REVIEW article
Front. Oncol.
Sec. Hematologic Malignancies
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1596947
Cancer associated fibroblasts in tumors: focusing on solid tumors and hematological malignancies
Provisionally accepted
- 1Department of Hematology, Affiliated Hospital of Guizhou Medical University, Guiyang, China
- 2Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China
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The co evolution of tumor cells and microenvironmental matrix components almost determines the series of processes involved in cancer occurrence and progression. However, many anti-cancer treatments are designed around tumor cells, neglecting the supportive role of stromal cells. Cancer-associated fibroblasts (CAFs), as the main stromal cells in tumor microenvironment, are currently considered as a key component promoting tumorigenesis, development, and regulating the transfer of tumor cells to distant locations through secretion of different growth factors, cytokines, chemokines, and the degradation of extracellular matrix. Therefore, the strategy of targeting both cancer cells and CAFs shows great potential in cancer treatment. In hematological malignancies, the role of CAFs in the progression of tumors has gradually been recently tapped. This review describes the role and functional characteristics of CAFs in tumors, mainly concentrates on the potential role of CAFs in the disease progression of hematological malignancies according to recent findings, and emphasizes the importance of CAFs as a key target involving 删除[睿熙]: focusing on 删除[睿熙]:to overcome tumor progression and improve treatment efficacy.
Keywords: Cancer associated fibroblasts, microenvironment, tumor progression, hematological malignancies, heterogeneity
Received: 20 Mar 2025; Accepted: 05 Jun 2025.
Copyright: © 2025 Pan, Zheng and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jishi Wang, Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou Province, China
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