Frontiers in Molecular Neuroscience | Brain Disease Mechanisms

Original Research

Published on 18 Jun 2025

Clusterin facilitates glioma progression via BCL2L1-dependent regulation of apoptotic resistance

in Brain Disease Mechanisms

Qingqing Xu
Xin Liu
Yibo Zhang
Shiyu Yuan
Wenli Huang
Mingshan Pi
Qi Xiong
Hongyan Zhou
Yuran Gui
Yifan Xiao

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1596021

286 views

Review

Accepted on 12 Jun 2025

Role of the Chaperonin TCP-1 Ring Complex (TRiC) in Protein Aggregation and Neurodegeneration

in Brain Disease Mechanisms

Vanlalrinchhani Varte
Diego E Rincon-Limas

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1617771

109 views

Original Research

Accepted on 11 Jun 2025

Critical Gene Network and Signaling Pathway Analysis of the Extracellular Signal-Regulated Kinase (ERK) Pathway in Ischemic Stroke

in Brain Disease Mechanisms

Run Mao
Lei Wang
Haitao Zhang
Jiaojiao Gong
Hua Liu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1604670

125 views

Review

Accepted on 11 Jun 2025

Mechanism of heme oxygenase-1 regulation of ferroptosis in vascular dementia

in Brain Disease Mechanisms

Xinyi Zou
Luoyang Cai
Jin Zhang
Ying Yuan
Jie Song
Zhao-duan Hu
Xiao-feng Ruan
Rui Peng
Xiao-ming Zhang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1585079

133 views

Review

Accepted on 10 Jun 2025

How Endothelial Cell Metabolism Shapes Blood-Brain Barrier Integrity in Neurodegeneration

in Brain Disease Mechanisms

Jiaxin Wang
Yuchun Chen
Shiteng Chen
Zihan Mu
Jun Chen

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1623321

Systematic Review

Accepted on 06 Jun 2025

Recognition of the Microbial Metabolite p-Cresol in Autism Spectrum Disorder: Systematic Review and Meta-Analysis

in Brain Disease Mechanisms

María Isabel Serrano-Tomás
Paulina Contreras-Romero
Mara Parellada
Javier Chaves
Javier Zamora
Martha B Hengst
Patricia Pozo
Rosa Del Campo
Sheyla Guzmán

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1576388

271 views

Original Research

Published on 27 May 2025

Exposure to a nanoplastic-enriched diet for fourteen days increases microglial immunoreactivity in the zebrafish telencephalon

in Brain Disease Mechanisms

Robert A. Mans
Hannah Kelehear
Sarah Rotschafer
Clare Ganas
Brendan Uche-Moon
Gabrielle Call
Callie C. Mauersberg
Justin Toller
Andrew Diamanduros

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1563086

1,190 views

Original Research

Accepted on 23 May 2025

Whole genome sequencing shows modulation of neurodegenerative genes by Withania somnifera in human SK-N-SH cells

in Brain Disease Mechanisms

Eshita Sharma
Dilip Mehta
Nikita Jadhav
Dhananya S
Manju Moorthy
Gopalakrishna Ramaswamy
Sujit Nair

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1512727

266 views

Mini Review

Published on 16 May 2025

Regulatory mechanism of circular RNAs in brain and neurodegenerative diseases

in Brain Disease Mechanisms

Mandana Amelimojarad
Melika Amelimojarad

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1507575

822 views

Original Research

Published on 09 May 2025

Changes in glycinergic neurotransmission alter mammalian retinal information processing

in Brain Disease Mechanisms

Anneka Joachimsthaler
Katharina Hauf
Anja Armbruster
Shiri Zayit-Soudry
Efrat Naaman
Ido Perlman
Rina Leibu
Alina Kurolap
Hagit Baris Feldman
Jan Kremers

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1564870

925 views

Editorial

Published on 08 May 2025

Editorial: SLC12A5-dependent neurological disorders

in Brain Disease Mechanisms

Igor Medina
Amy McTague
Coralie Di Scala
Claudio Rivera

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1611682

914 views

Review

Published on 01 May 2025

NFE2L1 as a central regulator of proteostasis in neurodegenerative diseases: interplay with autophagy, ferroptosis, and the proteasome

in Brain Disease Mechanisms

Hossein Khodadadi
Kamila Łuczyńska
Dawid Winiarczyk
Paweł Leszczyński
Hiroaki Taniguchi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1551571

1,357 views

Editorial

Published on 30 Apr 2025

Editorial: Neuro-immune interplay: unraveling the complexities of neurological complications and immunology

in Brain Disease Mechanisms

Pankaj Gaur
Kumar Vaibhav
Meenakshi Ahluwalia
Seema Gupta

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1607675

1,097 views

Original Research

Published on 28 Apr 2025

Traumatic brain injury and autophagy: a pilot study about the immunohistochemical expression of LC3B, Beclin 1, p62, and LAMP2A in human autoptic samples

in Brain Disease Mechanisms

Tommaso Livieri
Letizia Alfieri
Emiliana Giacomello
Djordje Alempijević
Tijana Petrovic
Yanko Georgiev Kolev
Davide Radaelli
Margherita Neri
Stefano D’Errico

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1562954

1,272 views

Brief Research Report

Published on 17 Apr 2025

Expression of SUR1 isoforms in the brain and heart after ischemia/reperfusion

in Brain Disease Mechanisms

Iván Alquisiras-Burgos
Irlanda Peralta-Arrieta
Mónica Espinoza-Rojo
Alejandro Salazar-Salgado
Iván Antonino-Olguín
Alicia Sánchez-Mendoza
María Sánchez-Aguilar
Martha-Eugenia Ruiz-Tachiquín
Hilda-Alicia Valdez-Salazar
Alma Ortiz-Plata

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1536409

1,088 views

Original Research

Published on 15 Apr 2025

Brain microvascular endothelial cells differentiated from a Friedreich’s Ataxia patient iPSC are deficient in tight junction protein expression and paracellularly permeable

in Brain Disease Mechanisms

Frances M. Smith
Daniel J. Kosman

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1511388

1,371 views