SYSTEMATIC REVIEW article
Front. Oncol.
Sec. Cancer Cell Signaling
Global research trends in signaling pathways of spasmolytic polypeptide-expressing metaplasia pathogenesis: a bibliometric analysis
Provisionally accepted
Qiumiao Xu
Zhijiang DaiChengjin Peng
Qinghong YanXiaoting ChenTongwei Liu
Ran ZhangGuoxin HuangXinyao Liu
Jingbin Wang*- Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, China
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Background: Signaling pathways associated with spasmolytic polypeptide-expressing metaplasia (SPEM) pathogenesis play a critical role in disease development, particularly in gastric cancer precursor lesions. However, global research trends in signaling pathways in SPEM pathogenesis remain undetermined. This study aims to fill this gap by conducting a comprehensive bibliometric analysis to map the field, identify key insights, and guide future research directions. Methods: Articles and reviews were retrieved from the Web of Science Core Collection up to June 8 2025. Bibliometric analysis and knowledge mapping were conducted via CiteSpace and Vosviewer. Results: A total of 89 papers from 221 institutions, 719 authors, and 56 journals across 21 countries/regions were included. The number of publications is growing slowly. Gastroenterology led in publication and cocitation counts. The United States and China were at the top in terms of publication numbers. Goldenring JR emerged as the most co-cited and most published author. Key findings indicate limited collaboration despite a foundation of ten pivotal articles. Research elucidating gene-pathway interplay and cytokine roles in SPEM pathogenesis has consequently sharpened the focus on developing pharmacological agents that target these pathways, defining a pivotal new direction for combating gastric precancerous lesions. Conclusion: By systematically reviewing signaling pathways in SPEM pathogenesis, this study provides critical guidance for future research strategic planning and collaboration. It highlights the urgent need for strengthened interdisciplinary and global partnerships to drive progress.
Keywords: Bibliometrics, Citespace, Knowledge mapping, signaling pathway, spasmolytic polypeptide-expressing metaplasia, VOSviewer
Received: 20 Mar 2025; Accepted: 28 Nov 2025.
Copyright: © 2025 Xu, Dai, Peng, Yan, Chen, Liu, Zhang, Huang, Liu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jingbin Wang
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