Frontiers in Molecular Neuroscience | Molecular Signalling and Pathways

Original Research

Accepted on 17 Nov 2025

Inhibition of pro-apoptotic UPR pathways PERK/CHOP and IRE1/JNK protects differentiated SH-SY5Y cells against rotenone-induced toxicity

in Molecular Signalling and Pathways

Natalia Siwecka
Wioletta Rozpędek-Kamińska
Michał Golberg
Wojciech Wiese
Grzegorz Galita
Ireneusz Majsterek

Frontiers in Molecular Neuroscience

Review

Published on 17 Nov 2025

Alpha-neurexins in health and disease

in Molecular Signalling and Pathways

Nicolas Chofflet
Manni Wang
Mathilde Chofflet
Hideto Takahashi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1716782

331 views

Editorial

Accepted on 14 Nov 2025

Editorial: Nutrient Signaling and Neuroendocrine Pathways in Brain-Organ Communication

in Molecular Signalling and Pathways

Hiroyuki Aizawa
Hiroaki Masuzaki

Frontiers in Molecular Neuroscience

135 views

Review

Accepted on 07 Nov 2025

Interplay between lipid droplets and Alpha-Synuclein: Implication in Parkinson's disease pathogenesis

in Molecular Signalling and Pathways

Walid Idi
Razan Sheta
Abid Oueslati

Frontiers in Molecular Neuroscience

112 views

Brief Research Report

Accepted on 07 Nov 2025

Hsd17b7 undergoes dynamic subcellular localization during Neuro2a differentiation

in Molecular Signalling and Pathways

Matthew Bispo
Ashley Marie Driver

Frontiers in Molecular Neuroscience

191 views

Brief Research Report

Published on 05 Nov 2025

Phosphoprofile reorganization of the actin binding protein Drebrin during long term depression

in Molecular Signalling and Pathways

Rafaela Pedro Silva
Till G. A. Mack
Marieluise Kirchner
Philipp Mertins
Britta J. Eickholt
Patricia Kreis

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1697642

782 views

Original Research

Published on 05 Nov 2025

Pex1 loss-of-function in zebrafish is viable and recapitulates hallmarks of Zellweger spectrum disorders

in Molecular Signalling and Pathways

Ursula Heins-Marroquin
Zlatan Hodzic
Beatriz Soares Carneiro da Silva
Agnes Hendriks
Floriane Gavotto
Marc O. Warmoes
Lisa Schlicker
Samy Omri
Christian Jäger
Enrico Glaab

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1634536

777 views

Original Research

Published on 28 Oct 2025

Analyses of exon 4a structure reveal the properties of Big tau related to distribution, function and aggregation

in Molecular Signalling and Pathways

Itzhak Fischer
Peter W. Baas

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1707820

736 views

Original Research

Published on 09 Oct 2025

Neuronal activity-dependent gene expression is stimulus-specific and changes with neuronal maturation

in Molecular Signalling and Pathways

Jeronimo Lukin
Maximiliano S. Beckel
Olivia Pedroncini
Sebastian A. Giusti
Giuliana C. Di Mauro
Ivana Marcela Linenberg
Ines Lucia Patop
Ariel Chernomoretz
Antonia Marin-Burgin
Sebastian Kadener

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1609772

2,454 views

Original Research

Accepted on 08 Oct 2025

Regulation of Granin Neuropeptide Gene Expression in Human Brain during Development

in Molecular Signalling and Pathways

Laura L Demsey
Sonia Podvin
Vivian Hook

Frontiers in Molecular Neuroscience

434 views

Original Research

Published on 03 Oct 2025

SIRT3 inhibits autophagy-dependent ferroptosis of HUVECs in the progression of pregnancy-induced hypertension by activating the PI3K/Akt/mTOR axis

in Molecular Signalling and Pathways

Yanchuan Li
Yanfeng Liu
Ziyun Shi
Meiqing He

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1620184

1,807 views

Original Research

Published on 22 Sep 2025

Cross-disease biomarker identification reveals shared diagnostic biomarkers for IVDD and NAFLD via bulk and single-cell RNA sequencing

in Molecular Signalling and Pathways

Jiasen Wei
Chenglong Ji
Lina Liu
Chen Yan
Linhui Han
Wenbo Lin
Ximing Xu
Kaiqiang Sun

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1639705

2,238 views

Review

Published on 22 Sep 2025

Advances in research on propofol-induced postoperative cognitive dysfunction via Piezo channels

in Molecular Signalling and Pathways

Han Xue
Xiaoyu Zhang
Chenxu Chou
Yulong Jia
Chunguang Hao
Xiaguang Duan

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1668523

2,664 views

Original Research

Published on 15 Sep 2025

Tamoxifen attenuates manganese-induced dysregulation of neuronal REST via the genomic ER-α mechanism

in Molecular Signalling and Pathways

Alexis Digman
Edward Pajarillo
Sanghoon Kim
Itunu Ajayi
Deok-Soo Son
Michael Aschner
Eunsook Lee

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1648904

2,033 views

Correction

Published on 09 Sep 2025

Correction: S-9-PAHSA ameliorates cognitive decline in a type 2 diabetes mouse model by inhibiting oxidative stress and apoptosis via CAIII modulation

in Molecular Signalling and Pathways

Xin-Ru Wang
Shan-Shan Huang
Meng Wang
Jin-Hong Lin
Jian-Tao Wang
Jiao-Qi Ren
Cheng-Feng He
Wen-Jiao Xue
Yin Wang
Xue-Chun Wang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1688881

1,720 views

Original Research

Published on 04 Sep 2025

Nfkbia-driven neuroinflammatory pathways mediate depression following spinal cord injury

in Molecular Signalling and Pathways

Aichun Yang
Guoyuan He
Yanling Song
Yujun Wen
Hechun Xia
Shenhong Gu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1596649

2,361 views