MINI REVIEW article
Front. Oncol.
Sec. Molecular and Cellular Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1595982
The Molecular Mechanism of Aerobic Exercise in miRNAs and The Anti-tumoral Effects
Provisionally accepted
- 1University of São Paulo, São Paulo, Brazil
- 2São Paulo State University, São Paulo, São Paulo, Brazil
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Consider modifying this statement to "This narrative review explores recent perspectives on the role of miRNAs in cancer, with particular emphasis on the potential link between moderate aerobic exercise, myomiRs, and the regulation of anti-tumoral immunity. Each of the discussed miRNAs is examined from two perspectives: their effects on both tumor cells and anti-tumoral immune responses, with the aim of evaluating the potential of exercise as a cancer treatment strategy. Thereby, the review addresses a gap in the current literature, where most studies have focused on only one of these aspects.
Keywords: Fabio Lira: Writing -original draft, Writing -review & editing. José Cesar Rosa Neto: Conceptualization, supervision, Writing -original draft, Writing -review & editing. Merve ÇULHA: Conceptualization, Writing -review & editing exercise-induced miRNAs, Cancer, aerobic exercise
Received: 19 Mar 2025; Accepted: 18 Jul 2025.
Copyright: © 2025 ÇULHA, Lira and Rosa Neto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: José Cesar Rosa Neto, University of São Paulo, São Paulo, Brazil
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.