ORIGINAL RESEARCH article
Front. Oncol.
Sec. Hematologic Malignancies
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1569433
Retrospective Analysis of HIV-Associated Lymphomas: Insights from a Single Romanian Center Over 15 Years
Provisionally accepted
Monica-Daniela Pădurariu-Coviț1,2
Iulia Chiscop3Cristian Gutu4
Anca Adriana Arbune5*
Elena Niculet6,7
Manuela Arbune4,8- 1Dunarea de Jos University, Galați, Romania
- 2Hematology Department, Sfantul Apostol Andrei Emergency County Hospital, Galati, Romania
- 3Clinical Surgical Department, Dunarea de Jos University, Galati, Romania
- 4Clinical Medical Department, Faculty of Medicine and Pharmacy, “Dunarea de Jos” University, Galati, Romania
- 5Neurology Department, Fundeni Clinical Institute, Bucharest, Romania
- 6Multidisciplinary Integrated Center for Dermatological Interface Research, Galti, Romania
- 7Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, Dunarea de Jos University, Galati, Romania
- 8Clinical Hospital for Infectious Diseases, Sfanta Cuvioasa Parascheva, Galati, Romania
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Lymphoma is a significant cause of mortality among people living with human immunodeficiency virus (PLWH). The objective of our study is to assess the characteristics of lymphomas in PLWH in a single centre from the southeast of Romania. Methods: We retrospectively analysed the prevalence, clinical, and demographic characteristics of patients with lymphoma associated with HIV/AIDS monitored over a period of 15 years. Kaplan-Meier analysis was used to estimate survival rates and evaluate the risk of mortality in lymphoma patients. Results: Among the 476 new cases of HIV/AIDS registered, 9 cases of lymphoma were identified, representing a prevalence of 1.89%. Overall mortality was 13.6%, with lymphoma contributing to 10.76% of HIV/AIDS-related deaths. The average age at lymphoma diagnosis was 37 years, with most patients being men and smokers with sexually transmitted HIV. Common co-infections included hepatitis B virus (HBV) and tuberculosis. Advanced-stage disease (Ann Arbor stage IV) and type B clinical symptoms were present in half of the cases. Oncological treatment was provided in 5 cases, achieving a survival rate of 30%. Conclusions: The high mortality highlights the need for early diagnosis and an integrated therapeutic approach to improve the prognosis of patients with HIV-associated lymphomas.
Keywords: HIV, aids, Lymphoma, antiretroviral treatment, Opportunistic Infections, non-AIDS co-morbidities Font: Bold Formatted: Indent: Left: -0, 38 cm Formatted: Not Highlight
Received: 31 Jan 2025; Accepted: 21 May 2025.
Copyright: © 2025 Pădurariu-Coviț, Chiscop, Gutu, Arbune, Niculet and Arbune. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Anca Adriana Arbune, Neurology Department, Fundeni Clinical Institute, Bucharest, Romania
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