REVIEW article
Front. Oncol.
Sec. Surgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1594848
A bibliometric analysis of liver cancer bone metastases: advances in mechanisms of occurrence and treatment options
Provisionally accepted
- 1First People's Hospital of Nanning, Nanning, Guangxi Zhuang Region, China
- 2People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China
- 3Nanning Eighth People's Hospital, nanning, China
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Background: Liver cancer ranks as the sixth most frequently diagnosed cancer and is the third leading cause of cancer-related deaths worldwide. Its poor prognosis is mainly due to tumor metastasis. Bone metastasis commonly occurs in the advanced stages of liver cancer and can significantly impact patients' quality of life and prognosis. However, current treatment methods for bone metastasis resulting from liver cancer have significant limitations. This article aims to review the latest research and trends in global studies on bone metastasis associated with liver cancer.Methods: This study used the Web of Science Core Collection to gather 3,347 articles on liver cancer with bone metastasis published from 2004 to 2024.The study applied bibliometric analysis methods, including CiteSpace, VOSviewer, and other tools, to examine countries, institutions, journal authors, keywords, and references.From 2004 to 2024, we collected 3,845 records, including 3,347 articles and 498 reviews from 92 countries. Publications had shown exponential growth, peaking in 2021 with an annual growth rate of 8.3%. The research involved 13,188 organizations. China had the most publications (n=970, 29%), followed by the United States (n=648, 19.4%), Japan (n=317, 9.5%), and Germany (n=228, 6.8%); Canada had a notably higher rate of international collaboration at 44.8%. In total, 830 journals contributed to this research. The most cited journal was "J Clinical Oncol" with 4,275 citations, while "New Engl J Med" had the highest impact factor at 158.5. The research involved 23,710 authors, with Wang, Xin and Zhang, Chao being the authors with the most publications. Wang Z published the first study on this topic in 2007. In 2008, Zhang Y, Wang Y, and Zhang J also began researching this area and have continued to be actively involved since then. The study referenced a total of 79,935 sources, with the paper by Sung H et al., published in CA Cancer J Clin in 2021, achieving the highest citation rate of 42.46.This study systematically summarizes research findings on liver cancer with bone metastasis from 2004 to 2024, It also identifies and predicts global research hotspots and trends.
Keywords: Bibliometric, liver cancer, bone metastasis, molecular, resection
Received: 17 Mar 2025; Accepted: 25 Jun 2025.
Copyright: © 2025 Wei, Lan, Lan and Gu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ronghe Gu, First People's Hospital of Nanning, Nanning, Guangxi Zhuang Region, China
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