Abstract
Male breast cancer represents only 1% of all breast malignancies, with ectopic breast cancer in men being even rarer and highly prone to diagnostic challenges. Extramammary Paget’s disease (EMPD), a rare cutaneous tumor with non-specific clinical symptoms, is susceptible to misdiagnosis. This report discusses the case of an older male patient who presented with a scrotal mass, later identified as ectopic breast invasive adenocarcinoma upon pathological examination post-lesion excision. Immunohistochemistry confirmed a triple-negative profile and EMPD diagnosis, with no malignancies detected in either breast. Despite multiple treatment regimens and recurrence following adjuvant chemotherapy, the disease progressed with associated chemotherapy-related side effects, resulting in a 25.5-month survival period. The scarcity of literature on male ectopic breast cancer complicates the understanding of its incidence and optimal treatment strategies, increasing the risk of misdiagnosis. This study highlights the diagnostic and therapeutic challenges of this rare case, emphasizing the need for early recognition of atypical manifestations. The manuscript aims to assist clinicians by sharing case-specific insights and reviewing pertinent literature to enhance comprehension and management of similarly rare cases.
Introduction
Embryonic mammary development begins around the fourth week of gestation, forming a ventral mammary ridge extending from the axilla to the inner thigh. Incomplete resorption of this tissue can lead to residual ectopic mammary glands (1). Although ectopic breast tissue undergoes similar pathophysiological changes as normal breast tissue, only an insignificant fraction (approximately 1%) develops cancer in these sites (2). Ectopic mammary glands are most commonly identified in the axillae of women, with cases in men, particularly in the scrotal region, being significantly rare and cancer in these sites even rarer. Paget’s disease (PD), initially described by James Paget in the breast in 1874, was later identified in the male genital region by Crocker in 1889. This condition primarily involves intraepidermal adenocarcinoma, characterized by malignant growth of non-keratinizing epithelial cells known as Paget cells. Scrotal involvement in extramammary PD (EMPD) is uncommon, accounting for only 14% of cases, compared to the vulvar type (65%) and perianal type (20%) (3). This study details a rare case of breast cancer originating in ectopic mammary tissue within the scrotum of a male patient, accompanied by EMPD of the scrotal skin, highlighting the diagnostic and therapeutic challenges posed by this uncommon condition.
Case report
In June 2020, a 63-year-old male patient with no family history of malignancies presented to our hospital’s surgical department with a 5-month history of a scrotal skin lesion near the base of the penis, accompanied by occasional pain, no discharge, and ineffective self-medication attempts. The patient reported no discomfort in the axilla or breast, and physical examination revealed no palpable masses. Ultrasound imaging showed subcutaneous hypoechoic tissue at the base of the penis, measuring 1.3 cm × 0.7 cm × 1.7 cm, with regular morphology, indistinct borders, and a significant blood flow signal. Moreover, imaging of the kidneys, ureter, and bladder (including the prostate) showed no abnormalities. Due to limited awareness of the condition, a multidisciplinary surgical strategy discussion was not conducted, and a simple excision of the scrotal mass was performed. Postoperative pathological examination confirmed the scrotal mass as an invasive adenocarcinoma. (Figure 1A), with EMPD of the scrotal skin (Figure 1B), as well as evidence of nerve invasion and cancerous embolism in the chorioallantoic duct. The immunohistochemical analysis revealed cytokeratin 7 (CK7) positivity, CK20 negativity, GATA3 positivity, gross cystic disease fluid protein 15 (GCDFP-15) negativity, and raised androgen receptor (AR) (3+, 60%) (Figures 1C–G), with estrogen receptor (ER) and progesterone receptor (PR) negativity, and a human epidermal growth factor receptor 2 (C-erB-2) score of 2+ (Figures 1H–J). Further Fluorescence In Situ Hybridization (FISH) testing yielded negative results. Based on these pathological and immunohistochemical results, a diagnosis of triple-negative invasive carcinoma of ectopic breast origin was made. Following the surgical procedure, the patient consulted the Thyroid and Breast Surgery Department for further breast examination. A positron emission tomography (PET)-computed tomography (CT) scan detected multiple lymph node metastases in the left inguinal region (Figure 2), leading to an inguinal lymph node dissection. Postoperative pathology confirmed metastasis from the scrotal invasive adenocarcinoma. Two months later, pelvic CT and magnetic resonance imaging (MRI) identified a space-occupying lesion in the left inguinal region (Figures 3A–D), raising suspicion for inguinal lymph node metastasis. Systemic chemotherapy and regular monitoring were recommended.
Figure 1
Figure 2
Figure 3
Based on the PET-CT findings and prior inguinal lymph node dissection, an aspiration biopsy was not performed for the suspected lymph node metastasis noted on pelvic imaging. The patient subsequently received four cycles of adjuvant chemotherapy with paclitaxel liposomal (175 mg/m²) and nedaplatin (75 mg/m²) from August to October 2020, resulting in disease stability upon follow-up. In August 2021, the patient presented again with a scrotal mass, which was excised and confirmed to be an invasive adenocarcinoma of ectopic mammary origin. During postoperative re-examination, an ultrasound of the inguinal lymph nodes once more indicated metastasis, prompting the patient to return to our department for further treatment. Further investigations revealed metastatic spread to the liver (Figures 3E–H), bilateral pubic bones, and the left acetabular bone (Figure 4). A liver mass biopsy confirmed metastatic invasive adenocarcinoma with immunohistochemistry consistent with triple-negative status. Programmed death-ligand 1 (PD-L1) testing indicated a combined positive score (CPS) of less than 1, assessed on the Dako platform with the 22C3 antibody clone using the CPS standard (Figure 1K), suggesting ineligibility for immune checkpoint inhibitor therapy. The patient experienced rapid disease progression, with multiple pathological examinations indicating ectopic breast origin. A physical and ultrasound examination of the breast and axilla revealed no significant abnormalities. Given the patient and their family’s urgent desire for treatment, chemotherapy with the TE regimen (albumin-bound paclitaxel 250 mg/m² and epirubicin 70 mg/m²) was initiated following a multidisciplinary consultation. Although denosumab has demonstrated better efficacy and safety over zoledronic acid for bone metastasis management, due to constraints related to national insurance coverage and personal financial limitations, the patient opted for zoledronic acid, administered every three weeks, to manage bone metastasis while minimizing financial burden. During this period, the treatment achieved partial remission (PR). However, after seven cycles, treatment was discontinued due to secondary neurotoxic effects, including head and facial paresthesia, and extremity numbness. The patient was subsequently transitioned to maintenance chemotherapy with capecitabine (1250 mg/m2). After two cycles, intrahepatic metastases progressed, promoting a repeat biopsy and confirming triple-negative status via immunohistochemistry. Subsequently, the patient received a single cycle of gemcitabine (1 g/m2), carboplatin (area under the curve [AUC] = 5), and bevacizumab (7.5 mg/kg). However, side effects, including grade 4 thrombocytopenia and grade 3 leukopenia, necessitated platelet transfusions, administration of recombinant human thrombopoietin, and support to restore leukocytes and platelets. Consequently, gemcitabine was not administered on day 8 of this cycle.
Figure 4
Upon discharge, the patient was referred to a higher-level hospital for further pathological evaluation. The findings revealed metastatic adenocarcinoma in the left inguinal lymph nodes (2/4), consistent with scrotal invasive adenocarcinoma, and a liver puncture showed metastatic adenocarcinoma. Given these results, scrotal ectopic breast origin was considered. Subsequently, the patient received vedolizumab (120 mg) at the same hospital. During hospitalization, the patient developed a high fever reaching 39.7°C, initially treated with piperacillin-tazobactam followed by meropenem; however, the infection persisted with limited improvement. Despite intensive treatment efforts from the medical team and the patient’ family, therapeutic options were limited due to specific molecular profiles and expression levels of relevant markers.
A comprehensive timeline chart was developed to visually represent the patient’s treatment history and key clinical events (Table 1). This table systematically documents the patient’s journey from initial symptom recognition to final treatment, highlighting significant interventions such as operation, imaging, and chemotherapy. By providing a clear overview of the treatment process and its influence on disease progression, this timeline is a valuable reference to inform clinical decision-making.
Table 1
| Date | Event | Category |
|---|---|---|
| January 2020 | Patient discovered a scrotal mass near the base of the penis, red with occasional pain. | Initial Observation |
| June 6, 2020 | Presented to Urology Department. | Initial Diagnosis |
| June 8, 2020 | Scrotal lesion excision surgery performed under spinal anesthesia. | Surgery |
| June 12, 2020 | Postoperative pathology showed invasive adenocarcinoma with Extramammary Paget's disease of the scrotal skin. | Pathology |
| June 28, 2020 | PET/CT showed multiple hypermetabolic lymph nodes in the left inguinal region, indicating metastasis. | Imaging |
| July 8, 2020 | Underwent inguinal lymph node dissection; multiple enlarged lymph nodes fused into a mass. | Surgery |
| August 6, 2020 | Chest-abdominal-pelvic CT showed left inguinal mass. | Imaging |
| August 13 - October 25, 2020 | Completed four cycles of chemotherapy with paclitaxel liposome and nedaplatin. | Chemotherapy |
| August 28, 2021 | Follow-up revealed a recurrent scrotal mass. | Follow-up |
| September 6, 2021 | Second scrotal lesion excision surgery performed. | Surgery |
| October 14, 2021 - March 6, 2022 | Seven cycles of TE regimen chemotherapy completed. | Chemotherapy |
| April 20, 2022 | Started capecitabine maintenance therapy. | Maintenance Therapy |
| May 11, 2022 | Enhanced CT showed multiple liver metastases, indicating disease progression. | Imaging |
| May 13, 2022 | Started treatment with gemcitabine, carboplatin, and bevacizumab; developed thrombocytopenia. | Chemotherapy |
| June 13, 2022 | Received disitamab vedotin treatment; developed fever during hospitalization. | Treatment |
| July 2022 | Patient passed away. | Outcome |
Comprehensive treatment timeline of the patient.
PET/CT, Positron Emission Tomography/Computed Tomography; CT, Computed Tomography; TE, Nab-Paclitaxel + Epirubicin; EMPD, Extramammary Paget's disease.
Discussion
Breast cancer is one of the most prevalent malignancies worldwide, predominantly affecting women and typically arising in the breast tissue. Ectopic breast cancer, a rare variant, develops along the embryonic milk line, which extends from the axilla to the groin, with the axilla being the most common site for ectopic breast cancer. To date, only three cases of male ectopic breast cancer outside the axilla have been documented in the English literature, with sites including the abdominal wall, perineum, and suprapubic region (4). In this report, a case of ectopic breast cancer is reported in the scrotum, situated within the perineal area. Furthermore, the patient was diagnosed with Paget’s disease, which added complexity to both the diagnostic and treatment approach (5).
Ectopic breast tissue is more susceptible to malignant transformation than normal breast tissue, primarily due to ductal stagnation. However, ectopic breast cancer remains uncommon, given the low incidence of ectopic breast tissue (6). The incidence of male breast cancer accounts for less than 1% of all breast cancers, and ectopic breast cancer represents approximately 0.3% to 0.6% of these cases (7, 8). The average age of diagnosis for ectopic breast cancer is approximately 54 years, roughly 6 years younger than the average age of diagnosis for conventional breast cancer (4). Ectopic breast cancer lacks distinct symptoms; common manifestations include palpable masses with or without tenderness, and skin changes such as erythema, ulcers, and other lesions (8, 9). However, due to the low incidence and its higher prevalence among women, there is limited diagnostic and treatment experience for male ectopic breast cancer, frequently resulting in delayed diagnosis. In the perineal region, EMPD can present with skin manifestations similar to those of ectopic breast cancer. Extramammary Paget’s disease is an adenocarcinoma originating in the skin or appendages, primarily affecting apocrine gland regions. Its main sites of occurrence are the vulva, followed by the perianal area, scrotum, penis, and axilla, predominantly affecting older individuals aged 60 to 70 years (10, 11). In a study of 246 Asian male patients with EMPD, the average age of onset was found to be 64 years (12). Research by Yin et al. indicates that the crude incidence rate of EMPD in mainland China is approximately 0.4 per million population (13). Besides being rare, EMPD presents with non-specific symptoms; initial manifestations commonly include itching, erythema, and dryness, which can progress to eczematous lesions, crusting, ulcers, or papillomatous changes. Therefore, patients may undergo prolonged treatments before a definitive diagnosis is made. Topical steroids or antifungal medications can further alter skin manifestations, complicating diagnostic processes (14).
Ectopic breast cancer and EMPD in the perineal region share similar clinical features, and the patient’s age of onset (63 years) aligns with the typical age range for EMPD, which can add to diagnostic challenges. Extramammary Paget’s disease is classified into primary and secondary types, with primary EMPD being CK7 positive and CK20 negative. Conversely, secondary EMPD is usually associated with an underlying malignancy and shows CK7 and CK20 positivity (15). In this case, the scrotal Paget’s disease is classified as primary EMPD, unrelated to ectopic breast cancer, with the scrotal lesions representing EMPD manifestations. The final diagnosis was ectopic breast cancer in the scrotum with coexisting EMPD.
Male ectopic breast cancer is sporadic, making the prognosis uncertain, and there is currently no established expert consensus on its management (16, 17). Treatment for male ectopic breast cancer generally follows protocols similar to those for primary breast cancer, primarily involving surgical excision, supported by chemotherapy, radiotherapy, endocrine therapy, targeted therapy, and the recently emerging immunotherapy. It is noteworthy that ectopic breast cancer exhibits greater aggressiveness than typical breast cancer, primarily in two aspects: first, the rate of lymph node positivity is higher than in breast cancer (18). Patients with vulvar ectopic breast cancer who underwent local wide excision and inguinal lymph node dissection showed pathological results indicating lymph node involvement in all cases (19). Second, ectopic breast cancer has a higher propensity for recurrence and metastasis, particularly to the bones and brain, following simple excision (20). Despite the increased likelihood of lymph node involvement, sentinel lymph node biopsy is not recommended for patients with ectopic breast cancer due to the reduced sensitivity of inguinal lymph nodes in dye uptake (21). To mitigate the risk of distant metastasis, postoperative local radiotherapy is recommended. Apart from traditional prognostic factors such as anatomical tumor-node-metastasis (TNM) staging, molecular subtype, histological grade, and Ki-67 index (22), genetic factors should be incorporated into traditional prognostic models, which could enhance prediction accuracy for male ectopic breast cancer. Currently, tests such as Oncotype DX (Exact Sciences Corporation, Madison, Wisconsin, USA) and MammaPrint (Agendia N.V., Amsterdam, The Netherlands) have shown utility in assessing the likelihood of distant metastasis (23, 24).
However, EMPD is relatively less invasive, with slow disease progression (17, 20). Surgical treatment remains the primary approach for EMPD, supplemented by options including laser ablation, radiotherapy, chemotherapy, and topical treatment comprising 5% imiquimod cream or cytotoxic agents combined with 1% fluorouracil cream (25, 26).
The patient’s prognosis was poor, with an overall survival of only 25.5 months. Critical contributing factors include the tumor’s triple-negative molecular subtype, which has limited treatment options; poor responsiveness to treatment, with rapid recurrence and metastasis following chemotherapy despite multiple treatment lines; and the rarity of the disease, which led to delayed diagnosis, limited understanding of its characteristics, and an initial treatment plan that was not optimally tailored to the patient’s specific needs.
Scrotal ectopic breast cancer and EMPD present with atypical symptoms and lack specific imaging findings, highlighting the importance of preoperative multidisciplinary consultation. Such consultation is essential for defining the surgical strategy, postoperative adjuvant treatment plan, and follow-up protocol. In this case, the patient did not undergo multidisciplinary evaluation, and only a simple lesion excision was performed, resulting in a non-standardized treatment course that led to recurrence and distant metastasis. Based on our experience, to minimize the risk of local recurrence, metastasis, or the malignant transformation of residual ectopic breast tissue, all cases of ectopic breast cancer are recommended to undergo evaluation by a multidisciplinary team (including surgeons, oncologists, radiation oncologists, radiologists, and pathologists) to address critical questions:
What should the surgical strategy be? Should a local excision or extensive resection be performed? Is sentinel lymph node biopsy necessary, or should lymph node dissection be considered?
What is the optimal adjuvant treatment? Given the rarity of ectopic breast cancer, treatment plans should be personalized, taking into account the patient’s risk factors, tumor characteristics, and overall health.
What is the best follow-up plan? What should be the frequency of follow-up visits? Which diagnostic tests should be included in the follow-up regimen?
Conclusion
Scrotal ectopic breast cancer and scrotal Paget’s disease are exceedingly uncommon conditions characterized by non-specific early symptoms and the lack of distinctive findings on imaging. Diagnosis relies entirely on histopathological examination. Therefore, when conventional treatments for skin lesions prove ineffective, a high index of suspicion should be maintained, and a biopsy should be performed. Once a diagnosis is confirmed, a multidisciplinary expert consultation is essential to create a personalized treatment plan tailored to the patient’s unique case.
Limitations
This study has several limitations. First, it is based on a single case, which limits the generalizability and extrapolation of the results. Second, the PD-L1 testing used the 22C3 diagnostic reagent. However, current research suggests that in triple-negative breast cancer, 22C3 and SP142 cannot be used interchangeably. Due to the limitations of the hospital platform, only 22C3 was available. Both reagents should ideally be tested simultaneously to ensure patients are not excluded from immunotherapy. Finally, after bone metastasis developed, zoledronic acid was chosen for treatment due to national insurance coverage and the patient’s financial constraints. Without significant economic pressure, denosumab, which is more effective with fewer side effects, should be the preferred treatment for bone metastasis.
Statements
Data availability statement
The original contributions presented in the study are included in the article/supplementary material. Further inquiries can be directed to the corresponding author.
Ethics statement
The studies involving humans were approved by Ethical Review Committee of Weifang People’s Hospital. The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study. Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.
Author contributions
SL: Funding acquisition, Writing – original draft. YN: Writing – original draft. CS: Writing – review & editing. KW: Writing – review & editing. MY: Writing – review & editing. XS: Writing – review & editing. YB: Writing – review & editing. JW: Writing – review & editing.
Funding
The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
1
SghaierSGHallebMMarghliIBouidaABen HassounaJCharguiRet al. Primary ectopic axillary breast cancer: a case series. J Med Case Rep. (2021) 15:412. doi: 10.1186/s13256-021-02998-w
2
GrosslN. Supernumerary breast tissue: historical perspectives and clinical features. South Med J. (2000) 93:29–32. doi: 10.1097/00007611-200093010-00005
3
DauendorfferJNHermsFBaroudjianBBasset-SeguinNCavelier-BalloyBFouéréSet al. Penoscrotal paget's disease. Ann Dermatol Venereol. (2021) 148:71–6. doi: 10.1016/j.annder.2020.08.051
4
FamáFCicciúMSindoniAScarfóPPollicinoAGiacobbeGet al. Prevalence of ectopic breast tissue and tumor: A 20-year single center experience. Clin Breast Cancer. (2016) 16:e107–12. doi: 10.1016/j.clbc.2016.03.004
5
ByonJHAnARShinJYChoiEJ. Ectopic male breast cancer in suprapubic area that relapsed with hematogenous metastasis. J Breast Cancer. (2021) 24:344–8. doi: 10.4048/jbc.2021.24.e21
6
CooperJCHewKEAudlinKMImDDMatsuoK. Synchronous of breast and vulvar Paget's disease: a case report. Eur J Gynaecol Oncol. (2012) 33:534–6. doi: 10.12892/ejgo201205534
7
EomHJKoBSSongIHGongGKimHH. Ectopic male breast cancer in the perineum: A case report. J Breast Cancer. (2017) 20:404–7. doi: 10.4048/jbc.2017.20.4.404
8
ZhongGBYeXQLiuJLXiaoSZHuangQHWeiW. Male accessory breast cancer on the abdominal wall: a case report and literature review. Onco Targets Ther. (2018) 11:6625–31. doi: 10.2147/OTT.S184185
9
Nihon-YanagiYUedaTKamedaNOkazumiS. A case of ectopic breast cancer with a literature review. Surg Oncol. (2011) 20:35–42. doi: 10.1016/j.suronc.2009.09.005
10
St ClaireKHooverAAshackKKhachemouneA. Extramammary paget disease. Dermatol Online J. (2019) 25:13030/qt7qg8g292. doi: 10.5070/D3254043591
11
ReddyVSGabaSTewariMPrakashGMittalS. Extramammary paget's disease of the penis and scrotum. Indian J Surg Oncol. (2024) 15:149–52. doi: 10.1007/s13193-023-01870-1
12
KangZZhangQZhangQLiXHuTXuXet al. Clinical and pathological characteristics of extramammary Paget's disease: report of 246 Chinese male patients. Int J Clin Exp Pathol. (2015) 8:13233–40.
13
NabavizadehRVashiKBNabavizadehBNarayanVMMasterVA. Extramammary Paget's disease: Updates in the workup and management. Asian J Urol. (2022) 9:451–9. doi: 10.1016/j.ajur.2022.08.001
14
ZhangNGongKZhangXYangYNaY. Extramammary Paget's disease of scrotum–report of 25 cases and literature review. Urol Oncol. (2010) 28:28–33. doi: 10.1016/j.urolonc.2008.07.002
15
KuanSFMontagAGHartJKrauszTRecantW. Differential expression of mucin genes in mammary and extramammary Paget's disease. Am J Surg Pathol. (2001) 25:1469–77. doi: 10.1097/00000478-200112000-00001
16
ChengYLiNEapenAParajuliRMehtaR. Somatic BRCA2 mutation-positive concurrent accessory male breast cancer (BC) and non-small cell lung cancer (NSCLC): excellent efficacy of palbociclib, fulvestrant and leuprolide in platinum-exposed and endocrine-refractory BC associated with cyclin D1 and FGFR1 amplification and of carboplatin, paclitaxel and radiation in NSCLC. Case Rep Oncol. (2019) 12:494–9. doi: 10.1159/000501304
17
WangCXGuoSLHanLN. Successful treatment of accessory breast cancer with endocrine therapy. J Zhejiang Univ Sci B. (2017) 18:70–5. doi: 10.1631/jzus.B1600220
18
RoutiotTMarchalCVerhaegheJLDepardieuCNetterEWeberBet al. Breast carcinoma located in ectopic breast tissue: a case report and review of the literature. Oncol Rep. (1998) 5:413–7. doi: 10.3892/or.5.2.413
19
Trambaiolo AntonelliCPortelliF. . Extramammary paget disease. In: van KriekenJ, editor. Encyclopedia of Pathology. Springer, Cham (2019). p. 4868–72.
20
BansalVYBansalVVShahSVBelligeAR. Primary ectopic breast carcinoma arising in the inguinal region in a male patient. J Cancer Res Ther. (2022) 18:837–9. doi: 10.4103/jcrt.JCRT_777_20
21
ChengPKongM. A case of vulvar ectopic breast tissue. Chin Clin J Obstetrics Gynecology. (2019) 20:77. doi: 10.13390/j.issn.1672-1861.2019.01.030
22
ViscontiGEltahirYVan GinkelRJBartJWerkerPM. Approach and management of primary ectopic breast carcinoma in the axilla: where are we? A comprehensive historical literature review. J Plast Reconstr Aesthet Surg. (2011) 64:e1–11. doi: 10.1016/j.bjps.2010.08.015
23
VinayDSKwonBS. Harnessing immune checkpoints for cancer therapy. Immunotherapy. (2018) 10:1265–84. doi: 10.2217/imt-2017-0168
24
RibasAWolchokJD. Cancer immunotherapy using checkpoint blockade. Science. (2018) 359:1350–5. doi: 10.1126/science.aar4060
25
BrownRSLankesterKJMcCormackMPowerDASpittleMF. Radiotherapy for perianal Paget's disease. Clin Oncol (R Coll Radiol). (2002) 14:272–84. doi: 10.1053/clon.2002.0092
26
BermanBSpencerJVillaAPoochareonVElgartG. Successful treatment of extramammary Paget's disease of the scrotum with imiquimod 5% cream. Clin Exp Dermatol. (2003) 28 Suppl 1:36–8. doi: 10.1046/j.1365-2230.28.s1.12.x
Summary
Keywords
scrotal mass, ectopic breast cancer, triple negative, Paget’s disease, treatments
Citation
Nie Y, Song C, Wang J, Wu K, Yu M, Shen X, Bian Y and Liu S (2024) Triple-negative ectopic breast cancer of the male scrotum: a case report. Front. Oncol. 14:1473881. doi: 10.3389/fonc.2024.1473881
Received
31 July 2024
Accepted
19 November 2024
Published
05 December 2024
Volume
14 - 2024
Edited by
Robert Wesolowski, The Ohio State University, United States
Reviewed by
Tito Brambullo, University of Padua, Italy
Arya Mariam Roy, University at Buffalo, United States
Updates
Copyright
© 2024 Nie, Song, Wang, Wu, Yu, Shen, Bian and Liu.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Shuzhen Liu, 18265617159@163.com
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.