ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1574911
This article is part of the Research TopicImmune Predictive and Prognostic Biomarkers in Immuno-Oncology: Refining the Immunological Landscape of CancerView all 13 articles
Immunological Features of Various Molecular Subtypes of Cervical Cancer and Their Prognostic Implications in the Context of Disulfidptosis
Provisionally accepted
- Jiaxing University Affiliated TCM Hospital, Jiaxing, China
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Cervical cancer ranks among the most prevalent malignancies impacting women globally. Disulfidptosis represents a recently identified pathway of cellular demise, although its role in the context of cervical cancer is not well elucidated.This research investigates the significance of Disulfidptosis-Related Genes (DRGs) within cervical cancer. Furthermore,it aims to analyze the differences in prognosis and immune infiltration among different molecular subtypes.We compiled genes associated with cervical cancer and disulfidptosis from a variety of databases to perform a differential expression analysis.Subsequently, the samples are grouped through consensus clustering.To evaluate immune cell infiltration, we employed CIBERSORT. Additionally, immune checkpoint genes (ICGs) were gathered from existing literature and databases, enabling statistical analyses of two subtype samples of cervical cancer (CESC). Following our analyses using GO, KEGG, and GSEA to compare the differences between the two subtypes.Lastly, a prognostic risk model was constructed using LASSO regression and validated using ROC.This study identified seven key genes: PCBP3, ARNT, ANP32E, DSTN, CD2AP, EPAS1, and ACTN1.The consensus clustering analysis showed differences in immune cell infiltration and DFS(disease-free survival) among the various clusters.The immune checkpoint gene CXCL1 displayed highly significant statistical differences between subtype A (Cluster 1) and subtype B (Cluster 2) in cervical cancer (CESC) samples.The gene set enrichment analysis identified the negative regulation of peptidase activity and the IL-17 signaling pathway, which link to subtype-specific differentially expressed genes (DEGs).Statistical analysis of the various subtypes of CESC samples highlighted the importance of subtypespecific therapeutic targets.Additionally, it seeks to enhance the accuracy of prognostic predictions, thereby establishing a foundation for the formulation of personalized treatment approaches.
Keywords: cervical cancer, disulfidptosis, Immune Cell Infiltration, Risk signature, Prognostic model
Received: 11 Feb 2025; Accepted: 25 Apr 2025.
Copyright: © 2025 Yao, Yang, Fu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yuanxin Fu, Jiaxing University Affiliated TCM Hospital, Jiaxing, China
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