Frontiers in Neuroscience | Neurodegeneration

Review

Published on 19 Dec 2025

Sigma receptors and mitochondria-associated ER membranes are converging therapeutic targets for Alzheimer’s disease

in Neurodegeneration

Madhura S. Lotlikar
Jacob C. Zellmer
Raja Bhattacharyya

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1733659

451 views

Systematic Review

Published on 17 Dec 2025

Effects of transcranial direct current stimulation on non-motor functions in individuals with Parkinson’s disease: a systematic review and meta-analysis

in Neurodegeneration

Qiyu Li
Hanmei Ye
Cheng Ye
Mi Huang

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1713623

356 views

Brief Research Report

Accepted on 16 Dec 2025

Heterozygous TREM2 (p.W44X) and PSEN1 (p.A431T) mutations in two Peruvian Families with Familial Alzheimer's Disease: Expanding the Genetic Landscape in Underrepresented Populations

in Neurodegeneration

Claudio Villegas-Llerena
Solange Paredes Moscosso
María Luisa Guevara-Fujita
Daisy Obispo
Nilton Custodio
Rosa Montesinos
Jose Francisco Parodi
Oscar Flores-Flores
John Hardy
Ricardo Fujita

Frontiers in Neuroscience

Original Research

Accepted on 16 Dec 2025

Glutathione Metabolism as a Key Regulator of Oxidative Hippocampal Injury in Sepsis-Associated Encephalopathy: An Integrated Proteomics and Metabolomics Study

in Neurodegeneration

Li Yanning
wang li nan
ma Teng
Peng Tao
Lijuan Wang
Junyan Wang
Yunhong Li
Yin Wang

Frontiers in Neuroscience

Original Research

Published on 16 Dec 2025

Sex differences in depression in Parkinson’s disease: cognitive dysfunction and female-specific associations

in Neurodegeneration

Huashuo Zhao
Yi Sun
Qiushuang Wang
Zixuan Zhao

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1704461

356 views

Original Research

Accepted on 15 Dec 2025

Cerebral responses to Famous face recognition as a potential functional biomarker of mild cognitive impairment

in Neurodegeneration

Michihiko Koeda
Yumiko Ikeda
Yoshiro Okubo
Amane Tateno

Frontiers in Neuroscience

120 views

Review

Published on 15 Dec 2025

ER stress sensors at the ER-mitochondrial interface, controlling mitochondrial health in neurodegenerative diseases

in Neurodegeneration

Chaitanya Kunja
Vaishali Kumar
Pradeep Kodam
Chamundeshwari Devi Gopu
Shuvadeep Maity

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1665272

436 views

Original Research

Accepted on 09 Dec 2025

Superoxide dismutase is associated with cerebral small vessel disease burden and vascular mild cognitive impairment in elderly patients

in Neurodegeneration

Xiaohua Xie
Meixi Li
Tianyuan Guan
Zhenjie Teng
Jing Feng
Jing Xu
Qianqian Qi
Yining Xiao
Peiyuan Lv
Yanhong Dong

Frontiers in Neuroscience

115 views

Original Research

Published on 08 Dec 2025

Modeling and validation in Parkinson’s disease patients with frailty

in Neurodegeneration

Guoyang Li
Guo Hong
Jing Huang
Wenli Zhang
Fengju Mao
Xiaoguang Luo

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1723707

532 views

Review

Published on 08 Dec 2025

Advancements in the application of brain-computer interfaces based on different paradigms in amyotrophic lateral sclerosis

in Neurodegeneration

Tong Li
Yuling Gao
Jiaqi Zhou
Yize Chen
Shengchao Zhang
Xiaoyang Gong
Yong Liu

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1658315

875 views

Review

Accepted on 04 Dec 2025

Tank-Binding Kinase 1 Regulates Inflammation and Autophagy in Glaucoma

in Neurodegeneration

Autumn B. Morgan
Denise M Inman

Frontiers in Neuroscience

187 views

Correction

Published on 04 Dec 2025

Correction: Network pharmacology analysis reveals neuroprotective effects of the Qin-Zhi-Zhu-Dan Formula in Alzheimer's disease

in Neurodegeneration

Wenxiu Xu
Beida Ren
Zehan Zhang
Congai Chen
Tian Xu
Shuling Liu
Chongyang Ma
Xueqian Wang
Qingguo Wang
Fafeng Cheng

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1752611

356 views

Original Research

Published on 04 Dec 2025

Depletion of CD169+ border-associated macrophages induces Parkinson’s disease-like behavior

in Neurodegeneration

Takuto Ohki
Kai Kitamura
Katsuhiro Tokutake
Sota Saeki
Michiro Yamamoto
Masaki Takasu
Hitoshi Hirata

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1688394

673 views

Original Research

Published on 04 Dec 2025

Nomogram to predict 5-year global cognitive impairment in de novo Parkinson disease with normal cognition at baseline

in Neurodegeneration

Xin Wang
Lu Tian

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1713488

596 views

Editorial

Published on 04 Dec 2025

Editorial: Exercise-induced neuroplasticity in neurodegeneration diseases, volume II

in Neurodegeneration

Laikang Yu
Lingxiao He
Yih-Kuen Jan

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1746951

566 views

Original Research

Published on 04 Dec 2025

Fourier transform infrared spectroscopy detects distinct TAR DNA-binding protein 43 signatures in frontotemporal lobar degeneration

in Neurodegeneration

Rodolfo G. Gatto
Oleksandr Gakh
Jordan M. Wilkins
Arenn F. Carlos
Hossam Youssef
Yong Guo
Jennifer L. Whitwell
Keith A. Josephs
Claudia F. Lucchinetti

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1649433

624 views

Original Research

Accepted on 03 Dec 2025

Clinical characteristics and risk factors of depression in prodromal Parkinson's disease

in Neurodegeneration

Jianxia Xu
Yali Wang
Yuqian Li
Hui Wang
Weiguo Liu

Frontiers in Neuroscience

106 views

Review

Accepted on 03 Dec 2025

Ferroptosis in Alzheimer's Disease: Molecular Mechanisms and Advances in Therapeutic Strategies

in Neurodegeneration

Ze Zhou
Yting Zhang
Siyi Liu
Haixia ， Tang
Lianhao Yang
Jiabao Liao
Yangming Lu
Shuovei Zhang
Zukun Chen
Ling Yang

Frontiers in Neuroscience

121 views

Correction

Published on 03 Dec 2025

Correction: Peak alpha frequency and alpha power spectral density as vulnerability markers of cognitive impairment in Parkinson's disease: an exploratory EEG study

in Neurodegeneration

Yuqing Zhao
Jiayu Cai
Jian Song
Haoran Shi
Weicheng Kong
Xinlei Li
Wei Wei
Xiehua Xue

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1745577

408 views

Original Research

Published on 03 Dec 2025

Brain atrophy and cholinergic denervation in progressive supranuclear palsy: an MRI and [18F]-FEOBV PET study

in Neurodegeneration

Prabesh Kanel
Stiven Roytman
Giulia Carli
Robert Vangel
Jaimie Barr
Fotini Michalakis
Christopher Chauncey Spears
Peter J. H. Scott
Roger L. Albin
Nicolaas I. Bohnen

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1695541

530 views

Original Research

Published on 02 Dec 2025

APOE ε4 allele drives female-specific Alzheimer’s disease progression via vascular dysfunction and tau spreading

in Neurodegeneration

Shuai Huang
Jiawei Wu
Ling He

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1683204

1,040 views

Original Research

Published on 02 Dec 2025

Saliva phosphorylated tau concentration is not associated with Alzheimer’s disease, cerebrospinal fluid or blood biomarkers

in Neurodegeneration

Helena Sophia Gleerup
Federica Sanna
Srinivas Koutarapu
Juan Lantero-Rodriguez
Laia Montoliu-Gaya
Jörg Hanrieder
Gunnar Brinkmalm
Thomas K. Karikari
Joel Simren
Peter Høgh

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1718237

914 views

Brief Research Report

Published on 01 Dec 2025

GABAergic neurons are a key cell type in a Drosophila model of PARK14/PLA2G6-associated neurodegeneration

in Neurodegeneration

Noah S. Meimoun
Shimshon Benji
William Z. Besharim
Yair Y. Cantor
Eitan S. Carroll
Benjamin I. Coplin
Moshe B. Davidovics
Michael Gerber
Philip M. Hirschprung
Ephraim I. Jacobson

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1534243

1,123 views

Original Research

Published on 01 Dec 2025

Changes in voxel-wise gray matter asymmetry over time

in Neurodegeneration

Florian Kurth
Nicolas Cherbuin
Christian Gaser
Eileen Luders

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1671341

845 views

2,246 articles

articles

Sigma receptors and mitochondria-associated ER membranes are converging therapeutic targets for Alzheimer’s disease

Effects of transcranial direct current stimulation on non-motor functions in individuals with Parkinson’s disease: a systematic review and meta-analysis

Heterozygous TREM2 (p.W44X) and PSEN1 (p.A431T) mutations in two Peruvian Families with Familial Alzheimer's Disease: Expanding the Genetic Landscape in Underrepresented Populations

Glutathione Metabolism as a Key Regulator of Oxidative Hippocampal Injury in Sepsis-Associated Encephalopathy: An Integrated Proteomics and Metabolomics Study

Sex differences in depression in Parkinson’s disease: cognitive dysfunction and female-specific associations

Cerebral responses to Famous face recognition as a potential functional biomarker of mild cognitive impairment

ER stress sensors at the ER-mitochondrial interface, controlling mitochondrial health in neurodegenerative diseases

Superoxide dismutase is associated with cerebral small vessel disease burden and vascular mild cognitive impairment in elderly patients

Modeling and validation in Parkinson’s disease patients with frailty

Advancements in the application of brain-computer interfaces based on different paradigms in amyotrophic lateral sclerosis

Tank-Binding Kinase 1 Regulates Inflammation and Autophagy in Glaucoma

Correction: Network pharmacology analysis reveals neuroprotective effects of the Qin-Zhi-Zhu-Dan Formula in Alzheimer's disease

Depletion of CD169+ border-associated macrophages induces Parkinson’s disease-like behavior

Nomogram to predict 5-year global cognitive impairment in de novo Parkinson disease with normal cognition at baseline

Editorial: Exercise-induced neuroplasticity in neurodegeneration diseases, volume II

Fourier transform infrared spectroscopy detects distinct TAR DNA-binding protein 43 signatures in frontotemporal lobar degeneration

Clinical characteristics and risk factors of depression in prodromal Parkinson's disease

Ferroptosis in Alzheimer's Disease: Molecular Mechanisms and Advances in Therapeutic Strategies

Correction: Peak alpha frequency and alpha power spectral density as vulnerability markers of cognitive impairment in Parkinson's disease: an exploratory EEG study

Brain atrophy and cholinergic denervation in progressive supranuclear palsy: an MRI and [18F]-FEOBV PET study

APOE ε4 allele drives female-specific Alzheimer’s disease progression via vascular dysfunction and tau spreading

Saliva phosphorylated tau concentration is not associated with Alzheimer’s disease, cerebrospinal fluid or blood biomarkers

GABAergic neurons are a key cell type in a Drosophila model of PARK14/PLA2G6-associated neurodegeneration

Changes in voxel-wise gray matter asymmetry over time