembowska

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1604262

262 views

Original Research

Published on 23 Jul 2025

Chronic reduction of synaptic proteins in the epileptogenic lesion of patients with hippocampal sclerosis

in Brain Disease Mechanisms

Akiko Oota-Ishigaki
Nami Suzuki
Keiya Iijima
Yutaro Takayama
Yuiko Kimura
Kotaro Hattori
Masaki Iwasaki
Takashi Hayashi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1635852

880 views

Original Research

Published on 14 Jul 2025

Inhibition of BET proteins modulates amyloid-beta accumulation and cognitive performance in middle-aged mice prenatally exposed to maternal immune activation

in Brain Disease Mechanisms

Marta Matuszewska
Anna Wilkaniec
Magdalena Gąssowska-Dobrowolska
Magdalena Cieślik
Gabriela Olech-Kochańczyk
Ewelina Pałasz
Elżbieta Gawinek
Marcin Strawski
Grzegorz A. Czapski

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1619583

1,130 views

Review

Published on 07 Jul 2025

Role of the chaperonin TCP-1 ring complex in protein aggregation and neurodegeneration

in Brain Disease Mechanisms

Vanlalrinchhani Varte
Diego E. Rincon-Limas

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1617771

1,453 views

Systematic Review

Published on 02 Jul 2025

Recognition of the microbial metabolite p-cresol in autism spectrum disorder: systematic review and meta-analysis

in Brain Disease Mechanisms

María Isabel Serrano-Tomás
Paulina Contreras-Romero
Mara Parellada
Javier Chaves-Cordero
Javier Zamora
Martha Hengst
Patricia Pozo
Rosa del Campo
Sheyla Guzmán-Salas

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1576388

1,464 views

Review

Published on 26 Jun 2025

Mechanism of heme oxygenase-1 regulation of ferroptosis in vascular dementia

in Brain Disease Mechanisms

Xin-yi Zou
Luo-yang Cai
Jin Zhang
Ying Yuan
Jie Song
Zhao-duan Hu
Xiao-feng Ruan
Rui Peng
Xiao-ming Zhang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1585079

1,494 views

Review

Published on 25 Jun 2025

How endothelial cell metabolism shapes blood–brain barrier integrity in neurodegeneration

in Brain Disease Mechanisms

Jiaxin Wang
Yuchun Chen
Shiteng Chen
Zihan Mu
Jun Chen

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1623321

1,688 views

Original Research

Published on 25 Jun 2025

Critical gene network and signaling pathway analysis of the extracellular signal-regulated kinase (ERK) pathway in ischemic stroke

in Brain Disease Mechanisms

Rui Mao
Lei Wang
Haitao Zhang
Jiaojiao Gong
Hua Liu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1604670

1,222 views

Original Research

Published on 25 Jun 2025

Whole-genome sequencing shows modulation of neurodegenerative genes by Withania somnifera in human SK-N-SH cells

in Brain Disease Mechanisms

Eshita Sharma
Dilip Mehta
Nikita Jadhav
Gunjan Gujrati
S. Dhananya
Manju Moorthy
Gopalakrishna Ramaswamy
Yundong Zhou
Sujit Nair

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1512727

2,323 views