Frontiers in Molecular Neuroscience | Brain Disease Mechanisms

Systematic Review

Published on 31 Oct 2025

FUS-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review

in Brain Disease Mechanisms

Seham Almalki
Mohamed Salama
Matthew J. Taylor
Zubair Ahmed
Richard I. Tuxworth

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1671910

835 views

Original Research

Accepted on 30 Oct 2025

Construction of a diagnostic prediction model for ischemic stroke using lactylation - related genes

in Brain Disease Mechanisms

Jierong Mo
Deyuan Ning
Shuyi Chen
Tianen Zhou
Peiyi Liu
Zhiquan Li
WenMin Tang
Guo Lianshan
Zhiyong Lin
Ran Zhan

Frontiers in Molecular Neuroscience

Opinion

Accepted on 29 Oct 2025

One RNA-binding protein, many decisions: integrating the transcript life cycle into neuronal regulation

in Brain Disease Mechanisms

Epaminondas Doxakis
Yuan Chao Xue
Anca Flavia Savulescu

Frontiers in Molecular Neuroscience

Systematic Review

Accepted on 27 Oct 2025

C9orf72-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA Damage Response: a systematic review

in Brain Disease Mechanisms

Seham Almalki
Mohamed Salama
Matthew J Taylor
Zubair Ahmed
Richard Ian Tuxworth

Frontiers in Molecular Neuroscience

237 views

Mini Review

Published on 24 Oct 2025

Proteostasis disruption and lipid dyshomeostasis in neurodegeneration: exploring common druggable targets across sporadic and monogenic disorders

in Brain Disease Mechanisms

Priscila Pereira Sena
Lea Friedrich
Alcibiades Villarreal
Florian Fath
Liubovi Sopco
Mar Hernández-Guillamon
Maria Luiza Saraiva-Pereira
Gabrielle Britton
Jonasz Jeremiasz Weber
Thorsten Schmidt

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1681079

638 views

Original Research

Accepted on 23 Oct 2025

Hypoxic Preconditioning Increases Mitochondrial Respiration and H2O2 Production

in Brain Disease Mechanisms

Lisa Bergmeister
Carolina Doerrier
Barbara Fogli
Tímea Komlódi
Amrei Fischer
Kerstin Springer
Christoph Schwarzer
Erich Gnaiger

Frontiers in Molecular Neuroscience

416 views

Review

Published on 23 Oct 2025

Ferroptosis as a potential therapeutic target for post-traumatic stress disorder

in Brain Disease Mechanisms

Qian Zhang
Jin-Dong Mao
Hui Chen
Min Wang
Yu-Mei Wu
Chuan Wang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1648047

1,704 views

Review

Published on 22 Oct 2025

Bridging prion biology and Alzheimer’s disease: from pathogenic seeds to precision therapeutics

in Brain Disease Mechanisms

Wenjin Wang
Zhanhui Feng
Lingfeng Shu
Yongmei Hu
Yuting Chen
Baihui Zhang
Hua Huang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1660151

774 views

Review

Published on 22 Oct 2025

Beyond cell-cell contact: therapeutic potential of Eph signaling in central nervous system tumors

in Brain Disease Mechanisms

Fernanda Cristina Poscai Ribeiro
Moisés Willian Aparecido Gonçalves
Aleff Mascarenhas Silva
Tayná Figueiredo Maciel
Reydson Alcides de Lima-Souza
João Figueira Scarini
Gary Chris Fillmore
Erika Said Abu Egal

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1658651

599 views

Review

Published on 21 Oct 2025

Targeting ER stress in skeletal muscle through physical activity: a strategy for combating neurodegeneration-associated muscle decline

in Brain Disease Mechanisms

Zhanguo Su
Lijuan Xiang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1639114

841 views

Mini Review

Published on 21 Oct 2025

Lysine α-ketoglutarate reductase as a therapeutic target for saccharopine pathway related diseases

in Brain Disease Mechanisms

Gabriel Vieira Valderrama
Gabriela Alves Moreira
Paulo Arruda

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1695490

560 views

Original Research

Accepted on 20 Oct 2025

MicroRNAs and rs1803274 SNP-based BuChe downregulation are associated with metabolic syndrome through ghrelin hydrolysis and expression quantitative traits loci regulation in PD patients

in Brain Disease Mechanisms

Guenson Chevalier
Lucas Daniel Udovin
Matilde Otero-Losada
Sofía Bordet
Santiago Perez-Lloret
Francisco Capani

Frontiers in Molecular Neuroscience

Original Research

Accepted on 20 Oct 2025

Focal postnatal deletion of Tsc2 causes epilepsy

in Brain Disease Mechanisms

Carlie McCoy
Mary Dusing
Lilian G Jerow
Grace C Winstel
Felix Zhan
Jason L Rogers
Madison Wesley
J Brian Otten
Steve C Danzer
Candi Lynn LaSarge

Frontiers in Molecular Neuroscience

330 views

Mini Review

Published on 09 Oct 2025

Food for thought: probiotic modulation of microglial activity in Parkinson's disease

in Brain Disease Mechanisms

Isabella Kroker Kimber
Marie-Ève Tremblay

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1690507

1,563 views

Review

Published on 08 Oct 2025

Peripheral–central immune interactions in Parkinson’s disease: insights into innate and adaptive immunity

in Brain Disease Mechanisms

Jarika Jahan Tumpa
Qurat Ul Ain Hayder
Nowshin Sharmily Maisa
Md. Nazmul Islam

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1682006

1,477 views

Review

Published on 25 Sep 2025

TRP channels in epileptogenesis: calcium dysregulation mechanisms and pharmacological targeting strategies

in Brain Disease Mechanisms

Guolong Deng
Dayuan Liu
Yunxiang Zhong
Muyao Wang
Baoshou Su
Hongli Jiang
Yihao Zhai
Hao Peng
Caicai Zhang
Jigao Feng

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1687359

1,706 views