Frontiers in Molecular Neuroscience | Brain Disease Mechanisms

Review

Published on 10 Jul 2026

Astrocyte epigenetics in development, aging, and neurodegeneration: a DNA methylation perspective

in Brain Disease Mechanisms

Uchit Bhaskar
Melanie A. Carless

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1876219

248 views

Mini Review

Accepted on 08 Jul 2026

Epidermal growth factor receptor modulation for neural repair: implications for neurodegenerative disease therapy

in Brain Disease Mechanisms

Marina Badenes
Abdulbasit Amin

Frontiers in Molecular Neuroscience

Review

Published on 08 Jul 2026

BDNF–amyloid-β Axis in Alzheimer’s disease: molecular mechanisms and therapeutic perspectives

in Brain Disease Mechanisms

Fangfang Liu
Yuanmao Huang
Aiping Wang
Peiyan Liu
Haolin Wu
Haofei Fan

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1884003

341 views

Original Research

Published on 08 Jul 2026

Prenatal and neonatal housing conditions affect anxiety-like behavior in adulthood in rats and interact with brain-derived neurotrophic factor (BDNF) Val66Met to alter expression of BDNF and stress markers in the ventral hippocampus

in Brain Disease Mechanisms

Maarten van den Buuse
Michelle Corrone
Emily J. Jaehne
Veronica Begni
Alessia Marchesin
Marco A. Riva

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1844602

377 views

Original Research

Published on 08 Jul 2026

16p11.2 microdeletion enhances gene expression variability between human IPSC-derived forebrain interneuron progenitor cells in culture

in Brain Disease Mechanisms

Yifei Yang
Idoia Quintana Urzainqui
Thomas Pratt

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1872405

341 views

Review

Accepted on 06 Jul 2026

Brain Heart Crosstalk After Ischemic Stroke Toward a Unified Framework for Pathophysiology and Precision Medicine

in Brain Disease Mechanisms

Pengpeng Li
Yangyang Gao
Wei Liu

Frontiers in Molecular Neuroscience

Original Research

Published on 06 Jul 2026

CircHomer1 may contribute to postoperative cognitive impairment by modulating Homer1b/mGluR5-associated signaling in the vCA1 region of aged mice

in Brain Disease Mechanisms

Wei Ran
Yiwei Shen
Ruixue Yuan
Jin Gao
Ning Liang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1859800

451 views

Original Research

Published on 06 Jul 2026

Altered cortical neuronal activity in functional esophageal disorders and its associations with chronic insomnia and peripheral inflammation: a resting-state fMRI study

in Brain Disease Mechanisms

Bei Peng
Likun Zhong
Jinfu Huang
Meng Cui
Dan Huang
Yinfei Ouyang
Xiaoli Liang
Haoqiang Li
Xinghua Huang
Zhiming Lin

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1871404

301 views

Review

Published on 03 Jul 2026

Histone lactylation-mediated glycolysis-ferroptosis axis in neurological diseases

in Brain Disease Mechanisms

Zengrong Wei
Lu Bai
Xueting Liu
Yanling Zhou
Lei Zheng
Baiwen Zhang
Long Wang
Wei Zou

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1820758

411 views

Original Research

Published on 02 Jul 2026

Modulation of the microbiota-lipid-brain axis by modified Chaihu-Longgu-Muli Decoction ameliorates chronic stress-induced depression

in Brain Disease Mechanisms

Yonghao Chen
Yongcheng Liu
Ruxi Tong
Lizhen Lin
Ming Zhu
Xuanbin Huang
Tianmin Wu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1865663

451 views

Original Research

Accepted on 01 Jul 2026

Use of the Behavioral Dyscontrol Scale-2 (BDS-2) to measure executive dysfunction in FXTAS

in Brain Disease Mechanisms

Seyedeh Ala Mokhtabad Amrei
Hasan Hasan
Ellery Santos
Hazel Maridith Barlahan Biag
Andrea Schneider
Jun Yi Wang
David Hessl
Kyoungmi Kim
Ezra Morrison
Flora Tassone

Frontiers in Molecular Neuroscience

134 views

Systematic Review

Accepted on 01 Jul 2026

Regulatory T Cells in Perioperative Neurocognitive Disorders: A Systematic Review with Structured Narrative Synthesis from Molecular Mechanisms to Clinical Translation

in Brain Disease Mechanisms

Yude Zhu
Ke Chai
Chenxu Chou
Xiaoyu Zhang
Yulong Jia
Xiaojun Ge
Xiaguang Duan

Frontiers in Molecular Neuroscience

131 views

Original Research

Accepted on 29 Jun 2026

Parental report–based assessment of sleep problems and mental health in an unreferred cohort of children with a fragile X premutation

in Brain Disease Mechanisms

Nicole D Tortora
Jessica Ezzell Hunter
Anne Glicksman
Tiffany McGuire
Shira Russell-Giller
Amanda Kenepp
Shantal Taveras
Sonia Seehra
Rachel Goldman
Veronica Hinton

Frontiers in Molecular Neuroscience

159 views

Editorial

Published on 19 Jun 2026

Editorial: Innovative approaches in glioma therapy: exploring new therapeutic frontiers, volume II

in Brain Disease Mechanisms

Pilar Marcos
Arturo Mangas
Rafael Coveñas

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1891346

696 views

Original Research

Published on 18 Jun 2026

Sex differences in plasma endocannabinoids and related lipids before and after single and repeated mTBI: an exploratory study of endolipid plasma biomarkers

in Brain Disease Mechanisms

Emily Richter
Taylor J. Woodward
Praveen P. Kulkarni
Craig F. Ferris
Heather B. Bradshaw

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1707732

1,086 views

Review

Published on 16 Jun 2026

Extracellular vesicles as nanocarriers in glioblastoma: implications for chemoresistance and immune evasion

in Brain Disease Mechanisms

Faezeh Ebrahimi
Taha Rahavi Ezabadi
Hale Asghari
Shima Rajaeinejad
Sahar Jalili
Shokuh Aghamirzaei
Erfan Shahabinejad
Fateme Sadat Kouchakzade
Farid Abbaspour
Abbas Lalegani

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1705115

1,688 views

Review

Published on 15 Jun 2026

Pathophysiology-driven neuroimaging: decoding brain injury in sepsis

in Brain Disease Mechanisms

Rui Yan
Guanghui Ma
Haixia Huang
Jinyuan Mei
Qizhang Yang
Ye Gong
Mi Tian

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1840888

667 views

Original Research

Published on 10 Jun 2026

Systemic TGF-β1 reduction contributes to neuronal GLUT4 trafficking impairment in acute hepatic encephalopathy

in Brain Disease Mechanisms

M. Popek
M. Zielińska

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1849470

701 views

Review

Published on 29 May 2026

Advances in pathogenesis, novel therapeutic strategies and interventions for age-related hearing loss

in Brain Disease Mechanisms

Zhiyang Wen
Yinfei Liang
Dongxue Wu
Huiqing Wu
Zhicheng Li
Gendi Yin
Xiangli Zeng

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1848164

1,461 views

Original Research

Published on 28 May 2026

Glymphatic dysfunction and neuroinflammation in FXTAS: evidence from DTI-ALPS and gene expression analysis

in Brain Disease Mechanisms

Andrea Elias-Mas
Esther Granell Moreno
Cèlia Painous Martí
Marta Rubio-Roy
Jorge Aguado-Gracia
Emma Muñoz-Moreno
Alejandro Hinojosa
Iñigo Herrero
Maria Isabel Alvarez-Mora
Randi Hagerman

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1856101

997 views

Mini Review

Published on 22 May 2026

Human iPSC-derived motor neurons as a platform for elucidating TDP-43-related amyotrophic lateral sclerosis pathogenesis: a mini review

in Brain Disease Mechanisms

Satoshi Yokoi
Yohei Iguchi
Masahisa Katsuno

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1864964

1,667 views

Brief Research Report

Published on 22 May 2026

Mass spectrometry-based proteomic profiling of human tauopathy brains suggests mitochondria-associated alterations

in Brain Disease Mechanisms

Alfi Raudatil Jannah
Mai Hasegawa
Jonathan Ham
Norikazu Hara
Tamao Tsukie
Ai Obinata
Masataka Kikuchi
Kensaku Kasuga
Haruyasu Yamaguchi
Hideomi Hamasaki

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1815858

1,282 views

Brief Research Report

Published on 13 May 2026

Caffeine attenuates cisplatin induced microglial reactivity and cognitive dysfunction

in Brain Disease Mechanisms

Alfredo Oliveros
Ivan Loncar
Marwan Mostafa
Michael Poleschuk
Ana M. Corujo
Bo Qin
Juhyun Song
Max A. Tischfield
Mi-Hyeon Jang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2026.1772430

1,374 views

Original Research

Accepted on 08 May 2026

SP16 Promotes Metabolic Reprogramming and Mrc1 Expression to Reverse LPS-Induced Cognitive Deficits: An Integrated Omics Analysis

in Brain Disease Mechanisms

Mengyao Qu
Yanan He
Lu Yu
Huikai Yang
Yixun Lu
Yingfu Li
Rui Wang
Miao Sun
Yulong Ma
Weidong Mi

Frontiers in Molecular Neuroscience

818 views

1,146 articles

articles

Astrocyte epigenetics in development, aging, and neurodegeneration: a DNA methylation perspective

Epidermal growth factor receptor modulation for neural repair: implications for neurodegenerative disease therapy

BDNF–amyloid-β Axis in Alzheimer’s disease: molecular mechanisms and therapeutic perspectives

Prenatal and neonatal housing conditions affect anxiety-like behavior in adulthood in rats and interact with brain-derived neurotrophic factor (BDNF) Val66Met to alter expression of BDNF and stress markers in the ventral hippocampus

16p11.2 microdeletion enhances gene expression variability between human IPSC-derived forebrain interneuron progenitor cells in culture

Brain Heart Crosstalk After Ischemic Stroke Toward a Unified Framework for Pathophysiology and Precision Medicine

CircHomer1 may contribute to postoperative cognitive impairment by modulating Homer1b/mGluR5-associated signaling in the vCA1 region of aged mice

Altered cortical neuronal activity in functional esophageal disorders and its associations with chronic insomnia and peripheral inflammation: a resting-state fMRI study

Histone lactylation-mediated glycolysis-ferroptosis axis in neurological diseases

Modulation of the microbiota-lipid-brain axis by modified Chaihu-Longgu-Muli Decoction ameliorates chronic stress-induced depression

Use of the Behavioral Dyscontrol Scale-2 (BDS-2) to measure executive dysfunction in FXTAS

Regulatory T Cells in Perioperative Neurocognitive Disorders: A Systematic Review with Structured Narrative Synthesis from Molecular Mechanisms to Clinical Translation

Parental report–based assessment of sleep problems and mental health in an unreferred cohort of children with a fragile X premutation

Editorial: Innovative approaches in glioma therapy: exploring new therapeutic frontiers, volume II

Sex differences in plasma endocannabinoids and related lipids before and after single and repeated mTBI: an exploratory study of endolipid plasma biomarkers

Extracellular vesicles as nanocarriers in glioblastoma: implications for chemoresistance and immune evasion

Pathophysiology-driven neuroimaging: decoding brain injury in sepsis

Systemic TGF-β1 reduction contributes to neuronal GLUT4 trafficking impairment in acute hepatic encephalopathy

Advances in pathogenesis, novel therapeutic strategies and interventions for age-related hearing loss

Glymphatic dysfunction and neuroinflammation in FXTAS: evidence from DTI-ALPS and gene expression analysis

Human iPSC-derived motor neurons as a platform for elucidating TDP-43-related amyotrophic lateral sclerosis pathogenesis: a mini review

Mass spectrometry-based proteomic profiling of human tauopathy brains suggests mitochondria-associated alterations

Caffeine attenuates cisplatin induced microglial reactivity and cognitive dysfunction

SP16 Promotes Metabolic Reprogramming and Mrc1 Expression to Reverse LPS-Induced Cognitive Deficits: An Integrated Omics Analysis