Frontiers in Molecular Neuroscience | Brain Disease Mechanisms

Original Research

Published on 12 Sep 2025

Neuroprotection against beta-amyloid toxicity by the novel estrogen receptor modulator STX requires convergent signaling pathways

in Brain Disease Mechanisms

Hun-Joo Lee
Zoe Bostick
John Doherty
Tracy L. Swanson
Martin J. Kelly
Joseph F. Quinn
Nora E. Gray
Philip F. Copenhaver

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1670646

426 views

Original Research

Published on 12 Sep 2025

Divergent and subnucleus-specific gene expression responses to chronic stress hormone exposure in the amygdala

in Brain Disease Mechanisms

Shuhei Ueda
Manami Kakita
Masahito Hosokawa
Koji Arikawa
Kiyofumi Takahashi
Ryusuke Shiota
Masaki Kakeyama
Hiroko Matsunaga
Haruko Takeyama
Sayaka Takemoto-Kimura

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1659846

635 views

Review

Accepted on 09 Sep 2025

TRP Channels in Epileptogenesis: Calcium Dysregulation Mechanisms and Pharmacological Targeting Strategies

in Brain Disease Mechanisms

Guolong Deng
Dayuan Liu
Yunxiang Zhong
Wang Muyao
Su Baoshou
Jiang Hongli
Zhai Yihao
Hao Peng
Jigao Feng
Caicai Zhang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1687359

149 views

Review

Accepted on 08 Sep 2025

FUS-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA Damage Response: a systematic review

in Brain Disease Mechanisms

Seham Almalki
Mohamed Salama
Matthew J Taylor
Zubair Ahmed
Richard Tuxworth

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1671910

207 views

Editorial

Accepted on 05 Sep 2025

Editorial: Innovative Approaches in Glioma Therapy: Exploring New Therapeutic Frontiers

in Brain Disease Mechanisms

Pilar Marcos
Arturo Mangas
Rafael Coveñas

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1697606

294 views

Original Research

Published on 03 Sep 2025

Delayed structural maturation of inner hair cell ribbon synapses in a mouse model of fragile X syndrome

in Brain Disease Mechanisms

M. Chojnacka
A. Skupien-Jaroszek
M. Dziembowska

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1604262

671 views

Review

Accepted on 02 Sep 2025

Targeting ER Stress in Skeletal Muscle Through Physical Activity: A Strategy for Combating Neurodegeneration-Associated Muscle Decline

in Brain Disease Mechanisms

Lijuan Xiang
Zhanguo Su

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1639114

286 views

Review

Published on 29 Aug 2025

IDH mutant high-grade gliomas

in Brain Disease Mechanisms

Santosh Valvi
Maryam Fouladi
Michael J. Fisher
Nicholas G. Gottardo

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1662414

836 views

Original Research

Published on 22 Aug 2025

Organelle stresses and energetic metabolisms promote endothelial–to–mesenchymal transition and fibrosis via upregulating FOSB and MEOX1 in Alzheimer’s disease

in Brain Disease Mechanisms

Fatma Saaoud
Mohammed Ben Issa
Lu Liu
Keman Xu
Yifan Lu
Ying Shao
Baosheng Han
Xiaohua Jiang
Xiaolei Liu
Avrum Gillespie

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1605012

1,377 views

Editorial

Published on 14 Aug 2025

Editorial: Imaging brain network and brain energy metabolism impairments in brain disorders

in Brain Disease Mechanisms

Yuhei Takado
Mor Mishkovsky
Tomokazu Tsurugizawa

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1676946

797 views

Original Research

Published on 13 Aug 2025

ACTN2, regulated by PRDM9, affects the growth and inflammation of vascular smooth muscle cells by interacting with PDLIM1 in intracranial aneurysms

in Brain Disease Mechanisms

Guangxu Zhang
Jinbing Zhao
Zhiqiang Yu
Hongyi Liu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1606973

921 views

Original Research

Published on 08 Aug 2025

Neuronal expression of S100B triggered by oligomeric Aβ peptide contributes to protection against cytoskeletal damage and synaptic loss

in Brain Disease Mechanisms

Joana Saavedra
Mariana Nascimento
António J. Figueira
Marina I. Oliveira da Silva
Tiago Gião
João Oliveira
Márcia A. Liz
Cláudio M. Gomes
Isabel Cardoso

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1636365

1,382 views

Review

Published on 06 Aug 2025

Is postoperative cognitive dysfunction a disease of microglial inflammatory memory? A state-transition model from metabolic stress to epigenetic lock-in

in Brain Disease Mechanisms

Xiangyu Wu
Tingye He
Fei He
Li Liu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1648161

1,599 views

Original Research

Published on 23 Jul 2025

Chronic reduction of synaptic proteins in the epileptogenic lesion of patients with hippocampal sclerosis

in Brain Disease Mechanisms

Akiko Oota-Ishigaki
Nami Suzuki
Keiya Iijima
Yutaro Takayama
Yuiko Kimura
Kotaro Hattori
Masaki Iwasaki
Takashi Hayashi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1635852

1,112 views

Original Research

Published on 14 Jul 2025

Inhibition of BET proteins modulates amyloid-beta accumulation and cognitive performance in middle-aged mice prenatally exposed to maternal immune activation

in Brain Disease Mechanisms

Marta Matuszewska
Anna Wilkaniec
Magdalena Gąssowska-Dobrowolska
Magdalena Cieślik
Gabriela Olech-Kochańczyk
Ewelina Pałasz
Elżbieta Gawinek
Marcin Strawski
Grzegorz A. Czapski

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1619583

1,331 views

Review

Published on 07 Jul 2025

Role of the chaperonin TCP-1 ring complex in protein aggregation and neurodegeneration

in Brain Disease Mechanisms

Vanlalrinchhani Varte
Diego E. Rincon-Limas

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1617771

1,653 views