Frontiers in Molecular Neuroscience | Brain Disease Mechanisms

Original Research

Published on 09 Apr 2025

Profiling the expression and functional roles of mRNAs and lncRNAs associated with post-stroke aphasia

in Brain Disease Mechanisms

Yanling Xi
Hui Chang
Mei Qu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1513218

685 views

Mini Review

Published on 01 Apr 2025

Neurotrophic factor alpha 1 gene therapy in Alzheimer’s disease: scope and advancements

in Brain Disease Mechanisms

Ammara Shaikh
Fairus Ahmad
Seong Lin Teoh
Jaya Kumar
Mohamad Fairuz Yahaya

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1518868

1,937 views

Original Research

Published on 24 Mar 2025

The serum proteomic profile in patients with migraine

in Brain Disease Mechanisms

Yating Han
Yuan Wang
Xiajuan Zou
Huailian Guo

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1460403

1,192 views

Original Research

Published on 21 Mar 2025

Soy-based purified ingredient diet affects mouse gut permeability and the microbiome in fragile X mice

in Brain Disease Mechanisms

Cara J. Westmark

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1520211

1,564 views

Mini Review

Published on 19 Mar 2025

Elevated propionate and its association with neurological dysfunctions in propionic acidemia

in Brain Disease Mechanisms

Xiaoxin Chen
Qing Cheng
Guo-Fang Zhang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1499376

1,441 views

Original Research

Published on 04 Mar 2025

Bioenergetic-related gene expression in the hippocampus predicts internalizing vs. externalizing behavior in an animal model of temperament

in Brain Disease Mechanisms

Elaine K. Hebda-Bauer
Megan H. Hagenauer
Daniel B. Munro
Peter Blandino
Fan Meng
Keiko Arakawa
John D. H. Stead
Apurva S. Chitre
A. Bilge Ozel
Pejman Mohammadi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1469467

1,568 views
1 citation

Original Research

Published on 20 Feb 2025

Multi-omics-based phenotyping of AFG3L2-mutant lymphoblasts determines key factors of a pathophysiological interplay between mitochondrial vulnerability and neurodegeneration in spastic ataxia type 5

in Brain Disease Mechanisms

Menekse Oeztuerk
Diran Herebian
Kale Dipali
Andreas Hentschel
Nina Rademacher
Florian Kraft
Rita Horvath
Felix Distelmaier
Sven G. Meuth
Tobias Ruck

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1548255

1,471 views

Original Research

Published on 19 Feb 2025

Impaired cerebrospinal fluid circulation and cerebral lymphatic drainage in a rat model of chronic hydrocephalus

in Brain Disease Mechanisms

Dong Bin Back
Bo-Ryoung Choi
Kyoung Ja Kwon
Dong-Hee Choi
Chan Young Shin
Jongmin Lee
Hahn Young Kim

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1516265

1,878 views

Opinion

Published on 18 Feb 2025

Histone monoaminylation is a novel epigenetic mechanism in psychiatric disorders

in Brain Disease Mechanisms

Jacob Peedicayil
Samuel Santhosh

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1534569

1,193 views

Original Research

Published on 13 Feb 2025

Deciphering motor dysfunction and microglial activation in mThy1-α-synuclein mice: a comprehensive study of behavioral, gene expression, and methylation changes

in Brain Disease Mechanisms

Brett A. McGregor
Md. Obayed Raihan
Afrina Brishti
Junguk Hur
James E. Porter

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1544971

967 views

Review

Published on 11 Feb 2025

The emerging role of glycine receptor α2 subunit defects in neurodevelopmental disorders

in Brain Disease Mechanisms

Sean D. Fraser
Robert J. Harvey

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1550863

2,068 views

Original Research

Published on 05 Feb 2025

The effect of AKT inhibition in α-synuclein-dependent neurodegeneration

in Brain Disease Mechanisms

Bedri Ranxhi
Zoya R. Bangash
Zachary M. Chbihi
Sokol V. Todi
Peter A. LeWitt
Wei-Ling Tsou

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1524044

1,511 views
1 citation

Original Research

Published on 05 Feb 2025

Ectopic expression of the cation-chloride cotransporter KCC2 in blood exosomes as a biomarker for functional rehabilitation

in Brain Disease Mechanisms

L. Caccialupi Da Prato
A. Rezzag Lebza
A. Consumi
M. Tessier
A. Srinivasan
C. Rivera
J. Laurin
C. Pellegrino

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1522571

1,156 views

Original Research

Published on 29 Jan 2025

Short- and long-term changes in neurological, behavioural, and blood biomarkers following repeated mild traumatic brain injury in rats—potential biological sex-dependent effects

in Brain Disease Mechanisms

Rodrigo Moraga-Amaro
Oscar Moreno
Jordi Llop
Marion Bankstahl
Jens P. Bankstahl

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1488261

1,612 views

Review

Published on 27 Jan 2025

Regulatory mechanism of Reelin activity: a platform for exploiting Reelin as a therapeutic agent

in Brain Disease Mechanisms

Mitsuharu Hattori

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1546083

2,255 views
2 citations

Original Research

Published on 15 Jan 2025

Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library

in Brain Disease Mechanisms

Pavel Uvarov
Satoshi Fudo
Cem Karakus
Andrey Golubtsov
Federico Rotondo
Tatiana Sukhanova
Shetal Soni
Coralie Di Scala
Tommi Kajander
Claudio Rivera

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1505722

2,283 views