CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1606850
-1 -Case report: Diagnosing and Treating Gallbladder Neuroendocrine Neoplasms through Comparative Analysis: A Case Series and Literature Review
Provisionally accepted
- 1Department of Hepatobiliary and Pancreatic Surgery, Shaoxing People's Hospital, Shaoxing, China
- 2School of Medicine, Graduate School, Zhejiang University, Hangzhou, Zhejiang Province, China
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Background: Gallbladder neuroendocrine neoplasms (GB-NENs) are exceedingly rare in clinical practice. To date, no large-scale, multicenter prospective studies have been conducted on this disease, resulting in a lack of established diagnostic and therapeutic experience or consensus. This case series reports seven GB-NEN patients who underwent different treatment modalities with varying outcomes. By integrating our institutional experience with previous literature, we aim to provide some therapeutic recommendations for GB-NEN patients. Methods: The clinicopathological data of seven GB-NEN patients treated at our institution between June 2013 and June 2024 were retrospectively analyzed, with a focus on their treatment courses. Results: Seven GB-NEN patients did not exhibite specific clinical manifestations or distinctive imaging features. All patients underwent surgical intervention, including radical resection in four cases. The overall survival ranged from 3 to 55 months, with a median survival of 19 months. Conclusion: GB-NENs are highly aggressive and associated with poor prognosis. We recommend: 1) Radical cholecystectomy as the primary treatment for resectable GB-NENs; 2) Platinum-based chemotherapy as the first-line regimen, with close monitoring for drug resistance; 3) Early assessment of chemosensitivity to guide further treatment decisions, postoperative chemotherapy combined with adjuvant therapies may improve surgical efficacy.
Keywords: Neuroendocrine neoplasms, neuroendocrine carcinoma, Gallbladder, Surgery, adjuvant therapy
Received: 06 Apr 2025; Accepted: 26 May 2025.
Copyright: © 2025 Zhang, Li, Dong and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Baochun Lu, Department of Hepatobiliary and Pancreatic Surgery, Shaoxing People's Hospital, Shaoxing, China
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