Frontiers in Molecular Neuroscience | Brain Disease Mechanisms

Original Research

Published on 05 Feb 2026

Oxymatrine-associated protection in an MPTP mouse model is accompanied by increased miR-141-3p and reduced HMGB1

in Brain Disease Mechanisms

Ping Gan
Qi Zhao
Xing Yi
Yi-Ming Hua
Yu-Fang Ding
Zhi-Mei Huang
Xing Ye
Jian Wu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1731850

428 views

Original Research

Accepted on 03 Feb 2026

Clinical and Genetic Determinants of Glioblastoma Multiforme Survival: A Retrospective Study

in Brain Disease Mechanisms

Julia Lara Gutiérrez-Arroyo
Pia Gallego Porcar
Elvira Carbonell Martínez
Luis German González Bonet
Maria Victoria Ibañez
María Díaz-Ruiz
Hugo Caballero-Arzapalo
Ariadna Soto
Guillermo Garcia-Oriola
José María Borras-Moreno

Frontiers in Molecular Neuroscience

213 views

Opinion

Published on 02 Feb 2026

Lysosome trafficking across intracellular and intercellular networks in the brain

in Brain Disease Mechanisms

Dylan T. Murphy
Chih Hung Lo

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1755292

723 views

Original Research

Accepted on 29 Jan 2026

T2-FLAIR hyperintensities in the inferior cerebellar peduncles and their association with clinical symptoms, molecular and MRI markers in male FMR1 premutation carriers

in Brain Disease Mechanisms

Andrea Elias
Irene Paracuellos-Ayala
Jun Yi Wang
Kyoungmi Kim
Flora Tassone
Andrea Schneider
David Hessl
Susan M Rivera
Randi Jenssen Hagerman

Frontiers in Molecular Neuroscience

256 views

Original Research

Published on 29 Jan 2026

The Nodding syndrome cerebrospinal fluid proteome: a lens into neurodevelopmental failure consistent with environmentally triggered MECP2 dysregulation?

in Brain Disease Mechanisms

Raquel Valdes Angues
Caesar Okot
Keith D. Zientek
Phillip A. Wilmarth
Ashok P. Reddy
Alfred Lucid Blair Odong
Valerie S. Palmer
Lucy Kipwola Abwola
Ensio Ogal
Geoffrey Okello

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1717920

561 views

Review

Accepted on 28 Jan 2026

Mesenchymal Stem Cells and the Central Nervous System: Historical Perspectives and Future Directions

in Brain Disease Mechanisms

Christopher Yates Mazurek
Julia Krystyna Kaniuk
Christopher Ahuja

Frontiers in Molecular Neuroscience

589 views

Original Research

Accepted on 28 Jan 2026

Temporal Lobe Epilepsy is associated with Neuroinflammation, Extracellular Matrix Remodeling, and Synaptic Protein Alterations

in Brain Disease Mechanisms

Sophia Auer
Lucas Hoffmann
Martin Schicht
Ingmar Blümcke
Friedrich Paulsen

Frontiers in Molecular Neuroscience

159 views

Editorial

Accepted on 27 Jan 2026

Editorial: Proteostasis disruption in neurodegenerative disorders: Mechanisms and treatment strategies

in Brain Disease Mechanisms

Jonasz Jeremiasz Weber
Hiroaki Taniguchi
Maxim Sokolov

Frontiers in Molecular Neuroscience

289 views

Systematic Review

Accepted on 26 Jan 2026

TDP-43 related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA Damage Response: a systematic review and narrative synthesis

in Brain Disease Mechanisms

Seham Almalki
Mohamed Salama
Matthew J Taylor
Zubair Ahmed
Richard Tuxworth

Frontiers in Molecular Neuroscience

316 views

Review

Accepted on 26 Jan 2026

Oxysterol Signaling in the Central Nervous system: Cellular Mechanisms and Implications for Neurodegeneration

in Brain Disease Mechanisms

Raphael Ricci
Cheng Xian Foo
Katharina Ronacher
Carlie L Cullen

Frontiers in Molecular Neuroscience

158 views

Opinion

Published on 26 Jan 2026

Multilayer modulation of the proteasome: new strategies for neuroprotection

in Brain Disease Mechanisms

Maxim Sokolov
Hiroaki Taniguchi
Jonasz Jeremiasz Weber

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1748434

632 views

Correction

Accepted on 22 Jan 2026

Correction: Bioenergetic-related gene expression in the hippocampus predicts internalizing vs. externalizing behavior in an animal model of temperament

in Brain Disease Mechanisms

Elaine Hebda-Bauer
Megan Hastings Hagenauer
Daniel Munro
Peter Blandino Jr.
Fan Meng
Keiko Arakawa
John Stead
Apurva Chitre
Ayse Bilge Ozel
Pejman Mohammadi

Frontiers in Molecular Neuroscience

134 views

Mini Review

Published on 16 Jan 2026

Endoplasmic reticulum protein retention and disturbed proteostasis is a common pathology for a subset of autism: evidence from mutations in GABAA receptors and GABA transporter 1

in Brain Disease Mechanisms

Jing-Qiong Kang
Aiden Delahanty

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1671331

845 views

Original Research

Published on 13 Jan 2026

Gene expression asymmetry in Parkinson’s disease: variation of CCT gene expression is correlated with hemisphere specific severity

in Brain Disease Mechanisms

Steven E. Pierce
Edwin J. C. van der Schans
Thomas M. Goralski
Elizabeth Ensink
Peipei Li
Michael X. Henderson
Gerhard A. Coetzee

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1743557

770 views

Review

Published on 12 Jan 2026

Structure and function of neurovascular unit in arterial hypertension

in Brain Disease Mechanisms

Ewa Kozniewska
Marta Aleksandrowicz

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1714892

957 views

Opinion

Published on 12 Jan 2026

Astrocyte epigenetics as a priority area in neuroscience research

in Brain Disease Mechanisms

Itzy E. Morales Pantoja
C. David Mintz

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1716805

1,671 views

Editorial

Published on 12 Jan 2026

Editorial: Advancing therapeutics for Alzheimer's disease and related dementias through multi-omics data analysis in ethnically diverse populations

in Brain Disease Mechanisms

Anjali Garg
Ravindra Kumar
Rajan Shrivastava
Deepesh Kumar Gupta
Bandana Kumari
Manish Kumar

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1767630

904 views

Original Research

Accepted on 08 Jan 2026

Emerging role of KDM5C in X-linked Intellectual Disability based on human genetic data and zebrafish models

in Brain Disease Mechanisms

Liao Baoqiong
Meihuan Chen
Huang Yun
Shuai Mei
Xu Liangpu
He Shuwen
Hailong Huang

Frontiers in Molecular Neuroscience

242 views

Original Research

Published on 07 Jan 2026

CHI3L1 monoclonal antibody therapy mitigates cognitive impairment by inhibiting neuroinflammation through ERK and NF-κB pathway in Tg2576 mice

in Brain Disease Mechanisms

Hyeon Joo Ham
Seung Sik Park
Yong Sun Lee
Tae Hun Kim
Dong Ju Son
Ji-Hun Kim
Key-Hwan Lim
Hanseul Park
Hye Jin Lee
Jaesuk Yun

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1728279

1,140 views

Original Research

Published on 05 Jan 2026

Interactome screening implicates BAG6 as a suppressor of UBQLN2 misfolding in ALS/FTD

in Brain Disease Mechanisms

Sang Hwa Kim
Claire E. Boos
Mark Scalf
Akasha K. Wilkemeyer
Lloyd M. Smith
Randal S. Tibbetts

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1720347

1,210 views

Mini Review

Published on 05 Jan 2026

Potential role of stress granules and myogranules in amyotrophic lateral sclerosis

in Brain Disease Mechanisms

Saddam Muhammad Ishaq
Aaron P. Russell

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1686230

1,195 views

Original Research

Published on 10 Dec 2025

A phage displaying an Aβ-interacting peptide mitigates neurotoxicity and prevents Aβ-driven gene expression changes

in Brain Disease Mechanisms

Laura Maria De Plano
Luigi Chiricosta
Simone D’Angiolini
Alessandra Saitta
Alessandra Trainito
Serena Silvestro
Sabrina Conoci
Salvatore Oddo
Antonella Caccamo

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1716626

1,346 views

Review

Published on 02 Dec 2025

Dynamic glycosylation remodeling in neurological disorders

in Brain Disease Mechanisms

Dan Xing
Yingxun Gong
Weiyi Xia
Huifang Tu
Limei Yuan
Yiqing Yin
Kaiyuan Wang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1674665

1,662 views

Original Research

Published on 25 Nov 2025

Construction of a diagnostic prediction model for ischemic stroke using lactylation-related genes

in Brain Disease Mechanisms

Jierong Mo
Deyuan Ning
Shuyi Chen
Tianen Zhou
Peiyi Liu
Zhiquan Li
Wenmin Tang
Lianshan Guo
Zhiyong Lin
Ran Zhan

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1672374

2,021 views

1,112 articles

articles

Oxymatrine-associated protection in an MPTP mouse model is accompanied by increased miR-141-3p and reduced HMGB1

Clinical and Genetic Determinants of Glioblastoma Multiforme Survival: A Retrospective Study

Lysosome trafficking across intracellular and intercellular networks in the brain

T2-FLAIR hyperintensities in the inferior cerebellar peduncles and their association with clinical symptoms, molecular and MRI markers in male FMR1 premutation carriers

The Nodding syndrome cerebrospinal fluid proteome: a lens into neurodevelopmental failure consistent with environmentally triggered MECP2 dysregulation?

Mesenchymal Stem Cells and the Central Nervous System: Historical Perspectives and Future Directions

Temporal Lobe Epilepsy is associated with Neuroinflammation, Extracellular Matrix Remodeling, and Synaptic Protein Alterations

Editorial: Proteostasis disruption in neurodegenerative disorders: Mechanisms and treatment strategies

TDP-43 related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA Damage Response: a systematic review and narrative synthesis

Oxysterol Signaling in the Central Nervous system: Cellular Mechanisms and Implications for Neurodegeneration

Multilayer modulation of the proteasome: new strategies for neuroprotection

Correction: Bioenergetic-related gene expression in the hippocampus predicts internalizing vs. externalizing behavior in an animal model of temperament

Endoplasmic reticulum protein retention and disturbed proteostasis is a common pathology for a subset of autism: evidence from mutations in GABAA receptors and GABA transporter 1

Gene expression asymmetry in Parkinson’s disease: variation of CCT gene expression is correlated with hemisphere specific severity

Structure and function of neurovascular unit in arterial hypertension

Astrocyte epigenetics as a priority area in neuroscience research

Editorial: Advancing therapeutics for Alzheimer's disease and related dementias through multi-omics data analysis in ethnically diverse populations

Emerging role of KDM5C in X-linked Intellectual Disability based on human genetic data and zebrafish models

CHI3L1 monoclonal antibody therapy mitigates cognitive impairment by inhibiting neuroinflammation through ERK and NF-κB pathway in Tg2576 mice

Interactome screening implicates BAG6 as a suppressor of UBQLN2 misfolding in ALS/FTD

Potential role of stress granules and myogranules in amyotrophic lateral sclerosis

A phage displaying an Aβ-interacting peptide mitigates neurotoxicity and prevents Aβ-driven gene expression changes

Dynamic glycosylation remodeling in neurological disorders

Construction of a diagnostic prediction model for ischemic stroke using lactylation-related genes