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Front. Oncol., 29 March 2022
Sec. Thoracic Oncology
Volume 12 - 2022 |

Case Report: Aumolertinib as Neoadjuvant Therapy for Patients With Unresectable Stage III Non-Small Cell Lung Cancer With Activated EGFR Mutation: Case Series

Shao Feng1† Zhang Qiang1† Cheng Wanwan2 Zeng Zhaozhun3 Xie Yuewu3 Fang Shencun2*
  • 1Department of Thoracic Surgery, Nanjing Chest Hospital, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China
  • 2Department of Respiratory Medicine, Nanjing Chest Hospital, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China
  • 3Medical Oncology Scientific Group of the Central Medical Department, Jiangsu Hansoh Pharmaceutical Group Co., Ltd., Shanghai, China

Background: There is no standard treatment for stage III lung cancer due to its low surgical resection rate, and improving PFS and survival of patients with III NSCLC has become an urgent challenge in clinical treatment. For EGFR mutation-positive patients, targeted therapy has the remarkable feature of high efficiency and low toxicity compared with first-line standard chemotherapy, and targeted neoadjuvant therapy needs to be further explored.

Method: We report 3 diagnosed cases of locally advanced unresectable NSCLC with EGFR-sensitive mutations who first received 1–2 cycles of preoperative chemotherapy neoadjuvant therapy and were treated with 110 mg daily of 3rd-generation EGFR-TKI aumolertinib instead because of poor efficacy or safety intolerance.

Result: After 2 cycles of aumolertinib treatment, all 3 patients achieved symptomatic remission and significant tumor size reduction and achieved downstaging to allow surgical treatment. No additional operative difficulties were added during the surgery. They continued to receive adjuvant therapy with the original dose of aumolertinib after surgical treatment, and no evidence of tumor recurrence was found until the most recent imaging examination. In addition, the course of neoadjuvant and adjuvant therapy was free of serious adverse effects.

Conclusion: Perioperative treatment of these three cases of locally advanced unresectable NSCLC with EGFR-sensitive mutations with the third-generation EGFR-TKI aumolertinib showed significant efficacy and excellent safety and may be a new option for targeted therapy in the perioperative period.


Patients with stage III non-small cell lung cancer (NSCLC) have considerable disease heterogeneity (1, 2). Treatment options include neoadjuvant therapy followed by surgical resection, adjuvant chemotherapy after surgery, or radical radiotherapy. A large meta-analysis confirmed the survival benefit of preoperative chemotherapy (3). However, the lung damage caused by preoperative chemotherapy may also make subsequent surgical resection more difficult (4, 5). No consensus exists with regard to optimal treatment approaches, particularly for unresectable advanced NSCLC characterized by single-site or multisite lymph node metastases identified by preoperative staging; the role of surgical resection after preoperative therapy remains controversial (68).

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) significantly prolong progression-free survival (PFS) in patients with advanced EGFR mutation-positive (EGFRm) NSCLC compared to chemotherapy as first-line therapy (911). Aumolertinib (HS-10296), a third-generation EGFR-TKI, has attracted much attention due to its reliable antitumor activity and favorable safety profile (1214).

Although EGFR-TKI was established as an effective first-line therapy for advanced EGFRm NSCLC (911), the efficacy and tolerability of EGFR-TKI preoperative induction therapy remain uncertain. We report three cases of stage III NSCLC with confirmed EGFR mutations, who reached a descending stage after preoperative neoadjuvant treatment with aumolertinib and had successful surgical resection of the malignant tumor.


Case 1

A 64-year-old Chinese male, a 40-year smoker and hypertension, presented to a local hospital in January 2021 with an irritating cough and sputum with blood in the sputum, and a computed tomography chest (CT) scan showed a 7.8 × 4.9-cm left upper lung space. Lung puncture biopsy showed squamous carcinoma, and immunohistochemistry showed high PD-L1 expression, TPS ≥ 90%, EGFR mutation (exon 19 deletion) by NGS, and clinical stage IIIC (T3N3M0). PET/CT showed left lung cancer with obstructive pneumonia, enlarged lymph nodes in the left clavicular region, posterior to the anterior vena cava, aortic window, left paratracheal area, and both hila, and increased FDG metabolism. Magnetic resonance imaging (MRI) of the brain showed no evidence of central nervous system (CNS) involvement, which made her malignancy compatible. Figure 1 shows the imaging findings of case 1.


Figure 1 Disease status before and after neoadjuvant chemotherapy and aumolertinib treatment. Computed tomography chest (CT) scan showed (A) pulmonary nodule in the left upper lobe of the lung, size 7.8 × 4.9 cm before chemotherapy. PET/CT showed (B) lymph node enlargement in the right hilar and pulmonary nodule in the left upper lobe before chemotherapy. (C) Stable disease (SD) based on imaging findings after 2 cycles of chemotherapy. (D) Pulmonary nodule in the left upper lobe of the lung, size 2.2 × 2.0× 1.8 cm after almost 2 months of aumolertinib treatment, with tumor remission reaching partial remission (PR).

Systemic chemotherapy was started in January 2021 with an initial dose of albumin-bound paclitaxel 400 mg and carboplatin 0.4 mg. Rash and pruritus developed during the second chemotherapy infusion of carboplatin, so treatment with carboplatin was discontinued. After 2 cycles of chemotherapy, objective tumor remission was evaluated as disease stabilization (SD) by RECIST 1.1 (efficacy evaluation criteria for solid tumors). After nearly 8 weeks of oral administration of the third-generation EGFR-TKI aumolertinib (110 mg/day) started in February 2021, imaging showed significant tumor regression, lesion volume reduction to 2.2 × 2.0 × 1.8 cm, partial remission (PR), and clinical stage reduction to stage IB (T2N0M0). After evaluation by the surgeon, the patient was eligible for surgery and underwent VATS left upper lung lobectomy + lymph node dissection with the patient’s consent in April 2021. Postoperative pathology showed interstitial fibrous lung tissue with numerous lymphocytic infiltrates, with large necrotic tissue and <10% residual tumor cells (major pathological response, MPR), which was considered as posttreatment changes of squamous carcinoma. There was no metastasis of cancer tissue in any of the lymph nodes examined. After discussion with the patient, he was willing to receive adjuvant therapy with aumolertinib, and the disease was judged to be stable by imaging results in February 2022.

Case 2

A 68-year-old Chinese male with grade 3 hypertension was admitted to the hospital in December 2020 with a 1-week history of pulmonary occupancy found on physical examination. Chest CT revealed a left lingual lobe occupancy with obstructive pneumonia and enlarged mediastinal and left axillary lymph nodes; the size of the tumor was 4.0 × 3.8 × 2.3 cm, and cranial MRI, abdominal ultrasound, and bone scan was unremarkable. Lung puncture biopsy was diagnosed as adenocarcinoma, and immunohistochemistry showed a negative PD-L1 expression with TMB: 6.38 mut/bp; NGS revealed that the patient had EGFR exon 21 L858R point mutation, combined with HEBB2 amplification, EGFR amplification, and TP53 mutation; and the clinical stage was IIIA (T2N2M0). The patient’s enlarged lymph node in the left hilum was completely fused with the left pulmonary artery trunk and could not be completely removed surgically, which was an unresectable stage III lung cancer. After 2 cycles of pemetrexed combined with carboplatin chemotherapy in December 2020, the tumor did not shrink significantly according to chest CT. Considering that the patient had EGFR 21 exon L858R mutation, she was treated with oral aumolertinib 110 mg/day in January 2021, and after nearly 2 months of treatment, chest CT indicated significant regression of the left hilar lymph nodes, and the mass volume was reduced to 1.2 × 1.0 × 1.5 cm, achieving PR; clinical stage was reduced to stage IB (T2N0M0); and the tumor was clearly demarcated from the left pulmonary artery trunk, which could be considered for surgical radical treatment. Figure 2 shows the imaging findings of case 2.


Figure 2 Disease status before and after neoadjuvant almonertinib therapy. Computed tomography chest (CT) scan showed (A) left lingual lobe occupancy with a size of 4.0 × 3.8 × 2.3 cm, and subaortic lymph nodes before aumolertinib treatment. (B) Left lingual lobe occupancy with a size of 1.2 × 1 × 1.5 cm, and subaortic lymph nodes after aumolertinib treatment.

Therefore, VATS left upper lung lobectomy and lymphatic dissection were performed on February 22, 2021. Postoperative pathology showed moderately differentiated adenocarcinoma with elastic plaque formation, tumor involvement in 0/10 lymph nodes, and residual tumor cells <10% (MPR). The postoperative pathological stage was stage IA (T1N0M0). After surgery, the patient had been receiving adjuvant therapy with aumolertinib for 11 months, and no evidence of malignancy recurrence was seen on spiral CT of the chest.

Case 3

A 60-year-old Chinese female with grade 2 hypertension was admitted with cough for 1 month. Chest CT showed a left lower lung occupancy with pulmonary atelectasis; PET/CT showed a left lower lung soft tissue mass (10.9 × 8.9 × 6.5 cm), left lower lobe bronchial truncation, aortic window, and multiple lymph node enlargement in the left hilar, and left lung cancer with obstructive pneumonia was considered. Lung puncture biopsy and immunohistochemistry diagnosed squamous carcinoma; immunohistochemistry results showed negative PD-L1 expression, and NGS test results were EGFR L858R mutation combined with TP53 mutation, clinical stage IIIB (T4N2M0). Thoracic surgery specialists consulted and judged that there was no indication for surgery for the time being and recommended medical treatment. Figure 3 shows the imaging findings of case 3.


Figure 3 Disease status before and after neoadjuvant chemotherapy and aumolertinib treatment. Computed tomography chest (CT) scan showed that (A) before chemotherapy, the size of the left lower lung soft tissue mass was 10.9 × 8.9 × 6.5 cm. PET/CT showed (B) mediastinal lymph node enlargement before chemotherapy. (C) Multiple lymph node enlargement in the left hilar before chemotherapy. CT scan showed that (D) after 2 cycles of chemotherapy, the disease was judged to be stable based on imaging findings. (E) After 2 cycles of aumolertinib treatment, the size of the left lower lung soft tissue mass was 3.0 × 4.0 × 4.0 cm, and the tumor achieved partial remission. (F) After 2 cycles of aumolertinib treatment, multiple lymph nodes disappeared in the left hilar.

The patient was treated with a chemotherapy regimen of albumin paclitaxel combined with carboplatin for two cycles in November 2020, and a chest CT review showed that the lesion was still stable, but the tumor did not shrink significantly. Therefore, the patient received oral aumolertinib (110 mg/day) for 2 cycles from January 2021, and the tumor shrank significantly from before to 3.0 × 4.0 × 4.0 cm, reaching PR and clinical stage down to stage IB (T2N0M0), which was eligible for surgery. Therefore, the patient requested surgical treatment and underwent VTAS left lower lung lobectomy, lymph node dissection, and pleural adhesion release in March 2021. Postoperative pathology showed focal fibrous tissue hyperplasia with inflammatory cell infiltration in lung tissue, focal bronchial epithelial adenoid formation, and mild alveolar epithelial cell hyperplasia; some multinucleated giant cell reaction was seen; posttreatment changes were considered; no tumor residual was seen; and the status of pathological complete response (pCR) was achieved. 0/10 lymph nodes had tumor involvement, and the postoperative pathological stage was stage 0 (T0N0M0). After surgery, the patient was treated with aumolertinib for adjuvant therapy, and the disease was judged to be stable on the chest CT findings in January 2022.


Three patients with unresectable stage III non-small-cell lung cancer were first treated with chemotherapy and were switched to aumolertinib for 2 cycles due to poor efficacy, and all achieved downstaging and met resectability criteria after neoadjuvant aumolertinib treatment. Postoperative pathology showed MPR in the first two cases and pCR in the last case. In addition, the safety profile of aumolertinib in neoadjuvant attempts was satisfactory, with no events that delayed surgery or increased surgical complications. Patient characteristics and treatment response before and after surgery are shown in Table 1.


Table 1 Patient characteristics and response to treatment before and after surgery (N = 3).

In this case series report, the first patient who received chemotherapy had a more severe rash and pruritus, which the physician judged to be a hypersensitivity reaction caused by carboplatin, which has been shown to predispose patients treated with carboplatin in combination with paclitaxel (15). Symptomatic treatment was replaced with oral aumolertinib and continued for 8 weeks, with imaging showing partial remission and no serious adverse events.

The second and third cases also received 2 cycles of preoperative chemotherapy without significant tumor remission. After chemotherapy and switching to oral aumolertinib treatment for 4–8 weeks with the patient’s consent, imaging showed that both patients responded well to treatment, with significant tumor volume reduction to a descending stage that allowed them to undergo surgery.

This may indicate an efficacy advantage of aumolertinib in the neoadjuvant phase of therapy. Similarly, results from the EMERGING-CTONG 1103 study showed a trend toward improved ORR, lymph node step-down, MPR, and R0 resection rates with neoadjuvant erlotinib compared to neoadjuvant chemotherapy for patients with EGFRm NSCLC, and significantly prolonged PFS (16). Evidence from case reports and small non-randomized clinical trials reported suggests that neoadjuvant EGFR-TKI therapy is potentially efficacious in patients with resectable NSCLC (1721). This suggests that neoadjuvant-targeted therapy modalities are potentially clinically applicable and may be a viable option for patients who are not optimal chemotherapy candidates due to medical comorbidities or who refuse chemotherapy.

Finally, overall oncologic outcomes may be influenced by the timing of surgical intervention after neoadjuvant therapy. A large retrospective study found that in patients with stage IIIa NSCLC, 1- and 3-year survival rates were significantly lower in the short-delayed group after preoperative neoadjuvant therapy compared with the long-delayed group (22). Due to the significant safety advantage of targeted agents over chemotherapy, preoperative EGFR-TKI neoadjuvant therapy may reduce lung injury and make surgery less difficult. Therefore, it may shorten the time between the end of neoadjuvant therapy and surgery, thus affecting prognostic survival. Currently, the optimal duration of preoperative induction-targeted therapy is unclear, and whether 6 weeks of EGFR-TKI induction therapy is sufficient has yet to be verified, so there may be a problem of insufficient induction-targeted therapy.

Aumolertinib has demonstrated excellent tumor remission and a favorable safety profile in the neoadjuvant and adjuvant phases of these three phase III NSCLC cases, which has implications in guiding targeted therapy in the perioperative setting of NSCLC. However, its ability to be a firm choice for neoadjuvant and adjuvant treatment of NSCLC still needs to be validated by large randomized controlled studies.

Data Availability Statement

The original contributions presented in the study are included in the article/supplementary material. Further inquiries can be directed to the corresponding author.

Ethics Statement

The studies involving human participants were reviewed and approved by the research ethics committee of the Affiliated Brain Hospital of Nanjing Medical University. The patients/participants provided their written informed consent to participate in this study.

Author Contributions

All authors contributed toward data analysis, drafting, and critically revising of the paper, gave final approval of the version to be published, and agree to be accountable for all aspects of the work.

Conflict of Interest

Authors ZZ and XY are employed by Jiangsu Hansoh Pharmaceutical Group Co., Ltd.

The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher’s Note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.


The authors thank the patients for their participation in the study and agreeing to the publishing of the report.


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Keywords: aumolertinib, NSCLC, neoadjuvant, EGFR, adjuvant

Citation: Feng S, Qiang Z, Wanwan C, Zhaozhun Z, Yuewu X and Shencun F (2022) Case Report: Aumolertinib as Neoadjuvant Therapy for Patients With Unresectable Stage III Non-Small Cell Lung Cancer With Activated EGFR Mutation: Case Series. Front. Oncol. 12:872225. doi: 10.3389/fonc.2022.872225

Received: 09 February 2022; Accepted: 28 February 2022;
Published: 29 March 2022.

Edited by:

Shi-Yong Sun, Emory University, United States

Reviewed by:

Sarah Gao, Yale Medicine, United States
Jun Wang, The First Affiliated Hospital of Shandong First Medical University, China

Copyright © 2022 Feng, Qiang, Wanwan, Zhaozhun, Yuewu and Shencun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Fang Shencun,

These authors have contributed equally to this work