Frontiers in Molecular Neuroscience | Brain Disease Mechanisms

Original Research

Published on 10 Dec 2025

A phage displaying an Aβ-interacting peptide mitigates neurotoxicity and prevents Aβ-driven gene expression changes

in Brain Disease Mechanisms

Laura Maria De Plano
Luigi Chiricosta
Simone D’Angiolini
Alessandra Saitta
Alessandra Trainito
Serena Silvestro
Sabrina Conoci
Salvatore Oddo
Antonella Caccamo

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1716626

1,411 views

Review

Published on 02 Dec 2025

Dynamic glycosylation remodeling in neurological disorders

in Brain Disease Mechanisms

Dan Xing
Yingxun Gong
Weiyi Xia
Huifang Tu
Limei Yuan
Yiqing Yin
Kaiyuan Wang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1674665

1,925 views

Original Research

Published on 25 Nov 2025

Construction of a diagnostic prediction model for ischemic stroke using lactylation-related genes

in Brain Disease Mechanisms

Jierong Mo
Deyuan Ning
Shuyi Chen
Tianen Zhou
Peiyi Liu
Zhiquan Li
Wenmin Tang
Lianshan Guo
Zhiyong Lin
Ran Zhan

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1672374

2,171 views

Original Research

Published on 19 Nov 2025

Predictive value of circulating SNHG1/miR-194-5p and carotid ultrasound for the onset of cerebral infarction in patients with transient cerebral ischemia

in Brain Disease Mechanisms

Wei Wang
Mingjia Lv
Xin Zhang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1689127

1,085 views

Original Research

Published on 19 Nov 2025

Hypoxic preconditioning increases mitochondrial respiration and H2O2 production

in Brain Disease Mechanisms

Lisa Bergmeister
Carolina Doerrier
Barbara Fogli
Tímea Komlódi
Amrei Fischer
Kerstin Springer
Christoph Schwarzer
Erich Gnaiger

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1628567

2,399 views

Systematic Review

Published on 18 Nov 2025

C9orf72-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review

in Brain Disease Mechanisms

Seham Almalki
Mohamed Salama
Matthew J. Taylor
Zubair Ahmed
Richard I. Tuxworth

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1671906

3,769 views
1 citation

Opinion

Published on 12 Nov 2025

One RNA-binding protein, many decisions: integrating the transcript life cycle into neuronal regulation

in Brain Disease Mechanisms

Epaminondas Doxakis
Yuan Chao Xue
Anca F. Savulescu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1716825

2,110 views

Original Research

Published on 10 Nov 2025

MicroRNAs and rs1803274 SNP-based BuChe downregulation are associated with metabolic syndrome through ghrelin hydrolysis and expression quantitative trait loci regulation in PD patients

in Brain Disease Mechanisms

Guenson Chevalier
Lucas Udovin
Matilde Otero-Losada
Sofia Bordet
Santiago Perez-Lloret
Francisco Capani

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1635201

1,514 views

Original Research

Published on 03 Nov 2025

Focal postnatal deletion of Tsc2 causes epilepsy

in Brain Disease Mechanisms

Carlie McCoy
Mary Dusing
Lilian G. Jerow
Grace C. Winstel
Felix Zhan
Jason L. Rogers
Madison Wesley
J. Brian Otten
Steve C. Danzer
Candi L. LaSarge

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1686023

2,534 views

Systematic Review

Published on 31 Oct 2025

FUS-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review

in Brain Disease Mechanisms

Seham Almalki
Mohamed Salama
Matthew J. Taylor
Zubair Ahmed
Richard I. Tuxworth

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1671910

3,514 views
1 citation

Mini Review

Published on 24 Oct 2025

Proteostasis disruption and lipid dyshomeostasis in neurodegeneration: exploring common druggable targets across sporadic and monogenic disorders

in Brain Disease Mechanisms

Priscila Pereira Sena
Lea Friedrich
Alcibiades Villarreal
Florian Fath
Liubovi Sopco
Mar Hernández-Guillamon
Maria Luiza Saraiva-Pereira
Gabrielle Britton
Jonasz Jeremiasz Weber
Thorsten Schmidt

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1681079

2,738 views

Review

Published on 23 Oct 2025

Ferroptosis as a potential therapeutic target for post-traumatic stress disorder

in Brain Disease Mechanisms

Qian Zhang
Jin-Dong Mao
Hui Chen
Min Wang
Yu-Mei Wu
Chuan Wang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1648047

3,290 views

Review

Published on 22 Oct 2025

Bridging prion biology and Alzheimer’s disease: from pathogenic seeds to precision therapeutics

in Brain Disease Mechanisms

Wenjin Wang
Zhanhui Feng
Lingfeng Shu
Yongmei Hu
Yuting Chen
Baihui Zhang
Hua Huang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1660151

3,088 views

Review

Published on 22 Oct 2025

Beyond cell-cell contact: therapeutic potential of Eph signaling in central nervous system tumors

in Brain Disease Mechanisms

Fernanda Cristina Poscai Ribeiro
Moisés Willian Aparecido Gonçalves
Aleff Mascarenhas Silva
Tayná Figueiredo Maciel
Reydson Alcides de Lima-Souza
João Figueira Scarini
Gary Chris Fillmore
Erika Said Abu Egal

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1658651

2,526 views

Review

Published on 21 Oct 2025

Targeting ER stress in skeletal muscle through physical activity: a strategy for combating neurodegeneration-associated muscle decline

in Brain Disease Mechanisms

Zhanguo Su
Lijuan Xiang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1639114

2,098 views

Mini Review

Published on 21 Oct 2025

Lysine α-ketoglutarate reductase as a therapeutic target for saccharopine pathway related diseases

in Brain Disease Mechanisms

Gabriel Vieira Valderrama
Gabriela Alves Moreira
Paulo Arruda

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1695490

1,930 views
1 citation

Mini Review

Published on 09 Oct 2025

Food for thought: probiotic modulation of microglial activity in Parkinson's disease

in Brain Disease Mechanisms

Isabella Kroker Kimber
Marie-Ève Tremblay

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1690507

3,195 views
1 citation

Review

Published on 08 Oct 2025

Peripheral–central immune interactions in Parkinson’s disease: insights into innate and adaptive immunity

in Brain Disease Mechanisms

Jarika Jahan Tumpa
Qurat Ul Ain Hayder
Nowshin Sharmily Maisa
Md. Nazmul Islam

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1682006

3,089 views

Review

Published on 25 Sep 2025

TRP channels in epileptogenesis: calcium dysregulation mechanisms and pharmacological targeting strategies

in Brain Disease Mechanisms

Guolong Deng
Dayuan Liu
Yunxiang Zhong
Muyao Wang
Baoshou Su
Hongli Jiang
Yihao Zhai
Hao Peng
Caicai Zhang
Jigao Feng

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1687359

2,964 views
1 citation

Editorial

Published on 22 Sep 2025

Editorial: Innovative approaches in glioma therapy: exploring new therapeutic frontiers

in Brain Disease Mechanisms

Pilar Marcos
Arturo Mangas
Rafael Coveñas

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1697606

2,303 views

Original Research

Published on 12 Sep 2025

Divergent and subnucleus-specific gene expression responses to chronic stress hormone exposure in the amygdala

in Brain Disease Mechanisms

Shuhei Ueda
Manami Kakita
Masahito Hosokawa
Koji Arikawa
Kiyofumi Takahashi
Ryusuke Shiota
Masaki Kakeyama
Hiroko Matsunaga
Haruko Takeyama
Sayaka Takemoto-Kimura

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1659846

3,392 views

Original Research

Published on 12 Sep 2025

Neuroprotection against beta-amyloid toxicity by the novel estrogen receptor modulator STX requires convergent signaling pathways

in Brain Disease Mechanisms

Hun-Joo Lee
Zoe Bostick
John Doherty
Tracy L. Swanson
Martin J. Kelly
Joseph F. Quinn
Nora E. Gray
Philip F. Copenhaver

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1670646

3,281 views
1 citation

Original Research

Published on 03 Sep 2025

Delayed structural maturation of inner hair cell ribbon synapses in a mouse model of fragile X syndrome

in Brain Disease Mechanisms

M. Chojnacka
A. Skupien-Jaroszek
M. Dziembowska

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1604262

2,147 views

Review

Published on 29 Aug 2025

IDH mutant high-grade gliomas

in Brain Disease Mechanisms

Santosh Valvi
Maryam Fouladi
Michael J. Fisher
Nicholas G. Gottardo

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1662414

6,414 views
2 citations

1,115 articles

articles

A phage displaying an Aβ-interacting peptide mitigates neurotoxicity and prevents Aβ-driven gene expression changes

Dynamic glycosylation remodeling in neurological disorders

Construction of a diagnostic prediction model for ischemic stroke using lactylation-related genes

Predictive value of circulating SNHG1/miR-194-5p and carotid ultrasound for the onset of cerebral infarction in patients with transient cerebral ischemia

Hypoxic preconditioning increases mitochondrial respiration and H2O2 production

C9orf72-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review

One RNA-binding protein, many decisions: integrating the transcript life cycle into neuronal regulation

MicroRNAs and rs1803274 SNP-based BuChe downregulation are associated with metabolic syndrome through ghrelin hydrolysis and expression quantitative trait loci regulation in PD patients

Focal postnatal deletion of Tsc2 causes epilepsy

FUS-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review

Proteostasis disruption and lipid dyshomeostasis in neurodegeneration: exploring common druggable targets across sporadic and monogenic disorders

Ferroptosis as a potential therapeutic target for post-traumatic stress disorder

Bridging prion biology and Alzheimer’s disease: from pathogenic seeds to precision therapeutics

Beyond cell-cell contact: therapeutic potential of Eph signaling in central nervous system tumors

Targeting ER stress in skeletal muscle through physical activity: a strategy for combating neurodegeneration-associated muscle decline

Lysine α-ketoglutarate reductase as a therapeutic target for saccharopine pathway related diseases

Food for thought: probiotic modulation of microglial activity in Parkinson's disease

Peripheral–central immune interactions in Parkinson’s disease: insights into innate and adaptive immunity

TRP channels in epileptogenesis: calcium dysregulation mechanisms and pharmacological targeting strategies

Editorial: Innovative approaches in glioma therapy: exploring new therapeutic frontiers

Divergent and subnucleus-specific gene expression responses to chronic stress hormone exposure in the amygdala

Neuroprotection against beta-amyloid toxicity by the novel estrogen receptor modulator STX requires convergent signaling pathways

Delayed structural maturation of inner hair cell ribbon synapses in a mouse model of fragile X syndrome

IDH mutant high-grade gliomas