REVIEW article
Front. Oncol.
Sec. Genitourinary Oncology
Potential role of exosomes derived from the tumor microenvironment in tumor progression and treatment
Provisionally accepted
- Department of Urology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China
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Exosomes are important intercellular communication substances that connect the intercellular communication between the tumor microenvironment and the premetastatic microenvironment during tumor progression. By carrying different regulatory substances, such as proteins, cytokines, nucleic acids, etc., to regulate tumor progression, including angiogenesis, invasion, metastasis, drug resistance and other aspects. In addition to their potential as diagnostic markers, exosomes can also be used as excellent drug delivery carriers. Due to their excellent targeting and histocompatibility, exosomes have considerable application prospects in tumor therapy. This reviews recent studies on tumor-related exosomes, summarizes the mechanisms of intercellular communication and regulation of exosomes in tumor microenvironment and pre-metastasis microenvironment, and summarizes the current research progress on exosomes in tumor therapy.
Keywords: exosome, Tumor Microenvironment, pre-metastatic microenvironment, progression, Treatment
Received: 25 Feb 2025; Accepted: 08 Dec 2025.
Copyright: © 2025 Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ying Yu
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.