ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1539215
This article is part of the Research TopicNutrition in Pancreatic Diseases: The Role of Nutritional Status and Nutrition Therapy in the Management of Pancreatitis and Pancreatic CancerView all 5 articles
The association between nutritional risk and survival time among patients with pancreatic cancer following pancreaticoduodenectomy: A retrospective cohort study
Provisionally accepted
- Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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Background: Nutritional problems are common in patients with pancreatic cancer. However, the relationship between Nutritional risk screening 2002 and survival of patients after pancreaticoduodenectomy remains inconclusive. This study aimed to examine the association between preoperative nutritional risk and survival time among adult Chinese patients with pancreatic cancer after pancreaticoduodenectomy.Methods: This study was conducted at Ruijin Hospital, affiliated with Shanghai Jiao Tong University School of Medicine in China. Patients aged 18 years or more who received pancreaticoduodenectomy for pancreatic cancer in our center between December 2019 and June 2022 from the follow-up database were included in the study. We retrospectively collected data on the demographics, disease, treatment, nutritional risk score, and survival time of patients with pancreatic cancer. Cox regression model was used to analysis the association between nutritional risk and survival time in different covariate models.Results: A total of 656 patients were included in the study, and the median survival time was 24.0 months (95% CI, 21.6-26.3). 29.1% of patients had nutritional risk on admission. At the end of the follow-up, a total of 364 (55.5%) patients had died. The overall 1-, 2-, 3-year survival rate of 656 patients with pancreatic cancer after pancreaticoduodenectomy was 72.7%, 49.8%, and 34.4%, respectively. In the Cox regression model with adjustment for age, education level, carbohydrate antigen 199 levels, neutrophil-lymphocyte ratio, tumor diameter, lymph node metastasis, distant organ metastasis, differentiation, nerve invasion, surgical margins, surgical time, intraoperative blood loss, postoperative complication, adjuvant chemotherapy, patients with nutritional risk score no less than 3 had lower survival time compared with those without nutritional risk (HR = 1.33, 95%CI:1.06-1.67; P = 0.015).Conclusions: Preoperative nutritional risk has a detrimental impact on survival in pancreatic cancer patients who underwent pancreaticoduodenectomy, and this relationship is stable. Nursing staff should early screen for nutritional risk by Nutritional Risk Screening - 2002 in patients with pancreatic cancer at diagnosis, and in conjunction with their doctors, develop and implement a timely nutritional treatment plan for those at risk to improve poor survival time.
Keywords: Nutritional risk, screening, Pancreatic Cancer, Pancreaticoduodenectomy, Survival
Received: 04 Dec 2024; Accepted: 30 May 2025.
Copyright: © 2025 Tian, Su, Chen, Zhang, Wu and Baiyong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Beiwen Wu, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Shen Baiyong, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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