REVIEW article
Front. Oncol.
Sec. Cancer Genetics
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1592467
The Regulatory Network of Epithelial-Mesenchymal Transition-Associated Non-Coding RNAs in Thyroid Cancer: Molecular Mechanisms, Clinical Implications, and Therapeutic Strategies
Provisionally accepted
- 1Lanzhou University Medical College, Lanzhou, Gansu, China
- 2Department of Endocrinology, First Hospital of Lanzhou University, Lanzhou, Gansu Province, China
- 3Institute of Clinical Research and Translational Medicine, Gansu Provincial Hospital, Lanzhou, Gansu Province, China
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Thyroid cancer represents the most prevalent malignant neoplasm within the endocrine system, exhibiting a steadily increasing global incidence. Non-coding RNAs (ncRNAs) have emerged as a pivotal focus in thyroid cancer research, demonstrating significant involvement in tumor progression through epigenetic regulation.Contemporary studies reveal widespread dysregulation of ncRNA expression profiles in thyroid malignancies, where differentially expressed ncRNAs exert either tumorsuppressive or oncogenic functions by modulating epithelial-mesenchymal transition (EMT) mechanisms. This review synthesizes current knowledge on EMT-related ncRNA mechanisms driving thyroid carcinogenesis and evaluates their diagnostic and therapeutic potential. By elucidating these molecular interactions, we aim to catalyze discovery of novel ncRNA-mediated pathways, advance targeted treatment strategies, and ultimately enhance clinical outcomes for thyroid cancer patients.
Keywords: thyroid cancer, Epithelial-Mesenchymal Transition, non-coding RNAs, miRNAs, CircRNAs, lncRNAs, diagnostic biomarkers
Received: 14 Mar 2025; Accepted: 13 May 2025.
Copyright: © 2025 Zhao, Tian, Peng, Ma and Fu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Songbo Fu, Lanzhou University Medical College, Lanzhou, Gansu, China
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