Frontiers in Molecular Neuroscience | Brain Disease Mechanisms

Original Research

Published on 19 Feb 2025

Impaired cerebrospinal fluid circulation and cerebral lymphatic drainage in a rat model of chronic hydrocephalus

in Brain Disease Mechanisms

Dong Bin Back
Bo-Ryoung Choi
Kyoung Ja Kwon
Dong-Hee Choi
Chan Young Shin
Jongmin Lee
Hahn Young Kim

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1516265

1,109 views

Opinion

Published on 18 Feb 2025

Histone monoaminylation is a novel epigenetic mechanism in psychiatric disorders

in Brain Disease Mechanisms

Jacob Peedicayil
Samuel Santhosh

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1534569

864 views

Original Research

Published on 13 Feb 2025

Deciphering motor dysfunction and microglial activation in mThy1-α-synuclein mice: a comprehensive study of behavioral, gene expression, and methylation changes

in Brain Disease Mechanisms

Brett A. McGregor
Md. Obayed Raihan
Afrina Brishti
Junguk Hur
James E. Porter

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1544971

714 views

Review

Published on 11 Feb 2025

The emerging role of glycine receptor α2 subunit defects in neurodevelopmental disorders

in Brain Disease Mechanisms

Sean D. Fraser
Robert J. Harvey

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1550863

1,446 views

Original Research

Published on 05 Feb 2025

The effect of AKT inhibition in α-synuclein-dependent neurodegeneration

in Brain Disease Mechanisms

Bedri Ranxhi
Zoya R. Bangash
Zachary M. Chbihi
Sokol V. Todi
Peter A. LeWitt
Wei-Ling Tsou

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1524044

1,110 views
1 citation

Original Research

Published on 05 Feb 2025

Ectopic expression of the cation-chloride cotransporter KCC2 in blood exosomes as a biomarker for functional rehabilitation

in Brain Disease Mechanisms

L. Caccialupi Da Prato
A. Rezzag Lebza
A. Consumi
M. Tessier
A. Srinivasan
C. Rivera
J. Laurin
C. Pellegrino

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1522571

886 views

Original Research

Published on 29 Jan 2025

Short- and long-term changes in neurological, behavioural, and blood biomarkers following repeated mild traumatic brain injury in rats—potential biological sex-dependent effects

in Brain Disease Mechanisms

Rodrigo Moraga-Amaro
Oscar Moreno
Jordi Llop
Marion Bankstahl
Jens P. Bankstahl

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1488261

1,216 views

Review

Published on 27 Jan 2025

Regulatory mechanism of Reelin activity: a platform for exploiting Reelin as a therapeutic agent

in Brain Disease Mechanisms

Mitsuharu Hattori

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1546083

1,547 views
1 citation

Original Research

Published on 15 Jan 2025

Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library

in Brain Disease Mechanisms

Pavel Uvarov
Satoshi Fudo
Cem Karakus
Andrey Golubtsov
Federico Rotondo
Tatiana Sukhanova
Shetal Soni
Coralie Di Scala
Tommi Kajander
Claudio Rivera

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1505722

1,728 views

Review

Published on 14 Jan 2025

Novel strategies targeting mitochondria-lysosome contact sites for the treatment of neurological diseases

in Brain Disease Mechanisms

Yinyin Xie
Wenlin Sun
Aoya Han
Xinru Zhou
Shijie Zhang
Changchang Shen
Yi Xie
Cui Wang
Nanchang Xie

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1527013

1,938 views

Editorial

Published on 13 Jan 2025

Editorial: Oxytosis/ferroptosis: unraveling the mechanisms and its multifaceted role in neurodegenerative diseases

in Brain Disease Mechanisms

Nawab John Dar
David Soriano Castell
Shahnawaz Ali Bhat
Pamela Maher

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1547301

1,016 views

Original Research

Published on 10 Jan 2025

Serum metabolomic signatures of patients with rare neurogenetic diseases: an insight into potential biomarkers and treatment targets

in Brain Disease Mechanisms

Nalaka Wijekoon
Lakmal Gonawala
Pyara Ratnayake
Darshana Sirisena
Harsha Gunasekara
Athula Dissanayake
Dhammika Amaratunga
Harry W. M. Steinbusch
Yetrib Hathout
Eric P. Hoffman

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1482999

1,215 views

Original Research

Published on 10 Jan 2025

Neurotherapeutic impact of vanillic acid and ibudilast on the cuprizone model of multiple sclerosis

in Brain Disease Mechanisms

Rasha M. Alderbi
Mohammad Z. Alam
Badrah S. Alghamdi
Hadeil M. Alsufiani
Gamal S. Abd El-Aziz
Ulfat M. Omar
Maryam A. Al-Ghamdi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1503396

1,124 views
1 citation

Review

Published on 07 Jan 2025

Genetic and molecular mechanisms of hydrocephalus

in Brain Disease Mechanisms

Xuehai Deng
Yiqian Chen
Qiyue Duan
Jianlin Ding
Zhong Wang
Junchi Wang
Xinlong Chen
Liangxue Zhou
Long Zhao

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1512455

1,473 views

Review

Published on 24 Dec 2024

The role of Aha1 in cancer and neurodegeneration

in Brain Disease Mechanisms

Brian S.J. Blagg
Kevin C. Catalfano

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1509280

1,103 views

Original Research

Published on 20 Dec 2024

Analysis of the pathogenicity and pathological characteristics of NOTCH3 gene-sparing cysteine mutations in vitro and in vivo models

in Brain Disease Mechanisms

Zhenping Gong
Wan Wang
Ying Zhao
Yadan Wang
Ruihua Sun
Haohan Zhang
Fengyu Wang
Yaru Lu
Jiewen Zhang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1391040

1,285 views