REVIEW article
Front. Oncol.
Sec. Cancer Molecular Targets and Therapeutics
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1582361
This article is part of the Research TopicNovel Molecular Targets in Cancer TherapyView all 31 articles
Research Progress on NUSAP1 and Its Role in Digestive System Neoplasms
Provisionally accepted
- 1Nanchang University, Nanchang, Jiangxi Province, China
- 2Jiujiang University Affiliated Hospital, Jiujiang, China
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Nucleolar spindle-associated protein 1 (NUSAP1) is a microtubule-binding protein critical in the mitotic cell cycle. Its primary functions encompass maintaining microtubule stability, facilitating spindle assembly, regulating chromosome alignment, and modulating multiple signaling pathways. The incidence and mortality rates of digestive system neoplasms are among the highest of all malignant tumors. Therefore, identifying effective biological targets for targeted cancer control and treatment strategies is critical. Recent studies have demonstrated that NUSAP1 is highly expressed in various malignant tumors of the digestive system and plays a pivotal role in the initiation, progression, treatment, and prognosis of these tumors by regulating mitosis and key signaling pathways. The distinctive function of NUSAP1 positions it as a central molecule linking mitotic dysregulation with tumorigenesis, exhibiting dual potential as both a diagnostic marker and a therapeutic target. This article primarily reviews the structural characteristics, functional mechanisms, and related signaling pathways of NUSAP1, focusing on exploring the functional mechanisms of NUSAP1in digestive system neoplasms. The objective is to offer new research perspectives into the diagnosis, treatment, and prognosis evaluation of tumors.
Keywords: NUSAP1 1, digestive system neoplasms 2, signaling pathway 3, cell cycle 4, microtubule 5
Received: 24 Feb 2025; Accepted: 08 May 2025.
Copyright: © 2025 Fu, Zhuo and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tao Yu, Jiujiang University Affiliated Hospital, Jiujiang, China
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